Title: Book the Best Florence SPA Resorts from CA $110 - Spa Hotels in Florence, SC | Expedia.ca [Hotels in Florence](https://expedia.ca/Florence-Hotels.d1221.Travel-Guide-Hotels)[Vacation Rentals in Florence](https://expedia.ca/Florence-Vacation-Rentals.d1221.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.ca/Cheap-Flights-To-Florence.d1221.Travel-Guide-Flights)[Florence Car Rentals](https://expedia.ca/Car-Rentals-In-Florence.d1221.Car-Rental-Guide)[Florence Vacation Packages](https://expedia.ca/Florence.d1221.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/bb3e92b3001d46f023d4e565fc1d1eae.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Florence, SC from CA $110 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Florence Spa Hotels Tonight [Sep 22 - Sep 23](https://www.expedia.ca/Hotel-Search?regionId=1221&startDate=2025-09-22&endDate=2025-09-23&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 23 - Sep 24](https://www.expedia.ca/Hotel-Search?regionId=1221&startDate=2025-09-23&endDate=2025-09-24&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=1221&startDate=2025-09-26&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=1221&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Florence Spa Hotels ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/94a4d77a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/1e0c4eb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/f287bfc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence Center Florence 9.0/10 Wonderful (778) "My children stayed here and said it was super nice, very comfortable beds!!" CA $163 CA $182 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/0ea8f0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/22e67acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/c7afe694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence 9.2/10 Wonderful (1086) "Very comfortable beds" CA $150 CA $168 total includes taxes & fees Sep 25 - Sep 26 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/134f5e4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/5c516c39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/6aa9d343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/351de30c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites by Hilton Florence Florence 8.4/10 Very good (642) "Front desk hosts were very nice and helpful." CA $168 CA $194 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Homewood-Suites-By-Hilton-Florence.h21599838.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/d963a865.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Non Smoking](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/00af3161.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/434898b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/c68ab7f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Florence I-95 Florence 8.4/10 Very good (1006) "Good place to stay, good price" CA $149 CA $172 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) ![Laundry room](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/ae407b68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/ee8a37aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/281639d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/fd01d79e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Florence North I-95, SC Florence 7.8/10 Good (10) "Very nice " [](https://www.expedia.ca/Florence-Hotels-Spark-By-Hilton-Florence-North-I-95.h42602.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, Multiple Beds](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/236a2b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/ca4e1745.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9 AM to 9 PM, pool umbrellas](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/520a38b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott Florence Florence 9.0/10 Wonderful (653) "We stayed here for a quick night on a long drive home. The staff was professional and welcoming in the room was perfect." CA $153 CA $172 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/ebea43b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/b5687a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/8a1b879d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence Florence 8.8/10 Excellent (2374) "This is a really nice hotel. Thought the room was like perfect quite honestly and I would definitely stay here again" CA $98 CA $110 total includes taxes & fees Sep 23 - Sep 24 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC Florence 9.0/10 Wonderful (2146) "Great stay" CA $123 CA $137 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/5abcf1ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/3bae1a69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/1aa3f791.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/bf29fa04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Florence - Civic Center by IHG Florence 9.4/10 Exceptional (897) "Great bacon" CA $186 CA $208 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/8339db76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/01dca42d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/5b7b6acc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Florence I-95 Florence 8.2/10 Very good (1006) "Great clean place to stay!" CA $139 CA $161 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-06&endDate=2025-10-07®ionId=1221&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Florence ### Top Florence attractions for a relaxing vacation Florence, South Carolina, offers a pleasant blend of relaxation and exploration for travellers keen on spa hotel experiences. Begin your journey at the serene \*\*Florence County Museum\*\*, where you can immerse yourself in local art and history; the tranquil setting is perfect for unwinding after a day of pampering. For nature lovers, the \*\*Carolinas Hospital System Amphitheater\*\* hosts a variety of outdoor concerts and events, providing a delightful backdrop for evening strolls. Don't miss the chance to visit \*\*Timrod Park\*\*, a picturesque spot for a leisurely walk or picnic, surrounded by lush greenery. After a rejuvenating day, treat yourself to a sumptuous meal at one of Florence's many acclaimed restaurants, such as \*\*The Swamp Fox\*\*, where southern cuisine meets fine dining. The best area to stay for a spa-focused getaway is the vicinity around \*\*Lake Florence\*\*, where several upscale hotels offer spa services, allowing you to seamlessly transition from relaxation to exploration. Staying here not only provides access to luxurious amenities but also an inviting atmosphere where families can enjoy the outdoors while indulging in quality time together. ### Find the best hotels & resorts with spas in Florence For those seeking a relaxing escape in Florence, South Carolina, these hotels offer exceptional spa amenities to rejuvenate both body and mind. Discover the perfect retreat with our top recommendations. [Hotel Florence, Tapestry Collection by Hilton](https://www.expedia.ca/Florence-Hotels-Hotel-Florence.h6128999.Hotel-Information) - **Why it's great for tailored spa getaway:** Hotel Florence, part of the Tapestry Collection by Hilton, stands out as a premier choice for travellers seeking a serene spa experience. With an impressive guest review rating of 8.8, it offers a full-service spa featuring a diverse range of treatments such as Swedish massages, hot stone massages, and detoxification wraps, ensuring relaxation and rejuvenation for every guest. - **Other amenities:** Beyond its spa offerings, the hotel features 24-hour fitness facilities for those looking to maintain their workout routine. Guests can enjoy luxurious touches like bathrobes and designer toiletries in their rooms, as well as premium bedding for a restful night's sleep. The hotel also boasts convenient amenities such as accessible parking and a nearby grocery store, making it a comfortable and practical choice for a getaway. - **Nearby attractions:** Florence Museum - 2 km ## Top Florence Hotel Reviews ![Hampton Inn & Suites Florence-North-I-95](//images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg) ### Hampton Inn & Suites Florence-North-I-95 10/10 Excellent "Warm, friendly staff; exceptionally clean" [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![Courtyard by Marriott Florence](//images.trvl-media.com/lodging/1000000/90000/84600/84519/a86309c4_y.jpg) ### Courtyard by Marriott Florence 10/10 Excellent "Amazing hotel,very pet friendly they have a nice area dedicated behind the hotel for the dogs.Its very clean and reasonable,I recommend 100% for people with pets or family.The staffs were very friendly and they have very good selection of food as well." [](https://expedia.ca/Florence-Hotels-Courtyard-By-Marriott-Florence.h84519.Hotel-Information) ![Residence Inn Marriott Florence](//images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg) ### Residence Inn Marriott Florence 10/10 Excellent "We had a wonderful stay here. The room was very nice, with a kitchen, sitting area and king bed. Nice vanity in bath. But the mattress was soft, sinking in the middle. The staff here Charon and Cynthia serving breakfast were some of the nicest people we've met while eating breakfast. They displayed and kept the food items well stocked. The breakfast was great, we had sausage, both turkey and pork, eggs, toast, waffles, pastries, cereals, with a nut and topping station, juice, coffee, milk, yogurt, fresh pineapple, bananas, apples just to name a few. It was awesome!! Will be back here. I will have to say at check out the staff person was away with a note at the front desk, "I've walked away, will return later". This was the busiest time of day check out time and they weren't there to man the station. Only negative thing to say here. " [](https://expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Florence? > Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in Florence. Be sure to pay a visit to the museums during your stay. Spa hotels are a great way to break out of your routine and add a layer of luxury to your holiday. ### What is the best spa hotel in Florence? > [Hotel Florence, Tapestry Collection by Hilton](https://www.expedia.ca/Florence-Hotels-Hotel-Florence.h6128999.Hotel-Information) is a top spa hotel featuring a 24-hour fitness center, a bar, and a restaurant. Enjoy a facial, detox wrap, or Swedish massage at the onsite spa. ### How many spa hotels are there in Florence? > Among Expedia's 100 accommodation options in Florence, there is 1 spa hotel. ### What's there to see and do in Florence? > Enjoy all that Florence has to offer when you visit Florence Museum, Florence National Cemetery, and Magnolia Mall. If you have extra time while you're in the area, you might want to see Florence Veterans Park and Florence Civic Center. ### What is a Florence spa hotel? > Spa hotels in Florence provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. 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