Title: Puxico Vacation Packages & Trips 2026 | Expedia.ca [Hotels in Puxico](https://expedia.ca/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[Vacation Rentals in Puxico](https://expedia.ca/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Puxico Car Rentals](https://expedia.ca/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide) ![](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Puxico Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings Photo by Mike McClain - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Ready to book your vacation to Puxico? Choose your dates ## Puxico Hotel Deals ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO Fully refundableReserve now, pay when you stay CA $91 CA $96 total Apr 8 - Apr 9 includes taxes & fees 8/10 Very Good! (1,001 reviews) I stay here quite often in my travels. My room is almost always pretty clean - it is still a motel 6\. Sheets and towels are always clean. I usually order food and just stay in my room once it’s dark out because I’m not sure about the area - it’s outside of town. Reviewed on Apr 5, 2026 [](https://expedia.ca/Hotel-Search?startDate=08%2F04%2F2026&endDate=09%2F04%2F2026&selected=15689127&PinnedHotelID=15689127&HadPinnedHotel=true®ionId=553248634983343452) ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Poplar Bluff 2220 N Westwood Blvd Poplar Bluff MO Fully refundableReserve now, pay when you stay CA $145 CA $164 total May 3 - May 4 includes taxes & fees 9.2/10 Wonderful! (1,001 reviews) Clean Reviewed on Apr 5, 2026 [](https://expedia.ca/Hotel-Search?startDate=03%2F05%2F2026&endDate=04%2F05%2F2026&selected=41515&PinnedHotelID=41515&HadPinnedHotel=true®ionId=553248634983343452) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Poplar Bluff 3109 Oak Grove Poplar Bluff MO Fully refundableReserve now, pay when you stay CA $153 CA $173 total Apr 9 - Apr 10 includes taxes & fees 9.4/10 Exceptional! (884 reviews) Breakfast was really good and fresh. Room was clen Reviewed on Apr 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=09%2F04%2F2026&endDate=10%2F04%2F2026&selected=28807257&PinnedHotelID=28807257&HadPinnedHotel=true®ionId=553248634983343452) [See all 55 properties in Puxico](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=07%2F04%2F2026&endDate=08%2F04%2F2026®ionId=553248634983343452) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app