Title: 4 Stars Hotels in Otay Mesa, San Diego from CA $177 - Find Cheap Otay Mesa Hotels With 4 Stars | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Otay Mesa, San Diego from CA $177 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa 4 Star Hotels Tonight [Dec 25 - Dec 26](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-25&endDate=2025-12-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-26&endDate=2025-12-27&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa 4-star hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch TV with cable channels, Netflix, streaming services](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/ad56ea36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![The Views Ocean View Suite 1 King](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/a72d9dc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/b173351e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel del Coronado, Curio Collection by Hilton [](https://www.expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) Historic Downtown Coronado 8.4/10 Very good (1012) "Beautiful resort in the heart l" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marc CA $464 CA $591 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/60472bda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/d85ecd0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/23e38216.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hard Rock Hotel San Diego [](https://www.expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (3161) "Beautiful hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jordan M. CA $207 CA $303 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/771038f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/e4705932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/6ddceb14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel San Diego - Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Mission Valley 8.4/10 Very good (1422) "Great hotel in a great area - would definitely stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bhupinder CA $154 CA $177 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom | Living room](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/7182df27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/c69001c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Downtown Little Italy [](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (136) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacorey CA $171 CA $198 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/bd692b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![37-inch flat-screen TV with cable channels, TV, pay movies](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3840x5y0-f741e07a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2254) "Excelente hotel" ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Julio CA $167 CA $193 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/7442075b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2931) "Great boutique hotel!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maksim CA $196 CA $225 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/88f9cd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/5142b853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) Downtown San Diego 8.4/10 Very good (6024) "Always an amazing stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jana CA $185 CA $254 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/cfe599b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/451480f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Surfing/boogie boarding](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/bea79a30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/85a135ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego Bay Downtown [](https://www.expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-Bay-Downtown.h5328.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1550) "Very nice, and clean hotel. Friendly staff, and close to amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Araceli CA $234 CA $321 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-Bay-Downtown.h5328.Hotel-Information) ![Outdoor pool, open 7:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/56fafd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, minibar, desk](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/633cc48d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/116e1fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) University Heights 9.4/10 Exceptional (1354) "Room was clean and smelled so good, staff very friendly!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katrina CA $313 CA $359 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/52278530.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/d5c481f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/13038ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Mission Valley San Diego Hotel [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) Mission Valley 8.6/10 Excellent (1681) "I really enjoyed the stay. Staff was really awesome" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Glen CA $161 CA $186 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/1b87fc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, white sand](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/31f9c777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/ca66f35a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hospitality Suite, 1 King Bed, Bay View | Living room](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/d02824a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin San Diego Bayview [](https://www.expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Downtown.h27516.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1078) "I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alliyah CA $217 CA $292 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Downtown.h27516.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/b285d0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/489aa10f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/9f5b2440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 32.95 per person)](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/1a5a157b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Manchester Grand Hyatt San Diego [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (2871) "Lovely hotel with friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynnea CA $241 CA $354 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/5488e3f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/3be512ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/eb8b9673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Marquis San Diego Marina [](https://www.expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) Downtown San Diego 9.2/10 Wonderful (1954) "It's a great place to visit and share time with friends and family. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bertha CA $240 CA $350 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/0db99a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/0021e9c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/ffd00170.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/aa651342.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Hotel San Diego Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-Solamar-San-Diego.h1117693.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1172) "Amenities and location were great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie CA $233 CA $325 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/San-Diego-Hotels-Solamar-San-Diego.h1117693.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/21e561fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/d7a43de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/0dccf6b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/4d5866ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) Mission Valley 8.8/10 Excellent (1006) "Staff was polite , room service amazing " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Francois CA $190 CA $219 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/a9075ad6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner served](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/029abbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 5:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/7806cdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/169b339e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni San Diego Hotel at the Ballpark [](https://www.expedia.ca/San-Diego-Hotels-Omni-San-Diego-Hotel.h982408.Hotel-Information) Downtown San Diego 9.2/10 Wonderful (2054) "Very comfortable, nice location and good service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ALEXANDER CA $266 CA $370 total includes taxes & fees Dec 27 - Dec 28 [](https://www.expedia.ca/San-Diego-Hotels-Omni-San-Diego-Hotel.h982408.Hotel-Information) ![Room, 1 King Bed with Sofa bed, Marina View | View from room](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/16e63028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; Mexican cuisine](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/b3296075.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/1e020b70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton San Diego Resort [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) Harbor Island 8.4/10 Very good (3171) "Great stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $171 CA $246 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/27000000/26990000/26984300/26984236/8b765f45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/27000000/26990000/26984300/26984236/0c6804ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom | View from room](https://images.trvl-media.com/lodging/27000000/26990000/26984300/26984236/0496398f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, rooftop bar](https://images.trvl-media.com/lodging/27000000/26990000/26984300/26984236/c5154534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InterContinental San Diego by IHG [](https://www.expedia.ca/San-Diego-Hotels-InterContinental-San-Diego.h26984236.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1125) "Room was great, the amenities great, overall very nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Crystal CA $290 CA $415 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-InterContinental-San-Diego.h26984236.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7fe47de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/a9d5662a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 outdoor pools, a heated pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Point Resort & Spa [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) Mission Bay 8.6/10 Excellent (2354) "Great stay, top tier service and excellent customer care " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Meriem CA $177 CA $276 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/338bb608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/2312739a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/27f733a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/77c0542b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Downtown [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Downtown.h327441.Hotel-Information) Downtown San Diego 8.8/10 Excellent (1002) "Clean quiet as a vault friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $207 CA $240 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Downtown.h327441.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Otay-Mesa-San-Diego-Hotels.s40-n6263723-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Otay-Mesa-San-Diego-Hotels.s40-n6263723-0.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa. ![Pendry San Diego](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Pendry San Diego 550 J Street San Diego CA CA $376 CA $508 total Jan 19 - Jan 20, 2026 includes taxes & fees 9.2/10 Wonderful! (1,000 reviews) [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The US Grant, a Luxury Collection Hotel, San Diego](https://images.trvl-media.com/lodging/1000000/20000/10900/10802/e71c0bc8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The US Grant, a Luxury Collection Hotel, San Diego 326 Broadway San Diego CA CA $388 CA $450 total Jan 7 - Jan 8, 2026 includes taxes & fees 9/10 Wonderful! (1,002 reviews) [](https://expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information) ![Shore House at The Del, LXR Hotels & Resorts](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510728/w3840h2877x0y3-c3d52563_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Shore House at The Del, LXR Hotels & Resorts 1500 Orange Avenue Coronado CA CA $785 CA $940 total Jan 5 - Jan 6, 2026 includes taxes & fees 9.2/10 Wonderful! (114 reviews) [](https://expedia.ca/Coronado-Hotels-Shore-House-At-The-Del.h76510728.Hotel-Information) Still don't see what you're looking for? [See all properties in Otay Mesa.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6263723&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6263723&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6263723&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6263723&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6263723&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6263723&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Otay Mesa Hotel Reviews ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Excellent Location. Lots to see and do right on the boardwalk with a very short walk across the street to cruise terminal " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "Enjoyed my stay. The staff was friendly and helpful, the room was clean, comfortable and quiet. " [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Great " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Upon check-in the guest services was welcoming and knowledgeable. The room was clean and smelled good, meets and exceeded expectations." [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Clean room and friendly staff. Great views for the city. " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Legacy Resort Hotel & Spa](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4_y.jpg) ### Legacy Resort Hotel & Spa 10/10 Excellent "El está bien, cómodo, limpio y se mira bastante nuevo, si tuviera que decir algo mal, lo único sería el internet, el que es free no sirve absolutamente para nada prácticamente obligándote a comprar su paquete de internet que la verdad tampoco es que sea muy bueno, pienso que deberían mejorar eso al menos ya que uno está pagando debería ser por algo bueno. En todo lo demás está bastante bien y muy céntrico y cerca de todo. " [](https://expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Lafayette Hotel & Club](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3_y.jpg) ### Lafayette Hotel & Club 10/10 Excellent "Very clean and tidy, super beautiful." [](https://expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Wonderful restoration of the lobby and updating the rooms" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Margaritaville Hotel San Diego Gaslamp Quarter](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/0db99a00_y.jpg) ### Margaritaville Hotel San Diego Gaslamp Quarter 10/10 Excellent "Yes" [](https://expedia.ca/San-Diego-Hotels-Solamar-San-Diego.h1117693.Hotel-Information) ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Otay Mesa? > - Search for the lowest price from CA $450 ### What's the difference between 5-star and 4-star hotels in Otay Mesa? ### Does Otay Mesa have any 4-star all-inclusive resorts? ## Explore a world of travel with Expedia - 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