Otay Mesa
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
CA $130
per adult
94% of travellers recommend
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
CA $210
per adult
From Tijuana: Valle de Guadalupe Shared Winery Tour
CA $118
per adult
100% of travellers recommend
Introduction Rosarito Day Tour from San Diego
CA $219
per adult
Stand up Paddle Board Lesson on The San Diego Bay
CA $35
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is CA $216 per night from Oct 26 to Oct 27
CA $216
CA $300 total
Oct 26 - Oct 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very good! (6,349 reviews)
"The room was very clean and well maintained. The one problem I had with the room was that there was no place (other than the bed) to open up your bag so that you can get to the contents. A luggage caddy would have been nice."
Reviewed on Oct 9, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is CA $296 per night from Nov 1 to Nov 2
CA $296
CA $415 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,922 reviews)
"pictures of rooms and mis leading , the property is run down and mail pool was very dirty"
Reviewed on Oct 9, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
The price is CA $164 per night from Nov 1 to Nov 2
CA $164
CA $204 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
The price is CA $198 per night from Nov 1 to Nov 2
CA $198
CA $299 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
The price is CA $223 per night from Nov 9 to Nov 10
CA $223
CA $257 total
Nov 9 - Nov 10
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is CA $234 per night from Nov 9 to Nov 10
CA $234
CA $340 total
Nov 9 - Nov 10
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
