Title: 2 Stars Hotels in Puxico, Missouri from CA $89 - Find Cheap Puxico Hotels With 2 Stars | Expedia.ca [Puxico Travel Guide](https://expedia.ca/Puxico.dx553248634983343452)[Hotels in Puxico](https://expedia.ca/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[Vacation Rentals in Puxico](https://expedia.ca/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Flights to Puxico](https://expedia.ca/Cheap-Flights-To-Puxico.d553248634983343452.Travel-Guide-Flights)[Puxico Car Rentals](https://expedia.ca/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide)[Puxico Vacation Packages](https://expedia.ca/Puxico.d553248634983343452.Destination-Travel-Guides) ![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Mike McClain # 2 Stars Hotels in Puxico, Missouri from CA $89 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Puxico 2 Star Hotels Tonight [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-16&endDate=2025-12-17&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-17&endDate=2025-12-18&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Puxico 2-star hotels ![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/5b675ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/476a2a56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Poplar Bluff, MO [](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) Poplar Bluff 7.8/10 Good (1006) "Love the updated rooms and the vending area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathi CA $105 CA $110 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/99ef8265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/d71a605c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (855) "Very clean, great check in" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teresa CA $143 CA $162 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/f6482ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/e921a7b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/5904f90a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (796) "Staff was kind and provided a lot of information during check out." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shea CA $139 CA $155 total includes taxes & fees Jan 10 - Jan 11, 2026 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![In-room safe, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/fefbc3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/49fa46e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/a26934b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Poplar Bluff Missouri [](https://www.expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) Poplar Bluff 6.6/10 (623) "The lady at the front was very nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Travis CA $78 CA $89 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) ![Seasonal outdoor pool, open 10:00 AM to 9:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/8fbe165c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/9a624d3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/f3b3697d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/00fa2fb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dexter Inn [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) Dexter 7.0/10 Good (332) "Room was nice and spacious." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $93 CA $104 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8865f485.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/f5deab1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/eea0b1f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Dexter [](https://www.expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) Dexter 7.6/10 Good (385) "Very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dennis CA $102 CA $115 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1db8fd06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/0c2f5a12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/774fe752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/bac18eb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Poplar Bluff North [](https://www.expedia.ca/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information) Poplar Bluff 7.8/10 Good (398) "Good breakfast selection for the price and clean room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jared CA $131 CA $147 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/6497a67e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/e5416d3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/dcdd1977.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/cb936040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Dexter [](https://www.expedia.ca/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information) Dexter 6.8/10 (252) "The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $82 CA $92 total includes taxes & fees Jan 14 - Jan 15, 2026 [](https://www.expedia.ca/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information) ![Studio, 1 King Bed](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/w3836h2556x4y4-c3d811b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d18ea228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn By Hilton Dexter [](https://www.expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) Dexter 10/10 Exceptional (1) "Staff was helpful and professional. The rooms were clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $134 CA $151 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/5704c6ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/02df00ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/415149fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/012f90a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### OYO Hickory House Inn [](https://www.expedia.ca/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information) Dexter 5.4/10 (129) "Nice room very comfortable bed's" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose [](https://www.expedia.ca/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/0fce9903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Wappapello [](https://www.expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) Williamsville 10/10 Exceptional (1) "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dyann [](https://www.expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/de7e2348.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/7b7b54ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/d1a4afba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/71aa8e7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided [](https://www.expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) Greenville 10/10 Exceptional (5) "Cute, cozy, private getaway that you won't want to leave!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jade G. CA $209 CA $352 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) ![Fountain](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/9c3ffe6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/dc88ded9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin | Private kitchen](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/e045844c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/58560d42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bullwinkles Rustic Lodge [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) Poplar Bluff 8.4/10 Very good (212) "Had to " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93538000/93537915/a6031ae7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93538000/93537915/9c743b67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93538000/93537915/3268652c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93538000/93537915/ffdc5cdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Getaway on 270 Acres w/ Lake: Swim & Canoe [](https://www.expedia.ca/Advance-Hotels-Private-Getaway-On-270-Acres-W-Lake-Swim-Canoe.h93537915.Hotel-Information) Advance [](https://www.expedia.ca/Advance-Hotels-Private-Getaway-On-270-Acres-W-Lake-Swim-Canoe.h93537915.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Puxico-Hotels.s20-0-d553248634983343452.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Puxico-Hotels.s20-0-d553248634983343452.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Puxico. ![Holiday Inn Poplar Bluff by IHG](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Poplar Bluff by IHG 2781 N Westwood Blvd Poplar Bluff MO CA $139 CA $157 total Dec 21 - Dec 22 includes taxes & fees 8.6/10 Excellent! (702 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Drury Inn & Suites Poplar Bluff 2220 N Westwood Blvd Poplar Bluff MO CA $129 CA $146 total Dec 21 - Dec 22 includes taxes & fees 9.2/10 Wonderful! (960 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![EC Reed's Mercantile and Hotel](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/fc288d3b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### EC Reed's Mercantile and Hotel 301 1st St Marble Hill MO [Get rates](https://expedia.ca/Hotel-Search?startDate=30%2F12%2F2025&endDate=31%2F12%2F2025&selected=74660768&PinnedHotelID=74660768&HadPinnedHotel=true®ionId=553248634983343452) 9.6/10 Exceptional! (83 reviews) [](https://expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) Still don't see what you're looking for? [See all properties in Puxico.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248634983343452&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248634983343452&star=20&star=20&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248634983343452&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248634983343452&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248634983343452&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248634983343452&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Puxico Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness. [See all hotels in Puxico](https://www.expedia.ca/Hotel-Search?startDate=2025-12-30&endDate=2025-12-31&adults=2®ionId=553248634983343452) ![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=309&h=400&p=1&q=high) Photo by Mike McClain ## Top Puxico Hotel Reviews ![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg) ### Travelodge by Wyndham Dexter 10/10 Excellent "Staff was helpful and kind. The room was clean as well as the whole Hotel, although they should move the smoking area from right at the enrty way of the hotel." [](https://expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Staff was amazing and super nice. Room was very clean. " [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/de7e2348_y.jpg) ### Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided 10/10 Excellent "This place is amazing! We've stayed at a lot of different VRBOs and this is by far one of the best! Thanks for having us and we'll definitely be back" [](https://expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) ![Super 8 by Wyndham Poplar Bluff Missouri](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c_y.jpg) ### Super 8 by Wyndham Poplar Bluff Missouri 10/10 Excellent "Staff was friendly everything was quiet pleasant experience for an easy one night stay" [](https://expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) ![Econo Lodge Dexter](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/6497a67e_y.jpg) ### Econo Lodge Dexter 8/10 Good "Room was clean, staff was AMAZING breakfast was false advertising as they don’t have hot breakfast just things like cereal." [](https://expedia.ca/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information) ![Lake Wappapello](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32_y.jpg) ### Lake Wappapello 10/10 Excellent "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." [](https://expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ## Find out more about Puxico Want to get out of town on the cheap? Thanks to the low rates and great discounts at the top 2 Stars hotels in Puxico, Puxico you can sneak away on the trip of your dreams with plenty of cash to spare. In addition to the friendly staff and well-maintained surroundings, you’ll find comfortable rooms, complimentary bath products, and quiet sleeping areas, so you can kick back with all the basic conveniences after a long day. Plus, these properties are perfect, if you need a jumping-off point for exploring the local attractions. Several of the best hotels with 2 Stars in Puxico are situated just a stone’s throw from both public transportation and the city’s main freeways. Use the travel tools at Expedia.ca to search for options near your favorite neighborhood, find a cheap deal, and book your room. 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