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Sep 17 - Sep 18
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Our top choices for Southeast Missouri hotels

A motel with a covered entrance, a flag, and a phone number.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

1. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
CA $122
CA $133 total
includes taxes & fees
Sep 25 - Sep 26
Madison Inn Lodge
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.
A hotel room with two beds, a lamp, and a painting on the wall.
A building with a red awning labeled "Shepherd Mountain Inn."

2. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
CA $171
CA $187 total
includes taxes & fees
Sep 18 - Sep 19
Shepherd Mountain Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A hotel room with two beds, a brick wall, and a wooden headboard.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A restaurant with a brick wall, a flat-screen TV, and a bar area.

3. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
William
CA $111
CA $118 total
includes taxes & fees
Sep 21 - Sep 22
Drury Inn & Suites Jackson MO
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.
A gym with cardio equipment, a bench press, and a squat rack.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

4. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
ILUNGA
CA $80
CA $87 total
includes taxes & fees
Oct 11 - Oct 12
Baymont Inn and Suites by Wyndham Farmington, MO
A hotel room with two beds, a desk, a chair, a TV, and a lamp.
An outdoor pool area with lounge chairs and an umbrella.
A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.
A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

5. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
CA $174
CA $190 total
includes taxes & fees
Sep 20 - Sep 21
Fort Davidson Hotel
A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.
A laundry room with a front-loading washer and dryer, a door, and a light fixture.
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

6. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
CA $83
CA $90 total
includes taxes & fees
Sep 28 - Sep 29
Super 8 by Wyndham Farmington
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

7. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Theresa
CA $130
CA $146 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Poplar Bluff
A living room with a blue wall, a fireplace, a sofa, and a chair.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A brick building with a sign reading "Mercantile & Hotel".
A bar area with stools and a counter where a bartender is serving drinks.

8. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
CA $140
CA $153 total
includes taxes & fees
Sep 17 - Sep 18
EC Reed's Mercantile and Hotel
A cabin with a large window, surrounded by trees.
A cabin with a cozy interior, a dining area, and a visible window.

9. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
United States
Ronrecus
CA $141
CA $223 total
includes taxes & fees
Oct 15 - Oct 16
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

10. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
CA $139
CA $157 total
includes taxes & fees
Sep 24 - Sep 25
Drury Plaza Hotel Cape Girardeau Conference Center
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A spacious hotel lobby with a dining area, kitchen, and large windows.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

11. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
CA $152
CA $166 total
includes taxes & fees
Oct 4 - Oct 5
Crown Pointe Lodge, BW Signature Collection
A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.
A kitchen counter with a coffee machine, a kettle, and storage boxes.
A modern dining area with high tables and chairs, a television screen, and a view of the outdoors through large windows.
A conference room with tables and chairs, framed artwork on the walls, and a carpeted floor.

12. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
United States
David
CA $140
CA $161 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express & Suites Perryville by IHG
A spacious lobby with a reception desk, seating area, and large windows.
A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.
An indoor swimming pool with a clear view of the outside through large windows.
A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

13. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Paul
CA $145
CA $164 total
includes taxes & fees
Sep 27 - Sep 28
Drury Inn & Suites Poplar Bluff
A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.
A modern kitchen with granite countertops, wooden chairs, and a dining table. There are various food items and a sign indicating hot beverages.
An indoor swimming pool with clear lanes, a sunlit room with a view, and a staircase leading to an upper level.
A modern waiting area with a grey sofa, a small table, and a black office chair. There are two doors with signs indicating restrooms.

14. Quality Inn Farmington

Quality Inn Farmington
Farmington
United States
Desiree
CA $83
CA $95 total
includes taxes & fees
Oct 11 - Oct 12
Quality Inn Farmington
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

15. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
CA $141
CA $159 total
includes taxes & fees
Sep 27 - Sep 28
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.
A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.
A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.
A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

16. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
United States
paulette
CA $98
CA $112 total
includes taxes & fees
Sep 27 - Sep 28
Super 8 by Wyndham Perryville
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A hotel room with two beds, a nightstand, a lamp, and a chair.

17. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
CA $117
CA $127 total
includes taxes & fees
Sep 20 - Sep 21
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

18. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
Canada
Raidas
CA $100
CA $113 total
includes taxes & fees
Sep 27 - Sep 28
Pear Tree Inn Cape Girardeau West
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.
A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.
A view through a window with a stone wall and a wooden structure in the background.
A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

19. Sam A Baker State Park

Sam A Baker State Park
Patterson
United States
Charlie
CA $188
CA $199 total
includes taxes & fees
Oct 11 - Oct 12
Sam A Baker State Park
A narrow corridor with a bar area on the right, featuring a counter and hanging lights.
A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.
A large boulder in a natural setting with autumn-colored trees in the background.
A large rock formation with a clear sky and autumn foliage in the background.

20. Black River Motel and Restaurant

Black River Motel and Restaurant
Lesterville
United States
Douglas
CA $161
CA $171 total
includes taxes & fees
Sep 20 - Sep 21
Black River Motel and Restaurant
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Vacation Rentals in Southeast Missouri

Cabin
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.
A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.
A view through a window with a stone wall and a wooden structure in the background.
A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cabin
A cabin with a large window, surrounded by trees.
A cabin with a cozy interior, a dining area, and a visible window.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"I really enjoyed my time at the stay !"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Cabin
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.
A bedroom with a wooden bed, a bench, and a window.
A calm lake with a wooden dock and a forested island in the distance.

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Cottage
A dining area with a checkered tablecloth, wooden chairs, and a red rug.
A two-story house with a red exterior, a front porch, and a well-maintained lawn.
A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.
A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Vacation Home
A wooden deck with two Adirondack chairs and a hammock.
A spacious living room with a wooden ceiling, a fireplace, and a television.
A spacious living room with wooden floors, a stone fireplace, and a mounted television.
A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Aparthotel
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A building with a sign that reads "The Atrium Boutique Hotel".
A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.
A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Aparthotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A hallway with exposed brick walls, wooden flooring, and a white door.
A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cottage
A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage
A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.
A house with a red door, a porch with rocking chairs, and a wreath on the door.
A two-story house with a deck and a covered porch.
A spacious dining area with a stone wall, wooden furniture, and a fireplace.

40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
Poplar Bluff
"Beautiful place enjoyed our stay"
40-acre Poplar Bluff Nature Lovers Paradise!
Cottage
A cozy living room with wooden ceilings, a ceiling fan, two sofas, a coffee table, a rug, and a bookshelf with books and games.
A red house with a wooden deck, large sliding glass doors, and a chimney.
A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.
A dining area with a glass table and chairs, wooden flooring, and large windows.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cottage
A bedroom with a bed, nightstand, lamp, and curtains.
A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.
A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.
A single-story house with a front porch, a small front yard, and a red roof.

Cottage w/ Yard, Walk to Historic Attractions

Cottage w/ Yard, Walk to Historic Attractions
Ste Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage w/ Yard, Walk to Historic Attractions
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
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A river flowing through a forested area with a sandy beach.

Big Spring

9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Walnut Hollow Lake to K Bridge Recreation Area.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Good price, pleasant staff, clean room and facilities, filling buffet breakfast. Water for the shower could have been warmer."
Gaylon 1-night trip
Posted 3 hours ago
Pear Tree Inn Cape Girardeau West
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"Good place!"
Hazlo 3-night trip
Posted 4 hours ago
Days Inn and Suites by Wyndham Sikeston
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"An older hotel with some signs of wear and tear, but very clean with and excellent staff."
Joseph 2-night trip
Posted 4 hours ago
Comfort Inn Festus - St Louis South
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

8/10 Good
"Good location, great staff, clean rooms."
Rhonda 1-night trip
Posted 6 hours ago
Hampton Inn Poplar Bluff
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Great stay and friendly, nice staff! Loved it!"
Renee 1-night trip
Posted 1 day ago
Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good
"Had a king suite Couch and chairs were worn out, need to be replaced"
Charles 1-night trip
Posted 1 day ago
Baymont Inn and Suites by Wyndham Farmington, MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great experience- food, cleanliness, friendly staff"
Patti 1-night trip
Posted 3 days ago
Drury Plaza Hotel Cape Girardeau Conference Center
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope to go back!"
Lisa 2-night trip
Posted 4 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Serapia 1-night trip
Posted 4 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
CA $80
CA $87 total
Oct 11 - Oct 12
includes taxes & fees
8/10 Very good! (1,001 reviews)
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
CA $92
CA $105 total
Sep 22 - Sep 23
includes taxes & fees
7.2/10 Good! (1,001 reviews)
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
CA $100
CA $113 total
Sep 27 - Sep 28
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
CA $107
CA $125 total
Oct 11 - Oct 12
includes taxes & fees
7.8/10 Good! (1,007 reviews)
Comfort Inn Festus - St Louis South
The Farmstead Hotel

The Farmstead Hotel

778 E 3rd St Caruthersville MO
CA $119
CA $135 total
Sep 30 - Oct 1
includes taxes & fees
8.6/10 Excellent! (608 reviews)
The Farmstead Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO
CA $140
CA $160 total
Sep 27 - Sep 28
includes taxes & fees
9.4/10 Exceptional! (1,000 reviews)
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Southeast Missouri with star rating

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