A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Find hotels in Defiance, MO from CA $111

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 30 - Oct 1
Tomorrow
Oct 1 - Oct 2
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.
A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.
A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.
An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
O'Fallon
United States
Tim
CA $112
CA $132 total
includes taxes & fees
Oct 29 - Oct 30
Sleep Inn & Suites O'Fallon MO - Technology Drive
A multi-story hotel with a central entrance featuring a covered patio area.
A hotel with a swimming pool, outdoor seating, and a covered patio area.
A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.
A hotel room with a desk, chair, sofa, and a window with curtains.

2. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
O'Fallon
United States
Norman
CA $157
CA $186 total
includes taxes & fees
Oct 5 - Oct 6
Staybridge Suites O'Fallon Chesterfield by IHG
A hotel room with two beds, a desk with a chair, a television, and a window with curtains.
A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.
A modern hotel room with a desk, chair, and a large mirror.
A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
O'Fallon
United States
Greg
CA $126
CA $149 total
includes taxes & fees
Oct 15 - Oct 16
Holiday Inn Express St. Louis West - O'Fallon by IHG
An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.
A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.
A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.
A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

4. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
Chesterfield
United States
Bobbi jo
CA $181
CA $213 total
includes taxes & fees
Oct 8 - Oct 9
TownePlace Suites by Marriott St. Louis Chesterfield
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.
A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.
A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.
A modern bathroom with a large mirror, white vanity, and a bathtub.

5. The Wildwood Hotel

The Wildwood Hotel
Wildwood
United States
Ramona
CA $129
CA $150 total
includes taxes & fees
Oct 21 - Oct 22
The Wildwood Hotel
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.
A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.
A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".
A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

6. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
O'Fallon
United States
Gerald
CA $186
CA $219 total
includes taxes & fees
Oct 18 - Oct 19
Residence Inn by Marriott O'Fallon
A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.
A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.
A hotel room with two beds, a desk, a mirror, and a wardrobe.
An indoor swimming pool with a blue interior, surrounded by white chairs and tables, and a blue ceiling.

7. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
Chesterfield
United States
Donna
CA $116
CA $140 total
includes taxes & fees
Oct 26 - Oct 27
Comfort Inn & Suites Chesterfield - St. Louis
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.
A hotel with a covered entrance, multiple flags, and a well-maintained lawn.
A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.
A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
O'Fallon
United States
Kassie
CA $153
CA $182 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Garden Inn St. Louis/O'Fallon MO
Two people in a swimming pool with colorful inflatable rings.
A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.
A spacious lobby with a stone fireplace, a chandelier, and a staircase.
A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

9. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
Eureka
United States
Rob
CA $167
CA $195 total
includes taxes & fees
Oct 20 - Oct 21
Holiday Inn St. Louis West Six Flags by IHG
An outdoor patio area with wicker furniture and a central fire feature.
A hotel room with a bed, a sofa, a desk, and a chair.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.
A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

10. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
Chesterfield
United States
Kelly
CA $171
CA $199 total
includes taxes & fees
Oct 11 - Oct 12
Courtyard by Marriott St. Louis Chesterfield
A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.
A modern dining area with a long table, multiple chairs, and pendant lighting.
A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.
A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

11. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
Chesterfield
United States
Vijay
CA $188
CA $219 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites St. Louis/Chesterfield
A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.
A hotel room with a large bed, two sofas, a desk, and a TV.
A hotel room with a dining area, a fireplace, and a view of the outdoors.
An outdoor patio with a beige sofa set, two armchairs, and a table.

12. Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
Washington
United States
Michael Macumber
CA $183
CA $208 total
includes taxes & fees
Oct 5 - Oct 6
Best Western Plus Washington Hotel
A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.
A coffee station with two coffee machines and a display of coffee pods and cups.
A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.
A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Chesterfield
United States
Steven
CA $162
CA $188 total
includes taxes & fees
Oct 28 - Oct 29
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.
A hotel room with a bathroom, a bed, a nightstand, and a window.
A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.
A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.

14. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
Pacific
United States
Rachel
CA $138
CA $158 total
includes taxes & fees
Oct 28 - Oct 29
Quality Inn Near Six Flags St. Louis
A modern kitchen with a bar area, wooden cabinets, and pendant lighting.
A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.
A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.
A modern hotel entrance with a glass canopy, large windows, and a brick facade.

15. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
Chesterfield
United States
Chelsea
CA $184
CA $213 total
includes taxes & fees
Oct 8 - Oct 9
Hyatt Place St. Louis/Chesterfield
A spacious lobby with a central round table, two sofas, and a chandelier.
A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.
A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.
A buffet setup with various food items and a decorative vase of flowers.

16. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
Chesterfield
United States
Cassandra
CA $184
CA $214 total
includes taxes & fees
Oct 25 - Oct 26
Drury Plaza Hotel St. Louis Chesterfield
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.
A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.
A hotel room with two beds, a desk with a TV, a chair, and a lamp.
A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

17. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
Pacific
United States
Karen
CA $140
CA $160 total
includes taxes & fees
Oct 26 - Oct 27
Comfort Inn Near Six Flags St. Louis
A Super 8 hotel with a flat facade, multiple windows, and a parking lot.
A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.
A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.
A bathroom with a shower, a small white stool, and a towel rack.

18. Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
Eureka
United Kingdom
Claire
CA $95
CA $111 total
includes taxes & fees
Oct 18 - Oct 19
Super 8 by Wyndham Eureka/Six Flags Nearby
A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.
An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.
A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.
An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

19. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
St. Peters
United States
Ashley
CA $159
CA $183 total
includes taxes & fees
Oct 25 - Oct 26
Drury Inn & Suites St. Louis St. Peters
An outdoor patio with a built-in grill, seating area, and stone walls.
An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.
A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.
A multi-story hotel with a parking lot in front.

20. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
Chesterfield
United States
Chelsea
CA $268
CA $313 total
includes taxes & fees
Oct 15 - Oct 16
Residence Inn by Marriott St. Louis Chesterfield
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
See properties
A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)
Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Sugar Creek Winery

8.0/10 (1 review)
You can enjoy a tasting or tour at Sugar Creek Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
See properties

Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)
You can spend time exploring the galleries in Historic Daniel Boone Home and Heritage Center in Defiance. Stroll along the area's lakeside or simply enjoy its wineries.
See properties

Broemmelsiek Park

Broemmelsiek Park is just one of the places to see in Defiance, so why not enjoy the other things to explore during your travels? Amble around this family-friendly area's gardens or experience its festivals.
See properties

Yellow Farmhouse Winery

You can enjoy a tasting or tour at Yellow Farmhouse Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
See properties

Matson Hill Park Trailhead

You can take time to visit Matson Hill Park Trailhead during your travels to Defiance. While you're in the area, wander around the parks.
See properties

Hamburg Trail Trailhead

You can take time to visit Hamburg Trail Trailhead during your travels to Hamburg.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield

10/10 Excellent
"The hotel was very nice, modern, clean, comfortable. Hot breakfast was scrambled eggs, turkey bacon and pancake strips. Thanks!"
Michael 1-night trip
Posted 10 hours ago
Hyatt Place St. Louis/Chesterfield
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

10/10 Excellent
"Beds are very comfortable."
Jamie 2-night trip
Posted 14 hours ago
Drury Inn & Suites Southwest St. Louis
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

8/10 Good
"nice size free parking spots in the garage. Breakfast was slim. one morning just had sausage and eggs and waffles. next morning had biscuits and gravy and waffles. hotel was clean staffing was friendly. location was good. The cookies were delicious."
Scott 2-night trip
Posted 1 day ago
Country Inn & Suites by Radisson, St. Charles Historic District
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"Very nice hotel. Staff very friendly."
Cynthia 1-night trip
Posted 1 day ago
Ameristar Casino Resort and Spa
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

8/10 Good
"Hotel is in a safe, convenient location. NO elevator, but there was an entrance with no steps on the first level. The hallway is a little grody but the room was very clean and arranged in a very convenient way. Lots of space to set things out to organize. Full kitchen but no utensils or cooking pans or dishes. I suppose they would be stolen if they were provided. I did not need them anyway. No ice machine, but ice trays to make your own ice in the freezer. Nice TV with lots of channels. Comfortable bed but lumpy pillow. Nice shower and bathroom. Basically it was perfect for my purposes as I was attending a meeting just down the street at a more expensive hotel. Families do live there and there was more noise in the hall than some would probably like. I ignored it. The office does not open until 9 in the morning and I had to be at my meeting before that time on the day of checkout. So, I had to return in the afternoon as I wanted my checkout paper. The staff was very nice and very helpful."
Nelta 2-night trip
Posted 2 days ago
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

10/10 Excellent
"The room was clean and staff friendly breakfast was hot an ready to go."
Ashley 1-night trip
Posted 2 days ago
Drury Inn & Suites St. Louis St. Peters
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

10/10 Excellent
"Updated, clean and safe hotel. Location is perfect; within walking distance to many activities. Rooms are large and very comfortable. Breakfast is a welcome addition!"
Jamie 2-night trip
Posted 2 days ago
Comfort Suites St Charles - St Louis
The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"Clean friendly secure"
Margo 1-night trip
Posted 2 days ago
The Wildwood Hotel
Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent
"Clean, staff was nice, food was good"
Eryn 2-night trip
Posted 2 days ago
Drury Plaza Hotel St. Louis Creve Coeur

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO
CA $112
CA $132 total
Oct 29 - Oct 30
includes taxes & fees
Sleep Inn & Suites O'Fallon MO - Technology Drive
Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO
CA $121
CA $140 total
Oct 28 - Oct 29
includes taxes & fees
8/10 Very good! (1,003 reviews)
Country Inn & Suites by Radisson, St. Peters, MO
Quality Inn Foristell

Quality Inn Foristell

12 Highway W Foristell MO
CA $125
CA $142 total
Oct 26 - Oct 27
includes taxes & fees
Quality Inn Foristell
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO
CA $131
CA $150 total
Oct 28 - Oct 29
includes taxes & fees
8.4/10 Very good! (1,011 reviews)
Comfort Suites St Charles - St Louis
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO
CA $164
CA $188 total
Oct 18 - Oct 19
includes taxes & fees
8.2/10 Very good! (1,000 reviews)
Hampton Inn St. Charles St. Peters
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO
CA $202
CA $232 total
Oct 28 - Oct 29
includes taxes & fees
9.4/10 Exceptional! (1,091 reviews)
Country Inn & Suites by Radisson, St. Charles Historic District

Hotels in Defiance with star rating

Frequently asked questions

What is the best area to stay in Defiance?
The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.
When is the best time to go to Defiance?
The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from CA $111 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia