Title: Book The Best Hotels in East Prairie, MO for 2026 from CA $88 - Fully Refundable Options - Expedia.ca

[Vacation Rentals in East Prairie](https://expedia.ca/East-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[East Prairie Car Rentals](https://expedia.ca/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.ca/East-Prairie.d3000349349.Destination-Travel-Guides)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Sign in to save 10% or more on thousands of hotels  
[Sign in](https://www.expedia.ca/login)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Go beyond your typical stay in East Prairie

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-08&d1=2026-04-08&endDate=2026-04-10&d2=2026-04-10&travelerType=family_friendly)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-08&d1=2026-04-08&endDate=2026-04-10&d2=2026-04-10&amenities=POOL)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-08&d1=2026-04-08&endDate=2026-04-10&d2=2026-04-10&amenities=PETS)

## Check prices for these dates

Tonight

[Mar 25 - Mar 26](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-03-25&endDate=2026-03-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 26 - Mar 27](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-03-26&endDate=2026-03-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for East Prairie hotels

![Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/ef46b494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 By Wyndham Marston

[](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

Marston

8.2/10

Very good

(53 reviews)

"Room was clean and fairly priced. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mickey

CA $89

CA $102 total

includes taxes & fees

Apr 3 - Apr 4

[](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7bc13d14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/3fa32ded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/d5184d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7397c7ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Hearth Inn & Suites Union City

[](https://www.expedia.ca/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information)

Union City

8.6/10

Excellent

(556 reviews)

"Very clean nice staff and well run "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

zach

CA $87

CA $103 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,000 reviews)

"Very nice for overnight stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

CA $129

CA $149 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/7fdae22d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d0a59214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverstone Hotel Charleston-Sikeston

[](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

Charleston

6.8/10

(409 reviews)

"Clean "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chris

CA $79

CA $88 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/55808580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/e89ec295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/54eabc09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sleep Inn at Discovery Park of America

[](https://www.expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

Union City

9.2/10

Wonderful

(368 reviews)

"Great stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

CA $104

CA $124 total

includes taxes & fees

Apr 5 - Apr 6

[](https://www.expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

Sikeston

9.4/10

Exceptional

(64 reviews)

"Nice quiet hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

CA $139

CA $157 total

includes taxes & fees

Apr 5 - Apr 6

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/594efec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

Sikeston

8.4/10

Very good

(754 reviews)

"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

CA $90

CA $103 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(513 reviews)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

grant

CA $134

CA $151 total

includes taxes & fees

Apr 2 - Apr 3

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/c1609da5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/ba65d6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/97ce04e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/643f6c59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Union City US 51

[](https://www.expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

Union City

8.4/10

Very good

(500 reviews)

"All was pretty good except for the breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeffrey

CA $93

CA $111 total

includes taxes & fees

Apr 19 - Apr 20

[](https://www.expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/45782657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Handicap Room](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/6128b6d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/60633b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Reelfoot Lake Inn

[](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

Tiptonville

7.2/10

Good

(475 reviews)

"Everything great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jayla

CA $94

CA $108 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

![Premier Room, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 Bedroom, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### New Orleans Inn Portageville 

[](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

Portageville

8.0/10

Very good

(753 reviews)

"The staff was great very helpful and friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Javier

[](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

Charleston

6.8/10

(626 reviews)

"Affordable for a quick one night stay. Restaurant and gas station next to hotel."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Annette

CA $85

CA $95 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/327b8d22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston I-55

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

Sikeston

8.4/10

Very good

(1,001 reviews)

"nice and covenant have stay here a few times, staff always has a smile. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roger

CA $127

CA $145 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

Sikeston

8.6/10

Excellent

(450 reviews)

"Stay was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kourtney

CA $128

CA $145 total

includes taxes & fees

Apr 12 - Apr 13

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/fcfb42b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-c8905780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Sikeston

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

Sikeston

9.2/10

Wonderful

(15 reviews)

"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jason

CA $157

CA $177 total

includes taxes & fees

Apr 5 - Apr 6

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/3d86dbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn and Suites by Wyndham Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

Sikeston

7.2/10

Good

(1,000 reviews)

"Business friendly, clean room staff very friendly, accommodating."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janice

CA $94

CA $107 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/74187a0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/96f1c1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Cairo

6.6/10

(282 reviews)

"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maurice

CA $105

CA $117 total

includes taxes & fees

Mar 27 - Mar 28

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f7d6d20c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/2c1de1a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible (Hearing)](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f54017fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/4fbaaf96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Union City

[](https://www.expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

Union City

9.6/10

Exceptional

(175 reviews)

"Spotless , friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gail

CA $179

CA $212 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/8720ff7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eagle Inn Charleston

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

Charleston

6.6/10

(105 reviews)

"The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Britani

CA $88

CA $97 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/5bb06af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast area](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/f23217d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/6099e00f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/8abdb757.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn

[](https://www.expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information)

Marston

6.0/10

(119 reviews)

"Had a great time loved it "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shyianne

CA $76

CA $86 total

includes taxes & fees

Mar 27 - Mar 28

[](https://www.expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-08&endDate=2026-04-09&regionId=3000349349&adults=2&sort=RECOMMENDED&openPlayBack=true)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[

Sign up, it's free

](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)

## Stay near popular East Prairie attractions

### Big Oak Tree State Park

3.8/5 (8 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655754)

## Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

[See all hotels in East Prairie](https://www.expedia.ca/Hotel-Search?startDate=2026-04-08&endDate=2026-04-09&adults=2&regionId=3000349349)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=395&h=400&p=1&q=high)

## Top East Prairie Hotel Reviews

## Recent Reviews in East Prairie

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

2/10 Terrible

"There were roaches crawling up the wall when we went in and the outside was horrible! Looked like a vacant building!! I want my money back"

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

8/10 Good

"Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean rooms, friendly staff and convenient location."

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston I-55

10/10 Excellent

"Breakfast selection was fresh but not overwhelming in quality."

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Staff was amazing so friendly and welcoming. Room was very clean! "

[](https://expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Very nice and helpful staff "

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231_y.jpg)

### Reelfoot Lake Inn

6/10 Okay

"No stores close by . the room had a musty smell. In need of upgrade. "

[](https://expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

![Country Yard Inn and Suite](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a_y.jpg)

### Country Yard Inn and Suite

10/10 Excellent

"Very good location and very good price besides the staff was very friendly "

[](https://expedia.ca/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information)

## More cheap stays in East Prairie

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

CA $90

CA $103 total

Mar 26 - Mar 27

includes taxes & fees

8.4/10 Very Good! (754 reviews)

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $94

CA $107 total

Mar 29 - Mar 30

includes taxes & fees

7.2/10 Good! (1,000 reviews)

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

CA $104

CA $124 total

Apr 5 - Apr 6

includes taxes & fees

9.2/10 Wonderful! (368 reviews)

[](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

CA $128

CA $145 total

Apr 12 - Apr 13

includes taxes & fees

8.6/10 Excellent! (450 reviews)

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

CA $127

CA $145 total

Mar 29 - Mar 30

includes taxes & fees

8.4/10 Very Good! (1,001 reviews)

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

CA $134

CA $151 total

Apr 2 - Apr 3

includes taxes & fees

9/10 Wonderful! (513 reviews)

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

## Hotels in East Prairie with star rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

5 properties

[](https://expedia.ca/3Star-East-Prairie-Hotels.s30-0-d3000349349.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

28 properties

[](https://expedia.ca/2Star-East-Prairie-Hotels.s20-0-d3000349349.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### What is the best area to stay in East Prairie?

> This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.
> 
>   
> For travellers looking for a straightforward and practical base, staying near Main Street is ideal.

### When is the best time to go to East Prairie?

> These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.
> 
>   
> For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a East Prairie hotel booking with Expedia?

### How much is the nightly rate at a East Prairie hotel?

## Explore a world of travel with Expedia

- Lodging
- Flights
- Cars
- More ways to book

- [Advance Hotels ](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels)
- [Apartments in Baker ](https://www.expedia.ca/Baker-Apartments.d553248634983252914-aaApartments.Travel-Guide-Accommodation)
- [Apartments in Bell City ](https://www.expedia.ca/Bell-City-Apartments.d553248634983588961-aaApartments.Travel-Guide-Accommodation)
- [Cheap Hotels in Benton ](https://www.expedia.ca/Benton-Hotels-Cheap-Hotels.0-0-d553248634983369680-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Benton ](https://www.expedia.ca/Benton-Hotels-Luxury-Hotel.0-0-d553248634983369680-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Benton Hotels ](https://www.expedia.ca/Benton-Hotels.d553248634983369680.Travel-Guide-Hotels)
- [Bernie Hotels ](https://www.expedia.ca/Bernie-Hotels.d3000349284.Travel-Guide-Hotels)
- [Cheap Hotels in Bertrand ](https://www.expedia.ca/Bertrand-Hotels-Cheap-Hotels.0-0-d3000349285-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in Bertrand ](https://www.expedia.ca/Bertrand-Hotels-Hotel-With-Pool.0-0-d3000349285-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Bertrand Hotels ](https://www.expedia.ca/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels)
- [Motels in Bertrand ](https://www.expedia.ca/Bertrand-Motels.d3000349285-aaMotels.Travel-Guide-Accommodation)
- [Blodgett Hotels ](https://www.expedia.ca/Blodgett-Hotels.d3000349291.Travel-Guide-Hotels)
- [Apartments in Bloomfield ](https://www.expedia.ca/Bloomfield-Apartments.d6351829-aaApartments.Travel-Guide-Accommodation)
- [Bloomfield Hotels ](https://www.expedia.ca/Bloomfield-Hotels.d6351829.Travel-Guide-Hotels)
- [Resorts in Bloomfield ](https://www.expedia.ca/Bloomfield-Resort-Hotels.d6351829-aaResortHotels.Travel-Guide-Accommodation)
- [Apartments in Canalou ](https://www.expedia.ca/Canalou-Apartments.d3000349311-aaApartments.Travel-Guide-Accommodation)
- [Canalou Hotels ](https://www.expedia.ca/Canalou-Hotels.d3000349311.Travel-Guide-Hotels)
- [Cape Girardeau Hotels ](https://www.expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)
- [Catron Hotels ](https://www.expedia.ca/Catron-Hotels.d3000349317.Travel-Guide-Hotels)
- [Rv Parks in Chaffee ](https://www.expedia.ca/Chaffee-RV-Parks.d553248634983269107-aaRVParks.Travel-Guide-Accommodation)
- [B&B in Charleston ](https://www.expedia.ca/Charleston-Bed-And-Breakfast.d7182-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Cheap Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Cheap-Hotels.0-0-d7182-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Golf Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Golf-Hotel.0-0-d7182-tGolfHotel.Travel-Guide-Filter-Hotels)
- [Historic Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Historic-Hotel.0-0-d7182-tHistoricHotel.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in Charleston ](https://www.expedia.ca/Charleston-Hotels-Hotel-With-Pool.0-0-d7182-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Hotels with Free Breakfast in Charleston ](https://www.expedia.ca/Charleston-Hotels-Hotels-With-Free-Breakfast.0-0-d7182-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels)
- [Hotels with Free Parking in Charleston ](https://www.expedia.ca/Charleston-Hotels-Hotels-With-Free-Parking.0-0-d7182-tHotelswithFreeParking.Travel-Guide-Filter-Hotels)
- [Hotels with smoking rooms in Charleston ](https://www.expedia.ca/Charleston-Hotels-Hotels-With-Smoking-Rooms.0-0-d7182-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Pet-Friendly-Hotel.0-0-d7182-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Romantic Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Romantic-Hotel.0-0-d7182-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Spa Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Spa-Hotel.0-0-d7182-tSpaHotel.Travel-Guide-Filter-Hotels)
- [Charleston Hotels ](https://www.expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels)
- [Lodges in Charleston ](https://www.expedia.ca/Charleston-Lodges.d7182-aaLodges.Travel-Guide-Accommodation)
- [Resorts in Charleston ](https://www.expedia.ca/Charleston-Resort-Hotels.d7182-aaResortHotels.Travel-Guide-Accommodation)
- [Cabin Rentals in Commerce ](https://www.expedia.ca/Commerce-Cabins.d553248634983177483-aaCabins.Travel-Guide-Accommodation)
- [Mississippi County Hotels ](https://www.expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)
- [Apartments in Dexter ](https://www.expedia.ca/Dexter-Apartments.d55097-aaApartments.Travel-Guide-Accommodation)
- [Beach Hotel Hotels in Dexter ](https://www.expedia.ca/Dexter-Hotels-Beach-Hotel.0-0-d55097-tBeachHotel.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Dexter ](https://www.expedia.ca/Dexter-Hotels-Cheap-Hotels.0-0-d55097-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in Dexter ](https://www.expedia.ca/Dexter-Hotels-Hotel-With-Pool.0-0-d55097-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Hotels with Free Breakfast in Dexter ](https://www.expedia.ca/Dexter-Hotels-Hotels-With-Free-Breakfast.0-0-d55097-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Dexter ](https://www.expedia.ca/Dexter-Hotels-Pet-Friendly-Hotel.0-0-d55097-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Dexter Hotels ](https://www.expedia.ca/Dexter-Hotels.d55097.Travel-Guide-Hotels)
- [Motels in Dexter ](https://www.expedia.ca/Dexter-Motels.d55097-aaMotels.Travel-Guide-Accommodation)
- [Resorts in Dexter ](https://www.expedia.ca/Dexter-Resort-Hotels.d55097-aaResortHotels.Travel-Guide-Accommodation)
- [Hotels near eDen Spa & Salon ](https://www.expedia.ca/EDen-Spa-Salon-Hotels.0-l553248621532655776-0.Travel-Guide-Filter-Hotels)
- [Essex Hotels ](https://www.expedia.ca/Essex-Hotels.d553248634983169000.Travel-Guide-Hotels)
- [Gideon Hotels ](https://www.expedia.ca/Gideon-Hotels.d3000349377.Travel-Guide-Hotels)
- [Howardville Hotels ](https://www.expedia.ca/Howardville-Hotels.d553248634983363505.Travel-Guide-Hotels)
- [Hotels near Isle Casino Cape Girardeau ](https://www.expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels)
- [B&B in Kelso ](https://www.expedia.ca/Kelso-Bed-And-Breakfast.d553248634983171130-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Malden Hotels ](https://www.expedia.ca/Malden-Hotels.d8702.Travel-Guide-Hotels)
- [Hotels near Malden Regional ](https://www.expedia.ca/Malden-Regional-Airport-Hotels.0-aMAW-0.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Marston ](https://www.expedia.ca/Marston-Hotels-Cheap-Hotels.0-0-d55824-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Marston Hotels ](https://www.expedia.ca/Marston-Hotels.d55824.Travel-Guide-Hotels)
- [Lodges in Marston ](https://www.expedia.ca/Marston-Lodges.d55824-aaLodges.Travel-Guide-Accommodation)
- [Matthews Hotels ](https://www.expedia.ca/Matthews-Hotels.d553248634983428760.Travel-Guide-Hotels)
- [Lodges in Matthews ](https://www.expedia.ca/Matthews-Lodges.d553248634983428760-aaLodges.Travel-Guide-Accommodation)
- [Hotels with smoking rooms in Miner ](https://www.expedia.ca/Miner-Hotels-Hotels-With-Smoking-Rooms.0-0-d553248634983441802-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Miner ](https://www.expedia.ca/Miner-Hotels-Luxury-Hotel.0-0-d553248634983441802-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Miner Hotels ](https://www.expedia.ca/Miner-Hotels.d553248634983441802.Travel-Guide-Hotels)
- [Lodges in Miner ](https://www.expedia.ca/Miner-Lodges.d553248634983441802-aaLodges.Travel-Guide-Accommodation)
- [Apartments in Morehouse ](https://www.expedia.ca/Morehouse-Apartments.d553248634983462037-aaApartments.Travel-Guide-Accommodation)
- [Morehouse Hotels ](https://www.expedia.ca/Morehouse-Hotels.d553248634983462037.Travel-Guide-Hotels)
- [Cheap Hotels in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Cheap-Hotels.0-0-d3000445315-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Hotel-With-Pool.0-0-d3000445315-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Luxury-Hotel.0-0-d3000445315-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [New Madrid Hotels ](https://www.expedia.ca/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels)
- [B&B in Oran ](https://www.expedia.ca/Oran-Bed-And-Breakfast.d3000445386-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Hotels with a Pool in Oran ](https://www.expedia.ca/Oran-Hotels-Hotel-With-Pool.0-0-d3000445386-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Oran ](https://www.expedia.ca/Oran-Hotels-Luxury-Hotel.0-0-d3000445386-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Oran Hotels ](https://www.expedia.ca/Oran-Hotels.d3000445386.Travel-Guide-Hotels)
- [Inns in Oran ](https://www.expedia.ca/Oran-Inns.d3000445386-aaInns.Travel-Guide-Accommodation)
- [Cheap Hotels in Parma ](https://www.expedia.ca/Parma-Hotels-Cheap-Hotels.0-0-d553248634983328909-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Portageville ](https://www.expedia.ca/Portageville-Hotels-Cheap-Hotels.0-0-d183487-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Portageville Hotels ](https://www.expedia.ca/Portageville-Hotels.d183487.Travel-Guide-Hotels)
- [Lodges in Portageville ](https://www.expedia.ca/Portageville-Lodges.d183487-aaLodges.Travel-Guide-Accommodation)
- [Risco Hotels ](https://www.expedia.ca/Risco-Hotels.d3000349516.Travel-Guide-Hotels)
- [Cheap Hotels in Scott City ](https://www.expedia.ca/Scott-City-Hotels-Cheap-Hotels.0-0-d553248634983544376-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Scott City Hotels ](https://www.expedia.ca/Scott-City-Hotels.d553248634983544376.Travel-Guide-Hotels)
- [Apartments in Sikeston ](https://www.expedia.ca/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation)
- [Cheap Hotels in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Cheap-Hotels.0-0-d6058766-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with Kitchenettes in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Hotels-With-Kitchenettes.0-0-d6058766-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Pet-Friendly-Hotel.0-0-d6058766-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Sikeston Hotels ](https://www.expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)
- [Wilson City Hotels ](https://www.expedia.ca/Wilson-City-Hotels.d553248634983391595.Travel-Guide-Hotels)

- [Flights to Dexter ](https://www.expedia.ca/Cheap-Flights-To-Dexter.d55097.Travel-Guide-Flights)
- [Flights from Risco ](https://www.expedia.ca/lp/flights/3000349516/flights-from-risco)
- [Flights from Commerce ](https://www.expedia.ca/lp/flights/553248634983177483/flights-from-commerce)
- [Flights from Chaffee ](https://www.expedia.ca/lp/flights/553248634983269107/flights-from-chaffee)
- [Flights from Scott City ](https://www.expedia.ca/lp/flights/553248634983544376/flights-from-scott-city)
- [Flights from Detroit (DTW) to Sikeston (SIK) ](https://www.expedia.ca/lp/flights/dtw/sik/detroit-to-sikeston)
- [Flights from Edmonton (YEG) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yeg/cgi/edmonton-to-cape-girardeau)
- [Flights from Montreal (YUL) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yul/cgi/montreal-to-cape-girardeau)
- [Flights from Calgary (YYC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yyc/cgi/calgary-to-cape-girardeau)
- [Flights from Toronto (YYZ) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yyz/cgi/toronto-to-cape-girardeau)

- [Avis Rental Cars in Sikeston ](https://www.expedia.ca/Avis-Car-Rentals-In-Sikeston.d6058766-c41.Car-Rental-Guide-Suppliers)
- [Car rental Sikeston ](https://www.expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)
- [Hertz Rental Cars in Sikeston ](https://www.expedia.ca/Hertz-Car-Rentals-In-Sikeston.d6058766-c40.Car-Rental-Guide-Suppliers)
- [National Car Rental Rental Cars in Sikeston ](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Sikeston.d6058766-c42.Car-Rental-Guide-Suppliers)

- [Book Hotels in East Prairie on Expedia.com ](https://www.expedia.com/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app