Title: Mississippi County Vacation Packages & Trips 2025 | Expedia.ca [Mississippi County Hotels](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)[Vacation Rentals in Mississippi County](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Vacation-Rental-Destinations)[Mississippi County Car Rentals](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Car-Rental-Destinations) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Mississippi County Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Mississippi County Vacation Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? [Charleston](https://www.expedia.ca/Charleston.d7182.Destination-Travel-Guides) is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia. ## Mississippi County Hotel Deals ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Super 8 by Wyndham Charleston/Sikeston East MO 310 S Story St, Charleston, MO Fully refundableReserve now, pay when you stay CA $78 CA $86 total Nov 11 - Nov 12 includes taxes & fees 6.6/10 (601 reviews) Great experience Reviewed on Oct 28, 2025 [](https://expedia.ca/Hotel-Search?startDate=11%2F11%2F2025&endDate=12%2F11%2F2025&selected=988758&PinnedHotelID=988758&HadPinnedHotel=true®ionId=553248635976432410) ![Quality Inn Charleston - Sikeston](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Quality Inn Charleston - Sikeston 102 Drake St, I-57 Exit 10, Charleston, MO Fully refundableReserve now, pay when you stay CA $92 CA $102 total Nov 16 - Nov 17 includes taxes & fees 6.8/10 (406 reviews) Ladydi The only issue was the temperature display on the ac/heating unit went to E5 during the night and it was overly warm. I woke up because of this and was able to get the fan only running but it was still uncomfortable for me and I spent 5 hours tossing and turning with little sleep after that with ... Reviewed on Oct 22, 2025 [](https://expedia.ca/Hotel-Search?startDate=16%2F11%2F2025&endDate=17%2F11%2F2025&selected=20594&PinnedHotelID=20594&HadPinnedHotel=true®ionId=553248635976432410) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner, Sikeston, MO Fully refundableReserve now, pay when you stay CA $132 CA $152 total Nov 18 - Nov 19 includes taxes & fees 9.4/10 Exceptional! (1,002 reviews) Clean room, great location and friendly staff Reviewed on Nov 3, 2025 [](https://expedia.ca/Hotel-Search?startDate=18%2F11%2F2025&endDate=19%2F11%2F2025&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=553248635976432410) [See all 94 properties in Mississippi County](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=553248635976432410) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Frequently asked questions ### How much does a Mississippi County vacation package cost? > The most affordable Mississippi County package is , so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your traveling style. ### How do I get a cheap travel package to Mississippi County? > You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County vacation package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination. ### What are the top hotels in Mississippi County? > East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up [Super 8 by Wyndham Charleston MO](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) and [Quality Inn Charleston I-57](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information). ### How far in advance should I book my Mississippi County vacation? > Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure. ### What does an Expedia Mississippi County travel package include? > That depends on what you're looking for. If you're traveling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package. ### What should I know before booking a Mississippi County travel package? > You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organizing a luxury romantic escape or a budget solo adventure, explore our vacation packages today. ### Can I choose my airline with a Mississippi County Expedia vacation package? > Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organizing your Mississippi County adventure. ### If I'm not able to travel, can I cancel my Mississippi County vacation package? > Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County vacation package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our [Customer Service Portal](https://www.expedia.ca/service/?langid=4105) for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees. ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)