Title: Book the Best BUSINESS Hotels in Florida Keys in 2026 | Expedia.ca [Florida Keys Travel Guide](https://expedia.ca/Florida-Keys.dx6023765)[Hotels in Florida Keys](https://expedia.ca/Florida-Keys-Hotels.d6023765.Travel-Guide-Hotels)[Vacation Rentals in Florida Keys](https://expedia.ca/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)[Flights to Florida Keys](https://expedia.ca/Cheap-Flights-To-Florida-Keys.d6023765.Travel-Guide-Flights)[Things to do in Florida Keys](https://expedia.ca/Things-To-Do-In-Florida-Keys.d6023765.Travel-Guide-Activities)[Florida Keys Car Rentals](https://expedia.ca/Car-Rentals-In-Florida-Keys.d6023765.Car-Rental-Guide)[Florida Keys Vacation Packages](https://expedia.ca/Florida-Keys.d6023765.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Florida Keys Business Hotels Tonight [Mar 29 - Mar 30](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Mar 30 - Mar 31](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2026-03-30&endDate=2026-03-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Florida Keys business-friendly hotels ![Hibiscus Waterfront 2-Bedroom, Two Bath Master Suite (Brand New) | Terrace/patio](https://images.trvl-media.com/lodging/1000000/890000/882300/882254/55bf0b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hibiscus Waterfront 2-Bedroom, Two Bath Master Suite (Brand New) | Terrace/patio](https://images.trvl-media.com/lodging/1000000/890000/882300/882254/2d5dd8eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Private kitchen](https://images.trvl-media.com/lodging/1000000/890000/882300/882254/4077334d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, open 7:30 AM to 6:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/890000/882300/882254/ca18911f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lime Tree Bay Resort [](https://www.expedia.ca/Long-Key-Hotels-Lime-Tree-Bay-Resort.h882254.Hotel-Information) Long Key 9.2/10 Wonderful (1,207 reviews) "Very nice place, good for a relaxing weekend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) harm CA $242 CA $335 total includes taxes & fees Apr 29 - Apr 30 [](https://www.expedia.ca/Long-Key-Hotels-Lime-Tree-Bay-Resort.h882254.Hotel-Information) ![Room, 1 King Bed, Bay View | Beach/ocean view](https://images.trvl-media.com/lodging/1000000/10000/5800/5731/68e30233.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/5800/5731/363fe239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8 AM to 10 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/5800/5731/a2c239ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/5800/5731/2a165117.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Key Largo Manatee Bay [](https://www.expedia.ca/Key-Largo-Hotels-Hampton-Inn-Key-Largo-Manatee-Bay.h5731.Hotel-Information) Key Largo 8.8/10 Excellent (1,006 reviews) "Location was beautiful. Enjoyed the private beach and bar so much." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $249 CA $280 total includes taxes & fees Apr 26 - Apr 27 [](https://www.expedia.ca/Key-Largo-Hotels-Hampton-Inn-Key-Largo-Manatee-Bay.h5731.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/19900/19823/b7875c57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/19900/19823/d84b43ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/19900/19823/061698ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/20000/19900/19823/7bef632e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Marathon Florida Keys [](https://www.expedia.ca/Marathon-Hotels-Fairfield-Inn-Suites-By-Marriott-Marathon-Florida-Keys.h19823.Hotel-Information) Marathon 9.2/10 Wonderful (1,105 reviews) "Clean room and vety friendly staff! Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carolyn CA $311 CA $350 total includes taxes & fees Apr 27 - Apr 28 [](https://www.expedia.ca/Marathon-Hotels-Fairfield-Inn-Suites-By-Marriott-Marathon-Florida-Keys.h19823.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1190000/1186200/1186162/42d47c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/2000000/1190000/1186200/1186162/0f5b3686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1190000/1186200/1186162/aed267ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach/ocean view](https://images.trvl-media.com/lodging/2000000/1190000/1186200/1186162/2d6f6a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dove Creek Resort & Marina, Trademark Collection by Wyndham [](https://www.expedia.ca/Key-Largo-Hotels-Dove-Creek-Resort-Marina.h1186162.Hotel-Information) Key Largo 7.6/10 Good (1,006 reviews) "good location, good deal for the price" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marta CA $236 CA $310 total includes taxes & fees Apr 27 - Apr 28 [](https://www.expedia.ca/Key-Largo-Hotels-Dove-Creek-Resort-Marina.h1186162.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/900000/899000/898967/0e73156e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/900000/899000/898967/b411569e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/1000000/900000/899000/898967/7e708788.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Regional cuisine](https://images.trvl-media.com/lodging/1000000/900000/899000/898967/4e74ed3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Skipjack Resort & Marina [](https://www.expedia.ca/Marathon-Hotels-Skipjack-Resort-Marina.h898967.Hotel-Information) Marathon 8.6/10 Excellent (1,241 reviews) "The pool was ok. It was crowded for most of our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teresa CA $288 CA $381 total includes taxes & fees Apr 29 - Apr 30 [](https://www.expedia.ca/Marathon-Hotels-Skipjack-Resort-Marina.h898967.Hotel-Information) ![On the beach, sun loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f6566b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/04484d29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/02a3a50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/9f64224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Isla Bella Beach Resort & Spa [](https://www.expedia.ca/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) Marathon 9.2/10 Wonderful (1,111 reviews) "All rooms have an ocean view-beautiful for sure!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wanda CA $510 CA $665 total includes taxes & fees Apr 26 - Apr 27 [](https://www.expedia.ca/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2240000/2238900/2238823/d8c3b987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2240000/2238900/2238823/6bfa8d80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, Tempur-Pedic beds, in-room safe, desk](https://images.trvl-media.com/lodging/3000000/2240000/2238900/2238823/2c9a2986.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/3000000/2240000/2238900/2238823/6a9ed1c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gilbert's Resort [](https://www.expedia.ca/Key-Largo-Hotels-Gilberts-Resort.h2238823.Hotel-Information) Key Largo 8.6/10 Excellent (1,001 reviews) "Clean rooms, great staff. Always make a point of staying at Gilbert’s when we get the chance. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Murray CA $377 CA $425 total includes taxes & fees Apr 27 - Apr 28 [](https://www.expedia.ca/Key-Largo-Hotels-Gilberts-Resort.h2238823.Hotel-Information) ![4 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/24700/24615/cf132c1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/24700/24615/99dc8f4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/24700/24615/87058123.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free beach shuttle, kayaking](https://images.trvl-media.com/lodging/1000000/30000/24700/24615/b549f4a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Parrot Key Hotel & Villas [](https://www.expedia.ca/Key-West-Hotels-Parrot-Key-Hotel-Villas.h24615.Hotel-Information) Northside Resort 9.0/10 Wonderful (1,326 reviews) "Loved it here! Grounds, rooms and staff were all amazing ! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christina CA $412 CA $543 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Key-West-Hotels-Parrot-Key-Hotel-Villas.h24615.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/430000/428800/428789/27d5f1e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/430000/428800/428789/7e7da461.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/428800/428789/w3840h2556x0y0-04b24ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/428800/428789/1b910ab7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Marathon - Florida Keys [](https://www.expedia.ca/Marathon-Hotels-Hampton-Inn-Marathon-Florida-Keys.h428789.Hotel-Information) Marathon 9.0/10 Wonderful (1,002 reviews) "Very good place well maintained " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jorge CA $321 CA $361 total includes taxes & fees Apr 27 - Apr 28 [](https://www.expedia.ca/Marathon-Hotels-Hampton-Inn-Marathon-Florida-Keys.h428789.Hotel-Information) ![On the beach, beach cabanas, sun loungers](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/30a374ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/246f3120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/acafccbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/5f4107d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Faro Blanco Resort, Marathon Florida Keys [](https://www.expedia.ca/Marathon-Hotels-Courtyard-By-Marriott-Marathon-Florida-Keys.h10554536.Hotel-Information) Marathon 9.0/10 Wonderful (1,002 reviews) "beautiful property - clean, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) laurie CA $343 CA $441 total includes taxes & fees Apr 27 - Apr 28 [](https://www.expedia.ca/Marathon-Hotels-Courtyard-By-Marriott-Marathon-Florida-Keys.h10554536.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-12&endDate=2026-04-13®ionId=6023765&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Florida Keys Hotel Reviews ![Hawks Cay Resort](https://images.trvl-media.com/lodging/1000000/10000/6100/6068/8671ba74_y.jpg) ### Hawks Cay Resort 4/10 Poor "Not really, kids club closed." [](https://expedia.ca/Marathon-Hotels-Hawks-Cay-Resort.h6068.Hotel-Information) ![Reefhouse Resort & Marina](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/e9f2dff3_y.jpg) ### Reefhouse Resort & Marina 10/10 Excellent "Beautiful location" [](https://expedia.ca/Key-Largo-Hotels-Reefhouse-Resort-Marina.h3427.Hotel-Information) ![Fairfield Inn & Suites by Marriott Marathon Florida Keys](https://images.trvl-media.com/lodging/1000000/20000/19900/19823/b7875c57_y.jpg) ### Fairfield Inn & Suites by Marriott Marathon Florida Keys 10/10 Excellent "They have hammocks on the pool area looking at the pool and water canal/bay they have 2 pools 1 was heated the other one was not but overall is a pretty good hotel with pretty good breakfast." [](https://expedia.ca/Marathon-Hotels-Fairfield-Inn-Suites-By-Marriott-Marathon-Florida-Keys.h19823.Hotel-Information) ![Holiday Inn Key Largo by IHG](https://images.trvl-media.com/lodging/1000000/10000/7300/7230/855a0cf4_y.jpg) ### Holiday Inn Key Largo by IHG 8/10 Good "Breakfast very good! Staff great. Beautiful pools. Rooms are above average but need updating." [](https://expedia.ca/Key-Largo-Hotels-Holiday-Inn-Key-Largo.h7230.Hotel-Information) ![Kingsail Resort](https://images.trvl-media.com/lodging/2000000/1780000/1775600/1775568/96bf2fd2_y.jpg) ### Kingsail Resort 8/10 Good "Room was snall and quaint. Bed was hard unfortunately. Staff was wonderful. " [](https://expedia.ca/Marathon-Hotels-Kingsail-Resort.h1775568.Hotel-Information) ![Amara Cay Resort](https://images.trvl-media.com/lodging/1000000/70000/62000/61976/4186365f_y.jpg) ### Amara Cay Resort 10/10 Excellent "Property was truly beautiful with friendly staff and amazing amenities. The free shuttle to the other resorts was a great surprise as well. We took the Rum Runner for breakfast (shout out to Captain Dave and Bruce for being amazing). In my opinion, Amara Cay was the nicest of the three resorts if you’re looking for island luxury and a truly relaxing experience. Will definitely be visiting again!" [](https://expedia.ca/Islamorada-Hotels-Amara-Cay-Resort.h61976.Hotel-Information) ![Creekside Inn](https://images.trvl-media.com/lodging/2000000/1580000/1576800/1576773/4743fa46_y.jpg) ### Creekside Inn 4/10 Poor "This is right up against the road, so the noise is pretty bad. The air conditioning blows like a wind tunnel. The bathroom looks like it was recently updated in the 1980s. And hot is on the right at least on this room. The icing on the cake was the kids playing in the pool late at night and there was of course no one there to tell them to stop because the office closes down at 7:00 p.m." [](https://expedia.ca/Tavernier-Hotels-Creekside-Inn-Islamorada.h1576773.Hotel-Information) ![Cheeca Lodge & Spa](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/4608d7e2_y.jpg) ### Cheeca Lodge & Spa 10/10 Excellent "Outstanding " [](https://expedia.ca/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Playa Largo Resort & Spa, Autograph Collection](https://images.trvl-media.com/lodging/12000000/11920000/11919100/11919055/8c74658c_y.jpg) ### Playa Largo Resort & Spa, Autograph Collection 10/10 Excellent "Pool area is excellent, lots of lounge chairs available. All of the staff extremely friendly & helpful, stop at your lounge chair every 15 minutes to inquire if you need anything. Have stayed here 4 times now and would definitely recommend " [](https://expedia.ca/Key-Largo-Hotels-Playa-Largo-Resort-Spa.h11919055.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Florida Keys cost? ### What are the best business-friendly hotels in Florida Keys? ### How many business-friendly hotels are there in Florida Keys? ### What are the best cheap business-friendly hotels in Florida Keys? ### Are there any family-friendly hotels in Florida Keys that are also business friendly? ### Are there any 5-star business-friendly hotels in Florida Keys? ### Why book your business-friendly hotel in Florida Keys with Expedia? ### How can I find cheap business-friendly hotels in Florida Keys? ### What is there to do in Florida Keys near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Packages - More ways to book - [Hotels near Christ of the Abyss ](https://www.expedia.ca/Christ-Of-The-Abyss-Hotels.0-l6069273-0.Travel-Guide-Filter-Hotels) - [Hotels near John Pennekamp Coral Reef State Park ](https://www.expedia.ca/John-Pennekamp-Coral-Reef-State-Park-Hotels.0-l6068611-0.Travel-Guide-Filter-Hotels) - [John Pennekamp Coral Reef State Park ](https://www.expedia.ca/John-Pennekamp-Coral-Reef-State-Park-United-States-of-America.d6068611.Vacation-Attraction) - [Book Business Hotels in Florida Keys on Expedia.com ](https://www.expedia.com/Florida-Keys-Hotels-Business-Hotel.0-0-d6023765-tBusinessHotel.Travel-Guide-Filter-Hotels)