Title: Visit Otay Mesa: Best of Otay Mesa, San Diego Travel 2026 | Expedia Tourism - Expedia.ca [Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) # Otay Mesa ## San Diego ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Otay Mesa Things to do Hotels Where to stay [San Diego travel guide](https://expedia.ca/San-Diego.dx3073) --- ### Popular places to visit ![San Diego Zoo showing zoo animals, a pond and landscape views](https://images.trvl-media.com/place/502547/504b59eb-bcb1-4b86-9adb-3c97368fb431.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Zoo 4.5/5(417 reviews) See nature up-close and personal at one of the country’s largest and most educational zoos. [](https://expedia.ca/San-Diego-Zoo-San-Diego.d502547.Vacation-Attraction) ![San Diego Convention Center](https://images.trvl-media.com/place/6125294/2fc00620-42cd-4ab5-9c91-9e9ac3371200.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Convention Center 4.5/5(132 reviews) During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's entertainment choices and fascinating museums. [](https://expedia.ca/San-Diego-Convention-Center-Downtown-San-Diego.d6125294.Vacation-Attraction) ![Bayside Skyride at Sea World, San Diego, CA](https://images.trvl-media.com/place/3073/8f017bfb-436d-498f-a4c2-881869d60b1d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### SeaWorld 4.5/5(182 reviews) Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination. [](https://expedia.ca/SeaWorld-San-Diego.d502548.Vacation-Attraction) ![Mission Bay showing a beach](https://images.trvl-media.com/place/6185904/de90e297-f912-4798-a530-b3d83f0907a3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Bay 4.5/5(200 reviews) Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park. [](https://expedia.ca/Mission-Bay-San-Diego.d6185904.Vacation-Attraction) ![Mission Beach featuring tropical scenes, street scenes and a beach](https://images.trvl-media.com/place/506109/7668844c-8a76-415d-a747-d4762537804f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Beach 4.5/5(330 reviews) A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities. [](https://expedia.ca/Mission-Beach-Central-Mission-Beach.d506109.Vacation-Attraction) ![Disney Wonder Cruise Ship. Halloween on the High Seas. #lifeatexpedia #golden](https://images.trvl-media.com/place/3073/ef4c71e4-5b91-451a-a9f3-a12706cfa728.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Port of San Diego 4.5/5(277 reviews) Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area. [](https://expedia.ca/Port-Of-San-Diego-San-Diego.d6131855.Vacation-Attraction) ### Things to do ![Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster](https://mediaim.expedia.com/localexpert/2695478/c67b3942-2798-4132-a361-fcdf0964b01b.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster CA $144 per adult [](https://expedia.ca/things-to-do/tour-from-san-diego-to-rosarito-portales-puerto-nuevo-lobster.a2695478.activity-details) ![Crossing Borders: Tijuana Day Trip from San Diego](https://mediaim.expedia.com/localexpert/1385617/3024ad77-520e-43dd-9206-6235bfe2b229.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Crossing Borders: Tijuana Day Trip from San Diego CA $129 per adult **82%** of travellers recommend [](https://expedia.ca/things-to-do/crossing-borders-tijuana-day-trip-from-san-diego.a1385617.activity-details) ![Tijuana Urban Art Walk from San Diego ](https://mediaim.expedia.com/localexpert/3402914/27e36bfb-a851-45d4-a6be-2d4fa7f7a2e9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Tijuana Urban Art Walk from San Diego CA $111 per adult [](https://expedia.ca/things-to-do/tijuana-urban-art-walk-from-san-diego.a3402914.activity-details) ![Crossing Borders: Tijuana Day Trip from San Diego](https://mediaim.expedia.com/localexpert/48193768/b44264f9-db27-4b7e-bcd7-4af756e2b001.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Crossing Borders: Tijuana Day Trip from San Diego CA $129 per adult **90%** of travellers recommend [](https://expedia.ca/things-to-do/crossing-borders-tijuana-day-trip-from-san-diego.a48193768.activity-details) ![Introduction Rosarito Day Tour from San Diego](https://mediaim.expedia.com/localexpert/3406672/24b0dec6-19fb-4045-853b-5cd01404777e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Introduction Rosarito Day Tour from San Diego CA $218 per adult [](https://expedia.ca/things-to-do/introduction-rosarito-day-tour-from-san-diego.a3406672.activity-details) ![From Tijuana: Valle de Guadalupe Shared Winery Tour](https://mediaim.expedia.com/localexpert/48318065/7c11aa1b-54f4-48a9-89b8-61d2dfb76970.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### From Tijuana: Valle de Guadalupe Shared Winery Tour CA $113 per adult [](https://expedia.ca/things-to-do/from-tijuana-valle-de-guadalupe-shared-winery-tour.a48318065.activity-details) [See all activities in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities) --- ## Otay Mesa Hotel Deals ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA CA $272 CA $382 total Feb 13 - Feb 14 includes taxes & fees Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ... 8.8/10 Excellent! (3,287 reviews) Room was very clean and luxurious Reviewed on Feb 5, 2026 [](https://expedia.ca/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=1731557&PinnedHotelID=1731557&HadPinnedHotel=true®ionId=6263723) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Paradise Point Resort & Spa 1404 Vacation Rd San Diego CA CA $196 CA $298 total Mar 1 - Mar 2 includes taxes & fees Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ... 8.6/10 Excellent! (2,398 reviews) Clean Reviewed on Feb 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=01%2F03%2F2026&endDate=02%2F03%2F2026&selected=3731&PinnedHotelID=3731&HadPinnedHotel=true®ionId=6263723) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The DEXTRO Little Italy, BW Premier Collection 1617 1st Avenue San Diego CA CA $159 CA $184 total Feb 22 - Feb 23 includes taxes & fees Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ... 8.8/10 Excellent! (1,004 reviews) This place was really nice and cozy. Friendly staff. The only thing I didn’t like was we had to pay $35 per car for parking. Reviewed on Feb 2, 2026 [](https://expedia.ca/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=170338&PinnedHotelID=170338&HadPinnedHotel=true®ionId=6263723) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Sofia Hotel 150 W Broadway San Diego CA CA $141 CA $196 total Mar 8 - Mar 9 includes taxes & fees Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ... 8.4/10 Very Good! (1,738 reviews) Rooms were clean, the beds were soo comfy, and staff was nice. Reviewed on Feb 3, 2026 [](https://expedia.ca/Hotel-Search?startDate=08%2F03%2F2026&endDate=09%2F03%2F2026&selected=1573807&PinnedHotelID=1573807&HadPinnedHotel=true®ionId=6263723) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Dana on Mission Bay 1710 W Mission Bay Dr San Diego CA CA $224 CA $289 total Feb 22 - Feb 23 includes taxes & fees Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ... 8.8/10 Excellent! (4,053 reviews) The room was clean and comfortable. Unfortunately, the children playing in the pool until 9 pm was distracting to my stay. Reviewed on Feb 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=40953&PinnedHotelID=40953&HadPinnedHotel=true®ionId=6263723) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 3888 Greenwood St San Diego CA CA $185 CA $212 total Feb 16 - Feb 17 includes taxes & fees Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Port of ... 9.2/10 Wonderful! (606 reviews) room were very comfortable and me and my family enjoyed the breakfast included. My only problem was the bathroom door not closing right and having to leave it open do it did not slam shut. Reviewed on Feb 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=16%2F02%2F2026&endDate=17%2F02%2F2026&selected=12963301&PinnedHotelID=12963301&HadPinnedHotel=true®ionId=6263723) [See all 4,918 properties in Otay Mesa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=09%2F02%2F2026&endDate=10%2F02%2F2026®ionId=6263723) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Otay Mesa hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-02-08&endDate=2026-02-09)[Feb 8 - Feb 9](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-02-08&endDate=2026-02-09) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-02-09&endDate=2026-02-10)[Feb 9 - Feb 10](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-02-09&endDate=2026-02-10) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026)[Feb 13 - Feb 15](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026) --- ### Other neighbourhoods around Otay Mesa ![Petco Park showing a statue or sculpture](https://images.trvl-media.com/place/6034816/3b5523cf-9fe3-4419-a57d-df61b6834ac5.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### East Village Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park. [](https://expedia.ca/San-Diego-East-Village.dx553248633849130034) ![Gaslamp Quarter showing street scenes, night scenes and a city](https://images.trvl-media.com/place/6130021/5158ce24-3077-4ad7-bf7d-46fd554e646d.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gaslamp Quarter Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street. [](https://expedia.ca/San-Diego-Gaslamp-Quarter.dx6130021) ![US Grant Hotel](https://images.trvl-media.com/place/800123/772b9d6a-cdc3-400e-b3ed-61d10adc7912.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown San Diego 4.5/5(716 area reviews) Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options. [](https://expedia.ca/San-Diego-Downtown-San-Diego.dx800123) ![SanDiego_NorthPark_6346499_001](https://images.trvl-media.com/place/6346499/6374335e-0d00-4eb7-8271-3d9bb2afaf80.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### North Park 4/5(3 area reviews) North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum. [](https://expedia.ca/San-Diego-North-Park.dx6346499) ![Little Italy](https://images.trvl-media.com/place/6161280/027d3836-740c-44f0-bb0a-a8fb158f401a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Little Italy Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station. [](https://expedia.ca/San-Diego-Little-Italy.dx6161280) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Del Cerro 3/5(1 area review) Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out. [](https://expedia.ca/San-Diego-Del-Cerro.dx553248635976469597) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Otay Mesa ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app