A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Southeast Missouri Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for Southeast Missouri vacation rentals

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

1. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (109 reviews)
"I really enjoyed my time at the stay !"
United States
Ronrecus
The price is CA $144
CA $228 total
includes taxes & fees
Nov 1 - Nov 2
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.

2. Sam A Baker State Park

Sam A Baker State Park
2.0 star property
Patterson
9.0 out of 10, Wonderful, (6 reviews)
"Pet friendly, great staff. "
United States
Charlie
The price is CA $192
CA $204 total
includes taxes & fees
Oct 14 - Oct 15
Sam A Baker State Park
A cozy cabin-style room with a wooden interior, a sofa, a dining table, and a kitchen area.

3. Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!
Patterson
10.0 out of 10, Exceptional, (11 reviews)
"Easy check in, very quiet, very calming and relaxing. Overall great stay and great property manager. "
United States
Wyatt S.
The price is CA $107
CA $172 total
includes taxes & fees
Oct 5 - Oct 6
Cozy hobby farm cabin under the stars!
A cabin interior with a loft bed, a chair, and a ceiling fan.

4. Hillside Cabin #2 Annapolis, MO Black River

Hillside Cabin #2 Annapolis, MO Black River
Annapolis
9.4 out of 10, Exceptional, (63 reviews)
"great place to get away. plan to cook/grill there, or drive 30 minutes for food. however, this solitude and quiet is exactly why we booked here. and gorgeous roads, hikes, sites in every direction."
United States
Hans S.
The price is CA $172
CA $307 total
includes taxes & fees
Oct 4 - Oct 5
Hillside Cabin #2 Annapolis, MO Black River
A hot tub in a covered outdoor area with a view of a swimming pool and a wooden play structure in the background.

5. Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
Fredericktown
10.0 out of 10, Exceptional, (13 reviews)
"This was one of the best stays we have ever had! The owners Cathy and Richard are absolutely incredible! They go above and beyond to make sure you have the best time possible! The amities are just non stop! I 100% recommend and will definitely be back!"
United States
Lexis
The price is CA $249
CA $297 total
includes taxes & fees
Oct 5 - Oct 6
Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

6. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.8 out of 10, Exceptional, (8 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
The price is CA $108
CA $227 total
includes taxes & fees
Oct 3 - Oct 4
The Atrium - A Boutique Hotel
A compact kitchen with wooden cabinets, a large TV, and various kitchen utensils hanging on the wall.

7. FS Rental #4 Annapolis, MO Black River

FS Rental #4 Annapolis, MO Black River
Annapolis
9.4 out of 10, Exceptional, (9 reviews)
"Loved the cabin and the outdoor seating area. Definitely recommend for anyone traveling in the area. "
United States
Corey M.
The price is CA $155
CA $294 total
includes taxes & fees
Oct 8 - Oct 9
FS Rental #4 Annapolis, MO Black River
A kitchen with wooden cabinets, a central island with stools, a microwave, a refrigerator, and a stove.

8. Hillside Cabin #1 Annapolis, MO Black River

Hillside Cabin #1 Annapolis, MO Black River
Annapolis
9.6 out of 10, Exceptional, (41 reviews)
"Very grateful for this safe clean cabin. We were there during the terrible Black River flooding and thankfully this cabin was in safe high ground. "
United States
Leslie
The price is CA $188
CA $360 total
includes taxes & fees
Oct 5 - Oct 6
Hillside Cabin #1 Annapolis, MO Black River
A modern room with a large window, two chairs, a small wooden table, and a view of a forest.

9. RIVER and SKY Cabin; Hot Tub

RIVER and SKY Cabin; Hot Tub
Fredericktown
9.4 out of 10, Exceptional, (6 reviews)
"Great getaway"
United States
Anonymous traveller
The price is CA $226
CA $357 total
includes taxes & fees
Oct 8 - Oct 9
RIVER and SKY Cabin; Hot Tub
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.

10. Mountain View at Pickle & Perk

Mountain View at Pickle & Perk
Ironton
10.0 out of 10, Exceptional, (29 reviews)
"Perfect getaway, great experience. Hosts are phenomenal, food and coffee drinks are excellent. Highly recommend."
United States
Anonymous traveller
The price is CA $204
CA $291 total
includes taxes & fees
Oct 4 - Oct 5
Mountain View at Pickle & Perk
A kitchen with wooden cabinets, a microwave, a coffee maker, a stove, and a sink.

11. Clearwater Lake, cabin minutes from Bluff View Marina & boat dock

Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
Piedmont
10.0 out of 10, Exceptional, (47 reviews)
"Would stay here again"
United States
Steve A.
The price is CA $171
CA $209 total
includes taxes & fees
Oct 3 - Oct 4
Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
A kitchen with wooden cabinets, a toaster, and a dishwasher.

12. Lake Road Cabin C — Million Dollar Ozark View!

Lake Road Cabin C — Million Dollar Ozark View!
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Great cabin. Very quiet area. Nice fire pit."
United States
Heather the Librarian
The price is CA $154
CA $254 total
includes taxes & fees
Oct 4 - Oct 5
Lake Road Cabin C — Million Dollar Ozark View!
A table with two chairs under a large tree with a potted plant on it.

13. Pickleball Cafe & Micro Hotel

Pickleball Cafe & Micro Hotel
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Great place to get away. Loved the coffee . "
United States
Craig C.
The price is CA $242
CA $329 total
includes taxes & fees
Oct 5 - Oct 6
Pickleball Cafe & Micro Hotel
A window with a vase of flowers and a book on a wooden table.

14. The Sutton House 2 blocks from Main Street & Courthouse Square

The Sutton House 2 blocks from Main Street & Courthouse Square
Ironton
10.0 out of 10, Exceptional, (63 reviews)
"This property is beautiful and everything is thought of for the guests. The hosts were amazing. It is close to wonderful state parks. My family had a great time. I would stay here again!"
United States
Jennifer D.
The price is CA $240
CA $292 total
includes taxes & fees
Oct 8 - Oct 9
The Sutton House 2 blocks from Main Street & Courthouse Square
A cozy living room with a brown leather sofa, a small table with a lamp, and a wooden floor. A kitchen with wooden cabinets and a dining area with a table and chairs are visible in the background.

15. Small Town Lodge - Annapolis, MO Black River

Small Town Lodge - Annapolis, MO Black River
Annapolis
8.4 out of 10, Very good, (9 reviews)
"Owner communicated well and the place was a nice clean place for us to stay "
United States
Jeremy H.
The price is CA $188
CA $358 total
includes taxes & fees
Oct 8 - Oct 9
Small Town Lodge - Annapolis, MO Black River
A kitchen with dark cabinets, a stainless steel refrigerator, a built-in oven, a microwave, and a flat-screen TV mounted above the counter.

16. Hillside Cabin #5 Annapolis, MO

Hillside Cabin #5 Annapolis, MO
Annapolis
9.2 out of 10, Wonderful, (5 reviews)
"Great location and very clean."
United States
Mary C.
The price is CA $172
CA $307 total
includes taxes & fees
Oct 8 - Oct 9
Hillside Cabin #5 Annapolis, MO
A porch with four green Adirondack chairs, a small table, and string lights.

17. *State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
Ironton
10.0 out of 10, Exceptional, (41 reviews)
"Great place to stay!"
United States
Derek R.
The price is CA $196
CA $409 total
includes taxes & fees
Oct 28 - Oct 29
*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
A modern kitchen with dark cabinets, a built-in microwave, a flat-screen TV, and a large window with a view of the street.

18. Ironton Hub: Near Elephant Rocks & Shut-ins

Ironton Hub: Near Elephant Rocks & Shut-ins
3.0 star property
Ironton
The price is CA $142
CA $279 total
includes taxes & fees
Oct 5 - Oct 6
Ironton Hub: Near Elephant Rocks & Shut-ins
A dining area with a table and chairs, wooden cabinets, and a kitchen with an archway.

19. Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.

Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
Lesterville
9.0 out of 10, Wonderful, (20 reviews)
"Ellen is a Very communicative and helpful host. Property looks even better in person than in the pictures. Enjoyable stay!"
United States
Robert H.
The price is CA $427
CA $723 total
includes taxes & fees
Oct 8 - Oct 9
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
A modern kitchen with grey cabinets, a black refrigerator, and a microwave.

20. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Farmington
10.0 out of 10, Exceptional, (30 reviews)
"Very nice stay we enjoyed would definitely stay again"
United States
Ben C.
The price is CA $172
CA $340 total
includes taxes & fees
Oct 5 - Oct 6
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"
Herman 1-night trip
Posted 8 hours ago
Motel 6 Poplar Bluff, MO

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Southeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Missouri vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southeast Missouri vacation rentals we have selected for you start as low as CA $135 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Explore a world of travel with Expedia