Southeast Iowa Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

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  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

Your Southeast Iowa Vacation

Enjoy the flexibility to travel wherever your wanderlust takes you when you book a Southeast Iowa vacation package. From its rich history to a whole lot more, you can experience it all at your own speed. A carefully planned itinerary is a must for your trip to Southeast Iowa. Burlington, Mount Pleasant and Keokuk are a few of the most well-known cities here. Whether you're travelling for a few days or a few weeks, Expedia are here to help you organize your next dream Southeast Iowa vacation.

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Southeast Iowa Hotel Deals

Comfort Suites Burlington

Comfort Suites Burlington

1780 Stonegate Center Dr Burlington IA
Fully refundable
CA $150
CA $176 total
Nov 1 - Nov 2
includes taxes & fees
Comfort Suites Burlington
Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn

810 N Grand Avenue Mount Pleasant IA
Fully refundableReserve now, pay when you stay
CA $111
CA $124 total
Oct 18 - Oct 19
includes taxes & fees
8.2/10 Very good! (898 reviews)
"Room had bugs crawling on furniture. Got our room reservation wrong and refused to accommodate to the correct booking. Would not recommend staying here."

Reviewed on Oct 10, 2026

Best Western Mt. Pleasant Inn
Cobblestone Inn & Suites - Fort Madison

Cobblestone Inn & Suites - Fort Madison

4901 Avenue O Fort Madison IA
Fully refundableReserve now, pay when you stay
CA $135
CA $152 total
Oct 20 - Oct 21
includes taxes & fees
Cobblestone Inn & Suites - Fort Madison
See all 226 properties in Southeast Iowa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations

Stay near popular Southeast Iowa attractions

Joseph Smith Historic Site

9.2/10 (162 reviews)
You can learn about the history of Nauvoo when you stop by Joseph Smith Historic Site. While you're in the area, stroll along the riverfront.
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Historic Nauvoo

9.6/10 (269 reviews)
Find out about the history of Nauvoo when you spend time at Historic Nauvoo. While you're in the area, stroll along the riverfront.
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Lacey-Keosauqua State Park

8.6/10 (15 reviews)
Commune with nature and explore the great outdoors at Lacey-Keosauqua State Park during your travels in Keosauqua. Wander the parks and lakeside while you're in the area.
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Snake Alley

8.6/10 (172 reviews)
Learn about the local history of Burlington when you take a trip to Snake Alley. Visit the area's casinos, or simply enjoy its bars.
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Lake Sugema

7.0/10 (2 reviews)
Commune with nature and explore the great outdoors at Lake Sugema during your travels in Keosauqua. Wander the parks and lakeside while you're in the area.
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North Lee County Historical Society

7.6/10 (17 reviews)
You can browse the exhibits at North Lee County Historical Society, a museum with a storied past, during your travels to Fort Madison. While you're in the area, stroll along the riverfront.
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Lock and Dam No. 19

8.8/10 (52 reviews)
Learn about the local history of Keokuk with a stop at Lock and Dam No. 19. Wander the riverfront in this family-friendly area.
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Spirit Hollow Golf Club

7.2/10 (29 reviews)
Enjoy a round of golf in Burlington at Spirit Hollow Golf Club. Visit the area's casinos, or simply enjoy its bars.
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Frequently asked questions

How much does a Southeast Iowa vacation package cost?
From as little as , you can customize your Southeast Iowa package. Simply bundle hotels, flights and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Southeast Iowa?
Book everything in the one place with our Southeast Iowa vacation packages. We have deals on flights, hotels and more that'll keep your bank account happy and your adventurous side busy. And, with more than 550 airlines and 1,000,000 hotels around the globe to pick from, there are endless opportunities to mix and match as you want.
What are the top hotels in Southeast Iowa?
For properties in Nauvoo with cozy beds and friendly service, you can't top Congress Plaza Hotel and LondonHouse Chicago, Curio Collection by Hilton. If you're stopping by Burlington as well, you'll get a solid night's sleep at The Catfish Bend Inn & Spa or Super 8 by Wyndham Burlington.
How far in advance should I book my Southeast Iowa vacation?
Smart travelers often book as early as possible. You can generally browse through international airfares on Expedia up to a year before your intended flight. If you're booking last minute, there's no need to worry. Low prices occasionally occur just weeks before departure dates.
What does an Expedia Southeast Iowa travel package include?
Flights, hotels and rental cars, or any combination of them — it's your choice. Whether you're venturing to Southeast Iowa with the whole family or traveling with your friends, there's a package to suit every style and budget. Once you've made your booking, why not add on a few tours or activities?
What should I know before booking a Southeast Iowa travel package?
You'll pick up great savings when you bundle your hotels, flights and rental cars into a travel package. Plus, booking everything in one spot makes trip planning much easier. So why waste time or money? Whether you're organizing a luxury romantic escape or a budget solo adventure, explore our package deals today.
Can I choose my airline with a Southeast Iowa Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you've got lots of choice. Look through the available options and find out which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Iowa vacation package?
Because we understand life is full of surprises, the answer is yes. For further details, check out our Customer Service Portal. But generally speaking, if you've booked your Southeast Iowa vacation package in the last 24 hours, you may be able to change or cancel it for free. Your hotel, airline or car rental company may impose a fee if your booking is older than that.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.