Medical Center District Vacation Packages

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    Save up to CA $4,200 when you book a flight and hotel together*
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Top Holiday Package Deals in Medical Center District

Price found within the past 48 hours. Click for updated prices.
Hallmark Inn and Suites
Landing Apartments Near Southtown
Staybridge Suites San Antonio by IHG
Hotel Valencia Riverwalk
San Antonio Marriott Northwest Medical Center

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District

Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Jun 22 to Jun 23
CA $126
CA $149 total
Jun 22 - Jun 23
includes taxes & fees
8.4/10 Very Good! (3,445 reviews)
"We wouldn’t stay here again. The room was just okay :/ The shower had lukewarm water at best, showers were cold and uncomfortable. Breakfast was disgusting. The eggs tasted like the pan they had been cooked in. They were inedible and extremely greasy. The bedroom linens were very obviously stained. ..."

Reviewed on Jun 21, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $155 per night from Jul 5 to Jul 6
CA $155
CA $184 total
Jul 5 - Jul 6
includes taxes & fees
8.6/10 Excellent! (1,081 reviews)
"The hotel was great, booked the hotel for a family trip and my family loved the hotel. The lounge area is gorgeous. I would definitely recommend this hotel!"

Reviewed on Jun 18, 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $127 per night from Jul 7 to Jul 8
CA $127
CA $151 total
Jul 7 - Jul 8
includes taxes & fees
9.2/10 Wonderful! (1,345 reviews)
"Staff was friendly. I had read reviews about the elevator and not working before arrival so was aware. Thankfully we were only on the second floor so just took the stairs. The pool was so crowded both nights"

Reviewed on Jun 21, 2026

Drury Inn & Suites San Antonio Northwest Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Medical Center District vacation package cost?
Starting from just CA $690, a vacation package is your passport to low-priced travel. Create your own Medical Center District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Center District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Center District vacation package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your vacation your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Medical Center District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Center District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Center are two of the most well-known hotels in Medical Center District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Center District vacation?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Center District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Center District vacation.
What should I know before booking a Medical Center District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Center District Expedia vacation package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Center District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Center District vacation package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Center District vacation package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Discover the most popular places to visit in Medical Center District

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.