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Santee Vacation Rentals

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Our top choices for Santee vacation rentals

1. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
The price is CA $175
CA $504 total
includes taxes & fees
Sep 22 - Sep 23
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

2. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (15 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is CA $320
CA $711 total
includes taxes & fees
Sep 29 - Sep 30
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

3. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
8.8 out of 10, Excellent, (6 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
The price is CA $226
CA $635 total
includes taxes & fees
Sep 19 - Sep 20
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

4. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
The price is CA $243
CA $480 total
includes taxes & fees
Sep 20 - Sep 21
Lake Marion Condo, Boat Slip Included, Pet Friendly

5. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (99 reviews)
"If you’re looking for a quiet and peaceful getaway this place was great! The lake is beautiful and you can kayak or just sit out by the water and relax. The cute ducks in the property were my favorite. Would definitely go back again."
United States
Amber
The price is CA $105
CA $121 total
includes taxes & fees
Sep 21 - Sep 22
Bells Marina & Resort

6. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (37 reviews)
"Great place to stay on the lake! "
United States
Troy S.
The price is CA $106
CA $226 total
includes taxes & fees
Sep 17 - Sep 18
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

7. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Very convenient to the lake."
United States
John P.
The price is CA $132
CA $295 total
includes taxes & fees
Sep 29 - Sep 30
Country living lake style near Santee

8. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (35 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
The price is CA $106
CA $226 total
includes taxes & fees
Sep 23 - Sep 24
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

9. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
The price is CA $156
CA $251 total
includes taxes & fees
Sep 18 - Sep 19
Quiet 1-bedroom apartment in charming Elloree, SC

10. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.2 out of 10, Very good, (17 reviews)
"Great place to stay. "
United States
Scott J.
The price is CA $99
CA $173 total
includes taxes & fees
Sep 21 - Sep 22
Cozy Camping Cabin on Lake Marion near Congaree Nat Park

11. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is CA $174
CA $272 total
includes taxes & fees
Sep 20 - Sep 21
Modern apartment overlooking historic downtown Elloree, SC.

12. Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
The price is CA $128
CA $208 total
includes taxes & fees
Sep 26 - Sep 27
Cabin at the lake in Rimini, SC

13. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (24 reviews)
"Amazing "
United States
Fisher R.
The price is CA $166
CA $233 total
includes taxes & fees
Sep 23 - Sep 24
Country Resting Spot just off I95. 12 miles west on hwy 6.

14. Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Summerton
10.0 out of 10, Exceptional, (1 review)
"Great"
United States
Jeffrey T.
The price is CA $231
CA $420 total
includes taxes & fees
Sep 24 - Sep 25
Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

15. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (161 reviews)
"Allow us and four girls aka dogs a nice stop on way to and from Florida peaceful nice fenced yard will be back next year"
United States
Catrina C.
The price is CA $156
CA $269 total
includes taxes & fees
Sep 28 - Sep 29
Pet friendly country cottage with large fenced-in yard & horses on property

16. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (15 reviews)
"Great stay!"
United States
Hayden S.
The price is CA $174
CA $224 total
includes taxes & fees
Sep 20 - Sep 21
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

17. Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
10.0 out of 10, Exceptional, (1 review)
The price is CA $173
CA $611 total
includes taxes & fees
Sep 20 - Sep 21
Turtle Cove - Lake Living on Lake Marion

18. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
The price is CA $206
CA $391 total
includes taxes & fees
Sep 22 - Sep 23
Beautiful brick home w/ large porch and 3 bedrooms

19. Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.8 out of 10, Excellent, (26 reviews)
"Nice comfortable place to stay"
United States
Dylan H.
The price is CA $227
CA $730 total
includes taxes & fees
Oct 13 - Oct 14
Sweet Marion - Dock + Boat Ramp + Hot Tub!

20. Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina

Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
Eutaw Springs
The price is CA $244
CA $291 total
includes taxes & fees
Oct 1 - Oct 2
Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Find out more about Santee

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santee. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 8 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Santee National Wildlife Refuge are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee National Golf Club are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.