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Most Popular Florence Hotels

See all 86 Hotels in Florence
Baymont Inn & Suites Florence
Baymont Inn & Suites Florence

1826 W Lucas Street, Florence 29501-1230

2.0 out of 5.0
3.8 out of 5 (1,005 reviews)

Situated in Florence, this hotel is within 6 mi (10 km) of Mcleod Regional Medical Center, Florence Museum, and Florence Civi …

CA$83
Holiday Inn Ex Hotel & Suites Florence I-95 & I-20 Civic Ctr
Holiday Inn Ex Hotel & Suites Florence I-95 & I-20 Civic Ctr

3440 W Radio Dr, Florence 29501-7812

2.5 out of 5.0
4.5 out of 5 (313 reviews)

Located in the heart of Florence, this hotel is within 1 mi (2 km) of Florence Civic Center and Magnolia Mall. The Traces Gol …

CA$161
Americas Best Value Inn
Americas Best Value Inn

904 Radford Blvd, Dillon 29536

2.0 out of 5.0
2.3 out of 5 (127 reviews)

Situated in a rural location, this motel is 1.2 mi (2 km) from Dillon Motor Speedway and 1.7 mi (2.8 km) from Dillon County …

CA$58
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327

2101 Florence Harllee Blvd, Florence 29506-8245

2.5 out of 5.0
4.4 out of 5 (197 reviews)

Situated in Florence, this hotel is within 9 mi (15 km) of Francis Marion University, Eastern Carolina Agricultural …

CA$144
Fairfield Inn by Marriott Hartsville
Fairfield Inn by Marriott Hartsville

200 S 4th St, Hartsville 29550-5714

2.5 out of 5.0
4.4 out of 5 (126 reviews)

Situated in Hartsville, this hotel is within a 5-minute walk of Coker College and Hartsville Museum. Segars-McKinnon Heritage …

CA$130
Comfort Suites
Comfort Suites

2120 West Lucas Street, Florence 29501-1205

2.5 out of 5.0
4.5 out of 5 (168 reviews)

Situated near the airport, this hotel is within 6 mi (10 km) of Mcleod Regional Medical Center, Florence Museum, and Florence …

CA$132
The Landmark Inn
The Landmark Inn

1301 South 4th Street, Hartsville 29550

2.5 out of 5.0
3.4 out of 5 (12 reviews)

Situated in Hartsville, this motel is 1.7 mi (2.7 km) from Hartsville Museum and 1.7 mi (2.8 km) from Coker College. …

CA$81
Courtyard Florence
Courtyard Florence

2680 Hospitality Blvd, Florence 29501-7808

3.0 out of 5.0
4.3 out of 5 (82 reviews)

Situated in Florence, this hotel is within a 10-minute walk of Florence Civic Center and Magnolia Mall. Florence Museum and …

CA$183
Best Western Executive Inn
Best Western Executive Inn

1534 Highway 38 W, Latta 29565

2.5 out of 5.0
3.5 out of 5 (87 reviews)

Situated in Latta, this hotel is 11.6 mi (18.6 km) from Dillon County Theater and within 20 mi (32 km) of Dillon Motor …

CA$117
Americas Best Value Inn
Americas Best Value Inn

3024 TV Road, Florence 29501-0710

2.0 out of 5.0
2.4 out of 5 (101 reviews)

Situated in Florence, this hotel is within 9 mi (15 km) of Mcleod Regional Medical Center, Florence Museum, and Francis Mario …

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Florence Hotel Guide

There's a wide and varied assortment of accommodations for those who are searching for an affordable or upscale hotel in Florence. You will find no less than 21 places to stay within easy driving distance of Florence's downtown on Expedia's informative and up-to-date accommodation pages.

Those looking for a comfortable nights sleep close to the center of Florence will love the location and amenities of the Hotel Florence, an Ascend Hotel Collection Member.

The Residence Inn Marriott Florence is located 4 miles (6 kilometers) from the heart of Florence. Another hotel is the Courtyard Florence, which can be found 4 miles (6 kilometers) away. Two more options include the Springhill Suites Florence and the Holiday Inn Ex Hotel & Suites Florence I-95 & I-20 Civic Ctr.

Once you have really explored Florence, why don't you go a little more of the region? The South Carolina Midlands region has plenty of things to see. Spend time at South Carolina Midlands's historic mansions and gardens and also enjoy its rolling hills. Active travelers can try hiking, zip-lining and horse riding here.

Sumter is a major city located 40 miles (64 kilometers) from Florence which is home to Sumter Mall. This area of South Carolina Midlands has a number of accommodation options, including the Holiday Inn Express Sumter and Hampton Inn Manning.

If you're flying to Florence, the preferred airport is Florence Regional Airport. The closest Expedia-listed place to stay is Hotel Florence, an Ascend Hotel Collection Member.

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