Title: Top Hotels in New Madrid County | Expedia.ca [Vacation Rentals in New Madrid County](https://expedia.ca/Destinations-In-New-Madrid-County.d553248635976433157.Vacation-Rental-Destinations)[New Madrid County Car Rentals](https://expedia.ca/Destinations-In-New-Madrid-County.d553248635976433157.Car-Rental-Destinations)[New Madrid County Vacations](https://expedia.ca/New-Madrid-County.d553248635976433157.Destination-Travel-Guides) ![The best restaurant I have EVER been to! Hands down!!!](https://images.trvl-media.com/place/553248634983441802/03fb167a-d590-4293-9dd9-648c99605c85.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Coleman # Search New Madrid County Hotels - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in New Madrid County ![](https://mediaim.expedia.com/destination/2/798fcf2b70d51325aa2ef18edc87befc.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Sikeston [](https://expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels) ## Check prices for these dates Tonight [Dec 23 - Dec 24](https://www.expedia.ca/Hotel-Search?regionId=553248635976433157&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 24 - Dec 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976433157&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976433157&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976433157&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for New Madrid County hotels ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1009) "This our favorite place to stop for a good night sleep. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eileen CA $124 CA $142 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (449) "Friendly staff clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $134 CA $152 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/a2f06e13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/945fac08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily breakfast](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/d0c3544f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) Sikeston 9.4/10 Exceptional (1002) "Everything was clean, staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $103 CA $119 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn and Suites by Wyndham Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) Sikeston 7.2/10 Good (1002) "A great stay in every aspect. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gertrude CA $86 CA $99 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/327b8d22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) Sikeston 8.4/10 Very good (1008) "Great stay, everything was clean and comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles CA $104 CA $119 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/594efec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) [](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) Sikeston 8.4/10 Very good (722) "Stayed one night. Good rate for the Hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $76 CA $87 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Premier Room, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/a77daa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 Bedroom, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Orleans Inn Portageville [](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) Portageville 8.0/10 Very good (731) "Friendly sta" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa [](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Sikeston [](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) Sikeston 9.2/10 Wonderful (41) "THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) AHMAD CA $139 CA $157 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/ef46b494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 By Wyndham Marston [](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) Marston 7.8/10 Good (39) "Great hotel, great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dmitry CA $79 CA $91 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sikeston Southwest by IHG [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Sikeston 8.6/10 Excellent (443) "Staff was great. Hotel was clean. Great sleep. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey CA $128 CA $145 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/97dfc357.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/cc9ac69a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/715f35ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Sikeston/Miner Area [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information) Sikeston 6.8/10 (568) "Awesomeness " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rick CA $82 CA $93 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/fcfb42b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-c8905780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott Sikeston [](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information) Sikeston 9.0/10 Wonderful (8) "Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott CA $162 CA $184 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information) ![Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/5bb06af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/f23217d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/501c540f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/6099e00f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn [](https://www.expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) Marston 6.0/10 (116) "Had a great time loved it " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shyianne CA $59 CA $68 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/6afdbde2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/4da73ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7657c6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/1fa29b5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Sikeston I-55 [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information) Sikeston 8.4/10 Very good (282) "Room was clean, breakfast was very good. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Connie CA $122 CA $139 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/b7350700.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/980dd49e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/392abeff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Yard Inn and Suite [](https://www.expedia.ca/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) Sikeston 6.8/10 (121) "Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew CA $73 CA $87 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) ![Free self parking](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/w2880h1906x0y7-f34c7d0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/w2880h1912x0y4-0511a328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/w2880h1905x0y7-6be09486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/w2880h1906x0y7-e5745fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### OYO Malden Airport Inn [](https://www.expedia.ca/Malden-Hotels-Malden-Airport-Inn.h23265745.Hotel-Information) Malden 7.0/10 Good (68) "Clean room, quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer [](https://www.expedia.ca/Malden-Hotels-Malden-Airport-Inn.h23265745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1060h720x0y199-6f809fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/18e1eee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h809x0y1-d7340261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h1439x0y1-2bafdfca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room! [](https://www.expedia.ca/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information) New Madrid 10/10 Exceptional (1) "The host was very quick to respond and so great to work with for on our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica S. CA $275 CA $469 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/aab8c593.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/ee2b7138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, blender](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/6045fc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/f956f55c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Modern and Cozy Apartment with large windows and sunlight. [](https://www.expedia.ca/Sikeston-Hotels-Modern-And-Cozy-Apartment-With-Large-Windows-And-Sunlight.h76020481.Hotel-Information) Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Modern-And-Cozy-Apartment-With-Large-Windows-And-Sunlight.h76020481.Hotel-Information) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/60633b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/45782657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handicap Room](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/6128b6d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reelfoot Lake Inn [](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) Tiptonville 7.2/10 Good (461) "Bed bugs in two separate rooms, wouldn’t refund my room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacquelynn CA $96 CA $110 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88740000/88733200/88733109/2d097770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/89000000/88740000/88733200/88733109/360e1d34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/89000000/88740000/88733200/88733109/dcc34bb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88740000/88733200/88733109/54ccf231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dave's shallow lake at reelfoot lake lodging cabin 15 [](https://www.expedia.ca/Tiptonville-Hotels-Daves-Shallow-Lake-At-Reelfoot-Lake-Lodging.h88733109.Hotel-Information) Tiptonville 10/10 Exceptional (2) "We had a wonderful trip. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terri G. CA $278 CA $461 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Tiptonville-Hotels-Daves-Shallow-Lake-At-Reelfoot-Lake-Lodging.h88733109.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-06&endDate=2026-01-07®ionId=553248635976433157&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-New-Madrid-County.d553248635976433157.Hotel-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-New-Madrid-County.d553248635976433157.Hotel-Destinations) ## Top New Madrid County Hotel Reviews ![Hampton Inn By Hilton Dexter](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/w3836h2556x4y4-c3d811b2_y.jpg) ### Hampton Inn By Hilton Dexter 10/10 Excellent "Great stay " [](https://expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) ![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg) ### New Orleans Inn Portageville 10/10 Excellent "Friendly sta" [](https://expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Everything we just lovely " [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Great stay, everything was clean and comfortable. " [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Super spacious room and delightful staff. Recommended to ALL " [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Everything was well done" [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Econo Lodge](https://images.trvl-media.com/lodging/1000000/50000/40200/40136/1fd839ba_y.jpg) ### Econo Lodge 10/10 Excellent "Staff was very accommodating " [](https://expedia.ca/Kennett-Hotels-Econo-Lodge.h40136.Hotel-Information) ![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg) ### Travelodge by Wyndham Dexter 10/10 Excellent "Staff was helpful and kind. The room was clean as well as the whole Hotel, although they should move the smoking area from right at the enrty way of the hotel." [](https://expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 10/10 Excellent "Very clean environment. Staff is very nice and friendly. Will not mind staying here again in future. " [](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in New Madrid County - [Marston Hotels ](https://expedia.ca/Marston-Hotels.d55824.Travel-Guide-Hotels) - [New Madrid Hotels ](https://expedia.ca/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels) - [Matthews Hotels ](https://expedia.ca/Matthews-Hotels.d553248634983428760.Travel-Guide-Hotels) - [Morehouse Hotels ](https://expedia.ca/Morehouse-Hotels.d553248634983462037.Travel-Guide-Hotels) - [Lilbourn Hotels ](https://expedia.ca/Lilbourn-Hotels.d553248634983590625.Travel-Guide-Hotels) - [Gideon Hotels ](https://expedia.ca/Gideon-Hotels.d3000349377.Travel-Guide-Hotels) - [Risco Hotels ](https://expedia.ca/Risco-Hotels.d3000349516.Travel-Guide-Hotels) - [Howardville Hotels ](https://expedia.ca/Howardville-Hotels.d553248634983363505.Travel-Guide-Hotels) - [Canalou Hotels ](https://expedia.ca/Canalou-Hotels.d3000349311.Travel-Guide-Hotels) - [Tallapoosa Hotels ](https://expedia.ca/Tallapoosa-Hotels.d553248634983263480.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near New Madrid Historical Museum ](https://expedia.ca/New-Madrid-Historical-Museum-Hotels.0-l553248621532655748-0.Travel-Guide-Filter-Hotels) - [Hotels near Marston Community Center ](https://expedia.ca/Marston-Community-Center-Hotels.0-l553248622945532712-0.Travel-Guide-Filter-Hotels) - [Hotels near River Ridge Winery ](https://expedia.ca/River-Ridge-Winery-Hotels.0-l553248621532655749-0.Travel-Guide-Filter-Hotels) - [Hotels near Hunter-Dawson State Historic Site ](https://expedia.ca/Hunter-Dawson-State-Historic-Site-Hotels.0-l553248621532655794-0.Travel-Guide-Filter-Hotels) - [Hotels near Mississippi River ](https://expedia.ca/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels) - [Hotels near Reelfoot Lake ](https://expedia.ca/Reelfoot-Lake-Hotels.0-l553248635976195913-0.Travel-Guide-Filter-Hotels) - [Hotels near Reelfoot Lake State Park ](https://expedia.ca/Reelfoot-Lake-State-Park-Hotels.0-l553248621532655205-0.Travel-Guide-Filter-Hotels) - [Hotels near Century Casino Caruthersville ](https://expedia.ca/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels) - [Hotels near Central Park ](https://expedia.ca/Central-Park-Hotels.0-l6305608-0.Travel-Guide-Filter-Hotels) - [Hotels near Missouri National Guard Armory ](https://expedia.ca/Missouri-National-Guard-Armory-Hotels.0-l553248635976285533-0.Travel-Guide-Filter-Hotels) ### More Accommodation Types in New Madrid County - [Vacation Homes in New Madrid County ](https://expedia.ca/New-Madrid-County-Private-Vacation-Homes.d553248635976433157-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Lodges in New Madrid County ](https://expedia.ca/New-Madrid-County-Lodges.d553248635976433157-aaLodges.Travel-Guide-Accommodation) - [Motels in New Madrid County ](https://expedia.ca/New-Madrid-County-Motels.d553248635976433157-aaMotels.Travel-Guide-Accommodation) - [Cabin Rentals in New Madrid County ](https://expedia.ca/New-Madrid-County-Cabins.d553248635976433157-aaCabins.Travel-Guide-Accommodation) - [Cottages in New Madrid County ](https://expedia.ca/New-Madrid-County-Cottages.d553248635976433157-aaCottages.Travel-Guide-Accommodation) - [Apartments in New Madrid County ](https://expedia.ca/New-Madrid-County-Apartments.d553248635976433157-aaApartments.Travel-Guide-Accommodation) - [RV Parks in New Madrid County ](https://expedia.ca/New-Madrid-County-RV-Parks.d553248635976433157-aaRVParks.Travel-Guide-Accommodation) ### Explore more hotels - [Hampton Inn Sikeston ](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) - [New Orleans Inn Portageville ](https://expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) - [Fairfield Inn & Suites by Marriott Sikeston ](https://expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) - [Holiday Inn Express & Suites Sikeston Southwest by IHG ](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) - [Super 8 By Wyndham Marston ](https://expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) - 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[Things to do in Levy County](https://expedia.ca/Things-To-Do-In-Levy-County.d553248635976432502.Travel-Guide-Activities) Packages - [San Diego County Trip](https://expedia.ca/San-Diego-County.d178304.Destination-Travel-Guides) General - [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136) - [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828) - [Visit Parkville](https://expedia.ca/Parkville.dx9973) - [Visit Orange County](https://expedia.ca/Orange-County.dx603224) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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