Title: 10 Best Florence County Luxury Resorts & Hotels for 2025 | Expedia.ca [Florence County Hotels](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Hotel-Destinations)[Vacation Rentals in Florence County](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Vacation-Rental-Destinations)[Florence County Flights](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Flight-Destinations)[Florence County Car Rentals](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Car-Rental-Destinations)[Florence County Vacations](https://expedia.ca/Florence-County.d553248635976432658.Destination-Travel-Guides) ![Florence_FlorenceCivicCenter_6165605_0005](https://images.trvl-media.com/place/6165605/469ba674-c82b-48e7-81cb-5533222130a5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Luxury Hotels & Resorts in Florence County - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Florence County ![](https://mediaim.expedia.com/destination/1/bb3e92b3001d46f023d4e565fc1d1eae.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Florence [](https://expedia.ca/Florence-Hotels-Luxury-Hotel.0-0-d1221-tLuxuryHotel.Travel-Guide-Filter-Hotels) ## Check availability on Florence County Luxury Hotels Tonight [Nov 12 - Nov 13](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2025-11-12&endDate=2025-11-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 13 - Nov 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2025-11-13&endDate=2025-11-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2025-11-21&endDate=2025-11-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Florence County Luxury Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Florence-County-Luxury-Hotel.0-0-d553248635976432658-tLuxuryHotel.Hotel-Filter-Destinations)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Florence-County-Luxury-Hotel.0-0-d553248635976432658-tLuxuryHotel.Hotel-Filter-Destinations) ## Top Florence County Hotel Reviews ![Comfort Inn & Suites](//images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites 10/10 Excellent "The room was great, very clean & big. It was very comfortable. The staff was also great 👍, they were very accommodating, polite & kind. Good Place to Stay & I made sure to put their name in address in my book, because I'll definitely stay there again. I highly recommend The Comfort Inn & Suites." [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Florence](//images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695_y.jpg) ### La Quinta Inn & Suites by Wyndham Florence 10/10 Excellent "Friendly staff, clean just what I was looking for!" [](https://expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ![TownePlace Suites by Marriott Florence](//images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 10/10 Excellent "We are repeat customers. We find the hotel customer friendly with friendly staff, clean rooms and a breakfast that is good & filling to start the next if our trip." [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![Howard Johnson by Wyndham Florence](//images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Staff was super friendly!" [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Hampton Inn & Suites Florence-North-I-95](//images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg) ### Hampton Inn & Suites Florence-North-I-95 10/10 Excellent "Gladys at the reception was very friendly and very helpful!" [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![Park Inn by Radisson Florence, SC](//images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg) ### Park Inn by Radisson Florence, SC 10/10 Excellent "Room was comfortable. I didn't utilize the breakfast " [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![The Inn at the Crossroads](//images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76_y.jpg) ### The Inn at the Crossroads 10/10 Excellent "Need more than 1 table for continental breakfast. " [](https://expedia.ca/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Tru by Hilton Florence I-95](//images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d_y.jpg) ### Tru by Hilton Florence I-95 10/10 Excellent "Everything was FANTASTIC. Clean, spacious room, nice decor, games in the lobby and outside a big connect four board. Lots of fun available. Breakfast had something unique and INCREDIBLE. They had a vanilla yogurt machine dispensing farm fresh yogurt that tasted incredible!!!! I WILL be back!!! Oh- the bed was wonderful as well" [](https://expedia.ca/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) ![Aloft Florence](//images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/0724af0f_y.jpg) ### Aloft Florence 10/10 Excellent "just need more luggage carts " [](https://expedia.ca/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [5 Star Hotels in Florence](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Business Hotels in Charleston](https://www.expedia.ca/Charleston-Hotels-Business-Hotel.0-0-d179997-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Green Hotels in Charleston](https://www.expedia.ca/Charleston-Hotels-Green-Sustainable.0-0-d179997-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Charleston](https://www.expedia.ca/Charleston-Hotels-Hotel-With-Early-Check-In.0-0-d179997-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - 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