Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Stand up Paddle Board Lesson on The San Diego Bay
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
The location is very beautiful. The property sits on the water and has great views. The rooms are good size. The food was just ok, the location of the restaurant and bar are again very pretty . We waited 40 minutes one night to get some bread and a salad. We kept getting other people’s orders that ...
Reviewed on Mar 25, 2026
Best Western Seven Seas
Good location. Clean. Security on site.
Reviewed on Mar 25, 2026
Hard Rock Hotel San Diego
Staff was friendly and the view from our room was spectacular
Reviewed on Mar 25, 2026
Handlery Hotel
Pool was great, hotel is older and dated. Bathroom was very small and property could use an update. Staff was great though.
Reviewed on Mar 25, 2026
The DEXTRO Little Italy, BW Premier Collection
This hotel is in a great spot downtown, but be aware parking is $35 a day, so I chose to find street parking nearby instead. There is no elevator at the top floor of parking and you will have to walk alongside where cars are driving up. The cleanliness was excellent, the floor was very clean and ...
Reviewed on Mar 25, 2026
Days Inn by Wyndham San Diego Hotel Circle
Great front office staff! Spacious, Clean and comfortable room
Reviewed on Mar 25, 2026
Other neighbourhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
