Santee River Dam on Lake Marion, South Carolina, Aerial drone view of electric power lines

Santee Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Santee vacation rentals

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
8.4 out of 10, Very good, (5 reviews)
The price is CA $153
CA $548 total
includes taxes & fees
Jul 6 - Jul 7
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (43 reviews)
"Thanks again Mike for a great stay! All the best, Paul"
United States
Paul V.
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss

Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss
Santee
9.6 out of 10, Exceptional, (18 reviews)
"Great place to stay. "
United States
James
Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (14 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is CA $322
CA $711 total
includes taxes & fees
Jun 23 - Jun 24
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Clean, private, well maintained. Adequate parking for boaters. Excellent location for lake bound vacationers. Host very responsive."
United States
Jeffrey
The price is CA $133
CA $300 total
includes taxes & fees
Jun 21 - Jun 22
Country living lake style near Santee

Hobbs Haven at Lake Marion

Hobbs Haven at Lake Marion
Summerton
9.4 out of 10, Exceptional, (13 reviews)
"Great location and host."
United States
Jay M.
Hobbs Haven at Lake Marion

Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (147 reviews)
"Nice place, friendly hosts!"
United States
Dan R.
The price is CA $157
CA $287 total
includes taxes & fees
Jun 22 - Jun 23
Pet friendly country cottage with large fenced-in yard & horses on property

Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (93 reviews)
"Super quaint, quiet, nice little get away."
United States
Karen
The price is CA $108
CA $124 total
includes taxes & fees
Jun 21 - Jun 22
Bells Marina & Resort

Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.4 out of 10, Very good, (16 reviews)
"Great place to stay. "
United States
Scott J.
The price is CA $107
CA $186 total
includes taxes & fees
Jun 21 - Jun 22
Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (33 reviews)
"Will stay again."
United States
Robert B.
The price is CA $107
CA $228 total
includes taxes & fees
Jun 21 - Jun 22
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Blue Bird Manor 3-bedroom house located in the heart of Orangeburg

Blue Bird Manor 3-bedroom house located in the heart of Orangeburg
Orangeburg
10.0 out of 10, Exceptional, (2 reviews)
"Absolutely loved it such an adorable home a host had a a quick response as well as tips! Very happy with our stay"
United States
jessie j.
The price is CA $214
CA $310 total
includes taxes & fees
Jun 19 - Jun 20
Blue Bird Manor 3-bedroom house located in the heart of Orangeburg

Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
The price is CA $119
CA $199 total
includes taxes & fees
Jun 22 - Jun 23
Cabin at the lake in Rimini, SC

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (13 reviews)
"Great stay!"
United States
Hayden S.
The price is CA $175
CA $225 total
includes taxes & fees
Jul 4 - Jul 5
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

The Tee Vee Cove is the place to be located near great golfing, fishing and food

The Tee Vee Cove is the place to be located near great golfing, fishing and food
Elloree
9.4 out of 10, Exceptional, (3 reviews)
"Came to area for hiking. Plenty of spots and the location was great. Wonderful experience and enjoyed the outside patio in the evenings."
United States
Debra S.
The price is CA $209
CA $361 total
includes taxes & fees
Jun 18 - Jun 19
The Tee Vee Cove is the place to be located near great golfing, fishing and food

Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
The price is CA $182
CA $615 total
includes taxes & fees
Jun 25 - Jun 26
Turtle Cove - Lake Living on Lake Marion

Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is CA $161
CA $256 total
includes taxes & fees
Jun 28 - Jun 29
Modern apartment overlooking historic downtown Elloree, SC.

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
The price is CA $308
CA $742 total
includes taxes & fees
Jun 21 - Jun 22
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
Summerton
9.6 out of 10, Exceptional, (256 reviews)
"Beautiful Lake views and personal beach. Clean rooms, comfortable beds, lots of space. Host: great communication and instructions."
United States
Yvette G.
The price is CA $490
CA $887 total
includes taxes & fees
Jun 30 - Jul 1
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

Boat House (private Cabin) - Boat House (Private Cabin)

Boat House (private Cabin) - Boat House (Private Cabin)
Eutawville
10.0 out of 10, Exceptional, (1 review)
"This was a 1-night stop over for us, on the way to Florida. Unfortunately, we only had saltwater poles, or we would have loved to try our luck at fishing the lake. Fish were popping the water everywhere. We really enjoyed watching the gators cruising the lake as well! 1st for us. This was just a simple, no frills campground, but would love to ho back one day. Lodge was clean, and enjoyed sitting on the quiet back deck."
United States
Jaime W.
The price is CA $291
CA $449 total
includes taxes & fees
Jul 15 - Jul 16
Boat House (private Cabin) - Boat House (Private Cabin)

3-bedroom house in fabulous Summerton next to lake

3-bedroom house in fabulous Summerton next to lake
Summerton
The price is CA $307
CA $568 total
includes taxes & fees
Jul 2 - Jul 3
3-bedroom house in fabulous Summerton next to lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santee Hotel Reviews

Find out more about Santee

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santee. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: Visitors like this Santee vacation home rental. It is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Another good choice for your trip to Santee is Patio + Pool Table: Lake Marion Getaway.

How many vacation rentals are there in Santee?

Expedia has 7 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Taw Caw Creek are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee National Golf Club are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.