Southeast Missouri Vacation Packages

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

Top Southeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Rockwood Resort Motel

Rockwood Resort Motel

2.5 out of 5
Price was CA $1,309, price is now CA $1,287 per person
CA $1,287
per person
Aug 1 - Aug 8
found 16 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
8/10 Very Good! (51 reviews)
Just an older hotel but was clean and convenient to the area we wanted to stay.

Reviewed on May 6, 2026

Buddy's Harbor

Buddy's Harbor

2.5 out of 5
Price was CA $1,737, price is now CA $1,595 per person
CA $1,595
per person
Aug 1 - Aug 8
found 16 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9.4/10 Exceptional! (48 reviews)
We stayed with my family of 6 adults and 4 kids, and we thoroughly enjoyed the property. The access to the lake is convenient, the staff is friendly and the cottages are amazing. They have thought about every small detail. Would certainly come back.

Reviewed on May 26, 2026

Prime Spot, Breathtaking Views, Nearby Attractions

Prime Spot, Breathtaking Views, Nearby Attractions

2 out of 5
Price was CA $1,807, price is now CA $1,710 per person
CA $1,710
per person
Aug 1 - Aug 8
found 16 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
No reviews
Latibe Retreat Lakefront Condo for 4 w/ Balcony & Pool Access

Latibe Retreat Lakefront Condo for 4 w/ Balcony & Pool Access

4 out of 5
Price was CA $1,879, price is now CA $1,832 per person
CA $1,832
per person
Aug 1 - Aug 8
found 16 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
10/10 Exceptional! (1 review)
The lake view was beautiful and so was the room

Reviewed on Sep 16, 2025

Highland Lake View Incredible Location!

Highland Lake View Incredible Location!

4 out of 5
Price was CA $1,730, price is now CA $1,701 per person
CA $1,701
per person
Aug 1 - Aug 8
found 16 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
9.4/10 Exceptional! (3 reviews)
Very nice property and we had an amazing time!!

Reviewed on Jul 17, 2024

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Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $154 per night from Jun 14 to Jun 15
CA $154
CA $173 total
Jun 14 - Jun 15
includes taxes & fees
9.6/10 Exceptional! (1,012 reviews)
"Wonderful room and food offerings were extra thoughtful."

Reviewed on Jun 12, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $155 per night from Jul 9 to Jul 10
CA $155
CA $178 total
Jul 9 - Jul 10
includes taxes & fees
9.6/10 Exceptional! (1,011 reviews)
"Evening drinks and meal were included. Breakfast was also included and very good"

Reviewed on Jun 11, 2026

Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is CA $87 per night from Jun 30 to Jul 1
CA $87
CA $95 total
Jun 30 - Jul 1
includes taxes & fees
8/10 Very Good! (1,011 reviews)
"We arrived late, but the front desk clerk was friendly. We didn't realize there was no elevator and one of our party is unable to climb stairs. The clerk was quick to find us a room on the first floor. The associate keeping the breakfast supplied was also cheery and polite. When leaving the clerk ..."

Reviewed on Jun 12, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
See all 658 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Southeast Missouri attractions

Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travelers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your vacation savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks traveling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.