A paved courtyard with a brick pathway, trees, and a distant view of a road and buildings.

Southeast Iowa Vacation Rentals

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Our top choices for Southeast Iowa vacation rentals

Relax on the River and Enjoy Southeast Iowa's Beauty

Relax on the River and Enjoy Southeast Iowa's Beauty
Keosauqua
9.8 out of 10, Exceptional, (177 reviews)
"Hosts were very accommodating!"
United States
Judy S.
The price is CA $163
CA $253 total
includes taxes & fees
Jul 16 - Jul 17
Relax on the River and Enjoy Southeast Iowa's Beauty

Riverfront Cabin With Small Beach Short Drive From Nauvoo

Riverfront Cabin With Small Beach Short Drive From Nauvoo
Niota
8.4 out of 10, Very good, (51 reviews)
"Loved our stay, second time. Will be back "
United States
Leighanne W.
The price is CA $89
CA $162 total
includes taxes & fees
Jul 19 - Jul 20
Riverfront Cabin With Small Beach Short Drive From Nauvoo

Mississippi Muse, Modern & Chic 1BR Near Downtown, Quick Walk to Bakery & Pizza

Mississippi Muse, Modern & Chic 1BR Near Downtown, Quick Walk to Bakery & Pizza
Burlington
10.0 out of 10, Exceptional, (3 reviews)
"Amazing place with a phenomenal host! Very attentive to the small details and making you feel welcome and at home!"
United States
David B.
The price is CA $128
CA $372 total
includes taxes & fees
Jun 28 - Jun 29
Mississippi Muse, Modern & Chic 1BR Near Downtown, Quick Walk to Bakery & Pizza

"THE SHOP" retro 60's

"THE SHOP" retro 60's
Keosauqua
10.0 out of 10, Exceptional, (57 reviews)
The price is CA $135
CA $230 total
includes taxes & fees
Jul 8 - Jul 9
"THE SHOP" retro 60's

Charming One Bedroom home in Keosauqua near shops

Charming One Bedroom home in Keosauqua near shops
Keosauqua
9.0 out of 10, Wonderful, (12 reviews)
"Quiet, clean and comfortable. Nicely appointed. We saw a deer and a turkey when we stepped out of the house Sunday morning. Good communications. "
United States
Melinda L.
The price is CA $118
CA $227 total
includes taxes & fees
Jun 29 - Jun 30
Charming One Bedroom home in Keosauqua near shops

Mulholland Garden Apartment

Mulholland Garden Apartment
Nauvoo
9.2 out of 10, Wonderful, (43 reviews)
"The apartment was clean and spacious, very comfortable. The kitchen was well stocked. The host is welcoming and very helpful. "
United States
nancy
The price is CA $118
CA $155 total
includes taxes & fees
Jul 9 - Jul 10
Mulholland Garden Apartment

Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo

Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
Nauvoo
9.8 out of 10, Exceptional, (22 reviews)
"Convenient location, roomy, quiet."
United States
Jamie
The price is CA $184
CA $327 total
includes taxes & fees
Jun 29 - Jun 30
Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo

Stay in this Unique SE Iowa Apt

Stay in this Unique SE Iowa Apt
Fort Madison
10.0 out of 10, Exceptional, (16 reviews)
"Would definately stay here agan."
United States
Christina
The price is CA $83
CA $204 total
includes taxes & fees
Jul 8 - Jul 9
Stay in this Unique SE Iowa Apt

Nauvoo Country Cottage - Sleeps 12

Nauvoo Country Cottage - Sleeps 12
Niota
9.6 out of 10, Exceptional, (90 reviews)
"Very accommodating and nice stay. "
United States
Josh B.
The price is CA $284
CA $445 total
includes taxes & fees
Jun 27 - Jun 28
Nauvoo Country Cottage - Sleeps 12

Private Woodsy Cabin close to River and Keosauqua

Private Woodsy Cabin close to River and Keosauqua
Keosauqua
9.8 out of 10, Exceptional, (19 reviews)
The price is CA $172
CA $292 total
includes taxes & fees
Jun 28 - Jun 29
Private Woodsy Cabin close to River and Keosauqua

5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs

5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs
Nauvoo
9.6 out of 10, Exceptional, (25 reviews)
"Clean, close to shopping and sites. Owner was easy to work with."
United States
Lyndsay M.
The price is CA $227
CA $408 total
includes taxes & fees
Jun 27 - Jun 28
5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs

View Nauvoo and the Mighty Mississippi/Sidon

View Nauvoo and the Mighty Mississippi/Sidon
Nauvoo
9.6 out of 10, Exceptional, (42 reviews)
"Most beautiful view of the Mississippi! Home is very spacious and had everything we needed. Great location 5 minutes from Nauvoo. Very peaceful. Would definitely stay again. "
United States
Trent N.
The price is CA $206
CA $507 total
includes taxes & fees
Jul 2 - Jul 3
View Nauvoo and the Mighty Mississippi/Sidon

Nauvoo Windmill Farmhouse 10-12 people

Nauvoo Windmill Farmhouse 10-12 people
Niota
10.0 out of 10, Exceptional, (14 reviews)
"Great stay very peaceful "
United States
larry r.
The price is CA $419
CA $611 total
includes taxes & fees
Jul 12 - Jul 13
Nauvoo Windmill Farmhouse 10-12 people

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets
Nauvoo
9.0 out of 10, Wonderful, (4 reviews)
"Can’t say enough about the stunning view of the Mississippi River from every part of the home! The home was extremely comfortable for the two of us. We really enjoyed our stay!"
United States
Debbie L.
The price is CA $204
CA $466 total
includes taxes & fees
Jun 28 - Jun 29
PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

Hayfield Cabin

Hayfield Cabin
Niota
6.0 out of 10, (4 reviews)
"It looked like someone was living there. And saw someone lurking around the outside of the cabin. "
United States
Anthony P.
The price is CA $104
CA $185 total
includes taxes & fees
Jul 21 - Jul 22
Hayfield Cabin

Fairy Bowery

Fairy Bowery
Nauvoo
8.4 out of 10, Very good, (61 reviews)
"Great price for the area. "
United States
Brian
The price is CA $133
CA $171 total
includes taxes & fees
Jul 10 - Jul 11
Fairy Bowery

The Emerald Loft - Spa Shower Suite + King Bed Near Downtown, Steps from Bakery

The Emerald Loft - Spa Shower Suite + King Bed Near Downtown, Steps from Bakery
Burlington
10.0 out of 10, Exceptional, (2 reviews)
"Very nice and quiet. It wouldn’t be possible to find a nicer place to stay."
United States
Daniel O.
The price is CA $163
CA $453 total
includes taxes & fees
Jul 13 - Jul 14
The Emerald Loft - Spa Shower Suite + King Bed Near Downtown, Steps from Bakery

Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N

Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N
Burlington
10.0 out of 10, Exceptional, (20 reviews)
"We adore this place. It was our second stay and it was just as great as our first. The location is hard to beat, right downtown next to shops, the famous Snake Alley, and close to the river. Our host was very helpful and accommodating. We look forward to staying again."
United States
Steve Troester S.
The price is CA $180
CA $455 total
includes taxes & fees
Jun 28 - Jun 29
Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N

Walk to Nauvoo Temple: Remodeled Family Apartment

Walk to Nauvoo Temple: Remodeled Family Apartment
3.0 star property
Nauvoo
6.0 out of 10, (1 review)
"The apartment was fine and clean. The location was great. The beds were very uncomfortable"
United States
Bruce
The price is CA $521
CA $873 total
includes taxes & fees
Jun 29 - Jun 30
Walk to Nauvoo Temple: Remodeled Family Apartment

Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.

Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.
Nauvoo
10.0 out of 10, Exceptional, (6 reviews)
"We stayed here to be in good proximity to the church history sites. This place was convenient to everything. I would stay here again. "
United States
Sheilla P.
The price is CA $192
CA $307 total
includes taxes & fees
Jun 27 - Jun 28
Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Iowa Hotel Reviews

Find out more about Southeast Iowa

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Southeast Iowa. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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