Otay Mesa Vacation Packages

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Top Holiday Package Deals in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
Price was CA $1,515, price is now CA $896 per person
CA $896
per person
Jan 12 - Jan 16
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to San Diego (SAN)
8.8/10 Excellent! (2,743 reviews)
Small cozy room, afordable price, kid friendly.

Reviewed on Oct 30, 2026

Hotel Z

Hotel Z

3 out of 5
Downtown San Diego
Save 100% on your flight
Price was CA $1,719, price is now CA $1,084 per person
CA $1,084
per person
Jan 12 - Jan 16
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to San Diego (SAN)
9.2/10 Wonderful! (1,212 reviews)

Guesthouse Hotel at La Valle

Guesthouse Hotel at La Valle

4.5 out of 5
Price was CA $1,493, price is now CA $1,079 per person
CA $1,079
per person
Jan 4 - Jan 8
found 1 day ago
Roundtrip non-stop flight included
Vancouver (YVR) to San Diego (SAN)
9.2/10 Wonderful! (269 reviews)
Loved the property, great amenities, beautiful room and VERY comfortable bed and pillows. The front desk staff seemed to be quite new and not terribly well informed but I imagine that was unusual. I would definitely stay here again.

Reviewed on Oct 29, 2026

Twelve Senses Retreat

Twelve Senses Retreat

3 out of 5
Price was CA $2,161, price is now CA $1,591 per person
CA $1,591
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip non-stop flight included
Vancouver (YVR) to San Diego (SAN)
9.8/10 Exceptional! (45 reviews)

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was CA $1,341, price is now CA $1,017 per person
CA $1,017
per person
Nov 30 - Dec 4
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to San Diego (SAN)
9/10 Wonderful! (1,585 reviews)

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
A grand building with a central fountain, palm trees, and a flag.

Downtown San Diego

3 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
The price is CA $186 per night from Nov 29 to Nov 30
CA $186
CA $212 total
Nov 29 - Nov 30
includes taxes & fees
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $196 per night from Nov 22 to Nov 23
CA $196
CA $276 total
Nov 22 - Nov 23
includes taxes & fees
Wyndham San Diego Bayside
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is CA $228 per night from Nov 22 to Nov 23
CA $228
CA $332 total
Nov 22 - Nov 23
includes taxes & fees
Hard Rock Hotel San Diego
See all 5,079 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as CA $896, a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighborhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don't worry if you're rethinking your Otay Mesa vacation package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

CA $170
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Urban Art Walk from San Diego

Tijuana Urban Art Walk from San Diego

CA $113
per adult
Tijuana Urban Art Walk from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour

From Tijuana: Valle de Guadalupe Shared Winery Tour

CA $111
per adult
100% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
See all activities in San Diego

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.