Title: Top Hotels in Mississippi County | Expedia.ca

[Vacation Rentals in Mississippi County](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Vacation-Rental-Destinations)[Mississippi County Car Rentals](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Car-Rental-Destinations)[Mississippi County Vacations](https://expedia.ca/Mississippi-County.d553248635976432410.Destination-Travel-Guides)

![MAY 17 2019, HERMANN MISSOURI USA - The Hermann Bridge was a cantilevered truss bridge over the Missouri River at Hermann, Missouri between Gasconade and Montgomery County](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Top Cities in Mississippi County

![Cypress Trees on the Horizon.  A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.  ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Charleston

[](https://expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### East Prairie

[](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)

## Check prices for these dates

Tonight

[Mar 8 - Mar 9](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-03-08&endDate=2026-03-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 9 - Mar 10](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-03-09&endDate=2026-03-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Mississippi County hotels

![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

Charleston

6.8/10

(625 reviews)

"Affordable for a quick one night stay. Restaurant and gas station next to hotel."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Annette

CA $84

CA $94 total

includes taxes & fees

Mar 10 - Mar 11

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/08c2ace2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/7fdae22d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverstone Hotel Charleston-Sikeston

[](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

Charleston

6.8/10

(408 reviews)

"The staff was very friendly and accommodating "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Arturo

CA $95

CA $105 total

includes taxes & fees

Mar 10 - Mar 11

[](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/352edf3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/8720ff7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eagle Inn Charleston

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

Charleston

6.6/10

(105 reviews)

"Convenient "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marcelle

CA $87

CA $96 total

includes taxes & fees

Mar 10 - Mar 11

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/96f1c1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Cairo

6.6/10

(282 reviews)

"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6\. I was not satisfied at all."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

ReShena

CA $93

CA $103 total

includes taxes & fees

Mar 27 - Mar 28

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Mississippi County Hotel Reviews

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston I-55

10/10 Excellent

"All Ol"

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Overall our stay was great with the exception of the room smelling like a dog had been living there. The order was in the carpet and the bed covers. "

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"This hotel is awesome the breakfast and supper meals are awesome everything with this hotel is awesome "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg)

### Sleep Inn at Discovery Park of America

8/10 Good

"Nice clean rooms, pool and a good breakfast. Cant ask for anything more. We would definitely stay here again!"

[](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Very clean but sometimes noisy from outside traffic"

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"Fantastic room and super friendly staff. Hotel was way better than I expected. It was comfortable and clean with a great shower! "

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Hampton Inn Union City](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f7d6d20c_y.jpg)

### Hampton Inn Union City

10/10 Excellent

"It was a clean property with a normal breakfast that I expect from Hampton Inn (which is overall pleasant). I had no problems and the kids enjoyed the pool. I was pleasantly surprised with the gym equipment for a hotel."

[](https://expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Nice room"

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Quality Inn Union City US 51](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/c1609da5_y.jpg)

### Quality Inn Union City US 51

8/10 Good

"All was pretty good except for the breakfast."

[](https://expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

## Explore a world of travel with Expedia

- Explore a world of travel with Expedia

### Top cities in Mississippi County

- [Charleston Hotels ](https://expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels)
- [East Prairie Hotels ](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)
- [Bertrand Hotels ](https://expedia.ca/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels)
- [Wilson City Hotels ](https://expedia.ca/Wilson-City-Hotels.d553248634983391595.Travel-Guide-Hotels)
- [Anniston Hotels ](https://expedia.ca/Anniston-Hotels.d553248634983588922.Travel-Guide-Hotels)

### Hotels near popular Attractions

- [Hotels near Shawnee National Forest ](https://expedia.ca/Shawnee-National-Forest-Hotels.0-l553248635944113522-0.Travel-Guide-Filter-Hotels)
- [Hotels near Mississippi River ](https://expedia.ca/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels)
- [Hotels near Reelfoot Lake ](https://expedia.ca/Reelfoot-Lake-Hotels.0-l553248635976195913-0.Travel-Guide-Filter-Hotels)
- [Hotels near Ohio River ](https://expedia.ca/Ohio-River-Hotels.0-l681940626945888256-0.Travel-Guide-Filter-Hotels)
- [Hotels near Ohio River Valley ](https://expedia.ca/Ohio-River-Valley-Hotels.0-l6233674-0.Travel-Guide-Filter-Hotels)
- [Hotels near Discovery Park of America ](https://expedia.ca/Discovery-Park-Of-America-Hotels.0-l553248621561866880-0.Travel-Guide-Filter-Hotels)
- [Hotels near Reelfoot Lake State Park ](https://expedia.ca/Reelfoot-Lake-State-Park-Hotels.0-l553248621532655205-0.Travel-Guide-Filter-Hotels)
- [Hotels near Central Park ](https://expedia.ca/Central-Park-Hotels.0-l6305608-0.Travel-Guide-Filter-Hotels)
- [Hotels near Marston Community Center ](https://expedia.ca/Marston-Community-Center-Hotels.0-l553248622945532712-0.Travel-Guide-Filter-Hotels)
- [Hotels near Sikeston Depot Museum ](https://expedia.ca/Sikeston-Depot-Museum-Hotels.0-l6305602-0.Travel-Guide-Filter-Hotels)

### More Accommodation Types in Mississippi County

- [Vacation Homes in Mississippi County ](https://expedia.ca/Mississippi-County-Private-Vacation-Homes.d553248635976432410-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Lodges in Mississippi County ](https://expedia.ca/Mississippi-County-Lodges.d553248635976432410-aaLodges.Travel-Guide-Accommodation)
- [Cabin Rentals in Mississippi County ](https://expedia.ca/Mississippi-County-Cabins.d553248635976432410-aaCabins.Travel-Guide-Accommodation)
- [Motels in Mississippi County ](https://expedia.ca/Mississippi-County-Motels.d553248635976432410-aaMotels.Travel-Guide-Accommodation)
- [Cottages in Mississippi County ](https://expedia.ca/Mississippi-County-Cottages.d553248635976432410-aaCottages.Travel-Guide-Accommodation)
- [Apartments in Mississippi County ](https://expedia.ca/Mississippi-County-Apartments.d553248635976432410-aaApartments.Travel-Guide-Accommodation)
- [RV Parks in Mississippi County ](https://expedia.ca/Mississippi-County-RV-Parks.d553248635976432410-aaRVParks.Travel-Guide-Accommodation)
- [Condo Rentals in Mississippi County ](https://expedia.ca/Mississippi-County-Condos.d553248635976432410-aaCondos.Travel-Guide-Accommodation)

### Explore more hotels

- [Super 8 by Wyndham Charleston/Sikeston East MO ](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)
- [The Riverstone Hotel Charleston-Sikeston ](https://expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)
- [Drury Inn & Suites Sikeston, MO ](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)
- [Hampton Inn Sikeston ](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)
- [Best Western Plus Sikeston I-55 ](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)
- [Sleep Inn at Discovery Park of America ](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)
- [Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) ](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)
- [Great location just across the street from Reelfoot Lake close to boat ramps ](https://expedia.ca/Hornbeak-Hotels-Great-Location-Just-Across-The-Street-From-Reelfoot-Lake-Close-To-Boat-Ramps.h89872735.Hotel-Information)
- [Days Inn and Suites by Wyndham Sikeston ](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)
- [Country Yard Inn and Suite ](https://expedia.ca/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information)

[See a list of all hotels in Mississippi County](https://expedia.ca/All-Mississippi-County-Hotels.d553248635976432410.Travel-Guide-City-All-Hotels)

### More ways to book

- [Book Hotels in Mississippi County on Expedia.com ](https://www.expedia.com/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)

### Expedia's Latest Trends

Hotels

- [Luxury Hotels in Oakville](https://expedia.ca/Oakville-Hotels-Luxury-Hotel.0-0-d553248634983528485-tLuxuryHotel.Travel-Guide-Filter-Hotels)
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- [Hotels with Bar in Southeast Springfield](https://expedia.ca/Southeast-Springfield-Springfield-Hotels-Hotels-With-Bar.0-n553248635976480658-0-tHotelswithBar.Travel-Guide-Filter-Hotels)
- [Downtown St. Louis hotels](https://expedia.ca/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels)
- [Pet-friendly Hotels in St. Louis County](https://expedia.ca/Destinations-In-St-Louis-County-Pet-Friendly-Hotel.0-0-d553248635083900521-tPetfriendlyHotel.Hotel-Filter-Destinations)
- [Hotels with a Pool in Wentzville](https://expedia.ca/Wentzville-Hotels-Hotel-With-Pool.0-0-d7679-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Grandview](https://expedia.ca/Grandview-Hotels-Cheap-Hotels.0-0-d55734-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Texas County hotel](https://expedia.ca/Destinations-In-Texas-County.d553248635976433684.Hotel-Destinations)
- [Marriott Hotels & Resorts Hotels in Oakville](https://expedia.ca/Oakville-Hotels-Marriott-Hotels-Resorts.0-0-d553248634983528485--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels)
- [Hotels near Women's and Children's Hospital](https://expedia.ca/Womens-And-Childrens-Hospital-Hotels.0-l553248635974865886-0.Travel-Guide-Filter-Hotels)
- [Hotels near Powell Gardens](https://expedia.ca/Powell-Gardens-Hotels.0-l553248621532648297-0.Travel-Guide-Filter-Hotels)
- [Southeast Springfield hotels](https://expedia.ca/Southeast-Springfield-Springfield-Hotels.0-n553248635976480658-0.Travel-Guide-Filter-Hotels)
- [Power and Light District hotels](https://expedia.ca/Power-And-Light-District-Kansas-City-Hotels.0-n6162504-0.Travel-Guide-Filter-Hotels)
- [Downtown Kansas City hotels](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels)

Flights

- [Cheap Flights from Adair County](https://expedia.ca/lp/flights/553248635976433873/flights-from-adair-county)

Cars

- [Car rental St. Louis Airport (STL)](https://expedia.ca/Car-Rentals-In-Lambert-St-Louis-Intl.d5002323.Car-Rental-Guide)
- [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide)

Activities

- [Things to do in Maryland Heights](https://expedia.ca/Things-To-Do-In-Maryland-Heights.d7347.Travel-Guide-Activities)

Packages

- [St. Louis Zoo](https://expedia.ca/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction)
- [Missouri Botanical Gardens and Arboretum](https://expedia.ca/Missouri-Botanical-Gardens-And-Arboretum-St-Louis.d507258.Vacation-Attraction)
- [Starlight Theatre](https://expedia.ca/Starlight-Theatre-South-Kansas-City.d6069373.Vacation-Attraction)
- [St. Louis Art Museum](https://expedia.ca/St-Louis-Art-Museum-St-Louis.d502859.Vacation-Attraction)
- [Kansas City Zoo](https://expedia.ca/Kansas-City-Zoo-South-Kansas-City.d501349.Vacation-Attraction)

General

- [Visit Dutchtown](https://expedia.ca/St-Louis-Dutchtown.dx896162373499555840)
- [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136)
- [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828)
- [Visit Parkville](https://expedia.ca/Parkville.dx9973)
- [Visit River Market](https://expedia.ca/Kansas-City-River-Market.dx6192918)

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