Title: Southeast Missouri Vacation Rentals from CA $142: Short-Term Rentals for 2025 | Expedia.ca [Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard # Southeast Missouri Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 24 - Nov 25](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-24&endDate=2025-11-25&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 25 - Nov 26](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-25&endDate=2025-11-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-28&endDate=2025-11-30&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-05&endDate=2025-12-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Vacation Rentals in Southeast Missouri ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Williamsville 10/10 Exceptional (1) "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dyann CA $195 CA $205 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/2fc67c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, computer monitors](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/54de2de2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/1c2b5527.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/93347520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Leadwood 9.6/10 Exceptional (37) "Just what we expected. Very quiet and secluded. Close to towns. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cheyenne F. CA $51 CA $220 total includes taxes & fees Nov 27 - Nov 28 [](https://www.expedia.ca/Park-Hills-Hotels-Relax-And-Enjoy-The-Privacy.h73469992.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/54dccacb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/1072ccd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/c6fa156f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/16fef5e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Leadwood 9.6/10 Exceptional (21) "it was a nice cozy stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alvaro CA $51 CA $220 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Park-Hills-Hotels-Couples-Retreat-With-Hot-Tub.h78382544.Hotel-Information) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Private kitchen](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/98efa0e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e3c698b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/972e20f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in French Village 10/10 Exceptional (3) "Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Norma [](https://www.expedia.ca/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/ed5a3737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Cape Girardeau 10/10 Exceptional (26) "The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary C. CA $291 CA $425 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/107000000/106300000/106298200/106298151/ce2d3d0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106300000/106298200/106298151/51a8db81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106300000/106298200/106298151/37a6ca51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106300000/106298200/106298151/w1270h1656x10y0-bfc04963.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Perryville 10/10 Exceptional (5) "This place is perfect if you want a private upscale experience that is immersed in natural beauty. The treehouse is luxurious and so comfortable. We loved every minute of our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joel r. CA $353 CA $595 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Perryville-Hotels-TreeLoft-At-BaseCamp.h106298151.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/c37e5dfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8b525f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Jackson 10/10 Exceptional (3) "incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chandler G. CA $282 CA $444 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information) ![Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c7addad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Patterson 9.2/10 Wonderful (5) "Pet friendly, great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlie CA $176 CA $187 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/e186477c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/52de7a41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/c3fbac48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/1422cf76_edited_0171.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cottage in Ste. Genevieve 10/10 Exceptional (16) "Awesome from checking in to all of the place was excellent!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle A. CA $178 CA $314 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Ste-Genevieve-Hotels-Rivertown-Retreat-Historic-Dufour-House-Circa-1800Downtown-District-Sleeps-4.h106052541.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/109000000/108970000/108967900/108967867/0846a92b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108970000/108967900/108967867/70c9d97e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108970000/108967900/108967867/7c7445a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/109000000/108970000/108967900/108967867/e24e89df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Van Buren 9.0/10 Wonderful (15) "It was beautiful and homey. We really enjoyed our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $99 CA $237 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Van-Buren-Hotels-Charming-2-Bedroom-House-With-AC.h108967867.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/664fb1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/c0dd14ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/d9341c45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/af94ed61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in De Soto 10/10 Exceptional (40) "Had a great stay enjoyed the beds, porches and the chickens. Great mornings listening to the birds. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) posata c. CA $201 CA $380 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/De-Soto-Hotels-82-Acre-Hobby-Farm-With-Lincoln-Log-Cabin.h73274691.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/151932d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/8e6dee64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/38606e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/be129fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Farmington 10/10 Exceptional (7) "It is a very nice place and very comfortable has everything you could possibly need for homeaway from home." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott CA $171 CA $324 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Farmington-Hotels-The-Hideaway-2-Charming-2-Bedroom-House-In-Delightful-Farmington-With-WiFi.h106408017.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/93000000/92380000/92373100/92373041/bf97215e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92380000/92373100/92373041/0be26cf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/93000000/92380000/92373100/92373041/e617ec60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/93000000/92380000/92373100/92373041/dfb38ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Leadwood 9.8/10 Exceptional (14) "Well taken care of, nice amenities, comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel K. CA $104 CA $290 total includes taxes & fees Nov 29 - Nov 30 [](https://www.expedia.ca/Park-Hills-Hotels-In-Law-Suite.h92373041.Hotel-Information) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103410000/103404400/103404325/f1767a24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, toilet paper](https://images.trvl-media.com/lodging/104000000/103410000/103404400/103404325/20538dfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/104000000/103410000/103404400/103404325/9b89c178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103410000/103404400/103404325/2b430135.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Bonne Terre 9.2/10 Wonderful (17) "Really nice and enjoyable....would stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mark n. CA $71 CA $239 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Bonne-Terre-Hotels-The-Lux-Cozy-2-Bedroom-Apartment-With-AC-And-WiFi-In-Enjoyable-Bonne-Terre.h103404325.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/fcf2830c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/91a8cbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/04f26ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/426ccc72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Jackson 10/10 Exceptional (11) "Our stay was amazing. Everything was so clean organized, and anything you would possibly need was in the room. We will definitely be staying there again when in the area!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen P. CA $212 CA $261 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/107000000/106410000/106406100/106406059/5b688022.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106410000/106406100/106406059/b64100e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/107000000/106410000/106406100/106406059/877e8abc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106410000/106406100/106406059/d1f3492c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Farmington 10/10 Exceptional (11) "Great place and very comfortable! Hosts were super attentive when our door code didn’t work and got us sorted out right away. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyser B. CA $171 CA $330 total includes taxes & fees Nov 29 - Nov 30 [](https://www.expedia.ca/Farmington-Hotels-The-Hideaway-1-Charming-2-Bedroom-House-With-WiFi.h106406059.Hotel-Information) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/71c262d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room dining](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/946846b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/055f4f65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/w2098h1398x2y0-ee5ff79b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Middle Brook 10/10 Exceptional (1) "These newer cabins are clean and have everything you need. Highly recommend! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelly CA $395 CA $417 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/119000000/118210000/118202500/118202492/d475c4d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118210000/118202500/118202492/84b74ee3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118210000/118202500/118202492/fb53c0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/119000000/118210000/118202500/118202492/ded6f299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Van Buren 9.4/10 Exceptional (3) "Beautiful property. Would stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharon P. CA $232 CA $365 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Van-Buren-Hotels-Hilltop-House-2.h118202492.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/c347e331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/5869d4ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/358bd3b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/3ffdfe18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Ironton 9.4/10 Exceptional (16) "Place is nice & easy to find. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mercy CA $184 CA $274 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Arcadia-Hotels-Charming-2-Bedroom-Cabin-On-A-Beautiful-Private-Lake.h119310813.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-08&endDate=2025-12-09®ionId=6058763&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=VR_BF_PROMO_6058763) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals) ## Top Southeast Missouri Hotel Reviews ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Breakfast and super Kickoff was AWESOME? love this hotel!!!" [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "I did not stay for breakfast, but I did have a hot dinner that was excellent. I will recommend and stay at Drury Inn's the next time I travel." [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "Great room, close to downtown, awesome food options in the venue as well. Really nice views of the river." [](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Holiday Inn Poplar Bluff by IHG](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg) ### Holiday Inn Poplar Bluff by IHG 10/10 Excellent "Very spacious suite, awesome staff! " [](https://expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "This was a really great stay, which was part of my long roadtrip. The hotel was right off the interstate & wasn't too noisy. My room was pretty big which I really enjoyed! The bed was super comfy. The front desk woman was super friendly and welcoming. I was able to get Door Dash to deliver to the location so that was a plus! They had quite a lot of items for breakfast, so I was surprised about that for a Days Inn. Only thing I didn't like was lack of parking, but overall, I would definitely stay here again if I come back to the area." [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Clean and good service " [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "The place was nice and clean" [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Staff are wonderful, kind and welcoming! The happy hour is a great way to get out of your room and socialize. Lots of yummy food and drinks. " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg) ### The Farmstead Hotel 10/10 Excellent "Clean room! Very friendly and helpful staff, especially the lady from Blytheville that helped us check in the first night. Only complaint is that in the middle of the day, the lobby filled up with cigarette smoke because the back door was left open during smoke break. " [](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ## Find out more about Southeast Missouri You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded. As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Southeast Missouri. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do. ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca - All accommodation types in Southeast Missouri ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals](https://www.expedia.ca/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Tofino Vacation Rentals](https://www.expedia.ca/Tofino-Vacation-Rentals.d6094955.Travel-Guide-VacationRentals) - [Calgary Vacation Rentals](https://www.expedia.ca/Calgary-Vacation-Rentals.d178245.Travel-Guide-VacationRentals) - [Costa Rica Vacation Rentals](https://www.expedia.ca/Destinations-In-Costa-Rica.d42.Vacation-Rental-Destinations) - [Vancouver Island Vacation Rentals](https://www.expedia.ca/Vancouver-Island-Vacation-Rentals.d6058387.Travel-Guide-VacationRentals) - [Puerto Vallarta Vacation Rentals](https://www.expedia.ca/Puerto-Vallarta-Vacation-Rentals.d180016.Travel-Guide-VacationRentals) - [Hawaii Vacation Rentals](https://www.expedia.ca/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Toronto Vacation Rentals](https://www.expedia.ca/Toronto-Vacation-Rentals.d178314.Travel-Guide-VacationRentals) - [Banff Vacation Rentals](https://www.expedia.ca/Banff-Vacation-Rentals.d10550.Travel-Guide-VacationRentals) - [Penticton Vacation Rentals](https://www.expedia.ca/Penticton-Vacation-Rentals.d4135.Travel-Guide-VacationRentals) - [Osoyoos Vacation Rentals](https://www.expedia.ca/Osoyoos-Vacation-Rentals.d181782.Travel-Guide-VacationRentals) - [Mont Tremblant Vacation Rentals](https://www.expedia.ca/Mont-Tremblant-Vacation-Rentals.d55374.Travel-Guide-VacationRentals) - [Big White Ski Resort Vacation Rentals](https://www.expedia.ca/Big-White-Ski-Resort-Vacation-Rentals.d6058319.Travel-Guide-VacationRentals) - [Ontario Vacation Rentals](https://www.expedia.ca/Destinations-In-Ontario.d11178.Vacation-Rental-Destinations) - [British Columbia Vacation Rentals](https://www.expedia.ca/Destinations-In-British-Columbia.d11117.Vacation-Rental-Destinations) - [Prince Edward Island Vacation Rentals](https://www.expedia.ca/Destinations-In-Prince-Edward-Island.d6058122.Vacation-Rental-Destinations) - [Québec Vacation Rentals](https://www.expedia.ca/Quebec-Vacation-Rentals.d180017.Travel-Guide-VacationRentals) - [Vacation Homes in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Private-Vacation-Homes.d6058763-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Cabin Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Cabins.d6058763-aaCabins.Travel-Guide-Accommodation) - [Cottages in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Cottages.d6058763-aaCottages.Travel-Guide-Accommodation) - [Apartments in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Apartments.d6058763-aaApartments.Travel-Guide-Accommodation) - [Motels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Motels.d6058763-aaMotels.Travel-Guide-Accommodation) - [Farmstay in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Agritourism.d6058763-aaAgritourism.Travel-Guide-Accommodation) - [Lodges in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Lodges.d6058763-aaLodges.Travel-Guide-Accommodation) - [RV Parks in Southeast Missouri](https://expedia.ca/Southeast-Missouri-RV-Parks.d6058763-aaRVParks.Travel-Guide-Accommodation) - [Aparthotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Apart-Hotels.d6058763-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Bed-And-Breakfast.d6058763-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Villas in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Villas.d6058763-aaVillas.Travel-Guide-Accommodation) - [Condo Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Condos.d6058763-aaCondos.Travel-Guide-Accommodation) ### Expedia's Latest Trends Hotels - [Hotels in Maui](https://expedia.ca/Maui-Hotels.d180073.Travel-Guide-Hotels) - [Hotels near GEHA Field at Arrowhead Stadium](https://expedia.ca/GEHA-Field-At-Arrowhead-Stadium-Hotels.0-l6058069-0.Travel-Guide-Filter-Hotels) - [Hotels in Kauai](https://expedia.ca/Kauai-Hotels.d180075.Travel-Guide-Hotels) - [Hotels in Oahu](https://expedia.ca/Oahu-Hotels.d180077.Travel-Guide-Hotels) - [Hotels in Downtown St. Louis](https://expedia.ca/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels) - [Hotels in Napa Valley](https://expedia.ca/Napa-Valley-Hotels.d180046.Travel-Guide-Hotels) - [Hotels in Cape Cod](https://expedia.ca/Cape-Cod-Hotels.d180061.Travel-Guide-Hotels) - [All Inclusive Resorts and Hotels in Maui](https://expedia.ca/Maui-Hotels-All-Inclusive-Hotel.0-0-d180073-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Hotels near Women's and Children's Hospital](https://expedia.ca/Womens-And-Childrens-Hospital-Hotels.0-l553248635974865886-0.Travel-Guide-Filter-Hotels) - [Hotels in Power and Light District](https://expedia.ca/Power-And-Light-District-Kansas-City-Hotels.0-n6162504-0.Travel-Guide-Filter-Hotels) - [Hotels in Downtown Kansas City](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels) Flights - [Flights to Maui](https://expedia.ca/Cheap-Flights-To-Maui.d180073.Travel-Guide-Flights) - [Flights to Oahu](https://expedia.ca/Cheap-Flights-To-Oahu.d180077.Travel-Guide-Flights) - [Flights to Hawaii Island](https://expedia.ca/Cheap-Flights-To-Hawaii-Island.d180074.Travel-Guide-Flights) - [Flights to Kauai](https://expedia.ca/Cheap-Flights-To-Kauai.d180075.Travel-Guide-Flights) Cars - [Car rentals in Kauai](https://expedia.ca/Car-Rentals-In-Kauai.d180075.Car-Rental-Guide) - [Car rentals in Oahu](https://expedia.ca/Car-Rentals-In-Oahu.d180077.Car-Rental-Guide) - [Car rentals in Maui](https://expedia.ca/Car-Rentals-In-Maui.d180073.Car-Rental-Guide) - [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide) Activities - [Things to do in High Ridge](https://expedia.ca/Things-To-Do-In-High-Ridge.d553248634983579370.Travel-Guide-Activities) Packages - [Maui All-inclusive Vacation Packages](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations/180073/Maui) - [Oahu Vacations](https://expedia.ca/Oahu.d180077.Destination-Travel-Guides) - [Hawaii Island Vacations](https://expedia.ca/Hawaii-Island.d180074.Destination-Travel-Guides) - [Kauai Vacations](https://expedia.ca/Kauai.d180075.Destination-Travel-Guides) - [Maui Vacations](https://expedia.ca/Maui.d180073.Destination-Travel-Guides) Vacation Rentals - [Maui Vacation Rentals](https://expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) General - [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136) - [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828) - [Visit Parkville](https://expedia.ca/Parkville.dx9973) - [Visit Whidbey Island](https://expedia.ca/Whidbey-Island.dx500782) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)