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Our top choices for Southeast Missouri hotels

A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.
A laundry room with a front-loading washer and dryer, a door, and a light fixture.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

1. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
CA $84
CA $96 total
includes taxes & fees
Oct 23 - Oct 24
Super 8 by Wyndham Farmington
A motel with a covered entrance, a flag, and a phone number.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

2. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
CA $125
CA $137 total
includes taxes & fees
Oct 18 - Oct 19
Madison Inn Lodge
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A building with a red awning labeled "Shepherd Mountain Inn."
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.
A hotel room with two beds, a lamp, and a painting on the wall.

3. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
CA $174
CA $190 total
includes taxes & fees
Oct 19 - Oct 20
Shepherd Mountain Inn
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

4. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
CA $126
CA $145 total
includes taxes & fees
Oct 29 - Oct 30
Hampton Inn & Suites By Hilton Festus
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A gym with cardio equipment, a bench press, and a squat rack.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.
A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

5. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
Canada
Kim
CA $77
CA $88 total
includes taxes & fees
Nov 1 - Nov 2
Baymont Inn and Suites by Wyndham Farmington, MO
A hotel room with two beds, a desk, a chair, a TV, and a lamp.
A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".
A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.
An outdoor pool area with lounge chairs and an umbrella.

6. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
CA $177
CA $193 total
includes taxes & fees
Oct 18 - Oct 19
Fort Davidson Hotel
A hotel room with two beds, a nightstand, and a wall-mounted light fixture.
A compact kitchen with a microwave, a sink, and a small refrigerator.
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
A hotel room with a flat-screen TV, a desk with a chair, a sofa, a small table, and framed pictures on the wall.

7. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
CA $129
CA $144 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Poplar Bluff
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A hotel room with two beds, a brick wall, and a wooden headboard.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

8. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Lyn
CA $113
CA $120 total
includes taxes & fees
Nov 15 - Nov 16
Drury Inn & Suites Jackson MO
A hotel room with a bed, a sofa, a desk, and a chair.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

9. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
CA $163
CA $186 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites Farmington by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

10. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Darnetta
CA $140
CA $158 total
includes taxes & fees
Nov 1 - Nov 2
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

11. The Riverview

The Riverview
Cape Girardeau
United States
Scotty
CA $142
CA $160 total
includes taxes & fees
Oct 25 - Oct 26
The Riverview
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A spacious hotel lobby with a dining area, kitchen, and large windows.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

12. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
CURTIS
CA $143
CA $164 total
includes taxes & fees
Oct 25 - Oct 26
Crown Pointe Lodge, BW Signature Collection
A living room with a blue wall, a fireplace, a sofa, and a chair.
A brick building with a sign reading "Mercantile & Hotel".
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A bar area with stools and a counter where a bartender is serving drinks.

13. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
Miranda
CA $141
CA $154 total
includes taxes & fees
Oct 29 - Oct 30
EC Reed's Mercantile and Hotel
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.
A reception area with a wooden counter, a coffee machine, and a display of pastries.
A corner market with a refrigerated display case and a pantry area.
A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

14. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Nancy
CA $137
CA $155 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites by Marriott Poplar Bluff
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

15. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
CA $143
CA $162 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites by Marriott Sikeston
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

16. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
CA $113
CA $122 total
includes taxes & fees
Nov 16 - Nov 17
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.
A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.
A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.
A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

17. Hampton Inn Farmington

Hampton Inn Farmington
Farmington
United States
Charlie
CA $147
CA $169 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Farmington
A spacious lobby with a reception desk, seating area, and large windows.
A hotel room with a bed, a desk, a chair, a sofa, and a TV.
A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.
A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

18. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Dean
CA $133
CA $150 total
includes taxes & fees
Oct 25 - Oct 26
Drury Inn & Suites Poplar Bluff
A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.
A Holiday Inn Express & Suites building with a covered entrance and multiple windows.
A kitchen counter with a coffee machine, a kettle, and storage boxes.
A gym with treadmills, elliptical machines, and weight equipment.

19. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
United States
Perry
CA $134
CA $154 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites Perryville by IHG
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.
A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.
A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

20. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
CA $79
CA $91 total
includes taxes & fees
Oct 23 - Oct 24
Super 8 By Wyndham Marston
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Vacation Rentals in Southeast Missouri

Cabin
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.
A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.
A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.
A view through a window with a stone wall and a wooden structure in the background.

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cottage
A dining area with a checkered tablecloth, wooden chairs, and a red rug.
A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.
A two-story house with a red exterior, a front porch, and a well-maintained lawn.
A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Cabin
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.
Private kitchen
A rustic cabin with a wooden exterior, a small deck, and a picnic table.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"The stay here gets better every time."
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Aparthotel
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A building with a dark exterior, a large window, and a sign that reads "The Atrium."
A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.
A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Vacation Home
A wooden deck with two Adirondack chairs and a hammock.
A bedroom with a large bed, wooden ceiling, and a view of the outdoors.
A spacious living room with a wooden ceiling, a fireplace, and a television.
A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Aparthotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.
A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.
A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cottage
A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.
A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.
A single-story house with a front porch, a stone foundation, and a well-maintained lawn.
A spacious living area with a kitchen island, dining table, and a television.

Walk to Dtwn: Ironton Home in Historic District

Walk to Dtwn: Ironton Home in Historic District
Ironton
"Clean and comfortable "
Walk to Dtwn: Ironton Home in Historic District
Cottage
A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.
A house with a red door, a porch with rocking chairs, and a wreath on the door.
A room with wooden paneling, a ceiling fan, a dining table with chairs, and a sofa.
A two-story house with a deck and a covered porch.

40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
Poplar Bluff
"Beautiful place enjoyed our stay"
40-acre Poplar Bluff Nature Lovers Paradise!
Cottage
Interior
A wooden deck leading to a house with a wooden door and a small porch area.
Interior
A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage
A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.
A dining area with a glass table and chairs, wooden flooring, and large windows.
A red house with a wooden deck and stone steps leading to a porch.
A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cottage
A bedroom with a bed, nightstand, lamp, and curtains.
A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.
A single-story house with a front porch, a small front yard, and a red roof.
A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

Cottage w/ Yard, Walk to Historic Attractions

Cottage w/ Yard, Walk to Historic Attractions
Ste Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage w/ Yard, Walk to Historic Attractions
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
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A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

8/10 Good
"Check in was great around 6:30 PM. Room was clean and we had a restful night. Breakfast was disappointing. Not much variety, eggs were brown, and the 2% milk dispenser was empty. I waited about 10 minutes (at waffles instead) and still no milk. I went to the front desk to tell the lady they were out of milk and her response was "Well, he is probably in the kitchen, go look there!" I went there to look and nobody was to be found so I went back to the front desk. The lady said she would "call him". After a few more minutes "he" appeared and filled the empty milk container and replenished a few other item's. I guess the guy came in a back door but was definitely absent for a long time until I complained."
Mary 1-night trip
Posted 17 hours ago
Hampton Inn Poplar Bluff
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Great"
Tim 3-night trip
Posted 20 hours ago
Baymont Inn and Suites by Wyndham Farmington, MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great as usual"
Frank 1-night trip
Posted 22 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"The evening food was especially good! The two women working were outstanding and made the evening more fun. One's name was San."
Denise 1-night trip
Posted 23 hours ago
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"We arrived just before the evening meal was closing so the staff recommended we get something to eat and then check in. Very thoughtful!"
Caroline 1-night trip
Posted 1 day ago
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"It was nice having a 2 room suite. Plenty of room. Fridge with freezer was a plus."
Randy 1-night trip
Posted 2 days ago
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"We have stayed at the Pear Tree several times and never disappointed!! Great staff, clean rooms, generous breakfast. A special thanks to Lydia who took extra care to make our last stay remarkable. Thank you."
Sally 1-night trip
Posted 2 days ago
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"The room was clean, the pillows were great and the bed was comfy. the dinner service and breakfast were very nice and the staff was helpful and friendly! 10/10"
Cynthia 1-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"good, clean, affordable :)"
Nicholas 1-night trip
Posted 4 days ago
Super 8 by Wyndham Sikeston/Miner Area

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
CA $77
CA $88 total
Nov 1 - Nov 2
includes taxes & fees
8/10 Very good! (1,006 reviews)
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
CA $94
CA $107 total
Nov 8 - Nov 9
includes taxes & fees
7.2/10 Good! (1,002 reviews)
Days Inn and Suites by Wyndham Sikeston
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
CA $98
CA $110 total
Oct 22 - Oct 23
includes taxes & fees
Motel 6 Poplar Bluff, MO
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
CA $102
CA $115 total
Oct 25 - Oct 26
includes taxes & fees
9.2/10 Wonderful! (1,004 reviews)
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
CA $101
CA $118 total
Nov 8 - Nov 9
includes taxes & fees
Comfort Inn Festus - St Louis South
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
CA $129
CA $144 total
Nov 15 - Nov 16
includes taxes & fees
9.4/10 Exceptional! (987 reviews)
Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star rating

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