Title: Top 10 4 Star Hotels in Sikeston : Find a Four Star Hotel in Sikeston | Expedia.ca [Sikeston Travel Guide](https://expedia.ca/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.ca/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.ca/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Sikeston Car Rentals](https://expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.ca/Sikeston.d6058766.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/798fcf2b70d51325aa2ef18edc87befc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Coleman # 4 Star Hotels in Sikeston ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sikeston 4 Star Hotels Tonight [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-09-27&endDate=2025-09-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-09-28&endDate=2025-09-29&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sikeston 4 Star Hotels ![Honeymoon Suite, 1 King Bed, Non Smoking, Courtyard View | View from room](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/3020a524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/7e984039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Suite, 1 King Bed, Non Smoking, Park View](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/5dbc606e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free self parking](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/47d3c772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Davie School Inn Anna 10/10 Exceptional (51) "One of the coolest and unique places we’ve stayed. It’s clean, quiet and the decor is perfect for this converted school. It felt like a slumber party in a classroom! " [](https://www.expedia.ca/Anna-Hotels-Davie-School-Inn.h33418130.Hotel-Information) ![Street view](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/1b66adae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Urban Loft #3](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/c739acc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/0fbb921a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Urban Loft #3 | Living area](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/8f7a623b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Lofts Perryville [](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h39926011.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Sikeston-Hotels.s40-0-d6058766.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Sikeston-Hotels.s40-0-d6058766.Travel-Guide-Filter-Hotels) ## Sikeston and related destinations - Sikeston - Florence - Los Banos - Lima Explore Sikeston: its food, riverfront, university life, and more! [See all hotels in Sikeston](https://www.expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12&adults=2®ionId=6058766) ![](https://mediaim.expedia.com/destination/2/798fcf2b70d51325aa2ef18edc87befc.jpg?impolicy=fcrop&w=655&h=655&p=1&q=high) Photo by Ryan Coleman ## Top Sikeston Hotel Reviews ## Find out more about Sikeston If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Sikeston are calling your name. Known for providing first-rate service in amazing locations, each of the Sikeston 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Sikeston. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Sikeston, Missouri, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Sikeston hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Sikeston? > Expedia can help you easily locate the perfect 4-star hotel for your stay in Sikeston. Use our filter tool to fine-tune your search by things like budget, amenities and hotel star rating and get access to fabulous deals in a few clicks. > > > > - Search for the lowest price ### What's the difference between 5-star and 4-star hotels in Sikeston? > If you decide to spend your vacation at a 4-star hotel in Sikeston, you'll typically find plenty of amenities to ensure you're comfortable, such as a restaurant, pool and gym. You can enjoy high-quality service and upmarket accommodations. Go for a 5-star hotel and you'll get a few extra bells and whistles — think on-site spas, 24-hour front desk and nightly turndown services. You'll most likely get additional amenities and first-class services at a 5-star stay, though both are awesome options for luxury guests. ### Does Sikeston have any 4-star all-inclusive resorts? > Finding your dream vacation in Sikeston is as simple as entering in your dates and selecting our "All inclusive" filter. 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