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Hotels in Medical Center District, San Antonio from CA $80

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Tonight
May 14 - May 15
Tomorrow
May 15 - May 16
This weekend
May 17 - May 19
Next weekend
May 24 - May 26

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Medical Center District hotels and places to stay

Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free cabanas
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2750)
"Beautiful area, well cared for on the riverwalk. Saturday was very busy! We loved walking the riverwalk and seeing all the flowers and vegetation! Hotel was very nice and all employees very kind!"
The price is CA $238
CA $302 total
includes taxes & fees
May 26 - May 27
Hotel Contessa
Exterior
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2140)
"The Omni La Mansión Hotel at the Riverwalk in San Antonio was a perfect venue for my husband and I to spend our 50th wedding anniversary at! The location was perfect, the staff is incredibly knowledgeable of their jobs and they’re kind and courteous as well. It’s an older hotel which has been well maintained and updates have been made over the years. Our room was pretty, well equipped with amenities and very comfortable. We had a narrow balcony through our French doors which opened to the street...
The price is CA $257
CA $309 total
includes taxes & fees
May 28 - May 29
Omni La Mansion del Rio
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1066)
"Very friendly and helpful staff. Location close to Alamo and Riverwalk makes it the perfect weekend getaway "
The price is CA $259
CA $310 total
includes taxes & fees
May 26 - May 27
Grand Hyatt San Antonio River Walk
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Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.4 out of 10, Exceptional, (2602)
"We took a quick two day trip to San Antonio and truly enjoyed our stay at this hotel. The location is excellent - you can literally walk out onto the riverwalk from the basement. The staff at the front desk were always helpful and friendly, and the free daily happy hour was awesome! The only negative I would add is that the property feels a little dated, but for a 48 hour stay, it was perfect for our needs. I would definitely stay again!"
The price is CA $172
CA $204 total
includes taxes & fees
May 27 - May 28
Drury Plaza Hotel San Antonio Riverwalk
Pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very good, (1320)
"The property is a bit dated but good value for money overall. There is no daily cleaning service so you need to book this in advance. The staff are very friendly and helpful and the daily parking rate is pretty standard for downtown San Antonio"
The price is CA $142
CA $167 total
includes taxes & fees
Jun 2 - Jun 3
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Outdoor pool, sun loungers
Hampton Inn San Antonio-Downtown (River Walk)
2.5 star property
8.2 out of 10, Very good, (2640)
"Lots of people walking the area & homeless camps"
The price is CA $127
CA $150 total
includes taxes & fees
May 21 - May 22
Hampton Inn San Antonio-Downtown (River Walk)
Private pool
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1103)
"Great place! "
The price is CA $518
CA $669 total
includes taxes & fees
May 27 - May 28
La Cantera Resort & Spa
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2994)
"Everything was good, I don’t have any complaint "
The price is CA $130
CA $154 total
includes taxes & fees
May 15 - May 16
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Terrace/patio
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1264)
"Modern and clean hotel, view from the room was awesome and the staff were very helpful and accommodating. Late checkout was a bonus 😉"
The price is CA $261
CA $315 total
includes taxes & fees
May 28 - May 29
Canopy by Hilton San Antonio Riverwalk
Meeting facility
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
3.0 star property
8.4 out of 10, Very good, (1481)
"It was nice and clean beautiful view from window"
The price is CA $171
CA $202 total
includes taxes & fees
May 26 - May 27
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
Terrace/patio
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.4 out of 10, Very good, (226)
"We had a great experience with our room and the amazing bartender was so helpful!"
The price is CA $167
CA $197 total
includes taxes & fees
May 26 - May 27
AC Hotel by Marriott San Antonio Riverwalk
Exterior
Home2 Suites by Hilton San Antonio Downtown - Riverwalk, TX
3.0 star property
8.0 out of 10, Very good, (1001)
"Great stsy"
The price is CA $173
CA $205 total
includes taxes & fees
May 30 - May 31
Home2 Suites by Hilton San Antonio Downtown - Riverwalk, TX
3 outdoor pools, cabanas (surcharge), sun loungers
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1004)
"Great service; hotel is pretty; but a little inconvenience about repairing "
The price is CA $383
CA $520 total
includes taxes & fees
May 19 - May 20
Hyatt Regency Hill Country Resort & Spa
Exterior
O´Brien Historic Hotel
3.5 star property
7.8 out of 10, Good, (1006)
"Room was clean and cool. Convenient to venue All staff we dealt with were friendly, professional, and extremely helpful. "
The price is CA $167
CA $195 total
includes taxes & fees
May 21 - May 22
O´Brien Historic Hotel
Exterior
San Antonio Marriott Rivercenter on the River Walk
4.0 star property
8.8 out of 10, Excellent, (1002)
"Great Area!"
The price is CA $265
CA $350 total
includes taxes & fees
May 27 - May 28
San Antonio Marriott Rivercenter on the River Walk
Restaurant
Element San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (237)
"Simple design and very clean!"
The price is CA $156
CA $184 total
includes taxes & fees
May 21 - May 22
Element San Antonio Riverwalk
Exterior
Hampton Inn & Suites San Antonio Northwest/Medical Center
2.5 star property
8.0 out of 10, Very good, (1019)
"Everything was perfect"
The price is CA $121
CA $146 total
includes taxes & fees
May 21 - May 22
Hampton Inn & Suites San Antonio Northwest/Medical Center
Lobby
Aloft San Antonio UTSA Area
3.0 star property
8.8 out of 10, Excellent, (545)
"Very nice property "
The price is CA $115
CA $136 total
includes taxes & fees
May 26 - May 27
Aloft San Antonio UTSA Area
Suite, 2 Queen Beds
Comfort Inn and Suites Near Medical Center
2.5 star property
7.0 out of 10, Good, (483)
"It was overall a good experience, the room was a little humid even with the A/C on so hopefully the next visit will be a little better. "
The price is CA $80
CA $93 total
includes taxes & fees
May 19 - May 20
Comfort Inn and Suites Near Medical Center
Lobby
SpringHill Suites San Antonio Downtown/Riverwalk Area
3.0 star property
8.2 out of 10, Very good, (1003)
"Outstanding staff. Briefed us on what was going on in town, gave us tickets to an event. Were extremely friendly whenever we interacted with any of them. Great location. Nice breakfast"
The price is CA $138
CA $165 total
includes taxes & fees
May 30 - May 31
SpringHill Suites San Antonio Downtown/Riverwalk Area
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Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Fairfield Inn & Suites by Marriott San Antonio Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and free parking. Other favorite options in the area include Atria Inn & Suites and Courtyard by Marriott Medical Center San Antonio.

How many hotels will I be able to find in Medical Center District?

Expedia has 127 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.