Medical Center District Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top Holiday Package Deals in Medical Center District

Price found within the past 48 hours. Click for updated prices.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
Medical Center District
Price was CA $1,828, price is now CA $1,461 per person
CA $1,461
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip non-stop flight included
Calgary (YYC) to San Antonio (SAT)
8.4/10 Very good! (3,725 reviews)
Great, clean property, nice environment and people

Reviewed on Nov 12, 2026

The St. Anthony, A Luxury Collection Hotel, San Antonio

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 out of 5
Downtown San Antonio
Price was CA $3,190, price is now CA $2,410 per person
CA $2,410
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip non-stop flight included
Calgary (YYC) to San Antonio (SAT)
8.8/10 Excellent! (1,003 reviews)

Sítio El Tropicano

Sítio El Tropicano

4.5 out of 5
Downtown San Antonio
Price was CA $2,642, price is now CA $2,102 per person
CA $2,102
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip non-stop flight included
Calgary (YYC) to San Antonio (SAT)
No reviews

Mokara Hotel & Spa San Antonio

Mokara Hotel & Spa San Antonio

4.5 out of 5
Downtown San Antonio
Price was CA $3,290, price is now CA $2,672 per person
CA $2,672
per person
Dec 26 - Jan 2
found 4 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to San Antonio (SAT)
9.6/10 Exceptional! (1,002 reviews)

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
Medical Center District
Price was CA $1,801, price is now CA $1,469 per person
CA $1,469
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip non-stop flight included
Calgary (YYC) to San Antonio (SAT)
8.6/10 Excellent! (1,179 reviews)

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

4 out of top 10 points of interest in this area

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio

Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Dec 3 to Dec 4
CA $126
CA $150 total
Dec 3 - Dec 4
includes taxes & fees
8.4/10 Very good! (3,781 reviews)
"Great, clean property, nice environment and people"

Reviewed on Nov 12, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $133 per night from Dec 13 to Dec 14
CA $133
CA $159 total
Dec 13 - Dec 14
includes taxes & fees
San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $128 per night from Nov 22 to Nov 23
CA $128
CA $153 total
Nov 22 - Nov 23
includes taxes & fees
Drury Inn & Suites San Antonio Northwest Medical Center
See all 4,928 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Medical Center District vacation package cost?
Starting from just CA $1,461, a vacation package is your passport to low-priced travel. Create your own Medical Center District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Center District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Center District vacation package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your vacation your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Medical Center District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Center District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Center are two of the most well-known hotels in Medical Center District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Center District vacation?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Center District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Center District vacation.
What should I know before booking a Medical Center District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Center District Expedia vacation package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Center District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Center District vacation package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Center District vacation package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Stay near popular Medical Center District attractions

Cinemark San Antonio 16

You can take time to visit Cinemark San Antonio 16 during your travels to San Antonio.
See properties

Things to do

Entrance to the Hard Rock Cafe in San Antonio

Dining at Hard Rock Cafe San Antonio

CA $56
per traveller
76% of travellers recommend
Dining at Hard Rock Cafe San Antonio
San Antonio: Fredericksburg Wineries Day Trip with Tastings

San Antonio: Fredericksburg Wineries Day Trip with Tastings

CA $253
per adult
100% of travellers recommend
San Antonio: Fredericksburg Wineries Day Trip with Tastings
The Buckhorn Saloon & Museum and Texas Ranger Museum Admission

The Buckhorn Saloon & Museum and Texas Ranger Museum Admission

CA $33
per adult
84% of travellers recommend
The Buckhorn Saloon & Museum and Texas Ranger Museum Admission
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.