Defiance Vacation Rentals

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Our top choices for Defiance vacation rentals

Casa de Saint Charles

Casa de Saint Charles
Saint Charles
9.2 out of 10, Wonderful, (17 reviews)
"The home was perfect for our multi-family gathering. There was lots of room for everyone and the location was great for our needs."
United States
Karla Z.
The price is CA $170
CA $418 total
includes taxes & fees
Feb 12 - Feb 13
Casa de Saint Charles

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (30 reviews)
"Adorable place to stay!"
United States
Amy F.
The price is CA $223
CA $390 total
includes taxes & fees
Feb 10 - Feb 11
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

TJ’s Country Getaway- Dog Friendly

TJ’s Country Getaway- Dog Friendly
Union
10.0 out of 10, Exceptional, (45 reviews)
"It had everything you need for a relaxing stay. "
United States
Judith
The price is CA $101
CA $197 total
includes taxes & fees
Feb 16 - Feb 17
TJ’s Country Getaway- Dog Friendly

The Robins Nest by Innsbrook Vacations!

The Robins Nest by Innsbrook Vacations!
Innsbrook
9.6 out of 10, Exceptional, (5 reviews)
"Amazing place and property nearby, the overflow from lake is a must see . Just like a waterfall"
United States
John S.
The price is CA $257
CA $733 total
includes taxes & fees
Mar 8 - Mar 9
The Robins Nest by Innsbrook Vacations!

Tamm Loft | River view, Downtown WashMo, Dog-friendly

Tamm Loft | River view, Downtown WashMo, Dog-friendly
Washington
10.0 out of 10, Exceptional, (18 reviews)
"This is a beautiful place , well equipped kitchen . It was very clean too . It has located downtown and many restaurants in walking distance"
United States
Johanna D.
The price is CA $343
CA $438 total
includes taxes & fees
Feb 10 - Feb 11
Tamm Loft | River view, Downtown WashMo, Dog-friendly

Rustic Augusta Cabin by StayLage

Rustic Augusta Cabin by StayLage
Augusta
9.2 out of 10, Wonderful, (5 reviews)
"I booked this place wit spend some homely time with my kids and it was amazing, the place was clean they even dropped off some extra towels without us having to ask, it was truly amazing. Will definitely stay there again. "
United States
teresa s.
The price is CA $165
CA $435 total
includes taxes & fees
Feb 10 - Feb 11
Rustic Augusta Cabin by StayLage

Adorable Augusta Cabin

Adorable Augusta Cabin
Augusta
9.0 out of 10, Wonderful, (10 reviews)
"Absolutely beautiful area. Cabin is so cozy"
United States
Aaron
The price is CA $121
CA $288 total
includes taxes & fees
Feb 10 - Feb 11
Adorable Augusta Cabin

The Hidden Gem - 2BR Basement Apartment on 7 Acres

The Hidden Gem - 2BR Basement Apartment on 7 Acres
Moscow Mills
10.0 out of 10, Exceptional, (12 reviews)
"Great place, nice neighborhood. "
United States
Julie L.
The price is CA $188
CA $385 total
includes taxes & fees
Feb 10 - Feb 11
The Hidden Gem - 2BR Basement Apartment on 7 Acres

Spacious Cottage on Main st- Near Downtown

Spacious Cottage on Main st- Near Downtown
St. Charles Historic District
10.0 out of 10, Exceptional, (7 reviews)
"The house was perfect. Clean, organized and portrayed exactly as in the pictures. We loved our stay here. The host was punctual and attentive to all questions. We would definitely stay again. "
United States
Theresa P.
The price is CA $123
CA $294 total
includes taxes & fees
Feb 10 - Feb 11
Spacious Cottage on Main st- Near Downtown

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
St. Charles Historic District
9.4 out of 10, Exceptional, (13 reviews)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
The price is CA $122
CA $329 total
includes taxes & fees
Feb 10 - Feb 11
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

Aspen Sights by Innsbrook Vacations!

Aspen Sights by Innsbrook Vacations!
Innsbrook
9.6 out of 10, Exceptional, (13 reviews)
"Lovely weekend- enjoyed checking out Innsbrook"
United States
Denise L.
The price is CA $96
CA $302 total
includes taxes & fees
Feb 10 - Feb 11
Aspen Sights by Innsbrook Vacations!

Spacious Townhome Retreat by StayLage

Spacious Townhome Retreat by StayLage
O Fallon
9.8 out of 10, Exceptional, (10 reviews)
"Great quiet neighborhood close to everything!"
United States
Jen D.
The price is CA $183
CA $534 total
includes taxes & fees
Feb 10 - Feb 11
Spacious Townhome Retreat by StayLage

The Ridge by Innsbrook Vacations!

The Ridge by Innsbrook Vacations!
Innsbrook
9.6 out of 10, Exceptional, (22 reviews)
"Adorable property in an amazing resort community. Beds were comfortable, house was stocked with everything we needed. Had an amazing time!"
United States
Stephanie S.
The price is CA $331
CA $856 total
includes taxes & fees
Feb 26 - Feb 27
The Ridge by Innsbrook Vacations!

4 Bedroom Wentzville Home by StayLage

4 Bedroom Wentzville Home by StayLage
Wentzville
9.8 out of 10, Exceptional, (6 reviews)
"Amazing for attending the fireworks festivals nearby. Great shops walking distance for coffee and food"
United States
Tom K.
The price is CA $238
CA $694 total
includes taxes & fees
Feb 24 - Feb 25
4 Bedroom Wentzville Home by StayLage

VRBO Brick House of Washington

VRBO Brick House of Washington
Washington
10.0 out of 10, Exceptional, (16 reviews)
"Beautiful, comfy, huge, amazing pool and very kind hosts. A great spot to get together with old friends and their kids of all ages."
United States
Allison D.
The price is CA $295
CA $813 total
includes taxes & fees
Feb 10 - Feb 11
VRBO Brick House of Washington

Beautiful+Spacious+FencedYard🐕Grill+Patio+Walk2Park+27MileBikeTrail🚴‍♀️

Beautiful+Spacious+FencedYard🐕Grill+Patio+Walk2Park+27MileBikeTrail🚴‍♀️
St. Peters
10.0 out of 10, Exceptional, (23 reviews)
"Clean and close to everything you would want for a stay ."
United States
Judy H.
The price is CA $283
CA $555 total
includes taxes & fees
Feb 10 - Feb 11
Beautiful+Spacious+FencedYard🐕Grill+Patio+Walk2Park+27MileBikeTrail🚴‍♀️

Lake Aspen Hideaway by Innsbrook Vacations!

Lake Aspen Hideaway by Innsbrook Vacations!
Wright City
9.8 out of 10, Exceptional, (21 reviews)
"Check-in was easy and property was clean. Great place to stay!"
United States
Casey A.
The price is CA $96
CA $302 total
includes taxes & fees
Feb 10 - Feb 11
Lake Aspen Hideaway by Innsbrook Vacations!

Landing Apartments - Eureka

Landing Apartments - Eureka
4.0 star property
Eureka
Landing Apartments - Eureka

Woodland Retreat with a Swim Spa

Woodland Retreat with a Swim Spa
Innsbrook
9.6 out of 10, Exceptional, (23 reviews)
"Plenty of room for the 6 of us "
United States
Missy G.
The price is CA $246
CA $550 total
includes taxes & fees
Feb 10 - Feb 11
Woodland Retreat with a Swim Spa

Cozy Unit on Historic Main Street

Cozy Unit on Historic Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (11 reviews)
"Wonderful host and accomodations !"
United States
Matthew K.
The price is CA $139
CA $314 total
includes taxes & fees
Feb 15 - Feb 16
Cozy Unit on Historic Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Find out more about Defiance

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Defiance. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟: This vacation home rental outside of Defiance offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

How many vacation rentals will I find in Defiance?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.