A tree-lined landscape with a river and fields.

Find hotels in East Prairie, MO from CA $71

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for East Prairie hotels

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

1. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,006 reviews)
"Clean rooms, great parking, very nice staff"
United States
Shelley
The price is CA $103
CA $117 total
includes taxes & fees
Dec 7 - Dec 8
Best Western Plus Sikeston I-55
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

2. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place to stay!"
United States
Tiffany
The price is CA $133
CA $153 total
includes taxes & fees
Nov 15 - Nov 16
Drury Inn & Suites Sikeston, MO
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (830 reviews)
"This place is a gem for the rates they charge. The property is pretty old but well maintained and very clean. The staff is friendly and polite."
United States
Bartholomew
The price is CA $93
CA $106 total
includes taxes & fees
Nov 10 - Nov 11
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A buffet with various food items, including omelets and baked goods, served in metal containers.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.8 out of 10, Excellent, (522 reviews)
"I have always have a great stay each time I’ve been here. Beds comfortable and rooms very clean."
United States
Melissa
The price is CA $134
CA $153 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express & Suites Sikeston Southwest by IHG
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

5. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (696 reviews)
"It is a clean place, and we enjoyed our stay"
United States
Laura
The price is CA $82
CA $93 total
includes taxes & fees
Nov 15 - Nov 16
Super 8 by Wyndham Sikeston/Miner Area
A building with a fountain and flower beds in front.

6. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is CA $94
CA $105 total
includes taxes & fees
Nov 10 - Nov 11
The Riverstone Hotel Charleston-Sikeston
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

7. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,001 reviews)
"It was clean, the room was nice and roomy, bed was very comfortable. Some things were in need of minor repairs, but nothing major."
United States
Earl
The price is CA $94
CA $107 total
includes taxes & fees
Nov 10 - Nov 11
Days Inn and Suites by Wyndham Sikeston
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

8. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is CA $143
CA $162 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites by Marriott Sikeston
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

9. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (652 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is CA $142
CA $161 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Sikeston
Property amenity

10. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (31 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is CA $149
CA $169 total
includes taxes & fees
Nov 15 - Nov 16
TownePlace Suites by Marriott Sikeston
A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

11. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (322 reviews)
"The room was nice"
United States
Fred
The price is CA $123
CA $140 total
includes taxes & fees
Nov 30 - Dec 1
Comfort Inn & Suites Sikeston I-55
A hotel room with two beds, a desk, a chair, a TV, and a mirror.

12. Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (164 reviews)
"It was an ok room for the price paid."
United States
Marianne
The price is CA $76
CA $90 total
includes taxes & fees
Nov 10 - Nov 11
Country Yard Inn and Suite
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

13. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (82 reviews)
"Got there late and staff was very helpful. Room was clean and comfortable"
United States
Wendy
The price is CA $81
CA $93 total
includes taxes & fees
Nov 10 - Nov 11
Super 8 By Wyndham Marston
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

14. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is CA $93
CA $104 total
includes taxes & fees
Nov 9 - Nov 10
Eagle Inn Charleston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

15. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (685 reviews)
"Breakfast was light but good"
United States
zandra
The price is CA $83
CA $93 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel lobby with a reception desk, seating area, and a large window.

16. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is CA $97
CA $108 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cairo I-57
A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

17. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (450 reviews)
"Clean room, excellent staff, wonderful breakfast"
United States
Ben
The price is CA $97
CA $115 total
includes taxes & fees
Dec 6 - Dec 7
Sleep Inn at Discovery Park of America
A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

18. Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (358 reviews)
"It was the perfect stay."
United States
Kevin
The price is CA $140
CA $166 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express & Suites Union City by IHG
A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

19. Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (558 reviews)
"Awesome"
United States
Logan
The price is CA $95
CA $113 total
includes taxes & fees
Nov 29 - Nov 30
Quality Inn Union City US 51
A hotel lobby with a glass table and checkered chairs, an exit door, and a vending machine.

20. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (130 reviews)
"Quiet safe area."
United States
Frank
The price is CA $57
CA $71 total
includes taxes & fees
Nov 9 - Nov 10
Travel Inn Marston I-55 by Hotel O
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

10/10 Excellent
"when we arrived it took a few minutes to get waited on due to another customer arriving just before us, but the desk attendant was apologetic for the slight wait and dove right into helping me. very nice answered all my questions right before I asked most the time. the rooms were clean and roomy, nice clean bathroom with a walk in shower. Had all the little things from blow dryer to iron and ironing board, soaps shampoos microwave and mini fridge."
Barry 1-night trip
Posted 12 hours ago
Sleep Inn at Discovery Park of America

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
The price is CA $82 per night from Nov 15 to Nov 16
CA $82
CA $93 total
Nov 15 - Nov 16
includes taxes & fees

Hotels in East Prairie with star rating

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from CA $71 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia