Southeast Iowa Vacation Rentals from CA $74: Short-Term Rentals for 2026

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Our top choices for Southeast Iowa vacation rentals

A row of single-family homes with a well-maintained lawn and a tree in the foreground.

1. Nauvoo Vacation Villas & Condos

Nauvoo

Renae

CA $188 total

includes taxes & fees

Dec 11 - Dec 12

A living room with a grey sofa, a wooden coffee table, and a black metal shelf.

2. Stay in this Unique SE Iowa Apt

Fort Madison

Nicholas H.

CA $203 total

includes taxes & fees

Nov 20 - Nov 21

A room with a table and two chairs, a window with a view of a lake and greenery.

3. Riverfront Cabin With Small Beach Short Drive From Nauvoo

Niota

Anonymous traveller

CA $142 total

includes taxes & fees

Nov 16 - Nov 17

A stacked washer and dryer unit in a corner of a room with beige walls and a wooden floor.

4. The Red Front Suite - Sleeps 15

Nauvoo

Diane P.

CA $207 total

includes taxes & fees

Nov 16 - Nov 17

A dining area with a rectangular table surrounded by wooden chairs, a gray sofa, and a patterned rug.

5. Fairy Bowery

Nauvoo

Brian

CA $182 total

includes taxes & fees

Nov 22 - Nov 23

A white door with a small window and the text "Mulholland Garden" on it.

6. Mulholland Garden Apartment

Nauvoo

Adam

CA $183 total

includes taxes & fees

Nov 16 - Nov 17

7. Historic Nauvoo Apartment, family friendly.

Nauvoo

Derek H.

CA $183 total

includes taxes & fees

Nov 19 - Nov 20

A dining area with a wooden table and benches, white paneled walls, and a ceiling fan.

8. Nauvoo Country Cottage - Sleeps 12

Niota

Lisa G.

CA $205 total

includes taxes & fees

Nov 19 - Nov 20

A small building with a red roof, surrounded by dense greenery and trees.

9. Hayfield Cabin

Niota

charles

CA $165 total

includes taxes & fees

Nov 17 - Nov 18

A deck overlooking a body of water with a sunset in the background.

10. View Nauvoo and the Mighty Mississippi/Sidon

Nauvoo

Chris P.

CA $422 total

includes taxes & fees

Nov 16 - Nov 17

A modern living room with a grey sofa, a glass coffee table, and a dining area with a table and chairs.

11. "THE SHOP" retro 60's

Keosauqua

Kay H.

CA $225 total

includes taxes & fees

Nov 23 - Nov 24

A covered outdoor seating area with a wooden deck, a sofa, and a table.

12. Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill

Burlington

David B.

CA $327 total

includes taxes & fees

Dec 1 - Dec 2

A living room with a sofa, a rug, a fireplace, and a kitchen in the background.

13. Walking Distance to Temple and Downtown Nauvoo! Family Size Apt. W/ Full Kitchen

Nauvoo

Sheri J.

CA $256 total

includes taxes & fees

Dec 8 - Dec 9

A modern, single-story wooden cabin with a sloped roof and large windows, surrounded by a wooden deck and a fenced yard.

14. Relax on the River and Enjoy Southeast Iowa's Beauty

Keosauqua

Linda B.

CA $240 total

includes taxes & fees

Dec 10 - Dec 11

A single-story house with a stone facade, a gabled roof, and a front porch.

15. Charming One Bedroom home in Keosauqua near shops

Keosauqua

Donna P.

CA $228 total

includes taxes & fees

Dec 3 - Dec 4

A living room with a sectional sofa, a round coffee table, a lamp, a clock, and a view of the outdoors through a window.

16. Nauvoo Windmill Farmhouse 10-12 people

Niota

Mindy J.

CA $284 total

includes taxes & fees

Nov 12 - Nov 13

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a dishwasher.

17. 5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs

Nauvoo

Melissa E.

CA $322 total

includes taxes & fees

Nov 11 - Nov 12

A deck with a grill and chairs, a covered area with an umbrella, and a compass on the building.

18. Private Woodsy Cabin close to River and Keosauqua

Keosauqua

Julie

CA $271 total

includes taxes & fees

Nov 23 - Nov 24

A modern kitchen with a central island, bar stools, and a large window offering a view of the outdoors.

19. Brand New Spacious 2 BR Downtown Burlington! Unit 301S

Burlington

Roxane K.

CA $462 total

includes taxes & fees

Nov 17 - Nov 18

A rustic brick interior with a fireplace, a wooden stool, and a checkered rug.

20. Experience Beautiful Pioneer Home In Nauvoo!

Nauvoo

Darin B.

CA $512 total

includes taxes & fees

Nov 19 - Nov 20

View all properties

Find vacation rentals that suit your style

Top Southeast Iowa Hotel Reviews

A bedroom with a bed, a wooden headboard, a nightstand, a lamp, a rug, and a door.

Willard Richards Inn

Nauvoo

10/10 Excellent

James K

A large, two-story house with a porch, surrounded by lush green lawns and trees.

Evans Holly Grove Inn B&B

Burlington

10/10 Excellent

Al

A room with a large window, a sofa, and a chair.

Nauvoo Temple House Hotel

Nauvoo

10/10 Excellent

Talauna

An indoor swimming pool with a wooden ceiling and walls, a bench, and a rack of towels.

The Inn at Old Nauvoo

Nauvoo

10/10 Excellent

Raj

A spacious living area with a wooden staircase, a stone fireplace, and a reception desk.

Quality Inn & Suites Fort Madison near Hwy 61

Fort Madison

10/10 Excellent

Manuel

A spacious living room with a large sofa, two armchairs, a coffee table, and a fireplace.

AmericInn by Wyndham Mount Pleasant

Mount Pleasant

10/10 Excellent

Carlotta St

An indoor swimming pool with a wooden ceiling, grey tiled floor, and several lounge chairs and tables around the pool area.

Quality Inn & Suites Keokuk North

Keokuk

10/10 Excellent

Ronald Barry

A lobby with a fireplace, seating area, and an exit sign.

Comfort Suites Burlington

Burlington

10/10 Excellent

daniel

A modern lounge area with a stone fireplace, a blue sofa, and a small table.

Fairfield Inn & Suites by Marriott Burlington

Burlington

8/10 Good

Dianne

Find out more about Southeast Iowa

Everything you need to know about Southeast Iowa vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Iowa vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Iowa vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southeast Iowa vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Iowa. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Iowa vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southeast Iowa vacation rentals we have selected for you start as low as CA $74 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Southeast Iowa rentals

At Expedia, we put the best Southeast Iowa vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southeast Iowa rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Iowa vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Iowa. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Southeast Iowa Vacation Rentals

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Iowa vacation rentals

1. Nauvoo Vacation Villas & Condos

2. Stay in this Unique SE Iowa Apt

3. Riverfront Cabin With Small Beach Short Drive From Nauvoo

4. The Red Front Suite - Sleeps 15

5. Fairy Bowery

6. Mulholland Garden Apartment

7. Historic Nauvoo Apartment, family friendly.

8. Nauvoo Country Cottage - Sleeps 12

9. Hayfield Cabin

10. View Nauvoo and the Mighty Mississippi/Sidon

11. "THE SHOP" retro 60's

12. Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill

13. Walking Distance to Temple and Downtown Nauvoo! Family Size Apt. W/ Full Kitchen

14. Relax on the River and Enjoy Southeast Iowa's Beauty

15. Charming One Bedroom home in Keosauqua near shops

16. Nauvoo Windmill Farmhouse 10-12 people

17. 5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs

18. Private Woodsy Cabin close to River and Keosauqua

19. Brand New Spacious 2 BR Downtown Burlington! Unit 301S

20. Experience Beautiful Pioneer Home In Nauvoo!

Find vacation rentals that suit your style

Top Southeast Iowa Hotel Reviews

Willard Richards Inn

10/10 Excellent

Find out more about Southeast Iowa

Southeast Iowa vacation rentals: An excellent choice for every season

How to find incredible deals on Southeast Iowa rentals

Explore a world of travel with Expedia