Title: New Madrid County Vacations & Trips 2026 | Expedia.ca [New Madrid County Hotels](https://expedia.ca/Destinations-In-New-Madrid-County.d553248635976433157.Hotel-Destinations)[Vacation Rentals in New Madrid County](https://expedia.ca/Destinations-In-New-Madrid-County.d553248635976433157.Vacation-Rental-Destinations)[New Madrid County Car Rentals](https://expedia.ca/Destinations-In-New-Madrid-County.d553248635976433157.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/553248634983441802/03fb167a-d590-4293-9dd9-648c99605c85.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # New Madrid County Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings Photo by Ryan Coleman - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your New Madrid County Vacation With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? [Portageville](https://www.expedia.ca/Portageville.d183487.Destination-Travel-Guides). Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia. ## New Madrid County Hotel Deals ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay CA $135 CA $153 total Dec 28 - Dec 29 includes taxes & fees 8.8/10 Excellent! (444 reviews) Yes Reviewed on Dec 10, 2025 [](https://expedia.ca/Hotel-Search?startDate=28%2F12%2F2025&endDate=29%2F12%2F2025&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=553248635976433157) ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Sikeston 1239 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay CA $139 CA $157 total Dec 25 - Dec 26 includes taxes & fees 9.2/10 Wonderful! (40 reviews) Staff Reviewed on Dec 8, 2025 [](https://expedia.ca/Hotel-Search?startDate=25%2F12%2F2025&endDate=26%2F12%2F2025&selected=111247451&PinnedHotelID=111247451&HadPinnedHotel=true®ionId=553248635976433157) ![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### New Orleans Inn Portageville 600 US-61 Portageville MO Fully refundableReserve now, pay when you stay 8/10 Very Good! (726 reviews) Yes Reviewed on Dec 11, 2025 [Get rates](https://expedia.ca/Hotel-Search?startDate=31%2F12%2F2025&endDate=01%2F01%2F2026&selected=38979739&PinnedHotelID=38979739&HadPinnedHotel=true®ionId=553248635976433157) [](https://expedia.ca/Hotel-Search?startDate=31%2F12%2F2025&endDate=01%2F01%2F2026&selected=38979739&PinnedHotelID=38979739&HadPinnedHotel=true®ionId=553248635976433157) [See all 95 properties in New Madrid County](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=553248635976433157) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Frequently asked questions ### How much does a New Madrid County vacation package cost? ### How do I get a cheap travel package to New Madrid County? ### What are the top hotels in New Madrid County? ### How far in advance should I book my New Madrid County vacation? ### What does an Expedia New Madrid County travel package include? ### What should I know before booking a New Madrid County travel package? ### Can I choose my airline with a New Madrid County Expedia vacation package? ### If I'm not able to travel, can I cancel my New Madrid County vacation package? \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app