Find hotels in East Prairie, MO from CA $85
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in East Prairie
Family friendly
Apartment
Pet friendly
Waterpark
Condo
Check prices for these dates
Tonight
Aug 9 - Aug 10Tomorrow
Aug 10 - Aug 11Next weekend
Aug 14 - Aug 16In two weeks
Aug 21 - Aug 23Our top choices for East Prairie hotels
1. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Sally
CA $155
CA $178 total
includes taxes & fees
Aug 14 - Aug 15
2. Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MOCharleston
France
CA $77
CA $85 total
includes taxes & fees
Sep 9 - Sep 10
3. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
michael
CA $135
CA $153 total
includes taxes & fees
Aug 23 - Aug 24
4. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
Sharika West
CA $98
CA $112 total
includes taxes & fees
Aug 18 - Aug 19
5. Hampton Inn Sikeston
Hampton Inn SikestonSikeston
Brandi
CA $137
CA $155 total
includes taxes & fees
Aug 27 - Aug 28
6. Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
Kevin
CA $133
CA $151 total
includes taxes & fees
Aug 16 - Aug 17
7. The Riverstone Hotel Charleston-Sikeston
The Riverstone Hotel Charleston-SikestonCharleston
Bobby
CA $93
CA $103 total
includes taxes & fees
Sep 7 - Sep 8
8. Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55Sikeston
Starlette
CA $130
CA $148 total
includes taxes & fees
Aug 29 - Aug 30
9. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Dwain
CA $153
CA $174 total
includes taxes & fees
Aug 16 - Aug 17
10. Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham SikestonSikeston
Robert S
CA $89
CA $101 total
includes taxes & fees
Sep 3 - Sep 4
11. TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott SikestonSikeston
Jason
CA $152
CA $172 total
includes taxes & fees
Aug 16 - Aug 17
12. Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner AreaSikeston
James
CA $92
CA $104 total
includes taxes & fees
Aug 16 - Aug 17
13. Country Yard Inn and Suite
Country Yard Inn and SuiteSikeston
William
CA $78
CA $92 total
includes taxes & fees
Sep 8 - Sep 9
14. Eagle Inn Charleston
Eagle Inn CharlestonCharleston
Jackson
CA $97
CA $107 total
includes taxes & fees
Aug 10 - Aug 11
15. Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
Temera
CA $103
CA $117 total
includes taxes & fees
Aug 11 - Aug 12
16. Quality Inn Cairo I-57
Quality Inn Cairo I-57Cairo
Sharon
CA $100
CA $111 total
includes taxes & fees
Aug 15 - Aug 16
17. Travel Inn Marston I-55 by Hotel O
Travel Inn Marston I-55 by Hotel OMarston
Frank
CA $82
CA $102 total
includes taxes & fees
Aug 11 - Aug 12
18. Country Hearth Inn & Suites Union City
Country Hearth Inn & Suites Union CityUnion City
Jade
CA $79
CA $94 total
includes taxes & fees
Aug 22 - Aug 23
19. Sleep Inn at Discovery Park of America
Sleep Inn at Discovery Park of AmericaUnion City
Ben
CA $110
CA $131 total
includes taxes & fees
Aug 30 - Aug 31
20. Hospitality House Union City I 69 / US 51
Hospitality House Union City I 69 / US 51Union City
Richard
CA $79
CA $94 total
includes taxes & fees
Aug 11 - Aug 12
Stay near popular East Prairie attractions
Big Oak Tree State Park
8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
Learn more about East Prairie
Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.
See all hotels in East Prairie
Top East Prairie Hotel Reviews
Best Western Plus Sikeston I-55
10/10 Excellent
"Front desk was super helpful"
Holiday Inn Express & Suites Sikeston Southwest by IHG
8/10 Good
"Staff was super nice, giving us more than plenty towels upon request as I mentioned reviews found the suite was only equipped with towels for 2. A convenient and cozy place to stay for a night. Adequate hot breakfast. Gym is small with only bikes, treadmills and weights. The A/C on the wall in the gym was dripping hard. Our room was near the elevator and the wall seemed to be as thin as cardboard as I could hear every sound throughout the night. Bed mattress too soft for me."
Days Inn and Suites by Wyndham Sikeston
10/10 Excellent
"Was a very clean, quiet place to stay. My only complaint was the breakfast was disappointing. They only offered cereal or waffles. Being diabetic I couldn't have either 😥. Yogurt, fruit, eggs/bacon/sausage would be good options. The staff was very nice and helpful."
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
10/10 Excellent
"The property served its purpose for rest and cleanup at the last minute during my travels and the front desk clerk was nice and helpful."
Super 8 by Wyndham Sikeston/Miner Area
8/10 Good
"The room was clean and comfortable and properly updated. It's the best Super 8. I've stayed in a long time with nice new clean carpets everywhere and the hallway and the lobby. The only thing lacking was a mediocre breakfast."
Comfort Inn & Suites Sikeston I-55
8/10 Good
"Convenient to the interstate. Close to food selection. Nice breakfast bar. Overall well maintained."
Holiday Inn Express & Suites Union City by IHG
8/10 Good
"Nice, clean and great amenities. Very good breakfast. Very nice place to stay."
Duck Hunting, Fishing or Relaxing Family Vacation
8/10 Good
"We booked this for a quiet getaway. Everything was exactly as described and more. The kitchen was fully stocked with everything we needed except the groceries. We loved the dock, my husband even caught a few catfish. We only stayed 3 nights but will definitely be coming back for a longer stay."
The Riverstone Hotel Charleston-Sikeston
10/10 Excellent
"Definitely be back and will recommend to my family and friends"
More cheap stays in East Prairie
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
CA $89
CA $101 total
Sep 3 - Sep 4
includes taxes & fees
7.2/10 Good! (1,014 reviews)
Sleep Inn at Discovery Park of America
1111 BLue Heron Lane Union City TN
CA $110
CA $131 total
Aug 30 - Aug 31
includes taxes & fees
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
CA $133
CA $151 total
Aug 16 - Aug 17
includes taxes & fees
8.4/10 Very good! (1,005 reviews)
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
CA $135
CA $153 total
Aug 23 - Aug 24
includes taxes & fees
8.8/10 Excellent! (494 reviews)
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
CA $137
CA $155 total
Aug 27 - Aug 28
includes taxes & fees
Holiday Inn Express & Suites Union City by IHG
810 BREAM BOULEVARD Union City TN
CA $144
CA $170 total
Sep 6 - Sep 7
includes taxes & fees
9.4/10 Exceptional! (343 reviews)
Hotels in East Prairie with star rating
3 Star Hotels
6 properties
2 Star Hotels
25 properties
Frequently asked questions
Explore a world of travel with Expedia
- Cheap Hotels in Benton
- Rv Parks in Cape Girardeau
- Farmstay in Oak Ridge
- Lodges in Campbell
- Scott City Hotels
- Home Sweet Home
- Adults Only Resorts & in Cape Girardeau
- Relax in the country at Countryside Villas!
- Country Yard Inn and Suite
- Cabin Rentals in Allenville
- Hampton Inn Cape Girardeau I 55 East
- Houseboats in Wappapello
- Poplar Bluff Hotels
- Dexter Inn
- Oyo Hickory House Inn
- Cheap Hotels in Parma
- Advance Hotels
- Rv Parks in Haywood City
- Villas in Poplar Bluff
- Cheap Hotels in Cape Girardeau
- Holiday Inn Express Hotel & Suites Cape Girardeau I
- Jackson Hotels
- Pet-Friendly Hotels in Jackson
- Drury Plaza Hotel Cape Girardeau Conference Center
- Morehouse Hotels
- Comfort Inn & Suites Sikeston I
- Caruthersville Hotels
- Portageville Hotels
- Essex Hotels
- “Brickyard”
- Spa Hotels in Cape Girardeau
- Travel Inn & Suites
- Holiday Inn Express & Suites Sikeston Southwest by IHG
- Best Western Hotels in Charleston
- Town House Inn
- Rv Parks in Chaffee
- Hampton Inn Poplar Bluff
- Courtyard by Marriott Cape Girardeau Downtown
- Bullwinkles Rustic Lodge
- Cottages in Pocahontas
- Charleston Hotels
- Cheap Hotels in Portageville
- New Madrid Hotels
- Casino Hotels in Cape Girardeau
- Candlewood Suites Cape Girardeau by IHG
- Little Blue Cottage on Spanish
- Holiday Inn Poplar Bluff by IHG
- New Orleans Inn Portageville
- Dexter Hotels
- Hotels with Free Airport Shuttle in Cape Girardeau
- Flights from Grand Island (GRI) to Cape Girardeau (CGI)
- Flights from New York (JFK) to Cape Girardeau (CGI)
- Flights from Toronto (YTO) to Cape Girardeau (CGI)
- Flights from Eugene (EUG) to Cape Girardeau (CGI)
- Flights from Ocala (OCF) to Cape Girardeau (CGI)
- Flights to Butler County
- Flights from St. Louis (STL) to Poplar Bluff (POF)
- Flights from Edmonton (YEG) to Cape Girardeau (CGI)
- Flights from Chaffee
- Flights to Poplar Bluff
- Flights from Colombo (CMB) to Cape Girardeau (CGI)
- Flights to Dexter
- Flights from Stuart (SUA) to Cape Girardeau (CGI)
- Flights to Cape Girardeau
- Flights from Scott City
- Flights from Montreal (YUL) to Cape Girardeau (CGI)
- Flights from Toronto (YYZ) to Cape Girardeau (CGI)
- Flights from Kelso
- Flights from Bloomington (BMI) to Cape Girardeau (CGI)
- Flights to Caruthersville
- Flights from Vancouver (YVR) to Cape Girardeau (CGI)
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Detroit (DTW) to Sikeston (SIK)
- Flights to Sikeston
- Flights from Calgary (YYC) to Cape Girardeau (CGI)
