Find hotels in Southeast Missouri, MO from CA $86
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Sep 13 - Sep 14Tomorrow
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Sep 18 - Sep 20In two weeks
Sep 25 - Sep 27Our top choices for Southeast Missouri hotels
1. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
CA $121
CA $133 total
includes taxes & fees
Sep 14 - Sep 15
2. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
William
CA $111
CA $117 total
includes taxes & fees
Sep 21 - Sep 22
3. Shepherd Mountain Inn
Shepherd Mountain InnIronton
Katie
CA $171
CA $187 total
includes taxes & fees
Sep 14 - Sep 15
4. Fort Davidson Hotel
Fort Davidson HotelIronton
richard
CA $173
CA $189 total
includes taxes & fees
Sep 15 - Sep 16
5. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
CA $139
CA $156 total
includes taxes & fees
Sep 20 - Sep 21
6. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Theresa
CA $130
CA $145 total
includes taxes & fees
Sep 20 - Sep 21
7. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
CA $140
CA $159 total
includes taxes & fees
Sep 20 - Sep 21
8. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
ILUNGA
CA $79
CA $86 total
includes taxes & fees
Sep 20 - Sep 21
9. Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
David
CA $135
CA $154 total
includes taxes & fees
Oct 4 - Oct 5
10. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Susan
CA $152
CA $166 total
includes taxes & fees
Sep 14 - Sep 15
11. Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
David
CA $83
CA $90 total
includes taxes & fees
Sep 20 - Sep 21
12. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Scott Andrew
CA $141
CA $163 total
includes taxes & fees
Sep 18 - Sep 19
13. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Arsenia
CA $140
CA $159 total
includes taxes & fees
Oct 4 - Oct 5
14. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
JANEEN
CA $105
CA $114 total
includes taxes & fees
Sep 20 - Sep 21
15. Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
Stephanie
CA $118
CA $133 total
includes taxes & fees
Oct 11 - Oct 12
16. The Riverview
The RiverviewCape Girardeau
Alyssa
CA $141
CA $159 total
includes taxes & fees
Sep 20 - Sep 21
17. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Andrew
CA $129
CA $139 total
includes taxes & fees
Sep 16 - Sep 17
18. Quality Inn Farmington
Quality Inn FarmingtonFarmington
Desiree
CA $81
CA $93 total
includes taxes & fees
Sep 20 - Sep 21
19. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
ELAINE
CA $140
CA $159 total
includes taxes & fees
Sep 20 - Sep 21
20. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
Carlos
CA $140
CA $158 total
includes taxes & fees
Sep 20 - Sep 21
Vacation Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Vacation Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Big Spring
9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Didn't notice bathroom venting."
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
"Clean"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope to go back!"
The Riverview
10/10 Excellent
"I can’t rave enough about this hotel. 5 ♥️s. It takes zero effort to be kind. The staff is kind and helpful. Highly recommend to anyone staying in Cape Girardeau, MO. This hotel rises above the chain hotels 🏨."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Motel 6 Poplar Bluff, MO
10/10 Excellent
"Nice"
Best Western Plus Sikeston I-55
8/10 Good
"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
CA $79
CA $86 total
Sep 20 - Sep 21
includes taxes & fees
8/10 Very good! (1,011 reviews)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
CA $92
CA $105 total
Sep 15 - Sep 16
includes taxes & fees
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
CA $100
CA $113 total
Sep 20 - Sep 21
includes taxes & fees
9.2/10 Wonderful! (1,005 reviews)
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
CA $105
CA $123 total
Oct 4 - Oct 5
includes taxes & fees
The Farmstead Hotel
778 E 3rd St Caruthersville MO
CA $119
CA $135 total
Sep 21 - Sep 22
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
CA $140
CA $159 total
Sep 20 - Sep 21
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
3 Star Hotels
68 properties
2 Star Hotels
90 properties
Explore a world of travel with Expedia
- Crown Pointe Lodge
- Cabin Rentals in Centerville
- The Queen Bee Farm Stay/Hot tub
- Park Hills Hotels
- Hotels near Big River
- Cabin Rentals in Allenville
- French Village Hotels
- Dexter Inn
- Poplar Bluff Hotels
- Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
- Bonne Terre Hotels
- Cabin Rentals in Farmington
- Holiday Inn Poplar Bluff by IHG
- Resorts in Wayne County
- Secluded Cabin with Heated Pool
- Amazing lakeview Spring Lake Tree House #2 "LoveLight" w/ hot tub
- Pickleball Cafe & Micro Hotel
- Urban Loft #4 BLACK · Urban Loft above BrewCo & Restaurant
- Motels in Ellsinore
- Fredericktown Hotels
- Morehouse Hotels
- Rv Parks in Perryville
- Advance Hotels
- Quality Inn Perryville I
- Lazy River Cabin on the edge of town only 1/2 mile from Current River !
- Doniphan Hotels
- Bluebird Meadows W/hot Tub and Pool Special
- Silo Farm Haus
- Dexter Hotels
- B&B in Ste Genevieve
- Bullwinkles Rustic Lodge
- Pet-Friendly Hotels in Jackson
- Postcard Cabins St Francois
- Villas in Poplar Bluff
- Cheap Hotels in Viburnum
- Cottages in Pocahontas
- Cabin Rentals in Bonne Terre
- Oyo Hickory House Inn
- Condo Rentals in Fremont
- Scott City Hotels
- Rv Parks in Chaffee
- Hilton Hotels in Perryville
- Relax in the country at Countryside Villas!
- Apartments in Ozora
- Secluded Private Cabin with Pool
- Home Sweet Home
- Van Buren Hotels
- Farmstay in Oak Ridge
- Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
- Cabin Rentals in Southeast Missouri
- Cottages in Clearwater
- Cabin Rentals in Cadet
- Houseboats in Wappapello
- Spring Lake Ranch has a Private
- Alpaca Farm Stay
- Jackson Hotels
- Super 8 by Wyndham Perryville
- Motels in St Mary
- Winona Hotels
- Hilton Hotels in Ste Genevieve
- Triangle Inn Motel
- Hampton Inn Poplar Bluff
- Cheap Hotels in Bonne Terre
- Cabin Rentals in Leadwood
- Town House Inn
- Ozora Hotels
- Essex Hotels
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