Title: 10 Best Florence County Luxury Resorts & Hotels for 2026 | Expedia.ca [Florence County Hotels](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Hotel-Destinations)[Vacation Rentals in Florence County](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Vacation-Rental-Destinations)[Florence County Flights](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Flight-Destinations)[Florence County Car Rentals](https://expedia.ca/Destinations-In-Florence-County.d553248635976432658.Car-Rental-Destinations)[Florence County Vacations](https://expedia.ca/Florence-County.d553248635976432658.Destination-Travel-Guides) ![Florence_FlorenceCivicCenter_6165605_0005](https://images.trvl-media.com/place/6165605/469ba674-c82b-48e7-81cb-5533222130a5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6165605/469ba674-c82b-48e7-81cb-5533222130a5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Florence County ![Wyche Pavilion Greenville South Carolina ](https://images.trvl-media.com/place/1221/22638cec-95e4-4f53-af15-3963f8a47f19.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Florence [](https://expedia.ca/Florence-Hotels-Luxury-Hotel.0-0-d1221-tLuxuryHotel.Travel-Guide-Filter-Hotels) ![a stunning aerial panoramic shot of the blue waters of Lake Hartwell surrounded by vast miles of lush green trees and grass with powerful clouds at sunset in Fair Play South Carolina USA](https://images.trvl-media.com/place/8506/47c9f422-933e-4135-8743-774b754f1db4.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Lake City [](https://expedia.ca/Lake-City-Hotels-Luxury-Hotel.0-0-d8506-tLuxuryHotel.Travel-Guide-Filter-Hotels) ## Check availability on Florence County Luxury Hotels Tonight [Mar 16 - Mar 17](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2026-03-16&endDate=2026-03-17&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Mar 17 - Mar 18](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2026-03-17&endDate=2026-03-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2026-03-20&endDate=2026-03-22&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976432658&startDate=2026-03-27&endDate=2026-03-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Florence-County-Luxury-Hotel.0-0-d553248635976432658-tLuxuryHotel.Hotel-Filter-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Florence-County-Luxury-Hotel.0-0-d553248635976432658-tLuxuryHotel.Hotel-Filter-Destinations) ## Top Florence County Hotel Reviews ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg) ### Comfort Inn & Suites Florence Center Area 8/10 Good "Didn’t use the business facilities. Not even shore if they had a pool." [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Staybridge Suites Florence - Civic Center by IHG](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/89338f8a_y.jpg) ### Staybridge Suites Florence - Civic Center by IHG 10/10 Excellent "Stayed for one night while traveling to Florida. Very comfortable one bedroom suite. " [](https://expedia.ca/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f_y.jpg) ### Park Inn by Radisson Florence, SC 6/10 Okay "Was ok" [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "The staff is awesome really nice hotel exciting the expectations " [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Days Inn by Wyndham Florence/I-95 North](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/099eb7f9_y.jpg) ### Days Inn by Wyndham Florence/I-95 North 10/10 Excellent "Clean room, friendly staff and ample parking, breakfast is ok. " [](https://expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) ![Microtel Inn & Suites by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/200000/200000/199996/4d56e96c_y.jpg) ### Microtel Inn & Suites by Wyndham Florence 6/10 Okay "Booked because it was the lowest price for not a Motel 6 or Red Roof. Small room, no problem. Big fridge. Free coffee in the AM. Property is run down but bed and bathroom were clean. " [](https://expedia.ca/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-Florence.h199996.Hotel-Information) ![Hilton Garden Inn Florence](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/ddbd2495_y.jpg) ### Hilton Garden Inn Florence 8/10 Good "Didn't expect to pay $65 for breakfast buffet !" [](https://expedia.ca/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information) ![Hyatt Place Florence Downtown](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166_y.jpg) ### Hyatt Place Florence Downtown 10/10 Excellent "Was stay was wonderful and the staff was so kind and courteous. I had two different reservations bank to back and was very happy that I could keep the same room for both nights." [](https://expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Fairfield Inn & Suites by Marriott Florence I-20](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5dc20640_y.jpg) ### Fairfield Inn & Suites by Marriott Florence I-20 10/10 Excellent "Great stay" [](https://expedia.ca/Florence-Hotels-Fairfield-Inn-Suites-By-Marriott-Florence-I-20.h17035960.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [5 Star Hotels in Florence ](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Business Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Business-Hotel.0-0-d179997-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Green Hotels in Charleston ](https://www.expedia.ca/Charleston-Hotels-Green-Sustainable.0-0-d179997-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Charleston ](https://www.expedia.ca/Charleston-Hotels-Hotel-With-Early-Check-In.0-0-d179997-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - 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