Medical Center District Vacation Packages

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Top Holiday Package Deals in Medical Center District

Price found within the past 48 hours. Click for updated prices.
Hilton Palacio Del Rio

Hilton Palacio Del Rio

4 out of 5
Downtown San Antonio
Price was CA $1,542, price is now CA $1,251 per person
CA $1,251
per person
May 5 - May 10
found 21 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to San Antonio (SAT)
8.8/10 Excellent! (1,066 reviews)
Clean room, great staff, gave us bandaids, nice and easy, great smell.

Reviewed on Feb 22, 2026

Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
Far West Side
Price was CA $5,181, price is now CA $3,635 per person
CA $3,635
per person
Apr 5 - Apr 10
found 14 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to San Antonio (SAT)
8.8/10 Excellent! (1,001 reviews)
Felt like a vacation. It was perfect

Reviewed on Feb 11, 2026

Downtown San Antonio Apartments by Landing

Downtown San Antonio Apartments by Landing

4 out of 5
Downtown San Antonio
Price was CA $2,106, price is now CA $1,654 per person
CA $1,654
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to San Antonio (SAT)
No reviews
The St. Anthony, A Luxury Collection Hotel, San Antonio

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 out of 5
Downtown San Antonio
Price was CA $2,253, price is now CA $1,790 per person
CA $1,790
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to San Antonio (SAT)
8.8/10 Excellent! (1,000 reviews)
Lobby was absolutely beautiful!

Reviewed on Feb 23, 2026

Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 out of 5
Downtown San Antonio
Price was CA $1,853, price is now CA $1,506 per person
CA $1,506
per person
Apr 8 - Apr 13
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to San Antonio (SAT)
9.4/10 Exceptional! (601 reviews)
Room spotless and good

Reviewed on Feb 22, 2026

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Downtown - Riverwalk showing heritage architecture, boating and a river or creek

Downtown San Antonio

4 out of top 10 points of interest in this area
4/5(209 area reviews)

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio

Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $121 per night from Feb 24 to Feb 25
CA $121
CA $144 total
Feb 24 - Feb 25
includes taxes & fees
8.4/10 Very Good! (3,207 reviews)
Great room, delicious breakfast, front desk lady she was not in good mood and they never mentioned that one room allows just one vehicle so if you have an extra car you will have to pay $10 per night but overall good stay and yes I’ll will comeback.

Reviewed on Feb 23, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $138 per night from Feb 28 to Mar 1
CA $138
CA $164 total
Feb 28 - Mar 1
includes taxes & fees
8.6/10 Excellent! (1,019 reviews)
We couldn't get the AC to work correctly. We sweated throughout the night. Not good.

Reviewed on Feb 23, 2026

San Antonio Marriott Northwest Medical Center
Park Inn by Radisson

Park Inn by Radisson

2 out of 5
7500 Louis Pasteur Drive San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $87 per night from Mar 22 to Mar 23
CA $87
CA $102 total
Mar 22 - Mar 23
includes taxes & fees
7.2/10 Good! (1,003 reviews)
Good price. Good location. Not fancy

Reviewed on Feb 23, 2026

Park Inn by Radisson
See all 4,791 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Beach Vacations
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Family Vacations

Frequently asked questions

How much does a Medical Center District vacation package cost?
Starting from just CA $1,251, a vacation package is your passport to low-priced travel. Create your own Medical Center District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Center District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Center District vacation package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your vacation your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Medical Center District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Center District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Center are two of the most well-known hotels in Medical Center District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Center District vacation?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Center District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Center District vacation.
What should I know before booking a Medical Center District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Center District Expedia vacation package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Center District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Center District vacation package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Center District vacation package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Discover the most popular places to visit in Medical Center District

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.

USAA Corporate Office Headquarters

Things to do

San Antonio Zoo Any Day Ticket including ZooLights

San Antonio Zoo Any Day Ticket including ZooLights

CA $40
per adult
96% of travellers recommend
San Antonio Zoo Any Day Ticket including ZooLights
SEA LIFE San Antonio

SEA LIFE San Antonio

CA $34
per adult
78% of travellers recommend
SEA LIFE San Antonio
Entrance to the Hard Rock Cafe in San Antonio

Dining at Hard Rock Cafe San Antonio

CA $55
per traveller
74% of travellers recommend
Dining at Hard Rock Cafe San Antonio
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.