Otay Mesa
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
CA $129
per adult
92% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
CA $129
per adult
82% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
CA $116
per adult
100% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
CA $35
per adult
100% of travellers recommend
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
CA $137
per adult
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
The price is CA $219 per night from Jun 29 to Jun 30
CA $219
CA $249 total
Jun 29 - Jun 30
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very good! (1,757 reviews)
"Breakfast could have had some more fresh fruits besides apples!"
Reviewed on Jun 26, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is CA $339 per night from Jul 5 to Jul 6
CA $339
CA $471 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,776 reviews)
"I highly recommend staying here excellent experience!"
Reviewed on Jun 25, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is CA $229 per night from Jun 28 to Jun 29
CA $229
CA $315 total
Jun 28 - Jun 29
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very good! (6,228 reviews)
"The city view is amazing!"
Reviewed on Jun 27, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is CA $396 per night from Jun 30 to Jul 1
CA $396
CA $531 total
Jun 30 - Jul 1
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,671 reviews)
"The resort was beautiful! Felt like a tropical getaway, beautiful wildlife, room was was clean and well maintained, Restaurants on resort were amazing. My wife and I really enjoyed the spa! Great Resort!"
Reviewed on Jun 27, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is CA $244 per night from Jul 8 to Jul 9
CA $244
CA $351 total
Jul 8 - Jul 9
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,875 reviews)
"This stay was a last minute booking. I had previously booked somewhere else and that place was not good and we were so happy that Hard rock had a booking available. The stay was amazing. Parking was across the street and but easy access."
Reviewed on Jun 27, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
The price is CA $395 per night from Jun 30 to Jul 1
CA $395
CA $532 total
Jun 30 - Jul 1
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,197 reviews)
"The property was beautiful and well-maintained. The location was excellent! Lots of things to do on the resort. Also, their restaurants were excellent!"
Reviewed on Jun 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Lyceum Theatre is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
