Defiance Vacation Packages
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Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
Top Defiance Vacation Deals
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Price was CA $2,103, price is now CA $1,692 per person
CA $1,692
per person
Dec 16 - Dec 23
found 22 hours ago
Roundtrip flight included
Toronto (YYZ) to St. Louis (STL)
8.8/10 Excellent! (1,010 reviews)
A wonderful break from boring hotels! My kids loved all the artwork and the scavenger hunt. The pub food and drinks were fantastic, as was the hotel breakfast each morning. We will definitely plan to return.
Reviewed on Nov 9, 2026
Ameristar Casino Resort and Spa
Price was CA $2,151, price is now CA $1,809 per person
CA $1,809
per person
Dec 16 - Dec 23
found 22 hours ago
Roundtrip flight included
Toronto (YYZ) to St. Louis (STL)
8.6/10 Excellent! (1,080 reviews)
We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of hotel.
Reviewed on Nov 8, 2026
Defiance Hotel Deals
Sonesta ES Suites St. Louis - Chesterfield
15431 Conway Rd Chesterfield MO
The price is CA $131 per night from Nov 10 to Nov 11
CA $131
CA $152 total
Nov 10 - Nov 11
includes taxes & fees
8/10 Very good! (1,067 reviews)
"The doir had a gap that hardly let us lock it. A pan was put in the cupboard without being washed. The glass sliding door had not been wash from what i believe was dog smears all over it. Under coach was an empty wrapper from mcdonalds. And last ...gasket on freezer door fell off whenever you opened ..."
Reviewed on Nov 9, 2026
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
The price is CA $98 per night from Dec 6 to Dec 7
CA $98
CA $135 total
Dec 6 - Dec 7
includes taxes & fees
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
The price is CA $225 per night from Nov 16 to Nov 17
CA $225
CA $286 total
Nov 16 - Nov 17
includes taxes & fees
8.6/10 Excellent! (1,094 reviews)
"We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of ..."
Reviewed on Nov 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
What to do in Defiance
StL's Signature "Sights and Bites" - Private Tour in St. Louis
CA $247
per adult
Haunted Lemp Brewery Bottle Works Paranormal Tour
CA $35
per adult
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
