A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

1. St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (163 reviews)
"Very nice very clean property. Very much enjoyed our stay"
United States
Joe R.
The price is CA $177
CA $381 total
includes taxes & fees
Sep 27 - Sep 28
St. Charles 1860's Gem - Sleeps 6!

2. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (37 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
The price is CA $114
CA $277 total
includes taxes & fees
Sep 13 - Sep 14
Historic Main Street Studio | Dog-Friendly

3. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (116 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveller
The price is CA $173
CA $364 total
includes taxes & fees
Sep 13 - Sep 14
Prime Loft of Main Street

4. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
The price is CA $173
CA $364 total
includes taxes & fees
Sep 16 - Sep 17
Amazing Renovated Historic Loft on Main Street

5. 6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Excellent"
United States
Scott N.
The price is CA $137
CA $398 total
includes taxes & fees
Sep 13 - Sep 14
6th street 101 - Walk to Main St

6. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (189 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
The price is CA $173
CA $364 total
includes taxes & fees
Sep 14 - Sep 15
The Lofts of North Main Street

7. Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, Exceptional, (86 reviews)
"Quaint and quiet, with easy access to downtown St Charles."
United States
Jeffrey E.
The price is CA $180
CA $364 total
includes taxes & fees
Sep 13 - Sep 14
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

8. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
The price is CA $187
CA $501 total
includes taxes & fees
Sep 13 - Sep 14
Historic Main St. Customs House Upstairs Apartment

9. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, Exceptional, (42 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
The price is CA $152
CA $526 total
includes taxes & fees
Sep 13 - Sep 14
Historic Main St 2BR | Steps to Shops

10. 5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
St. Charles Historic District
8.8 out of 10, Excellent, (16 reviews)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
The price is CA $137
CA $351 total
includes taxes & fees
Sep 13 - Sep 14
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

11. Dog-Friendly 2BR | Walk to Main Street

Dog-Friendly 2BR | Walk to Main Street
Saint Charles
8.0 out of 10, Very good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
The price is CA $157
CA $413 total
includes taxes & fees
Sep 15 - Sep 16
Dog-Friendly 2BR | Walk to Main Street

12. Historic 1908 Frenchtown Home

Historic 1908 Frenchtown Home
St. Charles Historic District
8.8 out of 10, Excellent, (26 reviews)
"Great property in historic neighborhood. Listing was accurate. Neighbors were friendly and helpful. I stayed there by myself and felt very safe and comfortable in the neighborhood. I had a last-minute change in travel plans and needed to add on a night. The host was very responsive and accommodating to my request. Will definitely stay here again!"
United States
Kim V.
The price is CA $187
CA $459 total
includes taxes & fees
Sep 20 - Sep 21
Historic 1908 Frenchtown Home

13. Near Streets of St Charles | 2 King Beds

Near Streets of St Charles | 2 King Beds
Saint Charles
9.0 out of 10, Wonderful, (12 reviews)
"We really enjoyed our stay. The house was clean, spacious, and very accommodating. We stayed for a dance competition and the proximity to the convention center was unbeatable. "
United States
Chloe
The price is CA $157
CA $432 total
includes taxes & fees
Sep 13 - Sep 14
Near Streets of St Charles | 2 King Beds

14. The Global Getaway | World-Inspired 2-Bedroom Stay

The Global Getaway | World-Inspired 2-Bedroom Stay
St. Charles Historic District
10.0 out of 10, Exceptional, (1 review)
"Perfect location to Main Street.Hosts were easy to communicate with.No issues with the unit"
United States
Tony M.
The price is CA $191
CA $463 total
includes taxes & fees
Sep 13 - Sep 14
The Global Getaway | World-Inspired 2-Bedroom Stay

15. Pet-Friendly Duplex | Historic Main

Pet-Friendly Duplex | Historic Main
St. Charles Historic District
10.0 out of 10, Exceptional, (25 reviews)
"Great location"
United States
todd p.
The price is CA $187
CA $400 total
includes taxes & fees
Sep 13 - Sep 14
Pet-Friendly Duplex | Historic Main

16. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
10.0 out of 10, Exceptional, (11 reviews)
"Very close to downtown St. Charles and the Kati Trail. The home is cute and bed is comfortable. Easy check in process and fenced in back yard was nice to have."
United States
Jessica S.
The price is CA $176
CA $387 total
includes taxes & fees
Sep 21 - Sep 22
Walk to Main | Pet-Friendly Yard & Workspace

17. Historic Main St 1BR | Walk to Dining & Nightlife

Historic Main St 1BR | Walk to Dining & Nightlife
St. Charles Historic District
9.2 out of 10, Wonderful, (24 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
The price is CA $187
CA $374 total
includes taxes & fees
Sep 13 - Sep 14
Historic Main St 1BR | Walk to Dining & Nightlife

18. Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (10 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
The price is CA $177
CA $424 total
includes taxes & fees
Sep 27 - Sep 28
Cottage on Main st- Low Cleaning Fee

19. Cottage on Historic Main Street- Low Cleaning fee

Cottage on Historic Main Street- Low Cleaning fee
St. Charles Historic District
10.0 out of 10, Exceptional, (23 reviews)
"Great location to Main Street. "
United States
Daneen H.
The price is CA $194
CA $444 total
includes taxes & fees
Oct 1 - Oct 2
Cottage on Historic Main Street- Low Cleaning fee

20. HotTub-2br2b-near Historic Main Street

HotTub-2br2b-near Historic Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (21 reviews)
"Comfy beds, great location!"
United States
Jessie W.
The price is CA $199
CA $413 total
includes taxes & fees
Sep 21 - Sep 22
HotTub-2br2b-near Historic Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Find out more about St. Charles

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with St. Charles. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This St. Charles vacation home rental is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Some other top choices in St. Charles are St. Charles 1860's Gem - Sleeps 6! and Honky Tonk Hideaway | 2BR Near Historic Main St.

How many vacation rentals are there in St. Charles?

Expedia has 92 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.