Title: Book the Best Perryville FAMILY FRIENDLY Hotels - Kid-Friendly Hotels in Perryville, MO | Expedia.ca [Perryville Travel Guide](https://expedia.ca/Perryville.dx6134448)[Hotels in Perryville](https://expedia.ca/Perryville-Hotels.d6134448.Travel-Guide-Hotels)[Vacation Rentals in Perryville](https://expedia.ca/Perryville-Vacation-Rentals.d6134448.Travel-Guide-VacationRentals)[Perryville Car Rentals](https://expedia.ca/Car-Rentals-In-Perryville.d6134448.Car-Rental-Guide)[Perryville Vacation Packages](https://expedia.ca/Perryville.d6134448.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Family Hotels in Perryville, MO ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Perryville Family Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) ## Top Perryville Family Hotels ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.4/10 Exceptional (520) "Rooms were clean and everyone was really nice. Only thing I would say is that for the breakfast, the bacon wasn't quite all the way done other than that, a good experience." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) TEVIS CA $156 CA $178 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars)](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (636) "We had a restful stay very safe & clean! Friendly staff:)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel CA $118 CA $128 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/f0e5a143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/b6dd70b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/f803d387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG Murphysboro 9.4/10 Exceptional (490) "great property, great breakfast, friendly and knowledgable staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $146 CA $162 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/70460e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/bb7f277a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/a758bb0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/06dc4487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Jackson-Cape Girardeau Jackson 8.2/10 Very good (736) "Great area, fast check in, quiet, very spacious" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeanne CA $125 CA $135 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/193ecf29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/e2d9442e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/36b0a800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/df1ce01d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful location in the secluded woods Pomona 10/10 Exceptional (52) "Great privacy quiet location great communication" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary P. CA $139 CA $251 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/9f1b48ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/6b5538e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/5aaf2aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/w1170h1560x0y486-717b3c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Doves Nest Guest House
Tranquil & Relaxing Ste. Genevieve 9.8/10 Exceptional (49) "Outstanding! I highly recommend to everyone! So well decorated with every amenity! Great location and easy walk to restaurants and activities and shopping! Great hosts!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shari CA $140 CA $273 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Ste-Genevieve-Hotels-Doves-Nest-Guest-Housebr-Tranquil-Relaxing.h67135817.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/0cb5c163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/w1024h570x0y57-17016e83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/w1024h570x0y56-1ec5791d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/w1024h570x0y57-36b84305.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Your home away from home in downtown, historic Farmington! Farmington 10/10 Exceptional (33) "Great place to rest a recoup for weekend activities " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matt B. CA $163 CA $296 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Farmington-Hotels-Your-Home-Away-From-Home-In-Downtown.h100465272.Hotel-Information) ![Children's area](https://images.trvl-media.com/lodging/107000000/106170000/106166200/106166154/b4c6240f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/107000000/106170000/106166200/106166154/3c0c8aa3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106170000/106166200/106166154/4cccef11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, books](https://images.trvl-media.com/lodging/107000000/106170000/106166200/106166154/36384156.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Newly remodeled house minutes away from downtown, golf courses + BIG back yard Farmington 9.8/10 Exceptional (20) "This property worked well for our needs. Very convenient location to gas, food and golf course. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jill B. CA $184 CA $351 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Farmington-Hotels-Newly-Remodeled-House-Close-To-Downtown-And-Minutes-Away-From-Golf-Courses.h106166154.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/81000000/80620000/80618800/80618764/df12927d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/81000000/80620000/80618800/80618764/w1242h925x0y7-7980e614.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/81000000/80620000/80618800/80618764/c131a029.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/81000000/80620000/80618800/80618764/w1242h799x0y0-199e0666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dewey Cottage - Central to All of SEMO Adventures Farmington 9.6/10 Exceptional (20) "Comfortable house which our family appreciated, especially the neighborhood, the charming rooms and decor. The yard is lovely and appealing, too." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catherine R. CA $189 CA $314 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Farmington-Hotels-Dewey-Cottage-Central-To-All-Of-SEMO-Adventures.h80618764.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/331aa35f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/2383f778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/47ed6dc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/0de8e5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Sparta by IHG Sparta 9.2/10 Wonderful (354) "Highly recommend this hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia CA $167 CA $185 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Chester-Hotels-Holiday-Inn-Express-Hotel-Suites-Sparta.h1691121.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-02&endDate=2025-11-03®ionId=6134448&adults=2&travelerType=family_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Perryville Hotel Reviews ## Frequently asked questions ### What's Perryville like for family-friendly vacations? > If you've been thinking about a vacation with your kids, Perryville is a good choice. The excursions, parks, and swimming spots are just some of the things that make this a good place for family vacations. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 38.3 mi (61.7 km) from the city center. ### When's the best time to book a family-friendly vacation in Perryville? > The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 39°F. Average annual precipitation for Perryville is 48 inches. ### What's there to see and do with your family in Perryville? > While you and the family are vacationing in Perryville, you might want to check out some of the attractions here such as Popeye Museum, Mark Twain National Forest, and Mississippi River. 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