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Our top choices for Defiance hotels

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,002 reviews)
"Very clean place with great food and friendly staff. "
Canada
Kara
The price is CA $160
CA $187 total
includes taxes & fees
Apr 4 - Apr 5
Drury Inn & Suites Southwest St. Louis

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,174 reviews)
"Everything was great for overnight stay. "
United States
Regina
The price is CA $124
CA $143 total
includes taxes & fees
Apr 5 - Apr 6
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,003 reviews)
"The front desk stuff were nice and welcoming. The room was clean and the breakfast was great. "
United States
Dan
The price is CA $111
CA $127 total
includes taxes & fees
Apr 13 - Apr 14
Baymont by Wyndham Warrenton

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (890 reviews)
"It was a wonderful stay for my girls and her birthday. She had a blast and the room was Lovely 😍🌹"
United States
Amanda
The price is CA $143
CA $169 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express St. Louis West - O'Fallon by IHG

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (67 reviews)
"Staff was very friendly "
United States
Jessica
The price is CA $124
CA $146 total
includes taxes & fees
Apr 1 - Apr 2
WoodSpring Suites St Peters-OFallon

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (679 reviews)
"Property very clean staff was super helpful with questions. Would recommend this place! Breakfast was great!"
United States
Melissa
The price is CA $166
CA $190 total
includes taxes & fees
Apr 13 - Apr 14
Hampton Inn St. Louis Wentzville

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,009 reviews)
"Comfortable stay"
United States
Rebecca
The price is CA $105
CA $123 total
includes taxes & fees
Apr 15 - Apr 16
Sleep Inn & Suites O'Fallon MO - Technology Drive

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.8 out of 10, Exceptional, (1,116 reviews)
"It’s a great place very happy!"
United States
Chris
The price is CA $181
CA $209 total
includes taxes & fees
Apr 4 - Apr 5
Drury Plaza Hotel St. Louis Chesterfield

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,004 reviews)
"Everything was great as always at this location as i have stayed here many times"
United States
Gregory
The price is CA $147
CA $169 total
includes taxes & fees
Apr 12 - Apr 13
Hampton Inn St. Charles St. Peters

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (957 reviews)
"Comfy beds, but the trim, doors, and other finishings look pretty rough and in need of replacement. Simple enough breakfast and was just there for a night to sleep so it did the job."
United States
Laura
The price is CA $122
CA $137 total
includes taxes & fees
Apr 13 - Apr 14
Quality Inn Foristell

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,005 reviews)
"Great stay! Very clean and staff was very nice. Definitely will be staying there on my return visit to the area!"
United States
Roxanne
The price is CA $153
CA $176 total
includes taxes & fees
Apr 5 - Apr 6
Drury Inn & Suites St. Louis St. Peters

Super 8 by Wyndham Union

Super 8 by Wyndham Union
2.0 star property
Union
8.2 out of 10, Very good, (641 reviews)
"Pet friendly "
United States
Theresa
The price is CA $114
CA $126 total
includes taxes & fees
Apr 6 - Apr 7
Super 8 by Wyndham Union

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
Wentzville
9.4 out of 10, Exceptional, (51 reviews)
"Clean room and the suite was nice. "
United States
Elizabeth
The price is CA $210
CA $247 total
includes taxes & fees
Apr 3 - Apr 4
TownePlace Suites by Marriott Wentzville

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (398 reviews)
"Kelly & the other staff were wonderful. You breakfast options are great!"
United States
Cynthia
The price is CA $154
CA $186 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express & Suites St Peters by IHG

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,179 reviews)
"Great location, comfy and clean rooms "
United States
Nestor
The price is CA $118
CA $136 total
includes taxes & fees
Apr 5 - Apr 6
Wingate by Wyndham St. Louis/Fenton Route 66

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (244 reviews)
"The lady at the front desk was amazing!"
United States
Thomas
The price is CA $150
CA $173 total
includes taxes & fees
Apr 5 - Apr 6
Best Western Plus Fenton

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,006 reviews)
"Over all our stay was good. The room was a good size, we are thankful there was an ironing board and iron in the room. Good options at breakfast and the staff we encountered we are very pleasant. "
United States
Elizabeth
The price is CA $129
CA $148 total
includes taxes & fees
Apr 26 - Apr 27
Comfort Suites St Charles - St Louis

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,007 reviews)
"Clean rooms, friendly staff, great breakfast and kickback dinner."
United States
Amy
The price is CA $200
CA $232 total
includes taxes & fees
Apr 4 - Apr 5
Drury Plaza Hotel St. Louis St. Charles

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,639 reviews)
"Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. "
United States
Jessica
The price is CA $113
CA $131 total
includes taxes & fees
Apr 6 - Apr 7
The Wildwood Hotel

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (368 reviews)
"Excellent staff & very clean room"
United States
Karen
The price is CA $138
CA $157 total
includes taxes & fees
Apr 5 - Apr 6
Quality Inn Near Six Flags St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What is the best area to stay in Defiance?
The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.

This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.

For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.

Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.
When is the best time to go to Defiance?
The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.

Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.

Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.
How can I save on a Defiance hotel booking with Expedia?
Members always get our best prices. Find our best Defiance hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from CA $100 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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