Title: Book The Best Hotels in Pamplico, SC for 2026 from CA $85 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Pamplico](https://expedia.ca/Pamplico-Vacation-Rentals.d3000353197.Travel-Guide-VacationRentals)[Things to do in Pamplico](https://expedia.ca/Things-To-Do-In-Pamplico.d3000353197.Travel-Guide-Activities)[Pamplico Car Rentals](https://expedia.ca/Car-Rentals-In-Pamplico.d3000353197.Car-Rental-Guide)[Pamplico Vacation Packages](https://expedia.ca/Pamplico.d3000353197.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Pamplico, SC from CA $85 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Pamplico Pool [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-01-09&d1=2026-01-09&endDate=2026-01-11&d2=2026-01-11&amenities=POOL) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-01-09&d1=2026-01-09&endDate=2026-01-11&d2=2026-01-11&travelerType=family_friendly) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-01-09&d1=2026-01-09&endDate=2026-01-11&d2=2026-01-11&amenities=HOT_TUB) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-01-09&d1=2026-01-09&endDate=2026-01-11&d2=2026-01-11&amenities=PETS) ## Check prices for these dates Tonight [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-12-26&endDate=2025-12-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Pamplico hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/618b4a3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/321cbe11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/a6fa48ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/72e5d4f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Mullins - Marion [](https://www.expedia.ca/Florence-Hotels-Quality-Inn.h24816.Hotel-Information) Marion 7.6/10 Good (377) "It was ok clean would stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jeff CA $134 CA $146 total includes taxes & fees Dec 27 - Dec 28 [](https://www.expedia.ca/Florence-Hotels-Quality-Inn.h24816.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/51d8f371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2203) "Breakfast was great, room very clean ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leann CA $116 CA $130 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/b5687a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/ebea43b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/8a1b879d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Florence 8.6/10 Excellent (2514) "I nice place to stay, very quiet, good breakfast, nice staff, spotless room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $86 CA $96 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/5cc0357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/0cae09f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/744aa109.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Latta by IHG [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) Latta 9.6/10 Exceptional (534) "Everything great " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Caroline CA $153 CA $167 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/c7afe694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/0ea8f0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/83187168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1171) "Great location, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Defelicio CA $134 CA $150 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/0da1bc1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/6fee16b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/da02b608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/25ba1b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Executive Inn [](https://www.expedia.ca/Florence-Hotels-Best-Western-Executive-Inn.h1202776.Hotel-Information) Latta 8.2/10 Very good (937) "Would definitely stay again !!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $105 CA $114 total includes taxes & fees Jan 22 - Jan 23, 2026 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Executive-Inn.h1202776.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/870000/861500/861452/2d22b260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/870000/861500/861452/dd4c54c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/870000/861500/861452/c0e8f3c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Accessible bathroom](https://images.trvl-media.com/lodging/1000000/870000/861500/861452/6df09eae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Florence [](https://www.expedia.ca/Florence-Hotels-Super-8-By-Wyndham-Florence.h861452.Hotel-Information) Florence 7.0/10 Good (1000) "Clean room, Courteous Staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rhodney CA $76 CA $85 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Florence-Hotels-Super-8-By-Wyndham-Florence.h861452.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/cbc9a37d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/ad4579b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/bee831df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 9.0/10 Wonderful (1002) "Great experience in a nice hotel in downtown." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) HATIM CA $137 CA $153 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/bccde616.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/8339db76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/5b7b6acc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Florence I-95 [](https://www.expedia.ca/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) Florence 8.4/10 Very good (1002) "We enjoyed our stay. Everything stood out Staff, Clean room and Amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marita CA $128 CA $148 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/94a4d77a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/f287bfc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/1e0c4eb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence Center [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) Florence 9.0/10 Wonderful (826) "My go to stay while in Fairfax. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory CA $133 CA $149 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/6676431c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/024086db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/258371f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Florence Civic Center [](https://www.expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) Florence 7.8/10 Good (1256) "Room was spotless and the staff was friendly..." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Randy CA $102 CA $114 total includes taxes & fees Jan 25 - Jan 26, 2026 [](https://www.expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/824b9567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/7f29240e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/9f136d0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Florence [](https://www.expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) Florence 8.0/10 Very good (1668) "Clean room & breakfast was good. Checkin staff was great, friendly and professional. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cheryl CA $128 CA $143 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/200000/200000/199996/cbd95825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/200000/200000/199996/73965d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/200000/200000/199996/15aed007.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed, Accessible, Non Smoking | Bathroom shower](https://images.trvl-media.com/lodging/1000000/200000/200000/199996/7046523d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Florence [](https://www.expedia.ca/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-Florence.h199996.Hotel-Information) Florence 6.8/10 (1002) "Good stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jimmy CA $82 CA $92 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-Florence.h199996.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/37f52847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/bdf580c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) Florence 8.6/10 Excellent (1005) "Room was clean, staff was courteous and breakfast was great !" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela CA $156 CA $175 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![The Paris Room](https://images.trvl-media.com/lodging/49000000/48320000/48317800/48317795/97b38991.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![The Elon #9](https://images.trvl-media.com/lodging/49000000/48320000/48317800/48317795/efed05f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Catelaya](https://images.trvl-media.com/lodging/49000000/48320000/48317800/48317795/c0406b89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Tranquil Double room](https://images.trvl-media.com/lodging/49000000/48320000/48317800/48317795/fc0c91a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bella's Boutique Hotel [](https://www.expedia.ca/Hemingway-Hotels-Bellas-Boutique-Hotel.h48317795.Hotel-Information) Hemingway 6.2/10 (13) "Quaint and cozy, convenient for visiting family. The staff and owner were very welcoming and generous. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $89 CA $135 total includes taxes & fees Dec 27 - Dec 28 [](https://www.expedia.ca/Hemingway-Hotels-Bellas-Boutique-Hotel.h48317795.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, laptop workspace, soundproofing](https://images.trvl-media.com/lodging/1000000/10000/500/455/7442eef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/500/455/5074ad24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/500/455/af3985b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Inn [](https://www.expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) Florence 7.6/10 Good (1000) "Spotless room and courteous staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Krusaundra CA $122 CA $136 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/25cb76ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/bdaaa724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/c42cf41b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/41091644.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Florence North I-95, SC [](https://www.expedia.ca/Florence-Hotels-Spark-By-Hilton-Florence-North-I-95.h42602.Hotel-Information) Florence 8.0/10 Very good (29) "Friendly staff and clean environment " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) john CA $132 CA $154 total includes taxes & fees Jan 6 - Jan 7, 2026 [](https://www.expedia.ca/Florence-Hotels-Spark-By-Hilton-Florence-North-I-95.h42602.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/b1bbd639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/099eb7f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/dab62d55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/3ba2ede7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Florence/I-95 North [](https://www.expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) Florence 6.8/10 (1002) "Clean room , quite area , walking distance " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gisell CA $80 CA $90 total includes taxes & fees Jan 12 - Jan 13, 2026 [](https://www.expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/d963a865.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/434898b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Non Smoking](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/00af3161.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/43206f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Florence I-95 [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) Florence 8.4/10 Very good (1001) "Pool was clean good breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ann CA $140 CA $163 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/59604fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/16ca8b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/a2c60bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence-North-I-95 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) Florence 9.0/10 Wonderful (821) "We had our dog and the room was good and dog amenities helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia CA $157 CA $175 total includes taxes & fees Jan 7 - Jan 8, 2026 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-09&endDate=2026-01-10®ionId=3000353197&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPamplico-Hotels.d3000353197.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPamplico-Hotels.d3000353197.Travel-Guide-Hotels) ## More cheap stays in Pamplico ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Howard Johnson by Wyndham Florence 2038 W Lucas Street Florence SC CA $86 CA $96 total Dec 28 - Dec 29 includes taxes & fees 8.6/10 Excellent! (2,507 reviews) [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn & Suites Florence Civic Center 150 Dunbarton Dr Florence SC CA $102 CA $114 total Jan 25 - Jan 26, 2026 includes taxes & fees 7.8/10 Good! (1,253 reviews) [](https://expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Park Inn by Radisson Florence, SC 1729 Mandeville Road Florence SC CA $116 CA $130 total Jan 11 - Jan 12, 2026 includes taxes & fees 8.8/10 Excellent! (2,201 reviews) [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Best Western Inn](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Inn 1808 W Lucas Street Florence SC CA $122 CA $136 total Dec 28 - Dec 29 includes taxes & fees 7.6/10 Good! (1,008 reviews) [](https://expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Inn & Suites Florence Center Area 527 Woody Jones Blvd Florence SC CA $134 CA $150 total Jan 11 - Jan 12, 2026 includes taxes & fees 9/10 Wonderful! (1,176 reviews) [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Hampton Inn & Suites Florence-North-I-95](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn & Suites Florence-North-I-95 1735 Stokes Road Florence SC CA $157 CA $175 total Jan 7 - Jan 8, 2026 includes taxes & fees 8.8/10 Excellent! (820 reviews) [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ## Hotels in Pamplico with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 1 properties [](https://expedia.ca/4Star-Pamplico-Hotels.s40-0-d3000353197.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 13 properties [](https://expedia.ca/3Star-Pamplico-Hotels.s30-0-d3000353197.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 61 properties [](https://expedia.ca/2Star-Pamplico-Hotels.s20-0-d3000353197.Travel-Guide-Filter-Hotels) ## Recent reviews of Pamplico hotels ![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc_y.jpg) ### Quality Inn & Suites Florence Civic Center 5/5 Excellent "A few stains on the carpet but all around clean." A verified traveller stayed at Quality Inn & Suites Florence Civic Center Posted 3 days ago [](https://expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites Florence Center Area 5/5 Excellent "Everything was top notch. I would definitely stay there again." A verified traveller stayed at Comfort Inn & Suites Florence Center Area Posted 4 days ago [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Hampton Inn & Suites Florence-North-I-95](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg) ### Hampton Inn & Suites Florence-North-I-95 5/5 Excellent "We had our dog and the room was good and dog amenities helpful." A verified traveller from Virginia Beach stayed at Hampton Inn & Suites Florence-North-I-95 Posted 4 days ago [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 5/5 Excellent "Room was pretty clean, and in good shape. But the rowdy guess made it a little bit of a challenging experience. HOTEL staff all were very friendly and kind." A verified traveller from Huntingdon Valley stayed at TownePlace Suites by Marriott Florence Posted 5 days ago [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![Residence Inn Marriott Florence](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg) ### Residence Inn Marriott Florence 5/5 Excellent "Everything was nice annd cozy. The room was spotless and spacious. The staff was warm and welcoming " A verified traveller stayed at Residence Inn Marriott Florence Posted 6 days ago [](https://expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg) ### Park Inn by Radisson Florence, SC 5/5 Excellent "Every thing perfect as always" A verified traveller stayed at Park Inn by Radisson Florence, SC Posted 6 days ago [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Hyatt Place Florence Downtown](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321_y.jpg) ### Hyatt Place Florence Downtown 5/5 Excellent "Great experience in a nice hotel in downtown." A verified traveller from Orlando stayed at Hyatt Place Florence Downtown Posted 6 days ago [](https://expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 5/5 Excellent "Clean, safe room" A verified traveller stayed at Howard Johnson by Wyndham Florence Posted 6 days ago [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695_y.jpg) ### La Quinta Inn & Suites by Wyndham Florence 5/5 Excellent "Clean room & breakfast was good. Checkin staff was great, friendly and professional. " A verified traveller stayed at La Quinta Inn & Suites by Wyndham Florence Posted 7 days ago [](https://expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ## Frequently asked questions ### What's the best place for a stay in Pamplico? ### What are some of the best vacation rentals that Pamplico has to offer? ### If I need to cancel my hotel reservation in Pamplico, will I receive a refund? ### What is staying in Pamplico like? ### What should I see while I'm in Pamplico? ### What's the weather like in Pamplico? ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [5 Star Hotels in Florence ](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Aynor Hotels ](https://www.expedia.ca/Aynor-Hotels.d3000353082.Travel-Guide-Hotels) - [Coward Hotels ](https://www.expedia.ca/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - [Darlington Hotels ](https://www.expedia.ca/Darlington-Hotels.d7558.Travel-Guide-Hotels) - 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