Title: Car Rental Otay Mesa, CA - Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Otay Mesa Car Rental ## Search and Compare from Car Companies in Otay Mesa ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXCA-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself Members save 10% or more on over 1 million car rentals - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers to unlock big savings ## Top Car Deals in Otay Mesa \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people San Diego, California, USA ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=6263723&date1=31/12/2025&date2=02/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people San Diego, California, USA ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=6263723&date1=31/12/2025&date2=02/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people San Diego, California, USA ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=6263723&date1=31/12/2025&date2=02/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people San Diego, California, USA ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=6263723&date1=31/12/2025&date2=02/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in Otay Mesa [View all cars](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=6263723&date1=31/12/2025&date2=02/01/2026&crfrr=defaultFlex&SearchType=Place) ## Frequently asked questions ### How much is a rental car per day in Otay Mesa? ### What happens if I need to cancel my Otay Mesa car reservation? ### Where can I go on a road trip from Otay Mesa? > - You'll discover Santa Ana Zoo and lots more interesting attractions in Santa Ana. From Otay Mesa, it's roughly 153 kilometres away. > - Your next stop? It has to be Yorba Linda, which is around 161 kilometres away. Richard Nixon Library and Museum is one local draw card you really shouldn't miss. > - Venture into the outdoors and appreciate the serenity at Venice Beach. It's 209 kilometres from Otay Mesa. ### How do I find the best car rental deals in Otay Mesa with Expedia? ### How old do you have to be to rent a car in Otay Mesa? ### What do you need to rent a car in Otay Mesa? ### What is the cheapest car rental in Otay Mesa? ### Can I rent a car for a month or longer in Otay Mesa? ### Where can I find an Otay Mesa car rental if I am younger than 25? ## Car Rental Information | Popular car types: | [SUV](https://www.expedia.ca/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.ca/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.ca/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.ca/ground-transfers?rfrr=car.table.AirportTransportation) | ## Explore a world of travel with Expedia - Lodging - Flights - Cars - [Hotels near Brown Field Municipal ](https://www.expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Flights from Brown Field Municipal ](https://www.expedia.ca/lp/airports/sdm/flights-from-brown-field-municipal-airport) - [Flights from Aspen (ASE) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/ase/sdm/aspen-to-san-diego) - [Flights from Barcelona (BCN) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/bcn/sdm/barcelona-to-san-diego) - [Flights from Bakersfield (BFL) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/bfl/sdm/bakersfield-to-san-diego) - [Flights from León (BJX) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/bjx/sdm/leon-to-san-diego) - [Flights from Bangkok (BKK) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/bkk/sdm/bangkok-to-san-diego) - [Flights from Bellingham (BLI) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/bli/sdm/bellingham-to-san-diego) - [Flights from Nashville (BNA) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/bna/sdm/nashville-to-san-diego) - [Flights from Burlington (BTV) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/btv/sdm/burlington-to-san-diego) - [Flights from Paris (CDG) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/cdg/sdm/paris-to-san-diego) - [Flights from Calipatria (CLR) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/clr/sdm/calipatria-to-san-diego) - [Flights from Charlotte (CLT) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/clt/sdm/charlotte-to-san-diego) - [Flights from Compton (CPM) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/cpm/sdm/compton-to-san-diego) - [Flights from Cancun (CUN) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/cun/sdm/cancun-to-san-diego) - [Flights from Cincinnati (CVG) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/cvg/sdm/cincinnati-to-san-diego) - [Flights from Barstow (DAG) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/dag/sdm/barstow-to-san-diego) - [Flights from Denver (DEN) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/den/sdm/denver-to-san-diego) - [Flights from Dallas (DFW) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/dfw/sdm/dallas-to-san-diego) - [Flights from Detroit (DTW) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/dtw/sdm/detroit-to-san-diego) - [Flights from Ensenada (ESE) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/ese/sdm/ensenada-to-san-diego) - [Flights from Newark Liberty Intl. 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