Santee Vacation Rentals

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Our top choices for Santee vacation rentals

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (42 reviews)
"Great communication, always a great place to stay on our way to Florida. It’s only 2 miles from 95 and there are restaurants and an IGA for groceries. Thanks Mike, Paul"
United States
Paul V.
The price is CA $166
CA $487 total
includes taxes & fees
May 4 - May 5
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (11 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is CA $313
CA $695 total
includes taxes & fees
May 14 - May 15
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
7.4 out of 10, Good, (3 reviews)
"Beautiful listing beautiful views. Host very responsive and was quick to take care of any issues. You will enjoy your stay. "
United States
A P C.
The price is CA $122
CA $501 total
includes taxes & fees
May 4 - May 5
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (44 reviews)
"Great stay."
United States
Tim E.
The price is CA $129
CA $293 total
includes taxes & fees
May 4 - May 5
Country living lake style near Santee

Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.4 out of 10, Very good, (15 reviews)
"We enjoyed our stay. The only negative would be the fishing pier is no longer useable. "
United States
Derrick W.
The price is CA $104
CA $180 total
includes taxes & fees
May 4 - May 5
Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
The price is CA $170
CA $601 total
includes taxes & fees
May 4 - May 5
Turtle Cove - Lake Living on Lake Marion

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6
Summerton
9.0 out of 10, Wonderful, (28 reviews)
"Great place to stay on the lake! "
United States
Troy S.
The price is CA $121
CA $240 total
includes taxes & fees
May 10 - May 11
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6

Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (143 reviews)
"Our host was excellent and the fenced-in yard was perfect for our dog!"
United States
Michael H.
The price is CA $153
CA $275 total
includes taxes & fees
May 14 - May 15
Pet friendly country cottage with large fenced-in yard & horses on property

Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.8 out of 10, Good, (7 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
The price is CA $116
CA $193 total
includes taxes & fees
May 11 - May 12
Cabin at the lake in Rimini, SC

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (33 reviews)
"Will stay again."
United States
Robert B.
The price is CA $104
CA $221 total
includes taxes & fees
May 8 - May 9
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (11 reviews)
"Great stay!"
United States
Hayden S.
The price is CA $170
CA $219 total
includes taxes & fees
May 5 - May 6
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (93 reviews)
"Super quaint, quiet, nice little get away."
United States
Karen
The price is CA $130
CA $149 total
includes taxes & fees
May 20 - May 21
Bells Marina & Resort

The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more.

The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more.
Cross
10.0 out of 10, Exceptional, (1 review)
"The time at the sweet apartment was a relief for myself and my little one The utilities were nice and clean and we felt comfortable . Thank you so much."
United States
Lesley B.
The price is CA $189
CA $300 total
includes taxes & fees
May 4 - May 5
The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more.

Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is CA $156
CA $250 total
includes taxes & fees
May 4 - May 5
Modern apartment overlooking historic downtown Elloree, SC.

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
The price is CA $299
CA $724 total
includes taxes & fees
May 6 - May 7
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Blue Bird Manor 3-bedroom house located in the heart of Orangeburg

Blue Bird Manor 3-bedroom house located in the heart of Orangeburg
Orangeburg
10.0 out of 10, Exceptional, (1 review)
"Absolutely loved it such an adorable home a host had a a quick response as well as tips! Very happy with our stay"
United States
jessie j.
The price is CA $208
CA $301 total
includes taxes & fees
May 5 - May 6
Blue Bird Manor 3-bedroom house located in the heart of Orangeburg

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
Summerton
9.6 out of 10, Exceptional, (254 reviews)
"Could use a better cleaning service, but other than that it’s a house with plenty of room. "
United States
Megan A.
The price is CA $476
CA $858 total
includes taxes & fees
May 21 - May 22
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"Nice and quiet property. It served us well for the weekend "
United States
Mick S.
The price is CA $202
CA $384 total
includes taxes & fees
May 5 - May 6
Beautiful brick home w/ large porch and 3 bedrooms

The Tee Vee Cove is the place to be located near great golfing, fishing and food

The Tee Vee Cove is the place to be located near great golfing, fishing and food
Elloree
8.0 out of 10, Very good, (1 review)
"Came to area for hiking. Plenty of spots and the location was great. Wonderful experience and enjoyed the outside patio in the evenings."
United States
Debra S.
The price is CA $183
CA $362 total
includes taxes & fees
May 19 - May 20
The Tee Vee Cove is the place to be located near great golfing, fishing and food

Spacious Stylish One Bedroom Apartment

Spacious Stylish One Bedroom Apartment
Elloree
8.0 out of 10, Very good, (1 review)
"Very nice home! Pictures are as advertised and the home was very clean. The area surrounding the home is dilapidated, however, the home is very nice. The only two issues with the house are 1) the walls are very thin and you can hear the road noise and every step the people above take very clearly. 2) there is an issue with the municipal pipes of the town and my last night of the stay the water in the shower and bathroom sink was coming out yellow. Overall a very nice option in this small town."
United States
Joshua S.
The price is CA $231
CA $397 total
includes taxes & fees
May 4 - May 5
Spacious Stylish One Bedroom Apartment
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Find out more about Santee

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santee. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 8 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Taw Caw Creek are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.