Southeast Missouri
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
The price is CA $140 per night from Nov 8 to Nov 9
CA $140
CA $158 total
Nov 8 - Nov 9
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
The price is CA $126 per night from Nov 8 to Nov 9
CA $126
CA $141 total
Nov 8 - Nov 9
includes taxes & fees
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
The price is CA $131 per night from Nov 8 to Nov 9
CA $131
CA $151 total
Nov 8 - Nov 9
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (118 reviews)
"Team had daily contact with us. Beautiful setting."
Reviewed on Nov 1, 2026
Silo Farm Haus- located in the heart of wine country!
Ste. Genevieve MO
Stay at this vacation home in Ste Genevieve. Enjoy laundry facilities. Popular attractions Crown Valley Winery and Hawn State Park are located nearby.
10/10 Exceptional! (160 reviews)
"Visited for the weekend with my wife to celebrate our anniversary. The Silo Farm Haus was absolutely perfect! The views of the rolling farmland were gorgeous. Inside was cozy and beautifully decorated. We had a wonderful time and would highly recommend staying here if you get the chance."
Reviewed on Oct 19, 2026
Lake Wappapello
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions Poplar Bluff History Museum and North Main Street Historic District are located ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Southeast Missouri hotel availability
Stay near popular Southeast Missouri attractions
Things to do
Night Ghost Tour of Pythian Castle in Springfield Missouri
CA $28
per adult
96% of travellers recommend
Tour The Ozarks Private Springfield Brewery Tour
CA $302
per adult
Explore a world of travel with Expedia
- Postcard Cabins St Francois
- Farmstay in Oak Ridge
- Poplar Bluff Hotels
- Hampton Inn Poplar Bluff
- Spring Lake Ranch has a Private
- Crown Pointe Lodge
- Bullwinkles Rustic Lodge
- Holiday Inn Poplar Bluff by IHG
- Resorts in Wayne County
- Town House Inn
- Advance Hotels
- Super 8 by Wyndham Perryville
- Houseboats in Wappapello
- Villas in Poplar Bluff
- Cabin Rentals in Southeast Missouri
- Park Hills Hotels
- Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
- Bluebird Meadows W/hot Tub and Pool Special
- Motels in St Mary
- The Weber Farm
- French Village Hotels
- Cabin Rentals in Bonne Terre
- Motels in Ellsinore
- Home Sweet Home
- Cottages in Clearwater
- Hilton Hotels in Ste Genevieve
- Cabin Rentals in Centerville
- Pickleball Cafe & Micro Hotel
- Dexter Inn
- Quality Inn Perryville I
- Cheap Hotels in Bonne Terre
- B&B in Ste Genevieve
- Rv Parks in Perryville
- Rv Parks in Chaffee
- Amazing lakeview Spring Lake Tree House #2 "LoveLight" w/ hot tub
- Hotels near Big River
- Lazy River Cabin on the edge of town only 1/2 mile from Current River !
- The Queen Bee Farm Stay/Hot tub
- Essex Hotels
- Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
- Secluded Private Cabin with Pool
- Silo Farm Haus
- Cheap Hotels in Viburnum
- Relax in the country at Countryside Villas!
- Secluded Cabin with Heated Pool
- Hilton Hotels in Perryville
- Cabin Rentals in Allenville
- Jackson Hotels
- Apartments in Ozora
- Bonne Terre Hotels
- Cabin Rentals in Farmington
- Urban Loft #4 BLACK · Urban Loft above BrewCo & Restaurant
- Triangle Inn Motel
- Condo Rentals in Fremont
- Cabin Rentals in Cadet
- Dexter Hotels
- Cabin Rentals in Leadwood
- Ozora Hotels
- Pet-Friendly Hotels in Jackson
- Fredericktown Hotels
- Cottages in Pocahontas
- Van Buren Hotels
- Alpaca Farm Stay
- Oyo Hickory House Inn
- Flights from Bonne Terre
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- Flights from St. Louis (STL) to Poplar Bluff (POF)
- Flights from Toronto (YTO) to Cape Girardeau (CGI)
- Flights from Chaffee
