A calm lake surrounded by trees with autumn foliage.

Find Spa Hotels in Florence, SC from CA $217

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Our top choices for Florence hotels with a spa

1. Hyatt Place Florence Downtown

Hyatt Place Florence Downtown
3.0 star property
Florence
9.0 out of 10, Wonderful, (1,004 reviews)
"Great breakfast. Check-in and check-out was very easy."
United States
Jonathan
The price is CA $162
CA $182 total
includes taxes & fees
Nov 5 - Nov 6
Hyatt Place Florence Downtown

2. Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton
3.0 star property
Florence
8.8 out of 10, Excellent, (659 reviews)
"The house keeping people"
United States
WILLIE
The price is CA $194
CA $217 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Florence, Tapestry Collection by Hilton

3. Rodeway Inn Florence Downtown

Rodeway Inn Florence Downtown
2.0 star property
Florence
5.4 out of 10, (8 reviews)
"Air conditioning didn’t work on my last night, neither did the WiFi. Would not recommend"
United States
F
The price is CA $59
CA $69 total
includes taxes & fees
Dec 1 - Dec 2
Rodeway Inn Florence Downtown

4. The Urban Flats

The Urban Flats
4.0 star property
Florence
The price is CA $287
CA $532 total
includes taxes & fees
Nov 4 - Nov 5
The Urban Flats

5. Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC
2.5 star property
Florence
9.0 out of 10, Wonderful, (2,495 reviews)
"Would stay here again - convenient and comfortable"
United States
Amy
The price is CA $126
CA $141 total
includes taxes & fees
Nov 15 - Nov 16
Park Inn by Radisson Florence, SC

6. Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.0 out of 10, Wonderful, (1,384 reviews)
"Comfortable beds and clean environments."
United States
Steven
The price is CA $141
CA $158 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Inn & Suites Florence Center Area

7. Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2,755 reviews)
"Quiet clean and inexpensive stay, especially relative to neighboring locations"
United States
Carl
The price is CA $85
CA $95 total
includes taxes & fees
Nov 3 - Nov 4
Howard Johnson by Wyndham Florence

8. Holiday Inn Express & Suites Latta by IHG

Holiday Inn Express & Suites Latta by IHG
2.5 star property
Latta
9.4 out of 10, Exceptional, (659 reviews)
"Very nice facility and staff."
United States
Carey
The price is CA $141
CA $154 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express & Suites Latta by IHG

9. Quality Inn Mullins - Marion

Quality Inn Mullins - Marion
2.5 star property
Marion
7.6 out of 10, Good, (432 reviews)
"Staff was very friendly and helpful."
United States
Willie
The price is CA $104
CA $113 total
includes taxes & fees
Nov 22 - Nov 23
Quality Inn Mullins - Marion

10. Best Western Executive Inn

Best Western Executive Inn
2.5 star property
Latta
8.4 out of 10, Very good, (1,002 reviews)
"Room was clean and attractive. Hot water and the shower worked fine, as well as the tv. Breakfast was adequate for the price point of the Motel. No issues and will come back on my next trip north ."
United States
Robert
The price is CA $137
CA $149 total
includes taxes & fees
Nov 9 - Nov 10
Best Western Executive Inn

11. The Inn at the Crossroads

The Inn at the Crossroads
2.0 star property
Lake City
9.6 out of 10, Exceptional, (1,001 reviews)
"Great stay!!"
United States
Paige
The price is CA $151
CA $169 total
includes taxes & fees
Dec 2 - Dec 3
The Inn at the Crossroads

12. Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95
2.5 star property
Florence
9.0 out of 10, Wonderful, (1,002 reviews)
"Excellente hotel, clean, good breakfast, and quiet."
Canada
chantal
The price is CA $171
CA $192 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn & Suites Florence-North-I-95

13. Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC
2.5 star property
Florence
8.4 out of 10, Very good, (346 reviews)
"Great staff easy Check in I love staying here!!!"
United States
Alanya
The price is CA $106
CA $127 total
includes taxes & fees
Nov 8 - Nov 9
Spark by Hilton Florence North I-95, SC

14. TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence
3.0 star property
Florence
9.0 out of 10, Wonderful, (923 reviews)
"Fabulous pet-friendly place to stay."
United States
Ralph
The price is CA $153
CA $172 total
includes taxes & fees
Nov 8 - Nov 9
TownePlace Suites by Marriott Florence

15. Fairfield Inn & Suites by Marriott Florence I-20

Fairfield Inn & Suites by Marriott Florence I-20
3.0 star property
Florence
9.0 out of 10, Wonderful, (662 reviews)
"I enjoyed a two night stay here at Fairfield. The staff was completely awesome. The breakfast was amazing, so many options to choose from to meet every healthy meal plan. The amenities were very clean, modern and chic, providing an upscale experience. Overall experience was excellent!"
United States
Alma
The price is CA $165
CA $185 total
includes taxes & fees
Nov 5 - Nov 6
Fairfield Inn & Suites by Marriott Florence I-20

16. Tru by Hilton Florence I-95

Tru by Hilton Florence I-95
2.5 star property
Florence
8.6 out of 10, Excellent, (1,001 reviews)
"Great hotel and staff"
United States
Margarita
The price is CA $127
CA $151 total
includes taxes & fees
Nov 8 - Nov 9
Tru by Hilton Florence I-95

17. Affordable Suites Florence

Affordable Suites Florence
2.5 star property
Florence
9.2 out of 10, Wonderful, (231 reviews)
"Location is awesome and near everything the staff are very friendly and kind will definitely be coming back for more hotel stays"
United States
Cheyenne
The price is CA $99
CA $110 total
includes taxes & fees
Dec 3 - Dec 4
Affordable Suites Florence

18. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG
2.5 star property
Florence
8.6 out of 10, Excellent, (1,000 reviews)
"Good location- very good free breakfast"
United States
Christopher
The price is CA $170
CA $205 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

19. Quality Inn Dillon

Quality Inn Dillon
2.5 star property
Dillon
7.2 out of 10, Good, (854 reviews)
"Good and well maintained!"
United States
Elliot
The price is CA $126
CA $141 total
includes taxes & fees
Nov 4 - Nov 5
Quality Inn Dillon

20. Staybridge Suites Florence - Civic Center by IHG

Staybridge Suites Florence - Civic Center by IHG
3.0 star property
Florence
9.4 out of 10, Exceptional, (1,003 reviews)
"Enjoyed our stay."
United States
Tishia
The price is CA $187
CA $210 total
includes taxes & fees
Nov 15 - Nov 16
Staybridge Suites Florence - Civic Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Florence

Find out more about Florence

Top Florence attractions for a relaxing vacation

Florence, South Carolina, offers a pleasant blend of relaxation and exploration for travellers keen on spa hotel experiences. Begin your journey at the serene **Florence County Museum**, where you can immerse yourself in local art and history; the tranquil setting is perfect for unwinding after a day of pampering. For nature lovers, the **Carolinas Hospital System Amphitheater** hosts a variety of outdoor concerts and events, providing a delightful backdrop for evening strolls. Don't miss the chance to visit **Timrod Park**, a picturesque spot for a leisurely walk or picnic, surrounded by lush greenery. After a rejuvenating day, treat yourself to a sumptuous meal at one of Florence's many acclaimed restaurants, such as **The Swamp Fox**, where southern cuisine meets fine dining. The best area to stay for a spa-focused getaway is the vicinity around **Lake Florence**, where several upscale hotels offer spa services, allowing you to seamlessly transition from relaxation to exploration. Staying here not only provides access to luxurious amenities but also an inviting atmosphere where families can enjoy the outdoors while indulging in quality time together.

Find the best hotels & resorts with spas in Florence

For those seeking a relaxing escape in Florence, South Carolina, these hotels offer exceptional spa amenities to rejuvenate both body and mind. Discover the perfect retreat with our top recommendations.

Hotel Florence, Tapestry Collection by Hilton

  • Why it's great for tailored spa getaway: Hotel Florence, part of the Tapestry Collection by Hilton, stands out as a premier choice for travellers seeking a serene spa experience. With an impressive guest review rating of 8.8, it offers a full-service spa featuring a diverse range of treatments such as Swedish massages, hot stone massages, and detoxification wraps, ensuring relaxation and rejuvenation for every guest.
  • Other amenities: Beyond its spa offerings, the hotel features 24-hour fitness facilities for those looking to maintain their workout routine. Guests can enjoy luxurious touches like bathrobes and designer toiletries in their rooms, as well as premium bedding for a restful night's sleep. The hotel also boasts convenient amenities such as accessible parking and a nearby grocery store, making it a comfortable and practical choice for a getaway.
  • Nearby attractions: Florence Museum - 2 km

Top Florence Hotel Reviews

Frequently asked questions

Which hotels in Florence offer the best spa experiences?
For those seeking excellent spa experiences in Florence, the Hotel Florence, Tapestry Collection by Hilton is a highly rated option.

This 3-star hotel with an 8.8 rating provides a full-service spa that caters to a range of relaxation and rejuvenation needs. The treatment menu includes various massages such as deep tissue, hot stone, and Swedish, alongside prenatal massages and aromatherapy treatments. Guests can also indulge in facials and body treatments, including detoxification wraps. For a shared experience, couples treatment rooms are available. The hotel recommends booking massages and spa services in advance to ensure availability.
How much does a spa hotel in Florence cost?
Enjoy staying in a spa hotel in Florence, with plenty of hotels from CA $217 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, and may vary depending on the location, season, and hotel amenities. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a trip during the weekend or around public holidays.
Is it cheaper to book a spa hotel in Florence with flights as part of a package deal?
Booking a hotel and flight package on Expedia can be cheaper than booking flights and hotels separately. Bundling can lead to significant savings, especially for international travel or when booking well in advance. However, savings vary depending on factors like destination, travel dates, and availability, so it's wise to compare options. With access to over 300,000 hotels worldwide, Expedia makes it easy to build the perfect travel package.
Are there hotels in Florence that offer couples' spa treatments?
When looking for hotels in Florence that offer couples' spa treatments, the Hotel Florence, Tapestry Collection by Hilton is a great choice.

This 3-star hotel, with an 8.8 rating, features dedicated couples' treatment rooms. Its full-service spa offers a range of treatments, including deep tissue massage, hot stone massage, Swedish massage, and aromatherapy. Guests can also enjoy various body treatments such as body wraps and detoxification wraps, alongside facial treatments.
Are there any unique spa experiences available in Florence?
Yes, Florence, South Carolina offers several unique spa experiences that blend advanced medical aesthetics with traditional relaxation treatments.

The Spa at Hotel Florence features individual treatment rooms, a relaxation room, and a couples room, providing custom deep tissue, prenatal, aromatherapy, and hot stone massages, alongside personalised organic facials, advanced peels, and diamond-tipped microdermabrasion. Hotel guests can also enjoy treatments in their suites or penthouses.

Real Medical Spa and Aesthetics focuses on personalised, innovative skincare and rejuvenation treatments, combining state-of-the-art technology with tailored care to enhance natural beauty and long-term skin health.

Genesis Cosmetic Laser Centre is a modern medical spa offering advanced treatments like laser procedures, injectables, microneedling, and body sculpting, blending medical-grade skincare with spa luxury for anti-aging and confidence-boosting solutions.

Deluxe Medical Spa is known for its anti-aging facial treatments and body-sculpting procedures, emphasising safe, effective, and innovative medical spa experiences.

A Great Massage Spa offers traditional and Asian massage therapies, including hot stone and deep tissue massages, praised for relaxation and quality service.

Paris Nail Spa provides a luxury nail care experience with manicures, pedicures, hot stone therapy, and nail art, with a focus on hygiene and comfort.
Can I cancel my spa hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline. This is often within 24-48 hours of your scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use Expedia's "Fully refundable property" filter during your search to find the right spa hotel in Florence for you.
How can I save on a spa hotel in Florence with Expedia?
Find Florence spa hotel deals by joining One Key™, Expedia's free travel rewards program. As a member, you can unlock instant savings with Member Prices when you're logged in. For a quick weekend retreat, discover last-minute offers.

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