Title: Hotels by La Quinta Inn & Suites in Depew from CA $103 | Expedia.ca [Depew Travel Guide](https://expedia.ca/Depew.dx6338362)[Hotels in Depew](https://expedia.ca/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Flights to Depew](https://expedia.ca/Cheap-Flights-To-Depew.d6338362.Travel-Guide-Flights)[Things to do in Depew](https://expedia.ca/Things-To-Do-In-Depew.d6338362.Travel-Guide-Activities)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by La Quinta Inn & Suites in Depew from CA $103 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 20 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-20&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 21 - Dec 22](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-21&endDate=2025-12-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Depew La Quinta Inn & Suites ![Exterior](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/6499bfe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/06f2a4f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/43d786be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Buffalo Amherst [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) Buffalo 8.4/10 Very good (1966) "The hotel was great clean, accesable. quiet, close to UB" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bruce CA $108 CA $123 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/86fc2ca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/808282cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/38c1df33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/3f2fe391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Buffalo Airport [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-By-Wyndham-Buffalo-Airport.h27531.Hotel-Information) Buffalo 8.0/10 Very good (1354) "Close to airport. Has a free shuttle. Nice breakfast too" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Ajay CA $102 CA $116 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-By-Wyndham-Buffalo-Airport.h27531.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1820000/1818500/1818414/b908b841.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1820000/1818500/1818414/9308a223.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1820000/1818500/1818414/9a4a31e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/2000000/1820000/1818500/1818414/8b2a6da7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Lackawanna [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Lackawanna.h1818414.Hotel-Information) Buffalo 6.4/10 (1002) "Hotel and breakfast were very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth CA $110 CA $125 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Lackawanna.h1818414.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/13000000/12650000/12642000/12641974/ca4d4908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/13000000/12650000/12642000/12641974/53ab6b98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/13000000/12650000/12642000/12641974/0c697b56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12650000/12642000/12641974/f822a3c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Niagara Falls [](https://www.expedia.ca/Niagara-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Niagara-Falls.h12641974.Hotel-Information) La Salle 7.2/10 Good (1270) "Enjoyed our stay. Room was clean and lobby was well kept as well. Staff were helpful and friendly. Would definitely stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $90 CA $103 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Niagara-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Niagara-Falls.h12641974.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-03&endDate=2026-01-04®ionId=6338362&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels-La-Quinta-Inn-Suites.0-0-d6338362--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels-La-Quinta-Inn-Suites.0-0-d6338362--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) ## Top Depew Hotel Reviews ![M Hotel Buffalo](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593_y.jpg) ### M Hotel Buffalo 10/10 Excellent "Nicely located and the rooms are very spacious " [](https://expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![Garden Place Hotel](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg) ### Garden Place Hotel 10/10 Excellent "Good staff" [](https://expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 10/10 Excellent "." [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Hyatt Regency Buffalo / Hotel and Conference Center](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234_y.jpg) ### Hyatt Regency Buffalo / Hotel and Conference Center 10/10 Excellent "The bathroom could have used a deep clean, but beyond that everything was great. " [](https://expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Buffalo Amherst](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072_y.jpg) ### La Quinta Inn & Suites by Wyndham Buffalo Amherst 10/10 Excellent "The hotel and room were very clean, beds comfortable, and breakfast plentiful!" [](https://expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) ![The Richardson Hotel](https://images.trvl-media.com/lodging/19000000/18140000/18136300/18136290/16863301_y.jpg) ### The Richardson Hotel 10/10 Excellent "Stay at this property every year. Staff was excellent and the property is unique. Highly recommend. " [](https://expedia.ca/Buffalo-Hotels-Hotel-Henry-Urban-Resort.h18136290.Hotel-Information) ![Buffalo Airport Hotel](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d_y.jpg) ### Buffalo Airport Hotel 10/10 Excellent "The shuttle service was excellent, the staff was very attentive, and overall it was a very pleasant stay. Would definitely recommend for anyone needing to stay near the airport." [](https://expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ![Hilton Garden Inn Buffalo Airport](https://images.trvl-media.com/lodging/2000000/1350000/1348600/1348597/47d81773_y.jpg) ### Hilton Garden Inn Buffalo Airport 10/10 Excellent "Amazing stay! Staff are welcoming. Room was spotless. Great place to stay before flying out. The restaurant had the best wings and service! " [](https://expedia.ca/Buffalo-Hotels-Hilton-Garden-Inn-Buffalo-Airport.h1348597.Hotel-Information) ![Hampton Inn Buffalo - Amherst, NY](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f_y.jpg) ### Hampton Inn Buffalo - Amherst, NY 10/10 Excellent "Clean, well maintained, lovely breakfast, friendly staff. Recommended! 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