Plan your trip

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Find hotels in Defiance, MO from CA $90

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels

    Sign in

  • Be picky

    Search almost a million properties worldwide

  • Go beyond your typical stay in Defiance

    Hot tub

    Pet friendly

    Pool

    Cabin

    Spa

    Family friendly

    Apart hotel

    Apart­ment

    Condo

    Villa

    Waterpark

    Cottage

    Chalet

    Check prices for these dates

    Check prices for these dates, December 14–15, 2026

    View in a map

    Our top choices for Defiance hotels

    1. Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    2. Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    3. TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    4. Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    5. Residence Inn by Marriott O'Fallon

    A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

    6. The Wildwood Hotel

    A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

    7. Comfort Inn & Suites Chesterfield - St. Louis

    A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

    8. Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    9. Courtyard by Marriott St. Louis Chesterfield

    An outdoor patio area with wicker furniture and a central fire feature.

    10. Hampton Inn & Suites St. Louis/Chesterfield

    A modern hotel dining area with a long communal table, multiple chairs, and pendant lighting.

    11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

    A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

    12. Drury Plaza Hotel St. Louis Chesterfield

    A spacious lobby with a central round table, two sofas, and a chandelier.

    13. Holiday Inn St. Louis West Six Flags by IHG

    A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

    14. Quality Inn Near Six Flags St. Louis

    A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

    15. Hyatt Place St. Louis/Chesterfield

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    16. Best Western Plus Washington Hotel

    A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

    17. Comfort Inn Near Six Flags St. Louis

    An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

    18. Super 8 by Wyndham Eureka/Six Flags Nearby

    A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

    19. DoubleTree by Hilton Hotel St. Louis - Chesterfield

    A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

    20. AC Hotel by Marriott St. Louis Chesterfield

    A modern hotel with a prominent entrance, a landscaped courtyard, and a well-lit facade.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

    View all properties

    Hotels recommended for families in Defiance

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Residence Inn by Marriott O'Fallon

    A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

    The Wildwood Hotel

    A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

    Comfort Inn & Suites Chesterfield - St. Louis

    A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

    Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    Stay near popular Defiance attractions

    Chandler Hill Vineyards

    Rating: 7.8/10 (7 reviews)

    You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.

    See properties

    Historic Daniel Boone Home and Heritage Center

    Rating: 9.6/10 (4 reviews)

    You can spend time exploring the galleries in Historic Daniel Boone Home and Heritage Center in Defiance. Stroll along the area's lakeside or simply enjoy its wineries.

    See properties

    Sugar Creek Winery

    Rating: 8.0/10 (1 review)

    You can enjoy a tasting or tour at Sugar Creek Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.

    See properties

    Yellow Farmhouse Winery

    You can enjoy a tasting or tour at Yellow Farmhouse Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.

    See properties

    Matson Hill Park Trailhead

    You can take time to visit Matson Hill Park Trailhead during your travels to Defiance. While you're in the area, wander around the parks.

    See properties

    Broemmelsiek Park

    Broemmelsiek Park is just one of the places to see in Defiance, so why not enjoy the other things to explore during your travels? Amble around this family-friendly area's gardens or experience its festivals.

    See properties

    Hamburg Trail Trailhead

    You can take time to visit Hamburg Trail Trailhead during your travels to Hamburg.

    See properties

    Learn more about Defiance

    Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

    See all hotels in Defiance

    A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

    Top Defiance Hotel Reviews

    TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    Hyatt Place St. Louis/Chesterfield

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    Residence Inn by Marriott O'Fallon

    A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

    Drury Plaza Hotel St. Louis Chesterfield

    A spacious lobby with a central round table, two sofas, and a chandelier.

    Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

    A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

    Holiday Inn Express & Suites St Peters by IHG

    A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

    Holiday Inn Express & Suites Wentzville St Louis West by IHG

    A spacious lobby with a reception desk, seating area, and a conference room.

    Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    Courtyard by Marriott St. Louis Chesterfield

    An outdoor patio area with wicker furniture and a central fire feature.

    Hampton Inn & Suites St. Louis/Chesterfield

    A modern hotel dining area with a long communal table, multiple chairs, and pendant lighting.

    Comfort Inn & Suites Chesterfield - St. Louis

    A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

    Drury Inn & Suites St. Louis St. Peters

    A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

    Holiday Inn St. Louis West Six Flags by IHG

    A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

    Frequently Asked Questions

    What is the best area to stay in Defiance?

    The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.

    This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.

    For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.

    Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.

    When is the best time to go to Defiance?

    The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.

    Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.

    Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.

    Can I cancel my hotel reservation on Expedia?

    You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.

    How much is the nightly rate at a Defiance hotel?

    Prices for hotels in Defiance often vary, but you can find a great deal from CA $90 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

    Explore a world of travel with Expedia