Title: 4 Stars Hotels in Cape Girardeau, Missouri - Find Cheap Cape Girardeau Hotels With 4 Stars | Expedia.ca [Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Skyy # 4 Stars Hotels in Cape Girardeau, Missouri ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cape Girardeau 4 Star Hotels Tonight [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-09-28&endDate=2025-09-29&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-09-29&endDate=2025-09-30&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cape Girardeau 4 Star Hotels ![Honeymoon Suite, 1 King Bed, Non Smoking, Courtyard View | View from room](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/3020a524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Suite, 1 King Bed, Non Smoking, Park View](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/5dbc606e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/7e984039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free self parking](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/47d3c772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Davie School Inn Anna 10/10 Exceptional (51) "One of the coolest and unique places we’ve stayed. It’s clean, quiet and the decor is perfect for this converted school. It felt like a slumber party in a classroom! " [](https://www.expedia.ca/Anna-Hotels-Davie-School-Inn.h33418130.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Cape-Girardeau-Hotels.s40-0-d820.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Cape-Girardeau-Hotels.s40-0-d820.Travel-Guide-Filter-Hotels) ## Learn more about Cape Girardeau Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets. [See all hotels in Cape Girardeau](https://www.expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13&adults=2®ionId=820) ![](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=899&h=675&p=1&q=high) Photo by Skyy ## Top Cape Girardeau Hotel Reviews ## Find out more about Cape Girardeau If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Cape Girardeau are calling your name. Known for providing first-rate service in amazing locations, each of the Cape Girardeau 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Cape Girardeau. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Cape Girardeau, Missouri, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Cape Girardeau hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Cape Girardeau? > To find a 4-star hotel in Cape Girardeau that fits your budget, use Expedia's filter tool. Browse the availability during your vacation dates and use our pricing filter to set your maximum rate. You can also sort your results by the most affordable retreat first. > > > > - Search for the lowest price ### What's the difference between 5-star and 4-star hotels in Cape Girardeau? > Offering a friendly guest experience and upmarket décor, 4-star hotels are a fabulous option for your Cape Girardeau trip. These types of accommodations generally feature loads of useful amenities that make it a breeze to kick back and relax — think pillowtop mattresses, restaurants and gyms. Or enjoy even more lavishness at a 5-star hotel designed to pamper with exclusive perks and amenities. On-site health clubs, premium toiletries and world-class dining are typically included at these swanky retreats. ### Does Cape Girardeau have any 4-star all-inclusive resorts? > Finding your dream vacation in Cape Girardeau is as easy as entering your dates and destination, and clicking on our "All inclusive" filter. Stay and play where everything is already taken care of like your room, meals and activities, or opt for a standard 4-star resort in or around this sought-after destination. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [1 Star Hotels in Mackenzie](https://www.expedia.ca/1Star-Mackenzie-St-Louis-Hotels.s10-n553248634983448776-0.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Maryland Heights](https://www.expedia.ca/1Star-Maryland-Heights-Hotels.s10-0-d7347.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Ladue](https://www.expedia.ca/2Star-Ladue-St-Louis-Hotels.s20-n3000445131-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Breckenridge Hills](https://www.expedia.ca/5Star-Breckenridge-Hills-St-Louis-Hotels.s50-n553248634983537520-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Carondelet](https://www.expedia.ca/5Star-Carondelet-St-Louis-Hotels.s50-n553248635975855333-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Herculaneum](https://www.expedia.ca/5Star-Herculaneum-Hotels.s50-0-d3000349395.Travel-Guide-Filter-Hotels) - 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