Title: Southeast Missouri Vacation Rentals from CA $141: Short-Term Rentals for 2025 | Expedia.ca

  

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# Southeast Missouri Vacation Rentals

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## Check prices for these dates

In two weeks

[Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-10-17&endDate=2025-10-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In one month

[Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-10-31&endDate=2025-11-02&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-28&endDate=2025-11-30&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Vacation Rentals in Southeast Missouri

![Exterior](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/94cc7abb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/4e65fabc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/77123b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/e3a8a6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

De Soto

9.4/10

Exceptional

(153)

"Enjoyed our short stay, will definitely be back. "

[](https://www.expedia.ca/Farmington-Hotels-Holiday-Inn-Club-Vacations-Timber-Creek-Resort.h1858536.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/c5548b67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/1360d6ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/315251e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/9937503d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Treehouse and Hot Tub on 10acres - Pet Friendly!

Dittmer

9.2/10

Wonderful

(11)

"It is a good place to spend a pleasant time in peace and with a lot of tranquility. "

[](https://www.expedia.ca/Treehouse-And-Hot-Tub-On-10acres-Pet-Friendly.h95124119.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/c347e331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/358bd3b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/1c3a97fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/5cb6ee33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 2 bedroom cabin on a beautiful private lake.

Ironton

10/10

Exceptional

(10)

CA $182

CA $270 total

includes taxes & fees

Oct 15 - Oct 16

[](https://www.expedia.ca/Arcadia-Hotels-Charming-2-Bedroom-Cabin-On-A-Beautiful-Private-Lake.h119310813.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/w1525h2000x0y0-3cce06ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/c7fde387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/d4816ff1_edited_0721.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/b1b7b87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

Eminence

9.8/10

Exceptional

(12)

"My fiancè and I had a lovely time staying at this cute little cottage. The location is perfect. It's tucked away but close enough to all there is to see and do in Eminence. The hot tub in the patio with the tv was so cool. I definitely would stay here again!"

CA $279

CA $331 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/Eminence-Hotels-Springside-Cottage-In-Pleasant-Eminence-Great-Outdoor-Space-Large-Yard.h111491747.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/88708082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/c7ba1671.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/58073a16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/9ea8abbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### “The Cabin”@ Serenity Ranch. Centrally located to all the wonders of Shannon co.

Winona

10/10

Exceptional

(11)

"Had a great time. Loved the privacy and all the stocked kitchen amenities. AC was cold. That shower was amazing. Quiet retreat in proximity to Rocky Falls and our float trip on Jack's Fork! "

[](https://www.expedia.ca/Winona-Hotels-The-Cabin-Serenity-Ranch-Centrally-Located-To-All-The-Wonders-Of-Shannon-Co.h114607335.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/97025525.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/3eecb893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/e8397aaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/33230034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Kings Cabin on the edge of town only 1/2 mile from Current River !

Van Buren

9.6/10

Exceptional

(24)

"Very nice cabin! Better than staying at a hotel, at near the same price."

[](https://www.expedia.ca/Van-Buren-Hotels-Kings-Cabin-On-The-Edge-Of-Town-Only-12-Mile-From-Current-River.h91606513.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/2fc67c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/93347520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, computer monitors](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/54de2de2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/b5064413.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin 1 at the Pallet Factory

Leadwood

9.6/10

Exceptional

(33)

"Excellent will stay again!"

CA $51

CA $219 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/Park-Hills-Hotels-Relax-And-Enjoy-The-Privacy.h73469992.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/725f800a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

 

### The Twisted Sassafras Treehouse

Cape Girardeau

10/10

Exceptional

(24)

"Charming little treehouse. We wanted a private little getaway that was still semi close and it was perfect. The hot tub, the outdoor set up, the two person shower. Would highly recommend. "

CA $320

CA $459 total

includes taxes & fees

Nov 4 - Nov 5

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/b82525ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/3ab0bd80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/0c4eba22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/12b9dbcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Secluded cabin on private property

De Soto

10/10

Exceptional

(57)

"Beautiful quiet setting nice property "

[](https://www.expedia.ca/De-Soto-Hotels-Secluded-Cabin-On-Private-Property.h89989748.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/07947c99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/2ef177bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/a0e3b3dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/1cdd6e88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fox Pen Cabins Cabin #2 Not friendly for street bikes… Pet-Friendly

Eminence

10/10

Exceptional

(7)

"Great little cabin, roads to cabin not the best but worth it!"

[](https://www.expedia.ca/Eminence-Hotels-Fox-Pen-CabinsLitl-RedCabin-2Not-Friendly-For-Street-BikesPet-Friendly.h72655210.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/1e8bea93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

Cape Girardeau

8.6/10

Excellent

(43)

"We enjoy every time we stay here . We have stayed her many times. There is some repairs that need to be done . Also I think there needs to be a better way to cook besides a microwave. "

CA $113

CA $141 total

includes taxes & fees

Oct 8 - Oct 9

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6b76cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/ec557893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau

10/10

Exceptional

(142)

"Beautiful house. Great stay. Would definitely stay again!"

CA $209

CA $340 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/b0450c68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/5458231c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/dc4e06f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/555e828a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Clifford's Country Cottage

Bonne Terre

9.8/10

Exceptional

(20)

"Great place to stayLove the interiorPerfect set up for what we needed"

CA $174

CA $213 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/Bonne-Terre-Hotels-Cliffords-Country-Cottage.h106848020.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1020h683x4y0-fa4cb879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/67a4ab9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1024h480x0y101-641c723e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1014h683x5y0-c3534739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

 

### Collier Cabin in Pine Hollow ~ Eminence, MO

Birch Tree

9.8/10

Exceptional

(20)

"Best host’s around and a very private peaceful cabin. Everything about this place is great. Second time staying there and I will definitely be back!"

[](https://www.expedia.ca/Birch-Tree-Hotels-Collier-Cabin-In-Pine-Hollow-Eminence.h104123411.Hotel-Information)

![Smart TV, fireplace, video library](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/f948f069.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/abc1a4d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/d70c1885_edited_c93b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/a5241d57_edited_a6c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful 3-bedrm , 3.5 ba Log/Stone in Eminence MO. Will sleep up to 16 guests.

Eminence

9.8/10

Exceptional

(7)

"Our crew stayed here during a float trip and we had a blast! It was the perfect spot for a large group with plenty of space. "

[](https://www.expedia.ca/Eminence-Hotels-Beautiful-3-Bedrm.h114966382.Hotel-Information)

![Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c7addad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sam A Baker State Park

Patterson

9.2/10

Wonderful

(5)

"Pet friendly, great staff. "

CA $174

CA $185 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/a741342a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/bbdc94ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/d7c38180.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/bd987570.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Linkin: a cozy mountain cabin w/ king bed

Ironton

10/10

Exceptional

(8)

"Stayed two nights and me and the fiance couldn't have been happier. Plenty of things to do in a small area, with just as many good places to eat. Everything was spot on at the cabin. A previous night guest did bust the top of the bottom side hot plate but we wanted to eat out as much as we could do it didn't effect our stay. "

CA $230

CA $412 total

includes taxes & fees

Oct 8 - Oct 9

[](https://www.expedia.ca/Ironton-Hotels-The-Linkin-A-Cozy-Mountain-Cabin-W-King-Bed.h112714993.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/0fce9903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Wappapello

Williamsville

10/10

Exceptional

(1)

"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."

CA $193

CA $203 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/15c37025.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/1f8cdae2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/7f2cfbe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/8e499cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Secluded Ozarks Bunk House Cabin at Old Desperado Ranch

Eminence

10/10

Exceptional

(53)

"Property was beautiful, very secluded and relaxing. Property owners were very friendly hand helpful. Would definitely visit again. "

[](https://www.expedia.ca/Eminence-Hotels-Secluded-Ozarks-Bunk-House-Cabin-At-Old-Desperado-Ranch.h66199066.Hotel-Information)

![1 bedroom, iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/86d734a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/81907571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/f03e39eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/08a1bdfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful Modern Loft In Wine Country!

Ste. Genevieve

10/10

Exceptional

(265)

"Beautiful loft on beautiful property!"

CA $206

CA $249 total

includes taxes & fees

Oct 8 - Oct 9

[](https://www.expedia.ca/Ste-Genevieve-Hotels-Beautiful-Modern-Loft-In-Wine-Country.h23139432.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-20&endDate=2025-10-21&regionId=6058763&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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Save an average of 15% on thousands of hotels when you're signed in

[Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)

## Top Southeast Missouri Hotel Reviews

![Pear Tree Inn Sikeston](//images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg)

### Pear Tree Inn Sikeston

10/10 Excellent

"Clean and welcoming"

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](//images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"We had a restful stay very safe & clean! Friendly staff:)"

[](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Fairfield Inn & Suites by Marriott Poplar Bluff](//images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg)

### Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent

"Our arrival time was around midnight and we felt very safe coming in. This hotel has the best lighting all around the hotel. Actually the whole area. Our room was comfortable."

[](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

![Motel 6 Poplar Bluff, MO](//images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg)

### Motel 6 Poplar Bluff, MO

10/10 Excellent

"Check in was smooth and facilities are excellent "

[](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Holiday Inn Express & Suites Perryville by IHG](//images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg)

### Holiday Inn Express & Suites Perryville by IHG

10/10 Excellent

"Clean room great breakfast"

[](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![Pear Tree Inn Cape Girardeau Near the Medical Center](//images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg)

### Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent

"Very convenient and felt safe"

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Very nice and quiet "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"This is the best hotel experience for the price that I’ve ever had, and I travel a lot. Very generous social time with three free drinks and lots of complementary food. Everyone was lovely, bed comfortable, perfect temperature and no stale smell. Very clean. And so well priced! I wish all hotels were like this one!"

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![The Riverview](//images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"Hotel was very close to the Show Me Center. Very clean, quiet and comfortable room."

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

## Find out more about Southeast Missouri

**Everything you need to know about** **Southeast Missouri** **vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

**Southeast Missouri vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Missouri vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southeast Missouri vacation rentals we have selected for you start as low as CA $141 per night. Entering your travel dates in the search wizard you might find even better deals!

**How to find incredible deals on Southeast Missouri rentals**

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

## Explore a world of travel with Expedia

-   Trending destinations on Expedia.ca
-   All accommodation types in Southeast Missouri

### Trending destinations on Expedia.ca

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-   [Toronto Vacation Rentals](https://www.expedia.ca/Toronto-Vacation-Rentals.d178314.Travel-Guide-VacationRentals)
-   [Banff Vacation Rentals](https://www.expedia.ca/Banff-Vacation-Rentals.d10550.Travel-Guide-VacationRentals)
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-   [Osoyoos Vacation Rentals](https://www.expedia.ca/Osoyoos-Vacation-Rentals.d181782.Travel-Guide-VacationRentals)
-   [Mont Tremblant Vacation Rentals](https://www.expedia.ca/Mont-Tremblant-Vacation-Rentals.d55374.Travel-Guide-VacationRentals)
-   [Big White Ski Resort Vacation Rentals](https://www.expedia.ca/Big-White-Ski-Resort-Vacation-Rentals.d6058319.Travel-Guide-VacationRentals)
-   [Ontario Vacation Rentals](https://www.expedia.ca/Destinations-In-Ontario.d11178.Vacation-Rental-Destinations)
-   [British Columbia Vacation Rentals](https://www.expedia.ca/Destinations-In-British-Columbia.d11117.Vacation-Rental-Destinations)
-   [Prince Edward Island Vacation Rentals](https://www.expedia.ca/Destinations-In-Prince-Edward-Island.d6058122.Vacation-Rental-Destinations)
-   [Québec Vacation Rentals](https://www.expedia.ca/Quebec-Vacation-Rentals.d180017.Travel-Guide-VacationRentals)

-   [Vacation Homes in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Private-Vacation-Homes.d6058763-aaPrivateVacationHomes.Travel-Guide-Accommodation)
-   [Cabin Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Cabins.d6058763-aaCabins.Travel-Guide-Accommodation)
-   [Cottages in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Cottages.d6058763-aaCottages.Travel-Guide-Accommodation)
-   [Apartments in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Apartments.d6058763-aaApartments.Travel-Guide-Accommodation)
-   [Motels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Motels.d6058763-aaMotels.Travel-Guide-Accommodation)
-   [Farmstay in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Agritourism.d6058763-aaAgritourism.Travel-Guide-Accommodation)
-   [RV Parks in Southeast Missouri](https://expedia.ca/Southeast-Missouri-RV-Parks.d6058763-aaRVParks.Travel-Guide-Accommodation)
-   [Lodges in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Lodges.d6058763-aaLodges.Travel-Guide-Accommodation)
-   [Aparthotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Apart-Hotels.d6058763-aaApartHotels.Travel-Guide-Accommodation)
-   [B&B in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Bed-And-Breakfast.d6058763-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Villas in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Villas.d6058763-aaVillas.Travel-Guide-Accommodation)
-   [Condo Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Condos.d6058763-aaCondos.Travel-Guide-Accommodation)

### Expedia's Latest Trends

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-   [Hotels in Downtown Kansas City](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels)

Flights

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Cars

-   [Car rentals in Kauai](https://expedia.ca/Car-Rentals-In-Kauai.d180075.Car-Rental-Guide)
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-   [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide)

Activities

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Vacation Rentals

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General

-   [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136)
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-   [Visit Parkville](https://expedia.ca/Parkville.dx9973)
-   [Visit Whidbey Island](https://expedia.ca/Whidbey-Island.dx500782)

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![QR code to download the app](data:image/png;base64,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)