Title: Visit Southeast Missouri: Best of Southeast Missouri Tourism | Expedia Travel Guide - Expedia.ca [Hotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides) # Southeast Missouri ## Travel Guide ![Southeast Missouri](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Southeast Missouri](https://mediaim.expedia.com/destination/9/6c450e001334a84543e95019353aad53.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Southeast Missouri](https://mediaim.expedia.com/destination/9/a89308cd6725fa917758c794dd86c33d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/4ddf292149c3402549f16eb8c5528744.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/4ddf292149c3402549f16eb8c5528744.jpg) ![Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/71071bca60cf5af304b1d202a4f54f4d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/71071bca60cf5af304b1d202a4f54f4d.jpg) ## Visit Southeast Missouri Things to do - Southeast Missouri Hotel Deals - Vacation Rentals in Southeast Missouri ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO CA $74 CA $84 total Dec 22 - Dec 23 includes taxes & fees Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ... 8/10 Very Good! (1,007 reviews) The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe. Reviewed on Dec 7, 2025 [](https://expedia.ca/Hotel-Search?startDate=22%2F12%2F2025&endDate=23%2F12%2F2025&selected=16153&PinnedHotelID=16153&HadPinnedHotel=true®ionId=6058763) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO CA $124 CA $140 total Dec 16 - Dec 17 includes taxes & fees Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.4/10 Exceptional! (1,000 reviews) Great Reviewed on Dec 1, 2025 [](https://expedia.ca/Hotel-Search?startDate=16%2F12%2F2025&endDate=17%2F12%2F2025&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true®ionId=6058763) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverview 777 Main St Cape Girardeau MO CA $126 CA $143 total Dec 14 - Dec 15 includes taxes & fees Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ... 9.2/10 Wonderful! (466 reviews) Helpful staff, clean room. Reviewed on Nov 26, 2025 [](https://expedia.ca/Hotel-Search?startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&selected=105081384&PinnedHotelID=105081384&HadPinnedHotel=true®ionId=6058763) [See all 620 properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy 7555 State Hwy Y French Village MO Stay at this cabin in French Village. Enjoy free parking, patios, and climate control. 9.8/10 Exceptional! (44 reviews) The cabin was cozy and very peaceful such a good experience Reviewed on Nov 11, 2025 [](https://expedia.ca/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) ![Sam A Baker State Park](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sam A Baker State Park 5732 State Hwy Missouri 143 Patterson MO Stay at this cabin in Patterson. Enjoy free parking, a picnic area, and furnished patios. Popular attraction Sam A. Baker State Park is located nearby. 9.2/10 Wonderful! (5 reviews) We stayed two nights and we loved it. The property grounds and cabins are well maintained we will be back Reviewed on Oct 5, 2025 [](https://expedia.ca/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) ![The Twisted Sassafras Treehouse ](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Twisted Sassafras Treehouse Cape Girardeau MO Stay at this cabin in Cape Girardeau. Enjoy a garden, patios, and an in-room coffeemaker. Popular attractions Cape Girardeau Conservation Nature Center and Cape ... 10/10 Exceptional! (27 reviews) This is the perfect private romantic getaway! We had such a blast here. Definitely recommend! Reviewed on Nov 2, 2025 [](https://expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) [See all properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6058763&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Southeast Missouri hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058763&startDate=2025-12-12&endDate=2025-12-13)[Dec 12 - Dec 13](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058763&startDate=2025-12-12&endDate=2025-12-13) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058763&startDate=2025-12-13&endDate=2025-12-14)[Dec 13 - Dec 14](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058763&startDate=2025-12-13&endDate=2025-12-14) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058763&startDate=12%2F12%2F2025&endDate=14%2F12%2F2025)[Dec 12 - Dec 14](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058763&startDate=12%2F12%2F2025&endDate=14%2F12%2F2025) ### Popular places to visit ![Elephant Rocks State Park](https://mediaim.expedia.com/destination/2/86e50eabc9d5592586815e7688be64ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Elephant Rocks State Park You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. [](https://expedia.ca/Elephant-Rocks-State-Park-Ironton.d553248621532648464.Vacation-Attraction) ![Lake Wappapello](https://mediaim.expedia.com/destination/2/a6135d9f1717ada26d9944dd5bb40459.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lake Wappapello Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Lake-Wappapello-Wappapello.d553248621532648460.Vacation-Attraction) ![Rocky Falls](https://mediaim.expedia.com/destination/2/f2325d7f040c776e314b23ad9fbdb813.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Rocky Falls Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting. [](https://expedia.ca/Rocky-Falls-Winona.d553248621532648456.Vacation-Attraction) #### Southeast Missouri State University Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.ca/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) #### Century Casino Caruthersville Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Century-Casino-Caruthersville-Caruthersville.d553248621532655201.Vacation-Attraction) #### Isle Casino Cape Girardeau Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.ca/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction) ### Things to do ![Ozark Craft Beverage - Brewery Tour](https://mediaim.expedia.com/localexpert/5026127/bb50ed0e-b72f-4359-9f79-f93dc0acc935.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Ozark Craft Beverage - Brewery Tour CA $219 per adult [](https://expedia.ca/things-to-do/ozark-craft-beverage-brewery-tour.a5026127.activity-details) [See all activities in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities) ## Cities near Southeast Missouri ![Photo by Skyy ](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Cape Girardeau ![Photo by Sharon Blackmore](https://mediaim.expedia.com/destination/2/7d3373966b3b269f1b9eebf971209552.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Sullivan ![Poplar Bluff](https://mediaim.expedia.com/destination/9/6c450e001334a84543e95019353aad53.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Poplar Bluff ![Photo by Summer Williams](https://mediaim.expedia.com/destination/2/f2491779cf462fb153bab34fde97528f.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Fredericktown ## Explore a world of travel with Expedia - 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