Title: Car Rental Santee, SC - Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/9953/712fb946-715a-4a74-8bf7-2c2bbd891023.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santee Car Rental ## Search and Compare from Car Companies in Santee ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXCA-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself Members save 10% or more on over 1 million car rentals - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers to unlock big savings ## Top Car Deals in Santee \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Santee, South Carolina, USA ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santee,%20South%20Carolina,%20United%20States%20of%20America&dpln=9953&date1=21/12/2025&date2=23/12/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Santee, South Carolina, USA ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santee,%20South%20Carolina,%20United%20States%20of%20America&dpln=9953&date1=21/12/2025&date2=23/12/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Santee, South Carolina, USA ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santee,%20South%20Carolina,%20United%20States%20of%20America&dpln=9953&date1=21/12/2025&date2=23/12/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Santee, South Carolina, USA ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santee,%20South%20Carolina,%20United%20States%20of%20America&dpln=9953&date1=21/12/2025&date2=23/12/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in Santee [View all cars](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santee,%20South%20Carolina,%20United%20States%20of%20America&dpln=9953&date1=21/12/2025&date2=23/12/2025&crfrr=defaultFlex&SearchType=Place) ## Frequently asked questions ### How much is a rental car per day in Santee? ### What happens if I need to cancel my Santee car reservation? ### Where can I go on a road trip from Santee? > - Savannah is about 161 kilometres from Santee. Popular sights like Forsyth Park deserve to be high on your list while you're in town. > - Roughly 80 kilometres away, Columbia is also popular with travellers. Allow time to take in South Carolina State House while you're here. It's one of the reasons people love staying a while in this vibrant city. > - Biltmore Estate is situated 290 kilometres from Santee and is one of the region's most spectacular nature spots. Go for a wander around and enjoy the fresh air. ### How do I find the best car rental deals in Santee with Expedia? ### How old do you have to be to rent a car in Santee? ### What do you need to rent a car in Santee? ### What is the cheapest car rental in Santee? ### Can I rent a car for a month or longer in Santee? ### Where can I find a Santee car rental if I am younger than 25? ## Car Rental Information | Popular car types: | [SUV](https://www.expedia.ca/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.ca/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.ca/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.ca/ground-transfers?rfrr=car.table.AirportTransportation) | ## Explore a world of travel with Expedia - 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