Title: La Mesa Vacation Rentals from CA $141: Short-Term Rentals for 2026 | Expedia.ca [Hotels in La Mesa](https://expedia.ca/La-Mesa-Hotels.d8484.Travel-Guide-Hotels)[Flights to La Mesa](https://expedia.ca/Cheap-Flights-To-La-Mesa.d8484.Travel-Guide-Flights)[La Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesa.d8484.Car-Rental-Guide)[La Mesa Vacation Packages](https://expedia.ca/La-Mesa.d8484.Destination-Travel-Guides) ![View from Mount Helix, in La Mesa, near San Diego, California](https://images.trvl-media.com/place/8484/0fa3bc38-9bbb-4533-9232-a1a6e7720bc2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/8484/0fa3bc38-9bbb-4533-9232-a1a6e7720bc2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2026-02-13&endDate=2026-02-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2026-03-27&endDate=2026-03-29&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Apr 24 - Apr 26](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [May 22 - May 24](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for La Mesa vacation rentals ![Outdoor dining](https://images.trvl-media.com/lodging/69000000/68870000/68864800/68864775/d11be534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/69000000/68870000/68864800/68864775/8f91d728.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/69000000/68870000/68864800/68864775/7ebe9d8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/69000000/68870000/68864800/68864775/1271c2f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3 Bedroom House - Fire Pit Table, BBQ - 10 Guests [](https://www.expedia.ca/La-Mesa-Hotels-3-Bedroom-House-Fire-Pit-Table.h68864775.Hotel-Information) La Mesa 9.2/10 Wonderful (15 reviews) "We had a great time staying at the Fountain House. Everything was clean and comfortable. The neighborhood was quiet and located ideally for the various places we went while in La Mesa/SD area. The decor was very welcoming and up to date. We loved having our coffee in the front yard, which was refreshing with lots of shade. All details for our stay were clear, and all the things we needed were available (ice, glass ware, cooking utensils etc). We have zero complaints :) Thank you for hosting us." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chanel M. [](https://www.expedia.ca/La-Mesa-Hotels-3-Bedroom-House-Fire-Pit-Table.h68864775.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/124000000/123270000/123265200/123265181/3f30927d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/124000000/123270000/123265200/123265181/ae727f64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/124000000/123270000/123265200/123265181/c540c1b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123270000/123265200/123265181/c54c9ca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Mesa New 3BR Oasis with Pool and Games! [](https://www.expedia.ca/La-Mesa-Hotels-La-Mesa-New-3BR-Oasis-With-Pool-And-Games.h123265181.Hotel-Information) Mount Helix 10/10 Exceptional (1 review) "Yes, Excellent workspace." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stanley H. CA $201 CA $694 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-La-Mesa-New-3BR-Oasis-With-Pool-And-Games.h123265181.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125500000/125497000/125496913/0718bfdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/126000000/125500000/125497000/125496913/b9427f3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/126000000/125500000/125497000/125496913/18925ee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/126000000/125500000/125497000/125496913/5167be29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Modern cozy studio, driveway, and fenced bamboo patio. [](https://www.expedia.ca/La-Mesa-Hotels-Modern-Cozy-Studio.h125496913.Hotel-Information) La Mesa CA $103 CA $196 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-Modern-Cozy-Studio.h125496913.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/109000000/108780000/108777000/108776954/90a8461d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/109000000/108780000/108777000/108776954/1fe8182b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/109000000/108780000/108777000/108776954/1815436d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108780000/108777000/108776954/d3a64ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sunnyside Resort Spa, Beach, Zoo, Arcade [](https://www.expedia.ca/La-Mesa-Hotels-3-Bed2b-Sunnyside-Villa-Sauna.h108776954.Hotel-Information) La Mesa 9.6/10 Exceptional (17 reviews) "The house was very clean and located in a family-friendly neighborhood. Very nice stay.thank you!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jenna A. [](https://www.expedia.ca/La-Mesa-Hotels-3-Bed2b-Sunnyside-Villa-Sauna.h108776954.Hotel-Information) ![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121820000/121817600/121817509/52aafcdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121820000/121817600/121817509/c5c93f61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/122000000/121820000/121817600/121817509/0a0550a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/122000000/121820000/121817600/121817509/85cb7ac5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden [](https://www.expedia.ca/La-Mesa-Hotels-Mediterranean-Inspired-1BR-Guesthouse-Full-Kitchen.h121817509.Hotel-Information) Mount Helix CA $162 CA $417 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-Mediterranean-Inspired-1BR-Guesthouse-Full-Kitchen.h121817509.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/110000000/109720000/109718900/109718812/7f0c02f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, table tennis](https://images.trvl-media.com/lodging/110000000/109720000/109718900/109718812/dca5b67c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/110000000/109720000/109718900/109718812/9062ac6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109720000/109718900/109718812/ef0e899c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access [](https://www.expedia.ca/La-Mesa-Hotels-SDSUDowntown-10-Min-GameRoom-Fire-Pit-Free-Parking-Easy-Freeway-Access.h109718812.Hotel-Information) La Mesa 8.6/10 Excellent (7 reviews) "We stayed at this beautiful VRBO for our child’s college graduation in San Diego, and it couldn’t have been more perfect. The home was spotless, spacious, and exactly as described—if not better! Every room was thoughtfully appointed, and the beds were incredibly comfortable. The kitchen had everything we needed to cook family meals, and we loved gathering in the common areas to celebrate and relax.The location was ideal—close to the campus and shopping.Our host was responsive, welcoming, and... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michele G. CA $233 CA $546 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-SDSUDowntown-10-Min-GameRoom-Fire-Pit-Free-Parking-Easy-Freeway-Access.h109718812.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/106000000/105390000/105380700/105380638/db3a0fed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, oven, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/106000000/105390000/105380700/105380638/w4030h3024x0y0-ff0a1872.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/106000000/105390000/105380700/105380638/5e8ce6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/106000000/105390000/105380700/105380638/5efb1585_edited_2105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### An elegant, fully furnished guest house for 2-4 guest in San Diego [](https://www.expedia.ca/La-Mesa-Hotels-An-Elegant.h105380638.Hotel-Information) Mount Helix 9.0/10 Wonderful (2 reviews) "We love a simple no-nonsense place and this was perfect for us. The host is very responsive and was constantly checking in with us on what else we need to be comfortable to stay here. The area is close a lot of nice restaurants so that was a plus. We would love to stay here next time we visit San Diego." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darakhshan T. CA $194 CA $264 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-An-Elegant.h105380638.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/123000000/122950000/122947400/122947388/f7600228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/123000000/122950000/122947400/122947388/519d5bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/123000000/122950000/122947400/122947388/0582c090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, books, music library](https://images.trvl-media.com/lodging/123000000/122950000/122947400/122947388/6fc7575b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4BR/3Bth King Bed, Big Yard, Prime Area, Ranch [](https://www.expedia.ca/La-Mesa-Hotels-4BR3Bth-King-Bed.h122947388.Hotel-Information) La Mesa CA $150 CA $523 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-4BR3Bth-King-Bed.h122947388.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/125000000/124950000/124942400/124942352/d7147e4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, books, music library](https://images.trvl-media.com/lodging/125000000/124950000/124942400/124942352/b2614048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/125000000/124950000/124942400/124942352/d4e76651.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/125000000/124950000/124942400/124942352/0deacbde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 4BR/2BTH King Bed Ranch Style, Prime Area [](https://www.expedia.ca/La-Mesa-Hotels-Spacious-4BR2BTH-King-Bed-Ranch-Style.h124942352.Hotel-Information) La Mesa CA $162 CA $538 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-Spacious-4BR2BTH-King-Bed-Ranch-Style.h124942352.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/121000000/120770000/120768900/120768808/4ec2d8c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120770000/120768900/120768808/c891cade.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/121000000/120770000/120768900/120768808/c92597fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/121000000/120770000/120768900/120768808/207dc3c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxury 5BR Villa - Pool, Spa, Movie Theater, Game Room, Bar, & Outdoor Dining [](https://www.expedia.ca/La-Mesa-Hotels-Luxury-5BR-Villa-Pool.h120768808.Hotel-Information) Mount Helix CA $869 CA $2,652 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/La-Mesa-Hotels-Luxury-5BR-Villa-Pool.h120768808.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/38000000/37020000/37014000/37013939/6dd046c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/38000000/37020000/37014000/37013939/c75aad92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37020000/37014000/37013939/9ab8a533.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/38000000/37020000/37014000/37013939/596ef00a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stay in a Retro Camper | A Tiny Adventure Awaits [](https://www.expedia.ca/El-Cajon-Hotels-Flashback-Family-Fun-At-The-Retro-RV-Adventure-Glamp-In-Style-In-Bettie-Blue.h37013939.Hotel-Information) El Cajon 9.8/10 Exceptional (16 reviews) "We came down to Cali to get away from the Canadian cold and this little place was perfect for our family of three. Great location , cozy comfy Christmas for us :) " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Niki P. CA $116 CA $273 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/El-Cajon-Hotels-Flashback-Family-Fun-At-The-Retro-RV-Adventure-Glamp-In-Style-In-Bettie-Blue.h37013939.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/dd5fc603.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/b4a5f1e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/6521c599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/c76425ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sentral Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) Downtown San Diego 9.4/10 Exceptional (653 reviews) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) KELLY CA $161 CA $226 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/f051791c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/e8d02919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/b278e0ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Room, 1 Queen Bed (East - Freeway Facing)](https://images.trvl-media.com/lodging/105000000/104290000/104283900/104283827/61427440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Uptown Inn by Vantaggio - Limited Service Apart-Hotel [](https://www.expedia.ca/San-Diego-Hotels-Uptown-Inn.h104283827.Hotel-Information) Hillcrest 8.4/10 Very good (282 reviews) "The room was very small but very clean. Great place to stay for the short amount of time we needed it. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra CA $125 CA $141 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/San-Diego-Hotels-Uptown-Inn.h104283827.Hotel-Information) ![Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/6ef835b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/333bf268.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/aa1995cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/1b9a69bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City24 Hotel Little Italy Mission Hills [](https://www.expedia.ca/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) Middletown 9.6/10 Exceptional (113 reviews) "would definitely go back and stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kounwick CA $174 CA $242 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/84000000/83750000/83746100/83746027/90c57848.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/84000000/83750000/83746100/83746027/0b92d663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/84000000/83750000/83746100/83746027/87cc7eba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83750000/83746100/83746027/2c79ceb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego [](https://www.expedia.ca/San-Diego-Hotels-3bd-With-TV-And-AC.h83746027.Hotel-Information) Mount Hope 10/10 Exceptional (21 reviews) "Great stay, easy check in and check out. Clean and comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian M. CA $95 CA $381 total includes taxes & fees Feb 17 - Feb 18 [](https://www.expedia.ca/San-Diego-Hotels-3bd-With-TV-And-AC.h83746027.Hotel-Information) ![Deluxe Studio, 1 Queen Bed (Self Check-in with Virtual Front Desk)](https://images.trvl-media.com/lodging/16000000/15690000/15682000/15681965/834f95c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15690000/15682000/15681965/bc47b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite, 1 Queen Bed (Self Check-in with Virtual Front Desk) | Living area](https://images.trvl-media.com/lodging/16000000/15690000/15682000/15681965/f68e9f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/16000000/15690000/15682000/15681965/4bb2e41a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kasa Gaslamp Quarter San Diego [](https://www.expedia.ca/San-Diego-Hotels-Sonder-The-Marin.h15681965.Hotel-Information) Downtown San Diego 8.0/10 Very good (157 reviews) "Smelly building and elevator. Great location but super loud well into the night " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) alvaro [](https://www.expedia.ca/San-Diego-Hotels-Sonder-The-Marin.h15681965.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/115000000/114010000/114004400/114004343/a0b9715a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/115000000/114010000/114004400/114004343/25838722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/115000000/114010000/114004400/114004343/d1d79eba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/115000000/114010000/114004400/114004343/cb65148a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Suite In Charming,Historic OB Cottage-Yard/Patio-Blocks To Beaches/Shops [](https://www.expedia.ca/San-Diego-Hotels-Private-Suite-In-Charming.h114004343.Hotel-Information) Ocean Beach 9.6/10 Exceptional (4 reviews) "Lovely place in a lovely part of the world. Highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luke G. CA $104 CA $269 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/San-Diego-Hotels-Private-Suite-In-Charming.h114004343.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/104000000/103730000/103725100/103725013/51e419f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103725100/103725013/9165683b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103730000/103725100/103725013/7f1e98e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, stereo](https://images.trvl-media.com/lodging/104000000/103730000/103725100/103725013/01754d37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2BR House in Central San Diego, Right Next to SDSU, Free Parking [](https://www.expedia.ca/San-Diego-Hotels-2BR-House-In-Central-San-Diego.h103725013.Hotel-Information) Mid-City 9.8/10 Exceptional (11 reviews) "Our visit was short but really enjoyed our stay. Definitely will stay here again when traveling with family or friends. Place was clean and comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle M. CA $147 CA $446 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/San-Diego-Hotels-2BR-House-In-Central-San-Diego.h103725013.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/96000000/95840000/95830800/95830755/e308ed38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95840000/95830800/95830755/w508h683x258y0-4a62a1de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95840000/95830800/95830755/w508h683x259y0-12e4bc28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95840000/95830800/95830755/w508h683x258y0-4d2e56df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### George Gardens [](https://www.expedia.ca/Ramona-Hotels-George-Gardens.h95830755.Hotel-Information) Ramona 10/10 Exceptional (7 reviews) "Would stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David D. CA $129 CA $211 total includes taxes & fees Feb 28 - Mar 1 [](https://www.expedia.ca/Ramona-Hotels-George-Gardens.h95830755.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/102000000/101570000/101565500/101565470/05931e69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101570000/101565500/101565470/b7f103de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/102000000/101570000/101565500/101565470/f6ffcb38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/102000000/101570000/101565500/101565470/7ea36cbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Casita on Surf Ranch is centrally located. to all San Diego attractions [](https://www.expedia.ca/Lakeside-Hotels-The-Morey-De-Prieto-Surf-Ranch-Is-Centrally-Located-To-Everything-In-San-Diego.h101565470.Hotel-Information) Lakeside 9.8/10 Exceptional (6 reviews) "This place is so perfect. Stayed for my sons Wedding in Alpine. It has everything you need. The beds are grrat !" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robin S. CA $265 CA $508 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/Lakeside-Hotels-The-Morey-De-Prieto-Surf-Ranch-Is-Centrally-Located-To-Everything-In-San-Diego.h101565470.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-15&endDate=2026-02-16®ionId=8484&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Aparthotels [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=APART_HOTEL) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=VACATION_HOME) Apartments [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=APARTMENT) Villas [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=VILLA) Cottages [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=COTTAGE) Condos [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=CONDO) Cabins [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=CABIN) Houseboats [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+California%2C+United+States+of+America®ionId=8484&latLong=32.76783%2C-117.023086&adults=2&startDate=2026-05-02&d1=2026-05-02&endDate=2026-05-05&d2=2026-05-05&lodging=HOUSE_BOAT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Vacation-Rentals.d8484.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Vacation-Rentals.d8484.Travel-Guide-VacationRentals) ## Top La Mesa Hotel Reviews ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Room was clean and staff was outstanding." [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Everything excellent but expensive" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Was a comfortable Room. Shower tile looked pretty run down. But otherwise was a excellent place to stay before cruise." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "Always a good time" [](https://expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Location, view, staff. " [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Pendry San Diego](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Superb hotel. Well.positioned with very friendly staff " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Lafayette Hotel & Club](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3_y.jpg) ### Lafayette Hotel & Club 10/10 Excellent "Unique place to stay " [](https://expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Love this hotel. Best place to stay in San Diego " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ## Find out more about La Mesa You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded. As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with La Mesa. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do. ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca - All accommodation types in La Mesa ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals ](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals ](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals ](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals ](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals ](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - 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[Vacation Homes in La Mesa ](https://expedia.ca/La-Mesa-Private-Vacation-Homes.d8484-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Apartments in La Mesa ](https://expedia.ca/La-Mesa-Apartments.d8484-aaApartments.Travel-Guide-Accommodation) - [Condo Rentals in La Mesa ](https://expedia.ca/La-Mesa-Condos.d8484-aaCondos.Travel-Guide-Accommodation) - [Cottages in La Mesa ](https://expedia.ca/La-Mesa-Cottages.d8484-aaCottages.Travel-Guide-Accommodation) - [Villas in La Mesa ](https://expedia.ca/La-Mesa-Villas.d8484-aaVillas.Travel-Guide-Accommodation) - [Guest Houses in La Mesa ](https://expedia.ca/La-Mesa-Guest-Houses.d8484-aaGuestHouses.Travel-Guide-Accommodation) - [Resorts in La Mesa ](https://expedia.ca/La-Mesa-Resort-Hotels.d8484-aaResortHotels.Travel-Guide-Accommodation) - [Aparthotels in La Mesa ](https://expedia.ca/La-Mesa-Apart-Hotels.d8484-aaApartHotels.Travel-Guide-Accommodation) - [Motels in La Mesa ](https://expedia.ca/La-Mesa-Motels.d8484-aaMotels.Travel-Guide-Accommodation) - [Hostels in La Mesa ](https://expedia.ca/La-Mesa-Hostels.d8484-aaHostels.Travel-Guide-Accommodation) - [Cabin Rentals in La Mesa ](https://expedia.ca/La-Mesa-Cabins.d8484-aaCabins.Travel-Guide-Accommodation) - [B&B in La Mesa ](https://expedia.ca/La-Mesa-Bed-And-Breakfast.d8484-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Farmstay in La Mesa ](https://expedia.ca/La-Mesa-Agritourism.d8484-aaAgritourism.Travel-Guide-Accommodation) - [RV Parks in La Mesa ](https://expedia.ca/La-Mesa-RV-Parks.d8484-aaRVParks.Travel-Guide-Accommodation) - [Houseboats in La Mesa ](https://expedia.ca/La-Mesa-Houseboats.d8484-aaHouseboats.Travel-Guide-Accommodation) - [Inns in La Mesa ](https://expedia.ca/La-Mesa-Inns.d8484-aaInns.Travel-Guide-Accommodation) - [Residences in La Mesa ](https://expedia.ca/La-Mesa-Residences.d8484-aaResidences.Travel-Guide-Accommodation) - [Castles in La Mesa ](https://expedia.ca/La-Mesa-Castles.d8484-aaCastles.Travel-Guide-Accommodation) ## Frequently asked questions ### Are there vacation rentals in La Mesa? ### What are some of the best vacation rentals that La Mesa has to offer? ### How many vacation rentals are there in La Mesa? ### What can I see and do in La Mesa? ### What are vacation rentals like in La Mesa? ### Expedia's Latest Trends Hotels - 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