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Puxico Vacation Rentals

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Our top choices for Puxico vacation rentals

1. Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
9.2 out of 10, Wonderful, (5 reviews)
"Pet friendly. Family-friendly "
United States
Tonya
The price is CA $105
CA $111 total
includes taxes & fees
Aug 26 - Aug 27
Lake Wappapello

2. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello
Wappapello
10.0 out of 10, Exceptional, (1 review)
"Very cozy"
United States
Shea E.
The price is CA $206
CA $385 total
includes taxes & fees
Aug 26 - Aug 27
Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

3. Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Greenville
10.0 out of 10, Exceptional, (8 reviews)
"This place is amazing! We've stayed at a lot of different VRBOs and this is by far one of the best! Thanks for having us and we'll definitely be back"
United States
Joshua H.
The price is CA $211
CA $343 total
includes taxes & fees
Aug 26 - Aug 27
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

4. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
8.0 out of 10, Very good, (36 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
The price is CA $148
CA $296 total
includes taxes & fees
Aug 30 - Aug 31
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

5. Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!
Greenville
10.0 out of 10, Exceptional, (9 reviews)
"Easy check in, very quiet, very calming and relaxing. Overall great stay and great property manager. "
United States
Wyatt S.
The price is CA $102
CA $166 total
includes taxes & fees
Sep 9 - Sep 10
Cozy hobby farm cabin under the stars!

6. Hunting / Fishing Cabin at Lake Wappapello

Hunting / Fishing Cabin at Lake Wappapello
Williamsville
The price is CA $254
CA $433 total
includes taxes & fees
Aug 28 - Aug 29
Hunting / Fishing Cabin at Lake Wappapello

7. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Dexter
The price is CA $170
CA $212 total
includes taxes & fees
Sep 6 - Sep 7
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

8. Cozy 2-bedroom house in welcoming Poplar Bluff

Cozy 2-bedroom house in welcoming Poplar Bluff
Poplar Bluff
6.8 out of 10, (3 reviews)
"This property suited our needs just fine for an overnight stay on the way to Louisville."
United States
Carrie H.
The price is CA $229
CA $365 total
includes taxes & fees
Aug 31 - Sep 1
Cozy 2-bedroom house in welcoming Poplar Bluff

9. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Poplar Bluff
8.8 out of 10, Excellent, (15 reviews)
"House was great. Will definitely be back."
United States
Anonymous traveller
The price is CA $158
CA $390 total
includes taxes & fees
Sep 20 - Sep 21
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Puxico Hotel Reviews

Find out more about Puxico

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Puxico. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Are there vacation rentals in Puxico?

Yes, we offer vacation rentals close to popular sights in Puxico, or you can go with a more remote option if you're looking for a relaxing stay.

What's the top vacation rental that Puxico has to offer?

Private lake, beach & hot tub, romantic getaway or family vaca: This vacation home rental near Puxico is equipped with a hot tub, air-conditioning, and laundry facilities to help you feel comfortable during your stay.

What’s there to see and do in Puxico?

While exploring the area, visit family-friendly sights like Mo-Ark Regional Railroad Museum, or get outside and enjoy nature at Mark Twain National Forest. In the larger area, you’ll find Mingo Wilderness and Lake Wappapello.

What’s a vacation rental in Puxico like?

A vacation rental is a private property where you can stay for a couple of days or more in Puxico. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel right at home. If you're concerned about cleanliness, a vacation rental can provide a sense of privacy away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for a family getaway.