Photo by Bill Dillard

2 Stars Hotels in Southeast Missouri, Missouri from CA $76

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Check prices for these dates

Tonight
Nov 9 - Nov 10
Tomorrow
Nov 10 - Nov 11
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Our top choices for Southeast Missouri 2-star hotels

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,016 reviews)
"Everything was great about the stay!"
United States
Denise
The price is CA $126
CA $141 total
includes taxes & fees
Dec 6 - Dec 7
Hampton Inn Poplar Bluff
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

2. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,001 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is CA $102
CA $115 total
includes taxes & fees
Nov 15 - Nov 16
Pear Tree Inn Cape Girardeau West
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

3. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,003 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is CA $77
CA $88 total
includes taxes & fees
Nov 15 - Nov 16
Baymont Inn and Suites by Wyndham Farmington, MO
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

4. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,001 reviews)
"It was clean, the room was nice and roomy, bed was very comfortable. Some things were in need of minor repairs, but nothing major."
United States
Earl
The price is CA $94
CA $107 total
includes taxes & fees
Nov 11 - Nov 12
Days Inn and Suites by Wyndham Sikeston
A hotel lobby with a reception desk, two red armchairs, a floral centerpiece, a framed cityscape picture, and a dining area in the background.

5. Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (1,003 reviews)
"Check in was easy, the room was clean, price was good, and the breakfast was good."
United States
Michelle
The price is CA $97
CA $114 total
includes taxes & fees
Dec 1 - Dec 2
Comfort Inn Festus - St Louis South
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

6. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (653 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is CA $142
CA $161 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Sikeston
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

7. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (696 reviews)
"It is a clean place, and we enjoyed our stay"
United States
Laura
The price is CA $82
CA $93 total
includes taxes & fees
Nov 15 - Nov 16
Super 8 by Wyndham Sikeston/Miner Area
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

8. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is CA $100
CA $112 total
includes taxes & fees
Nov 10 - Nov 11
Motel 6 Poplar Bluff, MO
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

9. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is CA $140
CA $159 total
includes taxes & fees
Dec 8 - Dec 9
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

10. Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville
2.0 star property
Perryville
7.0 out of 10, Good, (464 reviews)
"Parking was good, smelled terribly"
United States
Jesse
The price is CA $101
CA $115 total
includes taxes & fees
Nov 10 - Nov 11
Days Inn by Wyndham Perryville
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

11. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
8.8 out of 10, Excellent, (702 reviews)
"Tucked away gem."
United States
christopher
The price is CA $143
CA $163 total
includes taxes & fees
Nov 19 - Nov 20
Crown Pointe Lodge, BW Signature Collection
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

12. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,007 reviews)
"Clean rooms, great parking, very nice staff"
United States
Shelley
The price is CA $103
CA $117 total
includes taxes & fees
Dec 7 - Dec 8
Best Western Plus Sikeston I-55
A hotel lobby with a reception desk, seating area, and a patterned carpet.

13. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (645 reviews)
"Excellent stay , couldn't believe the property was 10 years old , it looks like it was just built , great place , highly recommend ."
United States
allan p.
The price is CA $143
CA $163 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites Perryville by IHG
A modern kitchen with a coffee machine, a refrigerator, and a microwave.

14. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (690 reviews)
"Clean nice staff are great"
United States
Marisa
The price is CA $84
CA $96 total
includes taxes & fees
Nov 15 - Nov 16
Super 8 by Wyndham Farmington
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

15. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,002 reviews)
"Nice clean room"
United States
James
The price is CA $100
CA $121 total
includes taxes & fees
Nov 22 - Nov 23
Candlewood Suites Cape Girardeau by IHG
A hotel room with two beds, a TV, a desk, and a wardrobe.

16. The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (628 reviews)
"The rooms were nice and clean and the hotel itself appears to have been redone fairly recently. The staff is across the road at the casino tower a lot so that can be inconvenient for disabled people. We have been here twice to go to the casino and it has been fun both times!"
United States
Lauren
The price is CA $128
CA $145 total
includes taxes & fees
Dec 10 - Dec 11
The Farmstead Hotel
A modern retail area with a display of local items and snacks.

17. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (200 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is CA $120
CA $137 total
includes taxes & fees
Nov 15 - Nov 16
Tru By Hilton Cape Girardeau
A modern kitchen with a central island, built-in appliances, and a view into the dining area.

18. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
Festus
9.4 out of 10, Exceptional, (791 reviews)
"Hotel was very clean and comfortable to stay"
United States
Megnauth
The price is CA $141
CA $162 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

19. Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.2 out of 10, Good, (433 reviews)
"Great hotel with amazing staff!"
United States
Clay
The price is CA $83
CA $90 total
includes taxes & fees
Nov 13 - Nov 14
Super 8 by Wyndham Potosi
A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.

20. Quality Inn Farmington

Quality Inn Farmington
2.5 star property
Farmington
7.6 out of 10, Good, (938 reviews)
"Nice hotel."
United States
Tracy
The price is CA $90
CA $108 total
includes taxes & fees
Nov 12 - Nov 13
Quality Inn Farmington

Top Southeast Missouri Hotel Reviews

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff

10/10 Excellent

Great spot close to the college. Clean, quiet and staff were great
Canada
Sheila
Reviewed August 30, 2026
Hampton Inn Poplar Bluff

Find out more about Southeast Missouri

Want to get out of town on the cheap? Thanks to the low rates and great discounts at the top 2 Stars hotels in Southeast Missouri, Southeast Missouri you can sneak away on the trip of your dreams with plenty of cash to spare. In addition to the friendly staff and well-maintained surroundings, you’ll find comfortable rooms, complimentary bath products, and quiet sleeping areas, so you can kick back with all the basic conveniences after a long day. Plus, these properties are perfect, if you need a jumping-off point for exploring the local attractions.

Several of the best hotels with 2 Stars in Southeast Missouri are situated just a stone’s throw from both public transportation and the city’s main freeways. Use the travel tools at Expedia.ca to search for options near your favorite neighborhood, find a cheap deal, and book your room. You won’t believe how inexpensive your next vacation can be when you settle in at a top two star hotel in Southeast Missouri.

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