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Oct 11 - Oct 12
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Our top choices for Southeast Missouri hotels

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

1. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
CA $127
CA $146 total
includes taxes & fees
Oct 29 - Oct 30
Hampton Inn & Suites By Hilton Festus
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A building with a red awning labeled "Shepherd Mountain Inn."
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.
A hotel room with two beds, a lamp, and a painting on the wall.

2. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
CA $176
CA $192 total
includes taxes & fees
Oct 12 - Oct 13
Shepherd Mountain Inn
A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.
A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

3. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
CA $85
CA $97 total
includes taxes & fees
Oct 23 - Oct 24
Super 8 by Wyndham Farmington
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A gym with cardio equipment, a bench press, and a squat rack.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.
A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

4. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
stewart
CA $78
CA $89 total
includes taxes & fees
Nov 1 - Nov 2
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious lobby with a reception desk, seating area, and large windows.
A hotel room with a bed, a desk, a chair, a sofa, and a TV.
A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.
An indoor swimming pool with a clear view of the outside through large windows.

5. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Dean
CA $134
CA $151 total
includes taxes & fees
Oct 29 - Oct 30
Drury Inn & Suites Poplar Bluff
A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

6. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
CA $115
CA $126 total
includes taxes & fees
Nov 3 - Nov 4
Madison Inn Lodge
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A spacious hotel lobby with a dining area, kitchen, and large windows.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

7. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
CURTIS
CA $156
CA $179 total
includes taxes & fees
Oct 18 - Oct 19
Crown Pointe Lodge, BW Signature Collection
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Terrace/patio
Pool
Snack bar

8. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
CA $130
CA $145 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn Poplar Bluff
A living room with a blue wall, a fireplace, a sofa, and a chair.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A bar area with stools and a counter where a bartender is serving drinks.
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

9. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
Miranda
CA $150
CA $163 total
includes taxes & fees
Oct 12 - Oct 13
EC Reed's Mercantile and Hotel
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

10. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
CA $144
CA $164 total
includes taxes & fees
Oct 18 - Oct 19
Fairfield Inn & Suites by Marriott Sikeston
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A hotel room with two beds, a desk, a chair, and a view of the city.

11. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
CA $143
CA $162 total
includes taxes & fees
Oct 14 - Oct 15
The Riverview
A hotel room with two beds, a desk, a chair, a TV, and a lamp.
An outdoor pool area with lounge chairs and an umbrella.
A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.
A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

12. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
CA $171
CA $187 total
includes taxes & fees
Nov 10 - Nov 11
Fort Davidson Hotel
A hotel room with a bed, a sofa, a desk, and a chair.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

13. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
CA $168
CA $192 total
includes taxes & fees
Nov 1 - Nov 2
Holiday Inn Express & Suites Farmington by IHG
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.
An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.
A reception area with a wooden counter, a coffee machine, and a display of pastries.
A corner market with a refrigerated display case and a pantry area.

14. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Nancy
CA $138
CA $156 total
includes taxes & fees
Oct 18 - Oct 19
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A hotel room with two beds, a brick wall, and a wooden headboard.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

15. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Debra S
CA $114
CA $121 total
includes taxes & fees
Oct 18 - Oct 19
Drury Inn & Suites Jackson MO
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

16. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Curtis
CA $143
CA $161 total
includes taxes & fees
Nov 1 - Nov 2
Drury Plaza Hotel Cape Girardeau Conference Center
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.
A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

17. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
CA $80
CA $91 total
includes taxes & fees
Oct 21 - Oct 22
Super 8 By Wyndham Marston
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.
A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.
A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.
A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

18. Hampton Inn Farmington

Hampton Inn Farmington
Farmington
United States
Charlie
CA $141
CA $161 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn Farmington
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

19. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
CA $115
CA $125 total
includes taxes & fees
Nov 1 - Nov 2
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

20. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
CA $144
CA $163 total
includes taxes & fees
Oct 18 - Oct 19
Fairfield Inn & Suites by Marriott Cape Girardeau
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Vacation Rentals in Southeast Missouri

Cabin
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.
A view through a window with a stone wall and a wooden structure in the background.
A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.
A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cabin
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
Property amenity
A rustic cabin with a wooden exterior, a small deck, and a picnic table.
Private kitchen

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"The stay here gets better every time."
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Vacation Home
A wooden deck with two Adirondack chairs and a hammock.
A spacious living room with wooden floors, a stone fireplace, and a mounted television.
A spacious living room with a wooden ceiling, a fireplace, and a television.
A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Cottage
A dining area with a checkered tablecloth, wooden chairs, and a red rug.
A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.
A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.
An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Aparthotel
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A fireplace with a decorative mantel, a framed sign, and a small table with plants.
A building with a dark exterior, a large window, and a sign that reads "The Atrium."
A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Aparthotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.
A hallway with exposed brick walls, wooden flooring, and a white door.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cabin
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.
A wooden deck with a railing leading to a building with a metal roof and a brown door.
Front of property
A calm lake with a wooden dock and a forested island in the distance.

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Cottage
A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.
A single-story house with a front porch, a stone foundation, and a well-maintained lawn.
A covered porch with yellow chairs, a bench, and a small table.
A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Walk to Dtwn: Ironton Home in Historic District
Ironton
"Clean and comfortable "
Walk to Dtwn: Ironton Home in Historic District
Cottage
Interior
Interior
A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.
Interior

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage
A wooden deck with a hot tub, a small table, and a bench.
A rustic wooden interior with a dining table, chairs, a sofa, and a cowhide rug.
A rustic interior with a stone fireplace, wooden furniture, and a cozy seating area.
A rural property with a gravel driveway leading to a house with a porch, surrounded by lush greenery and trees.

Hot Tub & Creek Views: Secluded Perryville Cabin

Hot Tub & Creek Views: Secluded Perryville Cabin
Perryville
"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"
Hot Tub & Creek Views: Secluded Perryville Cabin
Cottage
A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.
A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.
A dining area with a glass table and chairs, wooden flooring, and large windows.
A red house with a wooden deck and stone steps leading to a porch.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
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A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

8/10 Good
"I only stayed here from midnight until 5:30. It was clean, however the bed was very thin and uncomfortable and the heat/ac didn't work correctly which happens sometimes. The thermostat said 75 and it was freezing. It was a good place to crash for a few hours."
Charles 1-night trip
Posted less than an hour ago
Motel 6 Poplar Bluff, MO
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"Nice clean large room, basic breakfest, plenty of parking"
Sherrie 1-night trip
Posted 7 hours ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Wonderful stay!"
Joanie 2-night trip
Posted 9 hours ago
Drury Inn & Suites Cape Girardeau
Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"The front desk staff were very kind and helpful. Everything was clean and there was a good breakfast!"
Tina 1-night trip
Posted 17 hours ago
Hampton Inn Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Room was clean and staff was very friendly"
Troy 1-night trip
Posted 2 days ago
Pear Tree Inn Cape Girardeau West
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"
Davonne 3-night trip
Posted 2 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."
Richard 1-night trip
Posted 2 days ago
Days Inn and Suites by Wyndham Sikeston
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent
"This place is absolutely gorgeous! We really enjoyed our stay. The silo farm haus was serene, clean and comfortable. Thank you for a wonderful stay!"
Kelsey B. 2-night trip
Posted 3 weeks ago
Silo Farm Haus- located in the heart of wine country!

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
CA $78
CA $89 total
Nov 1 - Nov 2
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
CA $95
CA $108 total
Nov 1 - Nov 2
includes taxes & fees
7.2/10 Good! (1,001 reviews)
Days Inn and Suites by Wyndham Sikeston
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
CA $101
CA $114 total
Oct 12 - Oct 13
includes taxes & fees
8/10 Very good! (1,002 reviews)
Motel 6 Poplar Bluff, MO
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
CA $103
CA $116 total
Oct 18 - Oct 19
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
CA $102
CA $119 total
Nov 1 - Nov 2
includes taxes & fees
Comfort Inn Festus - St Louis South
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
CA $130
CA $145 total
Oct 18 - Oct 19
includes taxes & fees
Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star rating

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