Title: Mississippi County Vacations & Trips 2026 | Expedia.ca [Mississippi County Hotels](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)[Vacation Rentals in Mississippi County](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Vacation-Rental-Destinations)[Mississippi County Car Rentals](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Mississippi County Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Mississippi County Vacation Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? [Charleston](https://www.expedia.ca/Charleston.d7182.Destination-Travel-Guides) is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=PKG_SPRING_PROMO_553248635976432410) ## Mississippi County Hotel Deals ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Super 8 by Wyndham Charleston/Sikeston East MO 310 S Story St Charleston MO Fully refundableReserve now, pay when you stay CA $85 CA $94 total Feb 14 - Feb 15 includes taxes & fees 6.6/10 (621 reviews) Affordable for a quick one night stay. Restaurant and gas station next to hotel. Reviewed on Jan 20, 2026 [](https://expedia.ca/Hotel-Search?startDate=14%2F02%2F2026&endDate=15%2F02%2F2026&selected=988758&PinnedHotelID=988758&HadPinnedHotel=true®ionId=553248635976432410) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay CA $128 CA $147 total Feb 18 - Feb 19 includes taxes & fees 9.4/10 Exceptional! (1,001 reviews) Great Reviewed on Feb 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=18%2F02%2F2026&endDate=19%2F02%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=553248635976432410) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay CA $129 CA $147 total Feb 28 - Mar 1 includes taxes & fees 8.8/10 Excellent! (476 reviews) The desk clerk was very welcoming. The hotel was clean and our room was nice. Good breakfast selection. Would definitely stay here again if in the area. Reviewed on Feb 7, 2026 [](https://expedia.ca/Hotel-Search?startDate=28%2F02%2F2026&endDate=01%2F03%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=553248635976432410) [See all 102 properties in Mississippi County](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=14%2F02%2F2026&endDate=15%2F02%2F2026®ionId=553248635976432410) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Frequently asked questions ### How much does a Mississippi County vacation package cost? ### How do I get a cheap travel package to Mississippi County? ### What are the top hotels in Mississippi County? ### How far in advance should I book my Mississippi County vacation? ### What does an Expedia Mississippi County travel package include? ### What should I know before booking a Mississippi County travel package? ### Can I choose my airline with a Mississippi County Expedia vacation package? ### If I'm not able to travel, can I cancel my Mississippi County vacation package? \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app