Best Western Hotels in Charleston
Missouri
United States of America
Hotels
Expedia.ca

Charleston Travel Guide Hotels in Charleston Flights to Charleston Car Rentals in Charleston Charleston Vacation Packages Vacation Rentals in Charleston

A sunset over a calm lake with tall trees reflected in the water.

Find Hotels by Best Western in Charleston from CA $79

Where to?

Dates

Travellers

Room 1

Adults

ChildrenAges 0 to 17

Need to book 9 or more rooms?

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Hotels recommended for families in Charleston

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

Drury Inn & Suites Sikeston, MO

3.0 star property

Sikeston

9.6 out of 10, Exceptional, (1,002)

9.6/10

Exceptional

(1,002)

The price is CA $133

CA $133

CA $153 total

includes taxes & fees

Nov 29 - Nov 30

Drury Inn & Suites Sikeston, MO

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property

Sikeston

8.4 out of 10, Very good, (831)

8.4/10

Very good

(831)

The price is CA $94

CA $94

CA $107 total

includes taxes & fees

Nov 24 - Nov 25

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

Days Inn and Suites by Wyndham Sikeston

2.0 star property

Sikeston

7.4 out of 10, Good, (1,000)

7.4/10

Good

(1,000)

The price is CA $94

CA $94

CA $107 total

includes taxes & fees

Nov 15 - Nov 16

Days Inn and Suites by Wyndham Sikeston

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

Best Western Plus Sikeston I-55

2.5 star property

Sikeston

8.4 out of 10, Very good, (1,009)

8.4/10

Very good

(1,009)

The price is CA $103

CA $103

CA $118 total

includes taxes & fees

Dec 7 - Dec 8

Best Western Plus Sikeston I-55

A buffet with various food items, including omelets and baked goods, served in metal containers.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property

Sikeston

8.8 out of 10, Excellent, (525)

8.8/10

Excellent

(525)

The price is CA $135

CA $135

CA $153 total

includes taxes & fees

Dec 13 - Dec 14

Holiday Inn Express & Suites Sikeston Southwest by IHG

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property

Sikeston

7.0 out of 10, Good, (696)

7.0/10

Good

(696)

The price is CA $82

CA $82

CA $94 total

includes taxes & fees

Nov 18 - Nov 19

Super 8 by Wyndham Sikeston/Miner Area

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

Hampton Inn Sikeston

2.5 star property

Sikeston

9.0 out of 10, Wonderful, (658)

9.0/10

Wonderful

(658)

The price is CA $144

CA $144

CA $164 total

includes taxes & fees

Nov 19 - Nov 20

Hampton Inn Sikeston

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A modern building with a flat roof and large windows.

Comfort Inn & Suites Sikeston I-55

2.5 star property

Sikeston

8.4 out of 10, Very good, (322)

8.4/10

Very good

(322)

The price is CA $119

CA $119

CA $136 total

includes taxes & fees

Nov 22 - Nov 23

Comfort Inn & Suites Sikeston I-55

Top Charleston Hotel Reviews

Drury Inn & Suites Sikeston, MO

Sikeston

10/10 Excellent

Manager’s reception is a hit!

Thomas R

Reviewed April 29, 2026Reviewed April 29, 2026

Drury Inn & Suites Sikeston, MO

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

10/10 Excellent

Absolutely excellent. Brand new hotel. Spotless. Staff were friendly and welcoming.

Tina

Reviewed July 26, 2025Reviewed July 26, 2025

Fairfield Inn & Suites by Marriott Sikeston

Best Western Plus Sikeston I-55

Sikeston

10/10 Excellent

Nice big room and was close to the freeway

BRIAN W

Reviewed June 7, 2024Reviewed June 7, 2024

Best Western Plus Sikeston I-55

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

10/10 Excellent

Friendly staff, clean room. Great food. Highly recommend this hotel.

Sareh

Reviewed August 9, 2026Reviewed August 9, 2026

Drury Plaza Hotel Cape Girardeau Conference Center

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

Pear Tree Inn Cape Girardeau West

Cape Girardeau

10/10 Excellent

Good location and reasonable prices

Raidas

Reviewed August 28, 2026Reviewed August 28, 2026

Pear Tree Inn Cape Girardeau West

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

10/10 Excellent

Good breakfast selection

Chevonne

Reviewed August 26, 2026Reviewed August 26, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A buffet with various food items, including omelets and other dishes, served in metal containers.

A hotel room with a bed, seating area, kitchenette, and a bathroom.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

10/10 Excellent

Good place, and good breakfast.

Patricio

Reviewed June 26, 2026Reviewed June 26, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Days Inn and Suites by Wyndham Sikeston

Sikeston

8/10 Good

Staff were great.

Ronald

Reviewed September 13, 2025Reviewed September 13, 2025

Days Inn and Suites by Wyndham Sikeston

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

A hotel room with a kitchenette, a bed, a desk, and a TV.

A hotel patio with a gazebo, outdoor seating, and a view of the road.

An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

10/10 Excellent

Clean and friendly

Brett

Reviewed June 2, 2025Reviewed June 2, 2025

Candlewood Suites Cape Girardeau by IHG

Explore a world of travel with Expedia

Lodging
Flights
Packages
Cars

“Brickyard”
Standard Link for “Brickyard”
Drury Plaza Hotel Cape Girardeau Conference Center
Standard Link for Drury Plaza Hotel Cape Girardeau Conference Center
Houseboats in Wappapello
Standard Link for Houseboats in Wappapello
Dexter Inn
Standard Link for Dexter Inn
Little Blue Cottage on Spanish
Standard Link for Little Blue Cottage on Spanish
New Orleans Inn Portageville
Standard Link for New Orleans Inn Portageville
Adults Only Resorts & in Cape Girardeau
Standard Link for Adults Only Resorts & in Cape Girardeau
Rv Parks in Chaffee
Standard Link for Rv Parks in Chaffee
Comfort Inn & Suites Sikeston I
Standard Link for Comfort Inn & Suites Sikeston I
Essex Hotels
Standard Link for Essex Hotels
The Weber Farm
Standard Link for The Weber Farm
Hampton Inn Cape Girardeau I 55 East
Standard Link for Hampton Inn Cape Girardeau I 55 East
Portageville Hotels
Standard Link for Portageville Hotels
Cheap Hotels in Parma
Standard Link for Cheap Hotels in Parma
Farmstay in Oak Ridge
Standard Link for Farmstay in Oak Ridge
Jackson Hotels
Standard Link for Jackson Hotels
Cottages in Pocahontas
Standard Link for Cottages in Pocahontas
Advance Hotels
Standard Link for Advance Hotels
Candlewood Suites Cape Girardeau by IHG
Standard Link for Candlewood Suites Cape Girardeau by IHG
Cabin Rentals in Brazeau Township
Standard Link for Cabin Rentals in Brazeau Township
Scott City Hotels
Standard Link for Scott City Hotels
Courtyard by Marriott Cape Girardeau Downtown
Standard Link for Courtyard by Marriott Cape Girardeau Downtown
Country Yard Inn and Suite
Standard Link for Country Yard Inn and Suite
Cabin Rentals in Allenville
Standard Link for Cabin Rentals in Allenville
Holiday Inn Express Hotel & Suites Cape Girardeau I
Standard Link for Holiday Inn Express Hotel & Suites Cape Girardeau I
Charleston Hotels
Standard Link for Charleston Hotels
Travel Inn & Suites
Standard Link for Travel Inn & Suites
Caruthersville Hotels
Standard Link for Caruthersville Hotels
Holiday Inn Express & Suites Sikeston Southwest by IHG
Standard Link for Holiday Inn Express & Suites Sikeston Southwest by IHG
Rv Parks in Haywood City
Standard Link for Rv Parks in Haywood City
Rv Parks in Cape Girardeau
Standard Link for Rv Parks in Cape Girardeau
Cheap Hotels in Benton
Standard Link for Cheap Hotels in Benton
Cheap Hotels in Cape Girardeau
Standard Link for Cheap Hotels in Cape Girardeau
Cheap Hotels in Portageville
Standard Link for Cheap Hotels in Portageville
Spa Hotels in Cape Girardeau
Standard Link for Spa Hotels in Cape Girardeau
Oyo Hickory House Inn
Standard Link for Oyo Hickory House Inn
Dexter Hotels
Standard Link for Dexter Hotels
Relax in the country at Countryside Villas!
Standard Link for Relax in the country at Countryside Villas!
Hotels with Free Airport Shuttle in Cape Girardeau
Standard Link for Hotels with Free Airport Shuttle in Cape Girardeau
New Madrid Hotels
Standard Link for New Madrid Hotels
Pet-Friendly Hotels in Jackson
Standard Link for Pet-Friendly Hotels in Jackson
Town House Inn
Standard Link for Town House Inn
Lodges in Campbell
Standard Link for Lodges in Campbell
Morehouse Hotels
Standard Link for Morehouse Hotels
Casino Hotels in Cape Girardeau
Standard Link for Casino Hotels in Cape Girardeau

Flights from Toronto (YTO) to Cape Girardeau (CGI)
Standard Link for Flights from Toronto (YTO) to Cape Girardeau (CGI)
Flights from New York (JFK) to Cape Girardeau (CGI)
Standard Link for Flights from New York (JFK) to Cape Girardeau (CGI)
Flights from Scott City
Standard Link for Flights from Scott City
Flights from Kelso
Standard Link for Flights from Kelso
Flights to Dexter
Standard Link for Flights to Dexter
Flights from Los Angeles (LAX) to Poplar Bluff (POF)
Standard Link for Flights from Los Angeles (LAX) to Poplar Bluff (POF)
Flights from St. Louis (STL) to Poplar Bluff (POF)
Standard Link for Flights from St. Louis (STL) to Poplar Bluff (POF)
Flights from Bloomington (BMI) to Cape Girardeau (CGI)
Standard Link for Flights from Bloomington (BMI) to Cape Girardeau (CGI)
Flights from Grand Island (GRI) to Cape Girardeau (CGI)
Standard Link for Flights from Grand Island (GRI) to Cape Girardeau (CGI)
Flights from Edmonton (YEG) to Cape Girardeau (CGI)
Standard Link for Flights from Edmonton (YEG) to Cape Girardeau (CGI)
Flights from Chaffee
Standard Link for Flights from Chaffee
Flights from Vancouver (YVR) to Cape Girardeau (CGI)
Standard Link for Flights from Vancouver (YVR) to Cape Girardeau (CGI)
Flights from Detroit (DTW) to Sikeston (SIK)
Standard Link for Flights from Detroit (DTW) to Sikeston (SIK)
Flights from Montreal (YUL) to Cape Girardeau (CGI)
Standard Link for Flights from Montreal (YUL) to Cape Girardeau (CGI)
Flights to Sikeston
Standard Link for Flights to Sikeston
Flights from Toronto (YYZ) to Cape Girardeau (CGI)
Standard Link for Flights from Toronto (YYZ) to Cape Girardeau (CGI)
Flights from Colombo (CMB) to Cape Girardeau (CGI)
Standard Link for Flights from Colombo (CMB) to Cape Girardeau (CGI)
Flights from Eugene (EUG) to Cape Girardeau (CGI)
Standard Link for Flights from Eugene (EUG) to Cape Girardeau (CGI)
Flights from Stuart (SUA) to Cape Girardeau (CGI)
Standard Link for Flights from Stuart (SUA) to Cape Girardeau (CGI)
Flights from Calgary (YYC) to Cape Girardeau (CGI)
Standard Link for Flights from Calgary (YYC) to Cape Girardeau (CGI)
Flights from Ocala (OCF) to Cape Girardeau (CGI)
Standard Link for Flights from Ocala (OCF) to Cape Girardeau (CGI)
Flights to Cape Girardeau
Standard Link for Flights to Cape Girardeau
Flights to Caruthersville
Standard Link for Flights to Caruthersville

Wappapello Vacations
Standard Link for Wappapello Vacations
Visit Cape Girardeau
Standard Link for Visit Cape Girardeau

Car rental Cape Girardeau
Standard Link for Car rental Cape Girardeau
National Car Rental Rental Cars in Sikeston
Standard Link for National Car Rental Rental Cars in Sikeston
Hertz Rental Cars in Marble Hill
Standard Link for Hertz Rental Cars in Marble Hill
Cicar Rental Cars in Morley
Standard Link for Cicar Rental Cars in Morley

Find Hotels by Best Western in Charleston from CA $79

Change your mind

Treat yourself

Be picky

Check prices for these dates

Hotels recommended for families in Charleston

Drury Inn & Suites Sikeston, MO

Top Charleston Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

Explore a world of travel with Expedia