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Our top choices for Southeast Missouri hotels

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

1. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

CA $87 total

includes taxes & fees

Nov 2 - Nov 3

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

2. Super 8 by Wyndham Farmington

Farmington

Marisa

CA $95 total

includes taxes & fees

Nov 3 - Nov 4

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

3. Hampton Inn Farmington

Farmington

Charlie

CA $159 total

includes taxes & fees

Nov 19 - Nov 20

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

4. Shepherd Mountain Inn

Ironton

Jonathan

CA $189 total

includes taxes & fees

Oct 27 - Oct 28

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

5. Drury Inn & Suites Jackson MO

Jackson

Lyn

CA $118 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

6. Hampton Inn & Suites By Hilton Festus

Festus

Abram

CA $162 total

includes taxes & fees

Nov 1 - Nov 2

A motel with a covered entrance, a flag, and a phone number.

7. Madison Inn Lodge

Fredericktown

Bawan

CA $130 total

includes taxes & fees

Nov 2 - Nov 3

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

8. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Chris

CA $158 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

9. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Terry

CA $147 total

includes taxes & fees

Nov 1 - Nov 2

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

10. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

CA $162 total

includes taxes & fees

Nov 26 - Nov 27

A living room with a blue wall, a fireplace, a sofa, and a chair.

11. EC Reed's Mercantile and Hotel

Marble Hill

Jan

CA $151 total

includes taxes & fees

Nov 26 - Nov 27

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

12. Fort Davidson Hotel

Ironton

richard

CA $191 total

includes taxes & fees

Oct 27 - Oct 28

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

13. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

CA $141 total

includes taxes & fees

Nov 8 - Nov 9

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

14. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

CA $153 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a reception desk, seating area, and large windows.

15. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

CA $142 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

16. Super 8 by Wyndham Perryville

Perryville

Matthew

CA $109 total

includes taxes & fees

Nov 8 - Nov 9

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

17. Super 8 By Wyndham Marston

Marston

Wendy

CA $90 total

includes taxes & fees

Oct 30 - Oct 31

A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

18. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Jose

CA $224 total

includes taxes & fees

Nov 24 - Nov 25

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

19. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

CA $189 total

includes taxes & fees

Nov 8 - Nov 9

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

20. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

J

CA $121 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Vacation Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "