Title: Effingham Vacation Home Rentals from CA $321: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in Effingham](https://expedia.ca/Effingham-Hotels.d553248635975849973.Travel-Guide-Hotels)[Vacation Rentals in Effingham](https://expedia.ca/Effingham-Vacation-Rentals.d553248635975849973.Travel-Guide-VacationRentals)[Effingham Car Rentals](https://expedia.ca/Car-Rentals-In-Effingham.d553248635975849973.Car-Rental-Guide)[Effingham Vacation Packages](https://expedia.ca/Effingham.d553248635975849973.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Effingham Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635975849973&startDate=2025-12-19&endDate=2025-12-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635975849973&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=553248635975849973&startDate=2026-01-09&endDate=2026-01-11&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975849973&startDate=2026-02-06&endDate=2026-02-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Effingham vacation homes ![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walking distance from one of South Carolina's top Medical centers. [](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) Florence 9.8/10 Exceptional (42) "The house was beautiful. We would stay there again!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie L. CA $185 CA $321 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/96e90379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/2b19bbbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/04c9cb2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/4c52a4d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet, Clean & Spacious 4bd near I-95 & Hospital with WiFi [](https://www.expedia.ca/Florence-Hotels-Quiet.h115638333.Hotel-Information) Florence 9.4/10 Exceptional (3) "Lovely place!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller CA $268 CA $599 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Florence-Hotels-Quiet.h115638333.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/90a72a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/2912e772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/b4721f87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/8f4ad967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence! [](https://www.expedia.ca/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information) Marion 9.0/10 Wonderful (6) "It was a great place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cindy N. CA $275 CA $820 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/78ec87e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/c362269a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's [](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) Florence 10/10 Exceptional (35) "Perfect stay for our family wedding weekend!! Home was immaculate and a perfect layout! Host has thought of everything you may need during your stay from extra linens to a fully stocked kitchen. Awesome location and super nice neighborhood!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy D. CA $342 CA $429 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/48ab0078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/35e44181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/fa8515b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/c60efe7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Perfect Stop • Near I-95, Downtown & Civic Center and Darlington [](https://www.expedia.ca/Florence-Hotels-Perfect-Stop-Near-I-95.h122683191.Hotel-Information) Florence 10/10 Exceptional (1) "It was perfect! And the host was the best everrrr I loved every second I will be returning! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimesha C. CA $295 CA $374 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Florence-Hotels-Perfect-Stop-Near-I-95.h122683191.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-27&endDate=2025-12-28®ionId=553248635975849973&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Apartments [](https://www.expedia.ca/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-13&d1=2026-03-13&endDate=2026-03-16&d2=2026-03-16&lodging=APARTMENT) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-13&d1=2026-03-13&endDate=2026-03-16&d2=2026-03-16&lodging=VACATION_HOME) Cottages [](https://www.expedia.ca/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-13&d1=2026-03-13&endDate=2026-03-16&d2=2026-03-16&lodging=COTTAGE) Cabins [](https://www.expedia.ca/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-13&d1=2026-03-13&endDate=2026-03-16&d2=2026-03-16&lodging=CABIN) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEffingham-Private-Vacation-Homes.d553248635975849973-aaPrivateVacationHomes.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEffingham-Private-Vacation-Homes.d553248635975849973-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Effingham Hotel Reviews ![Hampton Inn & Suites Florence-North-I-95](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg) ### Hampton Inn & Suites Florence-North-I-95 10/10 Excellent "Get place stay after a long drive. " [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites Florence Center Area 10/10 Excellent "Easy check in. Room was very clean. Easy on site parking." [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg) ### Park Inn by Radisson Florence, SC 10/10 Excellent "Friendly staff. Clean room. Comfortable bed" [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Days Inn by Wyndham Florence/I-95 North](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/b1bbd639_y.jpg) ### Days Inn by Wyndham Florence/I-95 North 10/10 Excellent "Clean room , quite area , walking distance " [](https://expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) ![Hampton Inn & Suites Florence Center](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg) ### Hampton Inn & Suites Florence Center 10/10 Excellent "Friendly staff and great breakfast" [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 10/10 Excellent "Staff was lovely and very helpful " [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![Tru by Hilton Florence I-95](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d_y.jpg) ### Tru by Hilton Florence I-95 10/10 Excellent "room was great.clean and warm....staying with hiltons..Sandy our golden gives them 4 woofs..." [](https://expedia.ca/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Room was very clean and functional. Breakfast isn’t much, but that’s ok for the price value " [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Home2 Suites by Hilton Florence, SC](https://images.trvl-media.com/lodging/8000000/7280000/7271300/7271220/25ce2409_y.jpg) ### Home2 Suites by Hilton Florence, SC 10/10 Excellent "Great breakfast buffett" [](https://expedia.ca/Florence-Hotels-Home2-Suites-By-Hilton-Florence.h7271220.Hotel-Information) ## Find out more about Effingham ## Effingham Vacation Homes information | Number of reviews | 85 | | ----------------- | ----------------- | | Accommodation | 29 Vacation Homes | | Lowest Price | CA $321 | | Highest Price | CA $820 | ## Explore a world of travel with Expedia - Lodging - Flights - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Florence ](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Coward Hotels ](https://www.expedia.ca/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - 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