Title: Book The Best Hotels in Puxico, MO for 2026 from CA $70 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Puxico](https://expedia.ca/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Puxico Car Rentals](https://expedia.ca/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide)[Puxico Vacation Packages](https://expedia.ca/Puxico.d553248634983343452.Destination-Travel-Guides) ![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Mike McClain ![](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Puxico Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Puxico%2C+Missouri%2C+United+States+of+America®ionId=553248634983343452&latLong=36.949775%2C-90.158434&adults=2&startDate=2026-03-02&d1=2026-03-02&endDate=2026-03-04&d2=2026-03-04&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=Puxico%2C+Missouri%2C+United+States+of+America®ionId=553248634983343452&latLong=36.949775%2C-90.158434&adults=2&startDate=2026-03-02&d1=2026-03-02&endDate=2026-03-04&d2=2026-03-04&amenities=POOL) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Puxico%2C+Missouri%2C+United+States+of+America®ionId=553248634983343452&latLong=36.949775%2C-90.158434&adults=2&startDate=2026-03-02&d1=2026-03-02&endDate=2026-03-04&d2=2026-03-04&amenities=PETS) ## Check prices for these dates Tonight [Feb 16 - Feb 17](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2026-02-16&endDate=2026-02-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 17 - Feb 18](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Puxico hotels ![Breakfast area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/f3b3697d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/df5fef26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/b7cdd094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/1413eaea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dexter Inn [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) Dexter 7.0/10 Good (335 reviews) "Nice rooms, friendly staff, " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sarah CA $84 CA $95 total includes taxes & fees Mar 16 - Mar 17 [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/caa808f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/8363a93f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/59b72b64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/cb936040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Dexter [](https://www.expedia.ca/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information) Dexter 6.8/10 (255 reviews) "Room was clean, staff was AMAZING breakfast was false advertising as they don’t have hot breakfast just things like cereal." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $81 CA $91 total includes taxes & fees Mar 17 - Mar 18 [](https://www.expedia.ca/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/eea0b1f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/7385d4a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/2812fc22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Dexter [](https://www.expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) Dexter 7.6/10 Good (395 reviews) "Clean room, friendly staff and quiet stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margo CA $114 CA $128 total includes taxes & fees Feb 17 - Feb 18 [](https://www.expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d3cfa5fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d18ea228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/f47e0ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/966bc5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn By Hilton Dexter [](https://www.expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) Dexter 10/10 Exceptional (12 reviews) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $144 CA $162 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/1eb5943b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/fb2e4094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/81d44800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/e9ec5dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### OYO Hickory House Inn [](https://www.expedia.ca/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information) Dexter 5.6/10 (135 reviews) "We enjoyed every moment of our stay. Wonderful service—everyone was friendly and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Albert [](https://www.expedia.ca/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/a0829ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/ac6df1a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/145de6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/c0aef459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EC Reed's Mercantile and Hotel [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) Marble Hill 9.6/10 Exceptional (84 reviews) "Cute room, great food, fun soda fountain and friendly owners! Will return! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/fa51e0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Tub, 2 Rooms)](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/7611279e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) Poplar Bluff 9.2/10 Wonderful (994 reviews) "Great location and room " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Curtis CA $128 CA $145 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/274be6ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (873 reviews) "Very clean and well maintained hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $142 CA $160 total includes taxes & fees Mar 12 - Mar 13 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/a07fa840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/412c9f32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/15d55416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Poplar Bluff, MO [](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) Poplar Bluff 7.8/10 Good (1,006 reviews) "Very clean and staff was very friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry CA $66 CA $70 total includes taxes & fees Feb 17 - Feb 18 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/a26934b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/2b360823.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/3340c554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/49fa46e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Poplar Bluff Missouri [](https://www.expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) Poplar Bluff 6.6/10 (633 reviews) "Very clean and staff was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dawn CA $75 CA $85 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/10259602.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/8df6c129.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/dc88ded9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/2fda33b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bullwinkles Rustic Lodge [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) Poplar Bluff 8.4/10 Very good (213 reviews) "Had to " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/b0632430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/f6482ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/bc31acbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/62b9e8ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (800 reviews) "Would stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $127 CA $143 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1db8fd06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1e44f2fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/0c2f5a12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/a73d6a9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Poplar Bluff North [](https://www.expedia.ca/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information) Poplar Bluff 7.8/10 Good (404 reviews) "Everything is fine " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bob CA $119 CA $135 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/8f51ba4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/838b706d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/419f7292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/1e3aea9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Poplar Bluff by IHG [](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) Poplar Bluff 8.8/10 Excellent (720 reviews) "Enjoyed the stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ranora CA $138 CA $155 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-02&endDate=2026-03-03®ionId=553248634983343452&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_553248634983343452) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels.d553248634983343452.Travel-Guide-Hotels) ## Learn more about Puxico Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness. [See all hotels in Puxico](https://www.expedia.ca/Hotel-Search?startDate=2026-03-02&endDate=2026-03-03&adults=2®ionId=553248634983343452) ![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=309&h=400&p=1&q=high) Photo by Mike McClain ## Top Puxico Hotel Reviews ![Hampton Inn By Hilton Dexter](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/w3836h2556x4y4-c3d811b2_y.jpg) ### Hampton Inn By Hilton Dexter 10/10 Excellent "Nice clean rooms, wonderful friendly staff. Very accommodating and suited our need well." [](https://expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Nice and welcoming " [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg) ### Travelodge by Wyndham Dexter 10/10 Excellent "Clean and quiet " [](https://expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg) ### Drury Inn & Suites Poplar Bluff 10/10 Excellent "All of it." [](https://expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Dexter Inn](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/4768517d_y.jpg) ### Dexter Inn 10/10 Excellent "Nice rooms, friendly staff, " [](https://expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg) ### Fairfield Inn & Suites by Marriott Poplar Bluff 10/10 Excellent "Very clean . Every staff member was genuinely friendly and cared about your needs. Very fast check in/out. Breakfast was better than most. Great coffee. " [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Hampton Inn Poplar Bluff](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg) ### Hampton Inn Poplar Bluff 10/10 Excellent "Clean room, good menu selections, great staff" [](https://expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Super 8 by Wyndham Poplar Bluff Missouri](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c_y.jpg) ### Super 8 by Wyndham Poplar Bluff Missouri 10/10 Excellent "Will be staying again. Thank you " [](https://expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) ![Shop House located 8 miles from Otter Slough Conservation Area](https://images.trvl-media.com/lodging/101000000/100180000/100176800/100176703/eb6bb38f_y.jpg) ### Shop House located 8 miles from Otter Slough Conservation Area 10/10 Excellent "Close to town, clean, friendly owner." [](https://expedia.ca/Dexter-Hotels-Shop-House-Located-8-Miles-From-Otter-Slough-Conservation-Area.h100176703.Hotel-Information) ## More cheap stays in Puxico ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO CA $66 CA $70 total Feb 17 - Feb 18 includes taxes & fees 7.8/10 Good! (1,004 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Super 8 by Wyndham Poplar Bluff Missouri](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Poplar Bluff Missouri 2831 N Westwood Blvd Poplar Bluff MO CA $75 CA $85 total Mar 8 - Mar 9 includes taxes & fees 6.4/10 (633 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) ![Dexter Inn](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/4768517d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Dexter Inn 1807 W Business US Highway 60 Dexter MO CA $84 CA $95 total Mar 16 - Mar 17 includes taxes & fees 6.8/10 (335 reviews) [](https://expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Travelodge by Wyndham Dexter 1608 E Business US 60 Dexter MO CA $114 CA $128 total Feb 17 - Feb 18 includes taxes & fees 7.4/10 Good! (393 reviews) [](https://expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Hampton Inn Poplar Bluff](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Poplar Bluff 2420 Crestwood Dr Poplar Bluff MO CA $127 CA $143 total Feb 22 - Feb 23 includes taxes & fees 9.2/10 Wonderful! (800 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn & Suites by Marriott Poplar Bluff 3109 Oak Grove Poplar Bluff MO CA $142 CA $160 total Mar 12 - Mar 13 includes taxes & fees 9.2/10 Wonderful! (873 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ## Hotels in Puxico with star rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 7 properties [](https://expedia.ca/3Star-Puxico-Hotels.s30-0-d553248634983343452.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 14 properties [](https://expedia.ca/2Star-Puxico-Hotels.s20-0-d553248634983343452.Travel-Guide-Filter-Hotels) ## Find out more about Puxico ### Top reasons to visit Puxico - **Outdoor Adventures:** Puxico is perfect for nature lovers, offering hiking trails and beautiful parks for exploration and relaxation. - **Romantic Getaways:** The charming atmosphere makes it an ideal spot for couples seeking a peaceful retreat. - **Arena Entertainment:** Visitors can enjoy various events and activities at the local arena, adding to the fun. - **Budget-Friendly Accommodations:** Puxico offers a range of comfortable hotels and motels to suit different budgets. - **Scenic Landscapes:** Highway 57 provides picturesque views, enhancing the travel experience in this quaint city. ### Find great hotels in Puxico Discover a variety of budget-friendly hotel accommodations in Puxico, Missouri, ranging from 2 to 2.5 stars. Ideal for both leisure and business travellers, the area features comfortable hotels and motels that cater to diverse needs, including pet-friendly options. Whether you're seeking a cozy place to relax or convenient amenities for work, Puxico has the perfect lodging for your visit. - **[Dexter Inn:](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information)** Located 22.5km from Puxico, Dexter Inn offers a charming retreat for pet lovers seeking a unique vacation experience. With a welcoming pet-friendly, this hotel allows certain pets onsite, ensuring that your furry friends can join in on the adventure. The property features a pet-friendly policy, including waived fees for service animals and specific restrictions applying to pets, primarily dogs and cats. Guests appreciate the warm ambiance and comfortable accommodations, making it a great choice for a relaxing getaway with pets. - **[Travelodge by Wyndham Dexter:](https://www.expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information)** Also situated 22.5km from Puxico, Travelodge by Wyndham Dexter caters to both business and pet travellers. This hotel provides an array of business amenities, including a Business Centre and Meeting Room, making it ideal for professionals on the go. The pet-friendly allows dogs onsite, ensuring that you can balance work and leisure. With a pet-friendly policy featuring waived fees for service animals, this hotel is a practical option for those who want to blend business with the comfort of having their pets nearby. - **[Econo Lodge Dexter:](https://www.expedia.ca/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information)** Positioned 22.5km from Puxico, Econo Lodge Dexter offers a budget-friendly option with a focus on both business and pet accommodation. This motel supplies essential business services while ensuring a welcoming environment for guests traveling with pets. With a pet-policy that permits animals onsite and waived fees for service animals, guests can enjoy peace of mind during their stay. The Econo Lodge is an excellent choice for those seeking value without compromising on comfort and convenience. ### Where to stay in Puxico Puxico, Missouri, offers a charming blend of outdoor adventures and scenic beauty, making it ideal for romantic getaways or family-friendly vacations. Explore the quaint city and its welcoming atmosphere, while nearby attractions beckon with their unique experiences. From the picturesque landscapes along Highway 57 to the peaceful surroundings reminiscent of New Mexico or Puerto Rico, Puxico promises a memorable escape for every type of traveller. - **[Wappapello:](https://www.expedia.ca/Wappapello-Hotels.d183505.Travel-Guide-Hotels)** Located a mere 9.7km from Puxico, Wappapello is a charming city known for its stunning outdoor scenery and romantic atmosphere. Visitors are drawn to Wappapello primarily for its recreational opportunities, including access to a beautiful lake and the expansive Wappapello Lake State Park. The area boasts various entertainment options, such as an arena for events and outdoor activities that allow for exploration and relaxation amidst nature. The peak travel season from April to June offers the best experiences for those wanting to partake in outdoor adventures. - **[Fisk:](https://www.expedia.ca/Fisk-Hotels.d553248634983120615.Travel-Guide-Hotels)** Situated 19.3km from Puxico, Fisk is a delightful city that attracts visitors year-round, with a notable peak from June to August. Known for its scenic landscapes and outdoor activities, Fisk offers a variety of attractions including a local casino and a golf course for those looking to indulge in leisure activities. The nearby lake and national state park provide opportunities for hiking, fishing, and enjoying the natural beauty of the region. Fisk's vibrant atmosphere makes it an ideal destination for couples seeking romance while exploring the great outdoors. - **[Dudley:](https://www.expedia.ca/Dudley-Hotels.d553248634983299889.Travel-Guide-Hotels)** Also located 19.3km from Puxico, Dudley is a quaint city that offers a peaceful escape for nature lovers. With a focus on outdoor experiences, visitors can enjoy the local recreational areas that promote a variety of activities. Dudley is in proximity to a picturesque river and a visitor centre that provides insights into the area's natural beauty and attractions. The peak travel months from June to August see a rise in visitors looking to immerse themselves in the serene landscapes and romantic settings that Dudley has to offer. ### Things to do in Puxico Puxico, Missouri, is a charming destination perfect for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can explore a variety of activities, including enjoying the recreational area, experiencing the arena entertainment facility, and playing a round of golf. With its scenic landscapes and inviting atmosphere, Puxico offers a delightful escape for tourists looking to unwind and connect with nature. **Recreation** At [Ozark Ridge Golf Course](https://www.expedia.ca/Ozark-Ridge-Golf-Course-Hotels.0-l553248621554123001-0.Travel-Guide-Filter-Hotels), located 35.4km from Puxico, you can enjoy a scenic day on the greens while soaking up the outdoors. The course offers a relaxed atmosphere, perfect for both novice and seasoned golfers looking to unwind amidst nature. ### Booking tips and Expedia advantages for Puxico When visiting Puxico, Missouri, consider exploring free attractions like Lake Wappapello and Lake Wappapello State Park. To save on accommodation, plan your trip in February or November to December when prices are lower, and aim for a Wednesday stay, as Saturdays are the most expensive. Use Expedia to compare hotel prices and consider booking a package that combines your hotel, flights, and activities for additional savings. Lastly, keep an eye out for local discounts and competitive rates to make the most of your travel budget. - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Puxico are February and November to December, where the prices are slightly lower. This is in comparison to April and June to July, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Puxico is Wednesday. The most expensive day to stay in Puxico is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia’s search tool to narrow down your options based on your budget, preferred location, and the type of accommodation you desire. To find the best prices and deals, simply adjust the price filter to sort from lowest to highest. - **Consider bundling your trip:** Consider saving some money by combining your Puxico hotel reservation with your flights and activities through an Expedia package. It's a smart way to get the most out of your travel experience! ### Find the best attractions in Puxico Puxico, Missouri, is an ideal destination for travellers seeking outdoor adventures and romantic getaways. The area boasts beautiful parks and nature reserves that offer eco-friendly experiences perfect for families. Whether you’re hiking through scenic landscapes or enjoying a leisurely stroll in the parks, Puxico provides a charming atmosphere for those looking to connect with nature and create lasting memories. - **Mingo Wilderness:** Located 4.8km from Puxico, Mingo Wilderness offers a serene escape into nature. Experience eco-friendly adventures through its scenic trails, where you can explore diverse wildlife and lush landscapes, perfect for hiking and birdwatching. - **Eagle Point Recreation Area:** Situated 11.3km away, Eagle Point Recreation Area is a family-friendly park boasting beautiful picnic spots and outdoor activities. Enjoy a day filled with hiking, fishing, or simply soaking up the eco-friendly atmosphere amidst stunning natural views. - **Spillway Recreation Area:** Also 11.3km from Puxico, Spillway Recreation Area is another excellent park for families. Engage in outdoor fun with trails, fishing opportunities, and a welcoming environment that connects you with nature. ### Best time to go to Puxico Visitor numbers in Puxico is generally unchanged in popularity throughout the year. The best time to visit Puxico is dependant on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly sunny with light rain. | **![calendar icon](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature icon](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain icon](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly cloudy icon](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation rate icon](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price icon](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | --------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------ | ------------------------------------------------------------------------------------------------------------------ | | January | 35.8°F (2.1°C) | Light Rain | Mostly Sunny | Slightly Low | Average | | February | 38.8°F (3.8°C) | Light Rain | Mostly Sunny | Slightly High | Slightly Low | | March | 49.1°F (9.5°C) | Light Rain | Mostly Sunny | Average | Average | | April | 57.9°F (14.4°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | May | 67.5°F (19.7°C) | Light Rain | Mostly Sunny | Average | Average | | June | 76.8°F (24.9°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | July | 79.7°F (26.5°C) | Light Rain | Mostly Sunny | Average | Slightly High | | August | 77.7°F (25.4°C) | Light Rain | Mostly Sunny | Average | Average | | September | 71.8°F (22.1°C) | Light Rain | Mostly Sunny | Slightly Low | Average | | October | 60.3°F (15.7°C) | Light Rain | Mostly Sunny | Slightly Low | Average | | November | 48.0°F (8.9°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | December | 40.6°F (4.8°C) | Light Rain | Mostly Sunny | Average | Slightly Low | ### The nearest major airports for your trip to Puxico For your trip to Puxico, Missouri, you can fly into two major airports. Cape Girardeau Municipal Airport (CGI) is located 61.2km away, with hotel options like the Drury Plaza Hotel, Drury Inn & Suites, and Courtyard by Marriott, all situated within 9.7km. Alternatively, Cairo Regional Airport (CIR) is 83.7km from Puxico, offering nearby accommodations such as Quality Inn, Super 8 by Wyndham, and Eagle Inn, all within 17.7km. Both airports provide good access to Puxico and a range of transportation services to ensure a smooth journey. ## Frequently asked questions ### When is the best time to go to Puxico? > These periods offer pleasant weather, with comfortable temperatures and generally less humidity, making it ideal for outdoor activities and exploring the local area. Spring brings blooming dogwoods and redbuds, while autumn showcases beautiful fall foliage, particularly in the surrounding Mingo National Wildlife Refuge. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Puxico hotel booking with Expedia? ### How much is the nightly rate at a Puxico hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Advance ](https://www.expedia.ca/Advance-Bed-And-Breakfast.d553248634983475122-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Advance ](https://www.expedia.ca/Advance-Hotels-Cheap-Hotels.0-0-d553248634983475122-tCheapHotels.Travel-Guide-Filter-Hotels) - [Advance Hotels ](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - [Lodges in Advance ](https://www.expedia.ca/Advance-Lodges.d553248634983475122-aaLodges.Travel-Guide-Accommodation) - [Motels in Advance ](https://www.expedia.ca/Advance-Motels.d553248634983475122-aaMotels.Travel-Guide-Accommodation) - 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