Florida Keys Spa Vacations
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Flight and Spa hotel deals in Florida Keys
Price found within the past 48 hours. Click for updated prices.
Cheeca Lodge & Spa
Matecumbe
Price was CA $4,957, price is now CA $3,117 per person
CA $3,117
per person
Jan 10 - Jan 16
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTT) to Miami (MIA)
9.2/10 Wonderful! (1,492 reviews)
Perfect halfway stop off for trip to The Keys .
Staff exceptionally helpful.. particularly ‘Fran’ I think that was her name on Front Desk.
Great pools and loved the bikes !
Rooms were spacious and comfy beds.
Recommend Lorelei Restaurant for something to eat off site ..!
Great stay, definitely recommend.
Reviewed on Nov 8, 2026
Islander Resort
Matecumbe
Price was CA $2,918, price is now CA $2,198 per person
CA $2,198
per person
Jan 10 - Jan 16
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTT) to Miami (MIA)
9.4/10 Exceptional! (1,147 reviews)
We absolutely loved our stay at Islander! It was such a peaceful, relaxing resort, and we’re so glad we chose it for our honeymoon. The staff was incredibly helpful and welcoming, and the shuttle service was a wonderful perk for getting to and from nearby restaurants. We also really enjoyed the resort’s amenities, especially kayaking, fishing, and bike riding. Everything from check-in to check-out was easy and seamless, making our stay that much more enjoyable. We would definitely stay at Islander again and highly recommend it to anyone looking for a relaxing getaway!
Reviewed on Nov 5, 2026
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View all trips5* Spa holidays in Florida Keys
Price found within the past 48 hours. Click for updated prices.
Cheeca Lodge & Spa
Matecumbe
Price was CA $4,957, price is now CA $3,117 per person
CA $3,117
per person
Jan 10 - Jan 16
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTT) to Miami (MIA)
9.2/10 Wonderful! (1,492 reviews)
Perfect halfway stop off for trip to The Keys .
Staff exceptionally helpful.. particularly ‘Fran’ I think that was her name on Front Desk.
Great pools and loved the bikes !
Rooms were spacious and comfy beds.
Recommend Lorelei Restaurant for something to eat off site ..!
Great stay, definitely recommend.
Reviewed on Nov 8, 2026
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See all available trips from Columbus to Florida Keys
View all trips3 Night Spa holidays in Florida Keys
Price found within the past 48 hours. Click for updated prices.
Cheeca Lodge & Spa
Matecumbe
Price was CA $1,677, price is now CA $1,303 per person
CA $1,303
per person
Dec 20 - Dec 23
found 1 day ago
Roundtrip flight included
Detroit (DTT) to Miami (MIA)
9.2/10 Wonderful! (1,492 reviews)
Perfect halfway stop off for trip to The Keys .
Staff exceptionally helpful.. particularly ‘Fran’ I think that was her name on Front Desk.
Great pools and loved the bikes !
Rooms were spacious and comfy beds.
Recommend Lorelei Restaurant for something to eat off site ..!
Great stay, definitely recommend.
Reviewed on Nov 8, 2026
Don't see what you're looking for?
See all available trips from Columbus to Florida Keys
View all trips4 Night Spa holidays in Florida Keys
Price found within the past 48 hours. Click for updated prices.
Cheeca Lodge & Spa
Matecumbe
Price was CA $5,330, price is now CA $4,034 per person
CA $4,034
per person
Dec 30 - Jan 3
found 5 hours ago
Roundtrip flight included
Detroit (DTT) to Miami (MIA)
9.2/10 Wonderful! (1,492 reviews)
Perfect halfway stop off for trip to The Keys .
Staff exceptionally helpful.. particularly ‘Fran’ I think that was her name on Front Desk.
Great pools and loved the bikes !
Rooms were spacious and comfy beds.
Recommend Lorelei Restaurant for something to eat off site ..!
Great stay, definitely recommend.
Reviewed on Nov 8, 2026
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See all available trips from Columbus to Florida Keys
View all tripsSpa Hotels in Florida Keys
Margaritaville Beach House Key West
2001 South Roosevelt Blvd Key West FL
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
Havana Cabana at Key West
3420 N. Roosevelt Blvd Key West FL
Book a stay at this business-friendly hotel in Key West. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the helpful ...
Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street Key West FL
Book a stay at this beach resort in Key West. Enjoy 2 outdoor pools, a full-service spa, and a private beach. Popular attractions Duval Street and South Beach ...
8.4/10 Very good! (1,011 reviews)
"Most amazing experience."
Reviewed on Nov 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
CA $63
per adult
94% of travellers recommend
Historic Key West Old Town Trolley Hop-On Hop-Off Tour
CA $79
per adult
88% of travellers recommend
Champagne and Sunsets: A Key West Catamaran Adventure
CA $83
per adult
94% of travellers recommend
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
