Book The Best Hotels in Southeast Missouri, MO for 2026 from CA $88 - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

1. Madison Inn Lodge

Fredericktown

Bawan

CA $123

CA $134 total

includes taxes & fees

Oct 1 - Oct 2

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

2. Shepherd Mountain Inn

Ironton

Michael

CA $173

CA $189 total

includes taxes & fees

Sep 24 - Sep 25

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

3. Fort Davidson Hotel

Ironton

richard

CA $175

CA $192 total

includes taxes & fees

Oct 1 - Oct 2

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

4. Drury Inn & Suites Jackson MO

Jackson

Thomas

CA $120

CA $126 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

5. Super 8 by Wyndham Farmington

Farmington

Marisa

CA $84

CA $91 total

includes taxes & fees

Oct 11 - Oct 12

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

6. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

CA $131

CA $147 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

7. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

CA $141

CA $159 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

8. Hampton Inn & Suites By Hilton Festus

Festus

Abram

CA $126

CA $144 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A swimming pool with a diving board, pool rules signs, and lounge chairs.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A modern dining area with high tables and chairs, a television screen, and a view of the outdoors through large windows.

9. Holiday Inn Express & Suites Perryville by IHG

Perryville

David

CA $142

CA $163 total

includes taxes & fees

Sep 27 - Sep 28

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

10. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

ILUNGA

CA $81

CA $88 total

includes taxes & fees

Oct 11 - Oct 12

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

11. Crown Pointe Lodge, BW Signature Collection

Farmington

Susan

CA $154

CA $167 total

includes taxes & fees

Oct 11 - Oct 12

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

12. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

CA $142

CA $161 total

includes taxes & fees

Oct 1 - Oct 2

A modern retail area with a display of local items and snacks.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

13. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

CA $126

CA $143 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

14. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

CA $132

CA $152 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

15. Super 8 by Wyndham Perryville

Perryville

paulette

CA $100

CA $115 total

includes taxes & fees

Oct 18 - Oct 19

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

16. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

CA $124

CA $134 total

includes taxes & fees

Sep 28 - Sep 29

A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

A view through a window with a stone wall and a wooden structure in the background.

A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

17. Sam A Baker State Park

Patterson

Charlie

CA $189

CA $201 total

includes taxes & fees

Oct 14 - Oct 15

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A hotel room with two beds, a desk, a chair, and a view of the city.

18. The Riverview

Cape Girardeau

Alyssa

CA $145

CA $163 total

includes taxes & fees

Sep 29 - Sep 30

A narrow corridor with a bar area on the right, featuring a counter and hanging lights.

A large boulder in a natural setting with autumn-colored trees in the background.

A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.

19. Black River Motel and Restaurant

Lesterville

Douglas

CA $163

CA $172 total

includes taxes & fees

Sep 24 - Sep 25

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

20. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

CA $142

CA $162 total

includes taxes & fees

Sep 27 - Sep 28

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Vacation Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A cabin surrounded by tall trees, accessible by a wooden bridge.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck, large sliding glass doors, and a chimney.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A river flowing through a forested area with a sandy beach.

Big Spring

9.8/10 (19 reviews)

Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Poplar Bluff

10/10 Excellent

"Clean room, staff"

Comfort Inn Festus - St Louis South

8/10 Good

"Our room was clean, the beds were comfortable. I liked the sink/mirror seperate from the toilet/shower. The breakfast was pretty typical for a complimentary breakfast. I was pleasantly surprised that they had real butter provided in the little refrigerator."

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Easy checkin, clean facilities, safe area. Quiet with a comfy bed."

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"Great stay, clean rooms, excellent breakfast! Will stay again if we are in the area."

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Great experience will definitely be doing it again"

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a very good value. It has been the best hotel I've stayed at in awhile."

Hampton Inn Poplar Bluff

10/10 Excellent

"It was a great experience."

Pear Tree Inn Cape Girardeau West

8/10 Good

"I was looking for something that was good quality and wouldn’t break my wallet. This place was what I was expecting. Lady working the breakfast was extremely polite and helpful."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Great customer service. Clean room and lobby. Breakfast could be better but had options. Pool clean and not freezing. Soap and shampoo options are lovely and very convenient."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

CA $81

CA $88 total

Oct 11 - Oct 12

includes taxes & fees

8/10 Very good! (1,001 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $93

CA $106 total

Oct 14 - Oct 15

includes taxes & fees

7.2/10 Good! (1,000 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $101

CA $114 total

Sep 27 - Sep 28

includes taxes & fees

9.2/10 Wonderful! (1,000 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

CA $108

CA $126 total

Oct 18 - Oct 19

includes taxes & fees

7.8/10 Good! (1,002 reviews)

The Farmstead Hotel

778 E 3rd St Caruthersville MO

CA $120

CA $137 total

Oct 6 - Oct 7

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

CA $142

CA $162 total

Sep 27 - Sep 28

includes taxes & fees

9.4/10 Exceptional! (1,001 reviews)

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

Book Hotels in Southeast Missouri on Expedia.com

Find hotels in Southeast Missouri, MO from CA $88

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Madison Inn Lodge

2. Shepherd Mountain Inn

3. Fort Davidson Hotel

4. Drury Inn & Suites Jackson MO

5. Super 8 by Wyndham Farmington

6. Hampton Inn Poplar Bluff

7. Drury Plaza Hotel Cape Girardeau Conference Center

8. Hampton Inn & Suites By Hilton Festus

9. Holiday Inn Express & Suites Perryville by IHG

10. Baymont Inn and Suites by Wyndham Farmington, MO

11. Crown Pointe Lodge, BW Signature Collection

12. Fairfield Inn & Suites by Marriott Cape Girardeau

13. Tru By Hilton Cape Girardeau

14. Drury Inn & Suites Sikeston, MO

15. Super 8 by Wyndham Perryville

16. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

17. Sam A Baker State Park

18. The Riverview

19. Black River Motel and Restaurant

20. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Vacation Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Lake Wappapello

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Urban Lofts

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Big Spring

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Poplar Bluff

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Drury Inn & Suites Hayti Caruthersville

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Days Inn and Suites by Wyndham Sikeston

Hampton Inn Poplar Bluff

Pear Tree Inn Cape Girardeau West

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

The Farmstead Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Southeast Missouri with star rating

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