Title: Book The Best Hotels in Southeast Missouri, MO for 2026 from CA $75 - Fully Refundable Options - Expedia.ca

[Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Bill Dillard

# Find hotels in Southeast Missouri, MO from CA $75

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## Go beyond your typical stay in Southeast Missouri

Cabin

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&lodging=CABIN)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&travelerType=family_friendly)

Hot tub

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&amenities=HOT_TUB)

Farm

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&lodging=AGRITOURISM)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&amenities=POOL)

Cottage

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&lodging=COTTAGE)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&lodging=APARTMENT)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&amenities=PETS)

Waterpark

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&amenities=WATER_PARK)

Villa

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-12&d1=2026-01-12&endDate=2026-01-14&d2=2026-01-14&lodging=VILLA)

## Check prices for these dates

Tonight

[Dec 29 - Dec 30](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-29&endDate=2025-12-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 30 - Dec 31](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-30&endDate=2025-12-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Southeast Missouri hotels

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Jackson MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

Jackson

9.6/10

Exceptional

(1004)

"Breakfast was great- staff was welcoming. Will stay there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

CA $113

CA $120 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/59050052.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/4ea0b11e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/0a692e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Poplar Bluff by IHG

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information)

Poplar Bluff

8.8/10

Excellent

(708)

"Amazing place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mladen

CA $150

CA $170 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Farmstead Hotel

[](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

Caruthersville

8.8/10

Excellent

(465)

"Clean room, very nice staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mack

CA $117

CA $133 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/db5aadc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Echo Bluff State Park

[](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

Eminence

9.6/10

Exceptional

(217)

"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joanne

CA $202

CA $214 total

includes taxes & fees

Jan 28 - Jan 29, 2026

[](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/ed042ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/8874e729.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

Sikeston

8.4/10

Very good

(1005)

"Great stay, everything was clean and comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Charles

CA $103

CA $118 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(1011)

"Great place and staff, very accommodating!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Megan

CA $123

CA $139 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/e7b8b662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/4329af11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

Sikeston

8.4/10

Very good

(725)

"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Todd

CA $76

CA $86 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/d71a605c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/99ef8265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Poplar Bluff

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(861)

"The rooms were very clean and well maintained and th e staff was great and the young lady who checked us in was awsome at her job she helped me get the smart tv workin and has a very professional and respectfull through the hole stay we thank this is the nicest hotel i ve stayed at by far andcwill be back "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Terry

CA $142

CA $161 total

includes taxes & fees

Jan 9 - Jan 10, 2026

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub)](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/83931306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Poplar Bluff

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

Poplar Bluff

9.2/10

Wonderful

(971)

"Nice room helpful staff. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Deborah

CA $144

CA $162 total

includes taxes & fees

Jan 10 - Jan 11, 2026

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/58027ab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/5b675ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 Poplar Bluff, MO

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

Poplar Bluff

8.0/10

Very good

(1004)

"It was a nice stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rebecca

CA $104

CA $114 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/08371d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1003)

"This our favorite place to stop for a good night sleep. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eileen

CA $123

CA $141 total

includes taxes & fees

Jan 3 - Jan 4, 2026

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/d42a6e3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Perryville by IHG

[](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

Perryville

9.2/10

Wonderful

(544)

"lean, updated rooms, friendly staff and great breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Linda

CA $124

CA $142 total

includes taxes & fees

Jan 1 - Jan 2, 2026

[](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![Children's play area - outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/5013cbb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/603f552a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Single Room](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/868bcfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Honeysuckle Inn - Mountain View

[](https://www.expedia.ca/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

Mountain View

8.6/10

Excellent

(334)

"Staff was very friendly."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joyce

CA $123

CA $133 total

includes taxes & fees

Jan 25 - Jan 26, 2026

[](https://www.expedia.ca/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/23ae42af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Building design](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/f4d876e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/7e9b49ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont Inn and Suites by Wyndham Farmington, MO

[](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

Farmington

8.0/10

Very good

(1009)

"Room was clean , staff was friendly !"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sally

CA $73

CA $83 total

includes taxes & fees

Jan 10 - Jan 11, 2026

[](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d234bb55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/e565804d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/5d1ea140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/3a2c35d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Farmington

[](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information)

Farmington

8.0/10

Very good

(612)

"Clean, friendly staff, quiet"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stacy

CA $72

CA $82 total

includes taxes & fees

Jan 5 - Jan 6, 2026

[](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/25677988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/f6482ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/5904f90a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Poplar Bluff

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(797)

"Staff was kind and provided a lot of information during check out."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shea

CA $150

CA $168 total

includes taxes & fees

Jan 10 - Jan 11, 2026

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(144)

"Clean room great breakfast "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carl

CA $120

CA $136 total

includes taxes & fees

Jan 8 - Jan 9, 2026

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/e9e97147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/e66aa4eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/6e70629c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Festus - St. Louis South

[](https://www.expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

Festus

8.0/10

Very good

(894)

"Breakfast was great! Location right off interstate was perfect. The property is a little old."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mindy

CA $127

CA $145 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/686f0126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(455)

"clean room, comfy bedding, nice staff, convenient location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alexa

CA $139

CA $157 total

includes taxes & fees

Jan 11 - Jan 12, 2026

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/fd23ac64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/72dcdb56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/15fecbba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/a26b8409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fort Davidson Hotel

[](https://www.expedia.ca/Farmington-Hotels-Fort-Davidson-Hotel.h12489555.Hotel-Information)

Ironton

9.2/10

Wonderful

(174)

"Friendly staff, spacious room, nice pool!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

SHARON

CA $164

CA $179 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Farmington-Hotels-Fort-Davidson-Hotel.h12489555.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-12&endDate=2026-01-13&regionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Vacation Rentals in Southeast Missouri

Vacation Home

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Private kitchen](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/98efa0e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/972e20f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Porch](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e72e4500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tiny Houses of French Village

[](https://www.expedia.ca/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

French Village

10/10

Exceptional

(3)

"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."

[](https://www.expedia.ca/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

Cottage

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/c2de0b90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/f8b751c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/e4f8cafe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Living area](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/6a2519cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 40-acre Poplar Bluff Nature Lovers Paradise!

[](https://www.expedia.ca/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information)

Poplar Bluff

10/10

Exceptional

(3)

"Beautiful place enjoyed our stay"

[](https://www.expedia.ca/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information)

Cabin

![Cabin, 1 Queen Bed | Private kitchen](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/6dbce3c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/169de09a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/151ee9e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/785ded9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.ca/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

French Village

9.8/10

Exceptional

(46)

"The cabin was cozy and very peaceful such a good experience "

[](https://www.expedia.ca/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

Cabin

![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/71c262d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/a7c4cf22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room dining](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/946846b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/055f4f65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Johnson's Shut-ins State Park

[](https://www.expedia.ca/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information)

Middle Brook

10/10

Exceptional

(1)

"These newer cabins are clean and have everything you need. Highly recommend! "

[](https://www.expedia.ca/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information)

Cabin

![Classic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ec7dbabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sam A Baker State Park

[](https://www.expedia.ca/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

Patterson

9.2/10

Wonderful

(5)

"Pet friendly, great staff. "

[](https://www.expedia.ca/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

Cottage

![House (3 Bedrooms) | Exterior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/a47c37db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/90a48852.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/c6a2f10e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/c9bb1a79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walk to Dtwn: Ironton Home in Historic District

[](https://www.expedia.ca/Ironton-Hotels-Walk-To-Dtwn-Ironton-Home-In-Historic-District.h116687024.Hotel-Information)

Ironton

10/10

Exceptional

(1)

"Clean and comfortable "

[](https://www.expedia.ca/Ironton-Hotels-Walk-To-Dtwn-Ironton-Home-In-Historic-District.h116687024.Hotel-Information)

Cottage

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/a4a2b46f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/a0ea408f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/13098805.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/bcc548cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 'turtle Rock' - Ironton Cabin w/ Furnished Patio!

[](https://www.expedia.ca/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information)

Ironton

10/10

Exceptional

(1)

"Stroller, pack n play and high chair. This was amazing "

[](https://www.expedia.ca/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information)

Cottage

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/4d1e86cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/b4a37e32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/f9e60430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/330effe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Belgrade Cottage w/ Wood-burning Stove!

[](https://www.expedia.ca/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information)

Belgrade

10/10

Exceptional

(1)

[](https://www.expedia.ca/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information)

[See all vacation rentals](https://expedia.ca/Hotel-Search?startDate=2026-01-26&endDate=2026-01-29&regionId=6058763&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true)

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## Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

[See all hotels in Southeast Missouri](https://www.expedia.ca/Hotel-Search?startDate=2026-01-12&endDate=2026-01-13&adults=2&regionId=6058763)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high)

Photo by Bill Dillard

### Stay near popular Southeast Missouri attractions

[](https://expedia.ca/Elephant-Rocks-State-Park-Hotels.0-l553248621532648464-0.Travel-Guide-Filter-Hotels)

![Elephant Rocks State Park](https://mediaim.expedia.com/destination/2/86e50eabc9d5592586815e7688be64ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648464)

[](https://expedia.ca/Lake-Wappapello-Hotels.0-l553248621532648460-0.Travel-Guide-Filter-Hotels)

![Lake Wappapello](https://mediaim.expedia.com/destination/2/a6135d9f1717ada26d9944dd5bb40459.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648460)

[](https://expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels)

#### Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621554122994)

[](https://expedia.ca/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels)

#### Century Casino Caruthersville

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655201)

[](https://expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels)

#### Isle Casino Cape Girardeau

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655780)

[](https://expedia.ca/Bonne-Terre-Mine-Hotels.0-l553248621532648467-0.Travel-Guide-Filter-Hotels)

#### Bonne Terre Mine

Commune with nature and explore the great outdoors at Bonne Terre Mine during your travels in Bonne Terre. You can seek out the golf courses while in the area. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648467)

## More cheap stays in Southeast Missouri

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

CA $73

CA $83 total

Jan 10 - Jan 11, 2026

includes taxes & fees

7.8/10 Good! (1,003 reviews)

[](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $86

CA $98 total

Jan 4 - Jan 5, 2026

includes taxes & fees

7.2/10 Good! (1,002 reviews)

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $96

CA $108 total

Jan 4 - Jan 5, 2026

includes taxes & fees

9/10 Wonderful! (1,001 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

CA $104

CA $114 total

Dec 30 - Dec 31

includes taxes & fees

7.8/10 Good! (1,000 reviews)

[](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

CA $124

CA $140 total

Jan 4 - Jan 5, 2026

includes taxes & fees

9.4/10 Exceptional! (1,000 reviews)

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove Poplar Bluff MO

CA $142

CA $161 total

Jan 9 - Jan 10, 2026

includes taxes & fees

9.4/10 Exceptional! (859 reviews)

[](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

## Hotels in Southeast Missouri with star-rating

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

2 properties

[](https://expedia.ca/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

53 properties

[](https://expedia.ca/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

142 properties

[](https://expedia.ca/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels)

## Recent reviews of Southeast Missouri hotels

![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg)

### Drury Inn & Suites Poplar Bluff

5/5 Excellent

"Comfy bed and pillows. Staff extremely friendly!"

A verified traveller stayed at Drury Inn & Suites Poplar Bluff

Posted 1 day ago

[](https://expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg)

### The Farmstead Hotel

5/5 Excellent

"Clean room, very nice staff"

A verified traveller stayed at The Farmstead Hotel

Posted 3 days ago

[](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

5/5 Excellent

"Friendly staff "

A verified traveller stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Posted 4 days ago

[](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Festus - St. Louis South](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70_y.jpg)

### La Quinta Inn & Suites by Wyndham Festus - St. Louis South

5/5 Excellent

"Room was clean. Towels were nice. Shower was hot. Breakfast was good. "

A verified traveller stayed at La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Posted 4 days ago

[](https://expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

5/5 Excellent

"Clean and very nice room "

A verified traveller stayed at Drury Inn & Suites Cape Girardeau

Posted 5 days ago

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

5/5 Excellent

"Our room was quiet and comfortable, the staff were super nice and professional, the breakfast was great, and they gave us a late checkout since my husband had to take an unexpected conference call. We will definitely come back."

A verified traveller stayed at Drury Inn & Suites Jackson MO

Posted 5 days ago

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg)

### Baymont Inn and Suites by Wyndham Farmington, MO

5/5 Excellent

"Reasonably priced spacious room. The bed was very comfortable and great water pressure for the shower. Incredibly friendly staff. Plenty of parking for truck with trailer and parking lots were well lit. Couple items in our room could use attention or update, but overall a great value and pleasant place to stay."

A verified traveller stayed at Baymont Inn and Suites by Wyndham Farmington, MO

Posted 5 days ago

[](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Pear Tree Inn Cape Girardeau Near the Medical Center](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg)

### Pear Tree Inn Cape Girardeau Near the Medical Center

5/5 Excellent

"Great stay"

A verified traveller stayed at Pear Tree Inn Cape Girardeau Near the Medical Center

Posted 6 days ago

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg)

### Hampton Inn Sikeston

5/5 Excellent

"clean room, comfy bedding, nice staff, convenient location "

A verified traveller stayed at Hampton Inn Sikeston

Posted 6 days ago

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

## Frequently asked questions

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Southeast Missouri hotel booking with Expedia?

### How much is the nightly rate at a Southeast Missouri hotel?

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