Scenic view of Fountain Lakes Park, in St. Charles, MO with colorful Autumn foliage and a cloudy sky reflected in a lake

St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres

St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres
Saint Charles
8.8 out of 10, Excellent, (3 reviews)
"We loved the location for our travel needs and we had everything we needed for a family of two adults and two dogs. "
United States
Leslie R.
The price is CA $308
CA $787 total
includes taxes & fees
Jun 16 - Jun 17
St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, Exceptional, (78 reviews)
"Great location and beautiful place. Had a wonderful time. "
United States
Ernest R.
The price is CA $154
CA $333 total
includes taxes & fees
Jun 14 - Jun 15
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres

St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres
Saint Charles
10.0 out of 10, Exceptional, (6 reviews)
"The home was very clean and had what we needed for our stay. The host was easy to communicate with and we had no issues. We would definitely stay again! "
United States
Mary L.
The price is CA $292
CA $1,052 total
includes taxes & fees
Jun 21 - Jun 22
St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres

Charming open 4bd and screen-in porch! Sleeps 10!

Charming open 4bd and screen-in porch! Sleeps 10!
Saint Charles
9.2 out of 10, Wonderful, (43 reviews)
"Everything about the property was great. Very roomy and felt like home. "
United States
Dan R.
The price is CA $275
CA $717 total
includes taxes & fees
Jun 16 - Jun 17
Charming open 4bd and screen-in porch! Sleeps 10!

Walk to St. Charles Entertainment

Walk to St. Charles Entertainment
Saint Charles
9.0 out of 10, Wonderful, (10 reviews)
"We really enjoyed our stay. The house was clean, spacious, and very accommodating. We stayed for a dance competition and the proximity to the convention center was unbeatable. "
United States
Chloe
The price is CA $173
CA $454 total
includes taxes & fees
Jun 14 - Jun 15
Walk to St. Charles Entertainment

Historic 1908 Frenchtown Home

Historic 1908 Frenchtown Home
St. Charles Historic District
8.6 out of 10, Excellent, (21 reviews)
"Very clean, older 2-bedroom home. Close to all the Main Street action. House had all the amenities we needed."
United States
Michele S.
The price is CA $226
CA $514 total
includes taxes & fees
Jun 28 - Jun 29
Historic 1908 Frenchtown Home

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (34 reviews)
"From the welcome email with clear concise directions on how to enter with door codes to a dwelling that had everything I needed with a very comfortable bed, it was a great stay and I wanted for nothing."
United States
Jacob G.
The price is CA $151
CA $326 total
includes taxes & fees
Jun 15 - Jun 16
Stay on Main Historic Studio

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (2 reviews)
"Excellent"
United States
Scott N.
The price is CA $138
CA $401 total
includes taxes & fees
Jun 21 - Jun 22
6th street 101 - Walk to Main St

Cottage on Historic Main Street- Low Cleaning fee

Cottage on Historic Main Street- Low Cleaning fee
St. Charles Historic District
10.0 out of 10, Exceptional, (19 reviews)
"A very quiet, clean and relaxing stay. "
United States
Dora S.
The price is CA $166
CA $412 total
includes taxes & fees
Jun 15 - Jun 16
Cottage on Historic Main Street- Low Cleaning fee

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (61 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
The price is CA $194
CA $391 total
includes taxes & fees
Jun 14 - Jun 15
Amazing Renovated Historic Loft on Main Street

Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (8 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
The price is CA $163
CA $414 total
includes taxes & fees
Jun 30 - Jul 1
Cottage on Main st- Low Cleaning Fee

Historic 5th Street House - Fully Rehabbed # 2

Historic 5th Street House - Fully Rehabbed # 2
St. Charles Historic District
8.6 out of 10, Excellent, (14 reviews)
"Wonderful place to stay would definitely recommend "
United States
Steven S.
The price is CA $138
CA $357 total
includes taxes & fees
Jun 16 - Jun 17
Historic 5th Street House - Fully Rehabbed # 2

The Driftwood Den | Boho-Inspired 2-Bedroom

The Driftwood Den | Boho-Inspired 2-Bedroom
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
The price is CA $189
CA $465 total
includes taxes & fees
Jun 16 - Jun 17
The Driftwood Den | Boho-Inspired 2-Bedroom

Spacious 2 Bedroom Townhome

Spacious 2 Bedroom Townhome
Saint Charles
8.0 out of 10, Very good, (16 reviews)
"This property was perfect for our needs. We enjoyed our stay and thank you for a seamless transaction! Much appreciated!"
United States
Elizabeth
The price is CA $166
CA $444 total
includes taxes & fees
Jun 14 - Jun 15
Spacious 2 Bedroom Townhome

The Original Custom House!

The Original Custom House!
St. Charles Historic District
9.6 out of 10, Exceptional, (38 reviews)
"The location is excellent. "
United States
McRay H.
The price is CA $226
CA $559 total
includes taxes & fees
Jun 14 - Jun 15
The Original Custom House!

2 Bdr Upstairs Apt Walking Distance to Main St

2 Bdr Upstairs Apt Walking Distance to Main St
Saint Charles
7.6 out of 10, Good, (4 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
The price is CA $189
CA $456 total
includes taxes & fees
Jun 16 - Jun 17
2 Bdr Upstairs Apt Walking Distance to Main St

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (175 reviews)
"Great place to stay. Our go to when visiting St.Charles or STL"
United States
jeramy p.
The price is CA $175
CA $368 total
includes taxes & fees
Jun 16 - Jun 17
The Lofts of North Main Street

Dog-Friendly Townhome Near Streets of Saint Charles

Dog-Friendly Townhome Near Streets of Saint Charles
Saint Charles
9.0 out of 10, Wonderful, (9 reviews)
"Very comfortable bed and pillows. Coffee was there when we woke up- everything provided."
United States
Barbara T.
The price is CA $189
CA $474 total
includes taxes & fees
Jun 16 - Jun 17
Dog-Friendly Townhome Near Streets of Saint Charles

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
10.0 out of 10, Exceptional, (5 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
The price is CA $173
CA $381 total
includes taxes & fees
Jun 15 - Jun 16
Duplex Hideaway in St. Charles, MO

St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (155 reviews)
"Clean house, everything worked, great location "
United States
Michael P.
The price is CA $178
CA $388 total
includes taxes & fees
Jul 5 - Jul 6
St. Charles 1860's Gem - Sleeps 6!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Find out more about St. Charles

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with St. Charles. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟: This St. Charles vacation home rental offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Some other top choices in St. Charles are The St. Charles Guest House, lovely historic home, fun for families and groups and St. Charles 1860's Gem - Sleeps 6!.

How many vacation rentals are there in St. Charles?

Expedia has 84 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.