Find hotels in San Diego Santa Fe Depot, CA from CA $104

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for San Diego Santa Fe Depot hotels

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
8.0 out of 10, Very good, (1,034 reviews)
"Great place to stay"
United States
Kimberly
The price is CA $152
CA $176 total
includes taxes & fees
May 10 - May 11
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.4 out of 10, Very good, (3,445 reviews)
"Nice hotel with great location "
United States
DIANA
The price is CA $204
CA $304 total
includes taxes & fees
May 10 - May 11
Sheraton San Diego Resort

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
Point Loma
7.4 out of 10, Good, (4,225 reviews)
"great place"
Canada
souheil
The price is CA $136
CA $156 total
includes taxes & fees
Apr 12 - Apr 13
Wyndham Garden San Diego Near SeaWorld

Westgate Hotel

Westgate Hotel
4.5 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1,008 reviews)
"Beautiful place "
United States
jamie
The price is CA $175
CA $251 total
includes taxes & fees
May 10 - May 11
Westgate Hotel

Bahia Resort Hotel

Bahia Resort Hotel
3.5 star property
Central Mission Beach
8.6 out of 10, Excellent, (1,967 reviews)
"We stay here a few times a year normally and love the location. "
United States
Lindsay
The price is CA $220
CA $330 total
includes taxes & fees
May 10 - May 11
Bahia Resort Hotel

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
Downtown San Diego
8.4 out of 10, Very good, (6,127 reviews)
"Clean room and great location "
United States
Evanthia
The price is CA $211
CA $292 total
includes taxes & fees
May 10 - May 11
Wyndham San Diego Bayside

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
Mission Hills
9.2 out of 10, Wonderful, (1,063 reviews)
"Clean room, friendly staff, and only a 15 minute walk to Old Town. Also conveniently located close to the airport just a short shuttle drive away. "
United States
Olivia
The price is CA $195
CA $224 total
includes taxes & fees
Apr 26 - Apr 27
Holiday Inn Express San Diego Airport - Old Town by IHG

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego
8.8 out of 10, Excellent, (1,397 reviews)
"Love this place, every detail was incredible. "
United States
Gerald
The price is CA $201
CA $231 total
includes taxes & fees
Apr 26 - Apr 27
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hotel Narcissus

Hotel Narcissus
2.0 star property
Logan Heights
9.8 out of 10, Exceptional, (9 reviews)
"Great time staying at narcissus would definitely be back!"
United States
Natalie
The price is CA $101
CA $253 total
includes taxes & fees
Apr 22 - Apr 23
Hotel Narcissus

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park
8.2 out of 10, Very good, (339 reviews)
"Nice staff and good breakfast."
United States
Carol
The price is CA $145
CA $167 total
includes taxes & fees
May 4 - May 5
Best Western San Diego Pacific Beach/Mission Bay

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2,081 reviews)
"good atmosphere, good staff, friendly staff, good food, pool is amazing, restaurants are affordable and excellent."
United States
Artsrun
The price is CA $331
CA $449 total
includes taxes & fees
May 1 - May 2
Marriott Marquis San Diego Marina

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego
8.4 out of 10, Very good, (1,948 reviews)
"Always a nice stay....staff is really friendly..."
United States
Jose R Espinoza
The price is CA $186
CA $213 total
includes taxes & fees
Apr 26 - Apr 27
Best Western Plus Hacienda Hotel Old Town

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1,392 reviews)
"The restaurant on site was delicious "
United States
Blanca
The price is CA $242
CA $351 total
includes taxes & fees
May 10 - May 11
San Diego Mission Bay Resort

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (3,667 reviews)
"The Waffle Spot is absolutely fantastic, great dining on site."
United States
Joshua
The price is CA $131
CA $151 total
includes taxes & fees
Apr 27 - Apr 28
Kings Inn San Diego

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.2 out of 10, Wonderful, (1,571 reviews)
"Everything about that stay was perfect"
United States
Victoria
The price is CA $345
CA $396 total
includes taxes & fees
Apr 16 - Apr 17
Lafayette Hotel & Club

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (2,024 reviews)
"The pool was nice, the bar and food wonderful."
United States
Darlene
The price is CA $282
CA $395 total
includes taxes & fees
May 10 - May 11
Hilton San Diego Bayfront

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
Point Loma
9.2 out of 10, Wonderful, (3,532 reviews)
"Really nice hotel, and the location is beautiful. "
United States
Gloire
The price is CA $228
CA $262 total
includes taxes & fees
Apr 27 - Apr 28
Bay Club Hotel & Marina

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
San Diego
9.2 out of 10, Wonderful, (1,713 reviews)
"Great location for the airport stay"
United States
Christopher
The price is CA $230
CA $265 total
includes taxes & fees
Apr 26 - Apr 27
Hampton Inn & Suites San Diego Airport Liberty Station

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (1,340 reviews)
"Was a great hotel. Great area right by all the recreational areas would recommend"
United States
Ernesto
The price is CA $187
CA $217 total
includes taxes & fees
Apr 27 - Apr 28
The DEXTRO Little Italy, BW Premier Collection

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
Point Loma
8.6 out of 10, Excellent, (3,567 reviews)
"Breakfast buffet was exceptional."
United States
Catherine
The price is CA $147
CA $169 total
includes taxes & fees
May 10 - May 11
Comfort Inn Sea World Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in San Diego Santa Fe Depot

Save an average of 15% on thousands of hotels when you're signed in

Top San Diego Santa Fe Depot Hotel Reviews

Recent Reviews in San Diego Santa Fe Depot

More cheap stays in San Diego Santa Fe Depot

Frequently asked questions

What's the area like around San Diego Santa Fe Depot?
San Diego Santa Fe Depot is located in a scenic area of San Diego known for its array of dining options and popular zoo. If you're looking for a convenient place to stay, check out the 887 hotels and other accommodations located within a mile of the station.
What's the best hotel to stay close to San Diego Santa Fe Depot?
Adjacent to San Diego Santa Fe Depot, Wyndham San Diego Bayside is one of the top choices for your stay based on our traveler data, and this hotel offers 3 restaurants and an outdoor pool. Other good options close by include Hard Rock Hotel San Diego and The DEXTRO Little Italy, BW Premier Collection.
How many hotels will I find close to San Diego Santa Fe Depot?
Expedia has 887 hotels and other accommodations within a mile from the station.
What can I see and do near San Diego Santa Fe Depot?
Study the collections at USS Midway Museum, Maritime Museum of San Diego, or San Diego Air and Space Museum. Hotel del Coronado, Star of India, and Our Lady of the Rosary Catholic Church are monuments to see when you're exploring the area around San Diego Santa Fe Depot. You can watch performances at San Diego Civic Theatre, The Rady Shell at Jacobs Park, and Humphreys Concerts by the Bay if you're interested in local theater.

Explore a world of travel with Expedia