Title: Mississippi County Vacations & Trips 2026 from CA $934 | Expedia.ca [Mississippi County Hotels](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)[Vacation Rentals in Mississippi County](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Vacation-Rental-Destinations)[Mississippi County Car Rentals](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Mississippi County Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Mississippi County Vacation Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? [Charleston](https://www.expedia.ca/Charleston.d7182.Destination-Travel-Guides) is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia. ## Top Mississippi County Vacation Deals Price found within the past 48 hours. Click for updated prices. ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Motel 6 Poplar Bluff, MO CA $934 per person Jun 23 - Jun 27 found 1 day ago Roundtrip non-stop flight included St. John's (YYT) to Cape Girardeau (CGI) 8/10 Very Good! (1,000 reviews) Overall stay was convenient. Reviewed on Mar 27, 2026 ## Mississippi County Hotel Deals ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Super 8 by Wyndham Charleston/Sikeston East MO 310 S Story St Charleston MO Fully refundableReserve now, pay when you stay CA $88 CA $97 total Apr 12 - Apr 13 includes taxes & fees 6.8/10 (628 reviews) Room was renovated and clean but the outside wasn’t updated. My children were scared to sleep there. Unfortunately no cable and when I asked to have it looked at nobody came. I just needed somewhere rest and it worked for that. But it wasn’t matching to the online photos. And a 100 dollar deposit ... Reviewed on Apr 2, 2026 [](https://expedia.ca/Hotel-Search?startDate=12%2F04%2F2026&endDate=13%2F04%2F2026&selected=988758&PinnedHotelID=988758&HadPinnedHotel=true®ionId=553248635976432410) ![The Riverstone Hotel Charleston-Sikeston](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverstone Hotel Charleston-Sikeston 102 Drake St Charleston MO Fully refundableReserve now, pay when you stay CA $111 CA $123 total May 2 - May 3 includes taxes & fees [](https://expedia.ca/Hotel-Search?startDate=02%2F05%2F2026&endDate=03%2F05%2F2026&selected=20594&PinnedHotelID=20594&HadPinnedHotel=true®ionId=553248635976432410) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay CA $131 CA $150 total Apr 9 - Apr 10 includes taxes & fees 9.6/10 Exceptional! (1,006 reviews) We decided we will stay here next year on our trip home from Texas. Reviewed on Apr 3, 2026 [](https://expedia.ca/Hotel-Search?startDate=09%2F04%2F2026&endDate=10%2F04%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=553248635976432410) [See all 107 properties in Mississippi County](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=04%2F04%2F2026&endDate=05%2F04%2F2026®ionId=553248635976432410) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Frequently asked questions ### How much does a Mississippi County vacation package cost? ### How do I get a cheap travel package to Mississippi County? ### What are the top hotels in Mississippi County? ### How far in advance should I book my Mississippi County vacation? ### What does an Expedia Mississippi County travel package include? ### What should I know before booking a Mississippi County travel package? ### Can I choose my airline with a Mississippi County Expedia vacation package? ### If I'm not able to travel, can I cancel my Mississippi County vacation package? \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app