Photo by Michele Butts

La Mesa Vacation Rentals

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Vacation Rentals in La Mesa

Our top choices for La Mesa vacation rentals

Little Italy Inn - Limited Service Apart Hotel

2.5 star property
7.8 out of 10, Good, (63)
"It was really quiet and just what we needed. The bed was very comfortable "
The price is CA $145
CA $165 total
includes taxes & fees
Sep 9 - Sep 10
Little Italy Inn - Limited Service Apart Hotel

Kasa Little Italy San Diego

4.5 star property
9.6 out of 10, Exceptional, (302)
"Clean room | nice staff | small but beautiful outdoor pool | all amenities were amazing and above and beyond expectations to the place."
The price is CA $171
CA $317 total
includes taxes & fees
Sep 15 - Sep 16
Kasa Little Italy San Diego

Uptown Inn by Vantaggio - Limited Service Apart-Hotel

2.5 star property
8.2 out of 10, Very good, (218)
"Great place to stay real close to airport and convention center. I would stay here again "
The price is CA $115
CA $130 total
includes taxes & fees
Oct 8 - Oct 9
Uptown Inn by Vantaggio - Limited Service Apart-Hotel

City24 Hotel Little Italy Mission Hills

4.5 star property
9.6 out of 10, Exceptional, (87)
"Great place to stay with my family of 9!!!"
The price is CA $175
CA $245 total
includes taxes & fees
Oct 6 - Oct 7
City24 Hotel Little Italy Mission Hills

Coronado Beach Resort

3.0 star property
9.0 out of 10, Wonderful, (726)
"Great spot by the beach"
The price is CA $321
CA $353 total
includes taxes & fees
Sep 16 - Sep 17
Coronado Beach Resort

Kasa Gaslamp Quarter San Diego

3.5 star property
8.0 out of 10, Very good, (130)
"Best place ive stay in gaslamp ,conviency wise "
The price is CA $131
CA $149 total
includes taxes & fees
Sep 30 - Oct 1
Kasa Gaslamp Quarter San Diego

"Entire" Luxury Beach Home Steps from Mission Beach with Hot Tub -Not a Condo!

9.6 out of 10, Exceptional, (197)
"Great spot! Perfect for a friends and family beach getaway :-)"
"Entire" Luxury Beach Home Steps from Mission Beach with Hot Tub -Not a Condo!

Breathtaking Oceanfront Pacific Beach Home

10.0 out of 10, Exceptional, (175)
"Another great stay. The place and the team check all the boxes! "
Breathtaking Oceanfront Pacific Beach Home

Spanish Style 3 Story House, Best Location in SD. Views of North Park, W/ AC.

5.4 out of 10, (3)
"This tri-level home was just right for our family of five. It was clean, the beds were very comfortable and we got to park in the garage. The neighborhood was quiet and the location was within 20 minutes of all our activities for the week. Our host was easy to work with. Definitely recommend :)"
The price is CA $377
CA $672 total
includes taxes & fees
Sep 16 - Sep 17
Spanish Style 3 Story House, Best Location in SD. Views of North Park, W/ AC.

East Village Apartments by Landing

2.5 star property
East Village Apartments by Landing

Heated pool, hot tub & waterslides near the beach!

9.8 out of 10, Exceptional, (200)
"In town for our son’s graduation from Marine Corp boot camp.The house was amazing and the host went out of her way to accommodate.Couldn’t be happier with our visit"
Heated pool, hot tub & waterslides near the beach!

Capri Beach Accommodations

3.5 star property
9.2 out of 10, Wonderful, (99)
"Beautiful place, unforgettable view and sunsets, beach in front of the building."
Capri Beach Accommodations

Luxury Gated Mission Bay Estate with Resort Style Pool!

9.2 out of 10, Wonderful, (244)
"Ari was an excellent host, very communicative and generous. We truly enjoyed our stay! "
Luxury Gated Mission Bay Estate with Resort Style Pool!

FLASH SALE!* FIRST CLASS  ACCOMMODATIONS AT COACH CLASS RATES! CLICK FOR DETAILS

10.0 out of 10, Exceptional, (235)
"Was an awesome spot for our family trip. Clean, only a few houses away from the beach, amply stocked and a very relaxing home. Would love to stay here on a future trip. "
FLASH SALE!* FIRST CLASS  ACCOMMODATIONS AT COACH CLASS RATES! CLICK FOR DETAILS

2 Day Mid-Week Specials/August/Sept/Pool/Views/Corporate Retreats

9.4 out of 10, Exceptional, (23)
"The view and location is 5 star plus. The bedrooms are fine and a bit run down and 3 star. Agent was great and the kitchen is well equipped. Overall a great rental for large groups. "
2 Day Mid-Week Specials/August/Sept/Pool/Views/Corporate Retreats

Heavily Discounted & Thoroughly Clean @ the Beach

9.0 out of 10, Wonderful, (86)
"Clean and comfortable home. Would definitely stay again!!"
Heavily Discounted & Thoroughly Clean @ the Beach

Mermaid Crossing: 9th fl oceanfront+pool+parking!

10.0 out of 10, Exceptional, (81)
"We spent 4 nights there. The location was perfect.The view of the ocean from our room was beautiful.We took advantage of the beach access every day.Also took in some activities in and around San Diego Bay.The room was just as advertised. Very happy with our time there."
Mermaid Crossing: 9th fl oceanfront+pool+parking!

Family Fun! Mission Bay view! 4bed/3 bath home

9.6 out of 10, Exceptional, (268)
"Very comfortable for children, parents and grandparents. Convenient location. Thoughtful and responsive owner."
Family Fun! Mission Bay view! 4bed/3 bath home

Inn at the Park by WorldMark

2.0 star property
Inn at the Park by WorldMark

Beachcomber Bliss Sleeps 4 Free Parking 2BLKS to Ocean

7.2 out of 10, Good, (18)
"Clean comfy beds. Close walk to beach and stores"
The price is CA $156
CA $328 total
includes taxes & fees
Sep 11 - Sep 12
Beachcomber Bliss Sleeps 4 Free Parking 2BLKS to Ocean
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top La Mesa Hotel Reviews

Find out more about La Mesa

Find out more about La Mesa

Everything you need to know about La Mesa vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the La Mesa vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect La Mesa vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

La Mesa vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in La Mesa. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A La Mesa vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of La Mesa vacation rentals we have selected for you start as low as CA $115 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on La Mesa rentals

At Expedia, we put the best La Mesa vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top La Mesa rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream La Mesa vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around La Mesa. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near Computer Museum of America, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best vacation rentals that La Mesa has to offer?

"Entire" Luxury Beach Home Steps from Mission Beach with Hot Tub -Not a Condo!: Visitors like this La Mesa vacation home rental. It is located on the beach and has a balcony, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a hot tub.

How many vacation rentals are there in La Mesa?

With 116 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit a family-friendly sight such as San Diego Zoo. While in the area, you can also visit popular places like Mission Bay and Petco Park.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.