Book The Best Hotels in Southeast Missouri, MO for 2026 from CA $88 - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A building with a red awning labeled "Shepherd Mountain Inn."

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Ironton

Michael

CA $175

CA $191 total

includes taxes & fees

Nov 6 - Nov 7

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

2. Super 8 by Wyndham Farmington

Farmington

Marisa

CA $85

CA $97 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Abram

CA $127

CA $145 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

4. Drury Inn & Suites Jackson MO

Jackson

Debra S

CA $114

CA $120 total

includes taxes & fees

Oct 12 - Oct 13

A motel with a covered entrance, a flag, and a phone number.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

5. Madison Inn Lodge

Fredericktown

Bawan

CA $115

CA $126 total

includes taxes & fees

Nov 3 - Nov 4

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A gym with cardio equipment, a bench press, and a squat rack.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

6. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Mark

CA $77

CA $88 total

includes taxes & fees

Nov 1 - Nov 2

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A spacious hotel lobby with a dining area, kitchen, and large windows.

7. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

CA $156

CA $178 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

CA $144

CA $163 total

includes taxes & fees

Oct 15 - Oct 16

A living room with a blue wall, a fireplace, a sofa, and a chair.

A bar area with stools and a counter where a bartender is serving drinks.

A brick building with a sign reading "Mercantile & Hotel".

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

9. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

CA $149

CA $163 total

includes taxes & fees

Oct 8 - Oct 9

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

10. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

CA $129

CA $145 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a bed, a sofa, a desk, and a chair.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

11. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

CA $173

CA $198 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

12. Fort Davidson Hotel

Ironton

richard

CA $178

CA $194 total

includes taxes & fees

Oct 8 - Oct 9

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

13. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Mary

CA $142

CA $160 total

includes taxes & fees

Oct 12 - Oct 13

A spacious lobby with a reception desk, seating area, and large windows.

An indoor swimming pool with a clear view of the outside through large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

14. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

CA $134

CA $151 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

15. The Riverview

Cape Girardeau

Alyssa

CA $148

CA $167 total

includes taxes & fees

Nov 4 - Nov 5

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

16. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

CA $144

CA $162 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

17. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

CA $102

CA $115 total

includes taxes & fees

Oct 18 - Oct 19

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

18. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

CA $144

CA $162 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

19. Super 8 by Wyndham Perryville

Perryville

paulette

CA $98

CA $112 total

includes taxes & fees

Oct 26 - Oct 27

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.

20. Hampton Inn Farmington

Farmington

Charlie

CA $153

CA $175 total

includes taxes & fees

Oct 25 - Oct 26

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Vacation Rentals in Southeast Missouri

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A bedroom with a wooden bed, a bench, and a window.

A calm lake with a wooden dock and a forested island in the distance.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A spacious living area with a kitchen island, dining table, and a television.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A red house with a wooden deck, large sliding glass doors, and a chimney.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A living room with a sofa, coffee table, TV stand, and ceiling fan.

A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

A single-story house with a front porch, a small front yard, and a red roof.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"We love staying in this hotel when we are traveling through the area. The staff are great, the rooms are consistently clean and the beds are very comfortable. We enjoy the complementary wine that is served each evening as well. Breakfast is good too."

Hampton Inn Poplar Bluff

10/10 Excellent

"Clean rooms, efficient staff, lovely breakfast. I appreciated the hotel sending a text after I checked in; it made it very easy to get questions answered."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Wonderful. Very clean, spacious and lovely staff. Breakfast was delicious also."

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."

Hampton Inn Sikeston

10/10 Excellent

"Clean, safe, quiet and a very good breakfast."

Comfort Inn Festus - St Louis South

8/10 Good

"These stay was good. Breakfast was your average Hotel breakfast no complaints other than staff continually let the coffee run out every morning. Staff at front desk were conversing with what must have been someone they knew because of the colorful language they were using. Very unprofessional."

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The stay here gets better every time."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Great place"

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

CA $77

CA $88 total

Nov 1 - Nov 2

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $94

CA $107 total

Nov 1 - Nov 2

includes taxes & fees

7.2/10 Good! (1,000 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $102

CA $115 total

Oct 18 - Oct 19

includes taxes & fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

CA $101

CA $118 total

Nov 1 - Nov 2

includes taxes & fees

7.8/10 Good! (1,003 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

CA $112

CA $126 total

Oct 8 - Oct 9

includes taxes & fees

8/10 Very good! (1,000 reviews)

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

CA $129

CA $145 total

Oct 18 - Oct 19

includes taxes & fees

9.4/10 Exceptional! (972 reviews)

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

Book Hotels in Southeast Missouri on Expedia.com

Find hotels in Southeast Missouri, MO from CA $88

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Super 8 by Wyndham Farmington

3. Hampton Inn & Suites By Hilton Festus

4. Drury Inn & Suites Jackson MO

5. Madison Inn Lodge

6. Baymont Inn and Suites by Wyndham Farmington, MO

7. Crown Pointe Lodge, BW Signature Collection

8. Fairfield Inn & Suites by Marriott Sikeston

9. EC Reed's Mercantile and Hotel

10. Hampton Inn Poplar Bluff

11. Holiday Inn Express & Suites Farmington by IHG

12. Fort Davidson Hotel

13. Drury Plaza Hotel Cape Girardeau Conference Center

14. Drury Inn & Suites Poplar Bluff

15. The Riverview

16. Fairfield Inn & Suites by Marriott Poplar Bluff

17. Pear Tree Inn Cape Girardeau West

18. Fairfield Inn & Suites by Marriott Cape Girardeau

19. Super 8 by Wyndham Perryville

20. Hampton Inn Farmington

Vacation Rentals in Southeast Missouri

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

The Atrium - A Boutique Hotel

Urban Lofts

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Hampton Inn Poplar Bluff

Drury Plaza Hotel Cape Girardeau Conference Center

Days Inn and Suites by Wyndham Sikeston

Hampton Inn Sikeston

Comfort Inn Festus - St Louis South

Drury Inn & Suites Cape Girardeau

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Super 8 by Wyndham Sikeston/Miner Area

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star rating

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