Title: Book The Best Hotels in Perryville, MO for 2026 from CA $91 - Fully Refundable Options - Expedia.ca [Perryville Travel Guide](https://expedia.ca/Perryville.dx6134448)[Vacation Rentals in Perryville](https://expedia.ca/Perryville-Vacation-Rentals.d6134448.Travel-Guide-VacationRentals)[Things to do in Perryville](https://expedia.ca/Things-To-Do-In-Perryville.d6134448.Travel-Guide-Activities)[Perryville Car Rentals](https://expedia.ca/Car-Rentals-In-Perryville.d6134448.Car-Rental-Guide)[Perryville Vacation Packages](https://expedia.ca/Perryville.d6134448.Destination-Travel-Guides) ![Arched train bridge](https://images.trvl-media.com/place/6134448/9dc94c46-c0ab-4d3f-b5fe-2d6ecd4d81c3/aerial-freight-train-crossing-concrete-arch-railroad-viaduct-rural-countryside-usa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Perryville, MO from CA $91 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Perryville Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Perryville%2C+Missouri%2C+United+States+of+America®ionId=6134448&latLong=37.722755%2C-89.877479&adults=2&startDate=2025-12-18&d1=2025-12-18&endDate=2025-12-20&d2=2025-12-20&amenities=PETS) Pool [](https://www.expedia.ca/Hotel-Search?destination=Perryville%2C+Missouri%2C+United+States+of+America®ionId=6134448&latLong=37.722755%2C-89.877479&adults=2&startDate=2025-12-18&d1=2025-12-18&endDate=2025-12-20&d2=2025-12-20&amenities=POOL) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Perryville%2C+Missouri%2C+United+States+of+America®ionId=6134448&latLong=37.722755%2C-89.877479&adults=2&startDate=2025-12-18&d1=2025-12-18&endDate=2025-12-20&d2=2025-12-20&amenities=HOT_TUB) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Perryville%2C+Missouri%2C+United+States+of+America®ionId=6134448&latLong=37.722755%2C-89.877479&adults=2&startDate=2025-12-18&d1=2025-12-18&endDate=2025-12-20&d2=2025-12-20&lodging=CABIN) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Perryville%2C+Missouri%2C+United+States+of+America®ionId=6134448&latLong=37.722755%2C-89.877479&adults=2&startDate=2025-12-18&d1=2025-12-18&endDate=2025-12-20&d2=2025-12-20&travelerType=family_friendly) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Perryville%2C+Missouri%2C+United+States+of+America®ionId=6134448&latLong=37.722755%2C-89.877479&adults=2&startDate=2025-12-18&d1=2025-12-18&endDate=2025-12-20&d2=2025-12-20&lodging=APARTMENT) ## Check prices for these dates Tonight [Dec 4 - Dec 5](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-04&endDate=2025-12-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 5 - Dec 6](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-05&endDate=2025-12-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 162 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/d42a6e3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.2/10 Wonderful (536) "Clean room and pleasant staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $121 CA $139 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/807f3a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/7f26b79f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible)](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/4e8bbceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Perryville Perryville 8.4/10 Very good (935) "The room was spotless, and the staff was extremely patient. Each one was very helpful. It was easy to get a good night's sleep - the building was very quiet." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia CA $88 CA $100 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/bf2aa006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/26f852d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily breakfast](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/6b56391d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/082d2613.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Perryville I-55 Perryville 6.6/10 (124) "Nice place would recommend Mary Jane’s if you’re looking for good food " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew CA $97 CA $111 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Perryville-Hotels-Quality-Inn.h84949.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/f6ab26a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/e7849830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/0ac21fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/97771aac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Perryville Perryville 6.8/10 (415) "Was a nice place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lesliee CA $91 CA $104 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) ![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/0b4f194a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/327c3e44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Lofts Perryville 9.2/10 Wonderful (17) "Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric [](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/331aa35f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/93f13efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/0de8e5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/47ed6dc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Sparta by IHG Sparta 9.2/10 Wonderful (368) "Bed was comfortable, breakfast was a 10/10! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Junior CA $111 CA $123 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Chester-Hotels-Holiday-Inn-Express-Hotel-Suites-Sparta.h1691121.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO Jackson 9.6/10 Exceptional (1002) "Breakfast was great- staff was welcoming. Will stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $116 CA $122 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/b6dd70b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/f0e5a143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/f803d387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG Murphysboro 9.4/10 Exceptional (509) "great property, great breakfast, friendly and knowledgable staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $133 CA $147 total includes taxes & fees Dec 6 - Dec 7 [](https://www.expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars)](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (659) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) GUY CA $109 CA $118 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/96e79bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 Queen Bed, Non Smoking | Room amenity](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/ca717d37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/46991f0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/7601c384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Sainte Genevieve Ste Genevieve 8.8/10 Excellent (610) "Excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $95 CA $106 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) ![Deluxe Studio Suite, 1 King Bed, Non Smoking | Jetted tub](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/d4b528ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/f64e14c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/30395b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Chester IL Chester 8.6/10 Excellent (349) "The room was clean and the staff were friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) RODNEY CA $82 CA $91 total includes taxes & fees Dec 13 - Dec 14 [](https://www.expedia.ca/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Economy Single Room, 1 Queen Bed, Kitchenette](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5eb3395a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Single Room, 1 Queen Bed, Kitchenette](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5dd1852e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/1aa84b52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Single Room, 1 Queen Bed, Kitchenette | Bathroom](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/324e501c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn Jackson 7.6/10 Good (422) "Room was clean and had a refrigerator and microwave for use if needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry CA $86 CA $94 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/c1fba8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/633eb669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/5aa6a52b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau Cape Girardeau 9.6/10 Exceptional (97) "It was a nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Douglas CA $122 CA $138 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34900000/34893300/34893294/a262c28f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![New Orleans Room](https://images.trvl-media.com/lodging/35000000/34900000/34893300/34893294/59cc6390.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Quebec Room](https://images.trvl-media.com/lodging/35000000/34900000/34893300/34893294/552f9a17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34900000/34893300/34893294/2880668c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Conner House B&B Prairie du Rocher 10/10 Exceptional (19) "Wonderful folks that work there. Nice b&b in a quiet , scenic area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bradley CA $196 CA $218 total includes taxes & fees Dec 5 - Dec 6 [](https://www.expedia.ca/Chester-Hotels-The-Conner-House-Bed-And-Breakfast.h34893294.Hotel-Information) ![Free self parking](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/a0b4cb43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/416a5c39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/41fbb4bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/3b572bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Triangle Inn Motel Ste Genevieve 8.0/10 Very good (42) "The staff was very accommodating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Herbert CA $107 CA $119 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Perryville-Hotels-Triangle-Inn-Motel.h29373308.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/700000/692700/692668/372ece1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/700000/692700/692668/d669a1ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Room, 1 King Bed | Bathroom](https://images.trvl-media.com/lodging/1000000/700000/692700/692668/a0a65b1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/700000/692700/692668/74f16cb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Briarwood Inn of Sparta Sparta 7.4/10 Good (122) "My stay was excellent. The owner even gave me a ride to church and I am very thankful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LaQuana CA $91 CA $101 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Chester-Hotels-Briarwood-Inn-Of-Sparta.h692668.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/70460e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/a758bb0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/eec0e02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/06dc4487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Jackson-Cape Girardeau Jackson 8.2/10 Very good (739) "Dirty " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jon CA $111 CA $121 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/987f0635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/765df2ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/5f391186.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/622c9d52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Madison Inn Lodge Fredericktown 7.6/10 Good (297) "Room was not exactly smelling nice, but room was clean and comfortable. The lodge was close to expressway and shopping. Staff was very friendly. I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve CA $109 CA $119 total includes taxes & fees Dec 5 - Dec 6 [](https://www.expedia.ca/Farmington-Hotels-Madison-Inn-Lodge.h59960.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/12000000/11250000/11249000/11249000/48d42b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/12000000/11250000/11249000/11249000/17e335b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/12000000/11250000/11249000/11249000/282a5f73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, towels](https://images.trvl-media.com/lodging/12000000/11250000/11249000/11249000/5fb20f40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sparta Motel Sparta 4.4/10 (66) "Walking distance to downtown Sparta, but property is old, unkept, in need of updates. Price charged for this kind of room is ridiculous. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chuck CA $92 CA $102 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Chester-Hotels-Sparta-Motel.h11249000.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-18&endDate=2025-12-19®ionId=6134448&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels.d6134448.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels.d6134448.Travel-Guide-Hotels) ## Perryville and related destinations - Perryville - Fergus Falls - Kewanee - Camden Historic battlefields and the charming downtown district tell stories of Missouri's Civil War past. Visit Perry County Heritage Tourism Centre and enjoy local wineries along the Mississippi Hills Wine Trail for a perfect weekend. [See all hotels in Perryville](https://www.expedia.ca/Hotel-Search?startDate=2025-12-18&endDate=2025-12-19&adults=2®ionId=6134448) ![Arched train bridge](https://images.trvl-media.com/place/6134448/9dc94c46-c0ab-4d3f-b5fe-2d6ecd4d81c3.jpg?impolicy=fcrop&w=899&h=599&p=1&q=high) ### Stay near popular Perryville attractions [](https://expedia.ca/National-Shrine-Of-Our-Lady-Of-The-Miraculous-Medal-Hotels.0-l553248621561876731-0.Travel-Guide-Filter-Hotels) #### National Shrine of Our Lady of the Miraculous Medal Find out about the history of Perryville when you take a trip to National Shrine of Our Lady of the Miraculous Medal. Take in the festivals while you're in the area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561876731) [](https://expedia.ca/Missouris-National-Veterans-Memorial-Hotels.0-l620724250067501056-0.Travel-Guide-Filter-Hotels) #### Missouri's National Veterans Memorial Learn about the local history of Perryville when you take a trip to Missouri's National Veterans Memorial. Amble around the area's parks or experience its festivals. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=620724250067501056) [](https://expedia.ca/Perryville-Country-Club-Hotels.0-l553248621564822920-0.Travel-Guide-Filter-Hotels) #### Perryville Country Club Enjoy a round of golf in Perryville at Perryville Country Club. Take in the festivals while you're in the area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621564822920) ## More cheap stays in Perryville ![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tru By Hilton Cape Girardeau 2520 Veterans Memorial Dr Cape Girardeau MO CA $122 CA $138 total Dec 14 - Dec 15 includes taxes & fees 9.6/10 Exceptional! (97 reviews) [](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Perryville by IHG 2020 Jefferson St Perryville MO CA $121 CA $139 total Dec 11 - Dec 12 includes taxes & fees 9.2/10 Wonderful! (536 reviews) [](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Holiday Inn Express & Suites Murphysboro - Carbondale by IHG](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG 120 MUDDY MONSTER ROAD Murphysboro IL CA $133 CA $147 total Dec 6 - Dec 7 includes taxes & fees 9.4/10 Exceptional! (507 reviews) [](https://expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Super 8 by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Perryville 1119 Vincent Dr Perryville MO CA $88 CA $100 total Dec 24 - Dec 25 includes taxes & fees 8.4/10 Very Good! (935 reviews) [](https://expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Baymont by Wyndham Chester IL](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont by Wyndham Chester IL 2150 State Street Chester IL CA $82 CA $91 total Dec 13 - Dec 14 includes taxes & fees 8.4/10 Very Good! (346 reviews) [](https://expedia.ca/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Holiday Inn Express Hotel & Suites Sparta by IHG](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/331aa35f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites Sparta by IHG 1301 N Market St Sparta IL CA $111 CA $123 total Dec 21 - Dec 22 includes taxes & fees 9/10 Wonderful! (368 reviews) [](https://expedia.ca/Chester-Hotels-Holiday-Inn-Express-Hotel-Suites-Sparta.h1691121.Hotel-Information) ## Hotels in Perryville with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 1 properties [](https://expedia.ca/4Star-Perryville-Hotels.s40-0-d6134448.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 12 properties [](https://expedia.ca/3Star-Perryville-Hotels.s30-0-d6134448.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 40 properties [](https://expedia.ca/2Star-Perryville-Hotels.s20-0-d6134448.Travel-Guide-Filter-Hotels) ## Recent reviews of Perryville hotels ![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg) ### Holiday Inn Express & Suites Perryville by IHG 5/5 Excellent "Clean" A verified traveller stayed at Holiday Inn Express & Suites Perryville by IHG Posted 2 days ago [](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Super 8 by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9_y.jpg) ### Super 8 by Wyndham Perryville 5/5 Excellent "The room and common area was very clean and attractive. But breakfast was a big disapp ointment. Maybe they ran out of bacon or sausage but it wasn't refilled so all of this left and 8:30 was waffles cereal and scrambled eggs." A verified traveller stayed at Super 8 by Wyndham Perryville Posted 2 days ago [](https://expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 5/5 Excellent "The staff was excellent!" A verified traveller stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Posted 3 days ago [](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Holiday Inn Express & Suites Murphysboro - Carbondale by IHG](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14_y.jpg) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG 5/5 Excellent "Room was spotless. Enjoyed our stay!" A verified traveller stayed at Holiday Inn Express & Suites Murphysboro - Carbondale by IHG Posted 4 days ago [](https://expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 5/5 Excellent "It was great" A verified traveller stayed at Drury Inn & Suites Jackson MO Posted 4 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Microtel Inn & Suites by Wyndham Sainte Genevieve](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/96e79bac_y.jpg) ### Microtel Inn & Suites by Wyndham Sainte Genevieve 5/5 Excellent "very clean" A verified traveller stayed at Microtel Inn & Suites by Wyndham Sainte Genevieve Posted 5 days ago [](https://expedia.ca/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) ![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg) ### Tru By Hilton Cape Girardeau 5/5 Excellent "Excellent service and Mia was outstanding. " A verified traveller stayed at Tru By Hilton Cape Girardeau Posted 6 days ago [](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Hot Tub & Creek Views: Secluded Perryville Cabin](https://images.trvl-media.com/lodging/116000000/115020000/115013900/115013833/762b23c1_y.jpg) ### Hot Tub & Creek Views: Secluded Perryville Cabin 5/5 Excellent "We were celebrating a 50th birthday and a ladies reunion with life long friends. The location was perfect! Cell service and internet are spotty which made for a perfect unplugged get away. I wish the hot tub had been a little more secure to get in and out of...but at our ages we are extra careful lol Hoping to make this an annual trip! Just watch out for the walnuts!!! Lol" A verified traveller stayed at Hot Tub & Creek Views: Secluded Perryville Cabin Posted 1 month ago [](https://expedia.ca/Perryville-Hotels-Hot-Tub-Creek-Views-Secluded-Perryville-Cabin.h115013833.Hotel-Information) ![Big Sky Cabin! Hot Tub! On the Wine Trail! Fire Pit! Pool Table! Large Deck! ](https://images.trvl-media.com/lodging/33000000/32070000/32068400/32068377/725ec117_y.jpg) ### Big Sky Cabin! Hot Tub! On the Wine Trail! Fire Pit! Pool Table! Large Deck! 5/5 Excellent "Host was great, contacted me to say thank you for renting his house. Hot tub was perfect which was one of main reasons for renting the house, along with the 2 bathrooms, and the location. A good floor plan for 2 or more people. It was just my friend and I so we loved having are own separate wings!!! It also was not hard to find and close to the bourbon bar and a few wineries. Once you get the lay of the area other wineries are not hard to find. Overall hard a great time." A verified traveller stayed at Big Sky Cabin! Hot Tub! On the Wine Trail! Fire Pit! Pool Table! Large Deck! Posted 1 month ago [](https://expedia.ca/Alto-Pass-Hotels-Rated1-Big-Sky-Cabin-On-The-Wine-Trail-Hot-Tub-FirePit-Pool-Table.h32068377.Hotel-Information) ## Frequently asked questions ### What are the best hotels in Perryville that travellers recommend? ### What are the top pet-friendly hotels in Perryville? ### What are the best budget hotels in Perryville? > Another excellent option is [Urban Lofts](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information), which boasts a traveller review score of 9.2\. This hotel offers a unique stay with family-friendly amenities like a kitchen for in-room dining and pet-friendly options, making it ideal for those traveling with furry friends. Guests appreciate the comfort of Egyptian cotton sheets and the convenience of free WiFi, ensuring a relaxed and enjoyable experience. > > > For those looking for more budget options, [Super 8 by Wyndham Perryville](https://www.expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) provides an affordable stay with an indoor pool and free breakfast, rated 8.4 by travellers. This property welcomes families with its accessible parking and 24-hour fitness facilities, making it a practical choice for those seeking value. > > > If you're traveling as a couple or solo, [Days Inn by Wyndham Perryville](https://www.expedia.ca/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) offers a cozy atmosphere with an outdoor seasonal pool and a business centre for those needing to catch up on work. [Quality Inn Perryville I-55](https://www.expedia.ca/Perryville-Hotels-Quality-Inn.h84949.Hotel-Information) features an inviting outdoor pool and hot tub, superb for leisurely afternoons, making it a nice retreat for couples or travellers looking to unwind. 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