Title: Top Hotels in Mississippi County | Expedia.ca

 

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## Go beyond your typical stay in Mississippi County

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-11-23&d1=2025-11-23&endDate=2025-11-25&d2=2025-11-25&travelerType=family_friendly)

Cabin

[](https://www.expedia.ca/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-11-23&d1=2025-11-23&endDate=2025-11-25&d2=2025-11-25&lodging=CABIN)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-11-23&d1=2025-11-23&endDate=2025-11-25&d2=2025-11-25&amenities=POOL)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-11-23&d1=2025-11-23&endDate=2025-11-25&d2=2025-11-25&amenities=PETS)

## Check prices for these dates

Tonight

[Nov 9 - Nov 10](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2025-11-09&endDate=2025-11-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Nov 10 - Nov 11](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2025-11-10&endDate=2025-11-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2025-11-21&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Hotels in Mississippi County

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

6.6/10

(604)

"Staff was great! Room was nice. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lana

CA $78

CA $86 total

includes taxes & fees

Nov 11 - Nov 12

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/074a1dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/94d9e92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/cde4423c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Charleston - Sikeston

Charleston

6.8/10

(406)

"I consistently choose to stay there due to positive past encounters."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

IMTIAZ

CA $92

CA $102 total

includes taxes & fees

Dec 2 - Dec 3

[](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information)

![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/d436dcb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/2b61a8ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eagle Inn Charleston

Charleston

6.8/10

(102)

"Did not look like the picture at all! They charged an extra $50 for amenities that were not used. The room was not clean. There was cockroaches. There were semis next-door that started up at 4:30 in the morning, but at this point, we had no choice because we came in really late and there wasn’t anything else around. Will not stay there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Natalie

CA $90

CA $99 total

includes taxes & fees

Nov 11 - Nov 12

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/c71a6d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

Cairo

6.6/10

(271)

"We had a quiet and convenient one night stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cindy

CA $97

CA $108 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/8a1aff87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/6520deeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/88161c16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/e22587fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom house near ball park in quiet neighborhood

Bardwell

10/10

Exceptional

(10)

"Quaint stay to see Grand and kids. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sheila C.

CA $126

CA $226 total

includes taxes & fees

Nov 17 - Nov 18

[](https://www.expedia.ca/Bardwell-Hotels-Charming-3-Bedroom-House-Near-Ball-Park-In-Quiet-Neighborhood.h106623184.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Mississippi County Hotel Reviews

![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room, great location and friendly staff"

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Pear Tree Inn Sikeston](//images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg)

### Pear Tree Inn Sikeston

10/10 Excellent

"Good breakfast options. Reasonable rate. Clean"

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](//images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"Yes "

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Sleep Inn at Discovery Park of America](//images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg)

### Sleep Inn at Discovery Park of America

10/10 Excellent

"Awesome room wonderful breakfast great staff"

[](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![ For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.](//images.trvl-media.com/lodging/35000000/34330000/34322400/34322352/537131b5_y.jpg)

### For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

10/10 Excellent

"Cypress Knee Lodge was a great gathering place for our hiking group. After nearly 20 years we don't hike much anymore, we are more of a card playing group now! We enjoyed the space, the views, the location, and the accommodations in general. All of this prove to be important because it rained every day we were at Reelfoot Lake. Watching hundreds of pelicans, cormorants, coots, and various other ducks was an added bonus! We would definitely stay here again. Thanks, Jim!"

[](https://expedia.ca/Hornbeak-Hotels-For-Larger-Groups-Right-On-Reelfoot-Lake-Private-Dock-And-Pier.h34322352.Hotel-Information)

![Hospitality House Union City I 69 / US 51](//images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/w1290h938x0y0-9734f59a_y.jpg)

### Hospitality House Union City I 69 / US 51

10/10 Excellent

"Upgraded to a king suite at no additional costs. Receptionst was very friendly and helpful."

[](https://expedia.ca/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information)

![Hampton Inn Sikeston](//images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"We had a great room. It was clean and the staff was friendly and helpful. The only thing that happened was the elevators went out during the night. I would definitely stay there again. "

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Super 8 by Wyndham Charleston/Sikeston East MO](//images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg)

### Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Great experience "

[](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](//images.trvl-media.com/lodging/1000000/40000/34800/34745/c7be0f94_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"Courteous staff. Clean, and a large room."

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

## Explore a world of travel with Expedia

-   Explore a world of travel with Expedia

### Top cities in Mississippi County

-   [Charleston Hotels](https://expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels)
-   [East Prairie Hotels](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)
-   [Bertrand Hotels](https://expedia.ca/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels)
-   [Wyatt Hotels](https://expedia.ca/Wyatt-Hotels.d553248634983534991.Travel-Guide-Hotels)
-   [Anniston Hotels](https://expedia.ca/Anniston-Hotels.d553248634983588922.Travel-Guide-Hotels)

### Hotels near popular Attractions

-   [Hotels near Ohio River Valley](https://expedia.ca/Ohio-River-Valley-Hotels.0-l6233674-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Shawnee National Forest](https://expedia.ca/Shawnee-National-Forest-Hotels.0-l553248635944113522-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Mississippi River](https://expedia.ca/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Ohio River](https://expedia.ca/Ohio-River-Hotels.0-l681940626945888256-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Reelfoot Lake](https://expedia.ca/Reelfoot-Lake-Hotels.0-l553248635976195913-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Discovery Park of America](https://expedia.ca/Discovery-Park-Of-America-Hotels.0-l553248621561866880-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Reelfoot Lake State Park](https://expedia.ca/Reelfoot-Lake-State-Park-Hotels.0-l553248621532655205-0.Travel-Guide-Filter-Hotels)
-   [Hotels near New Madrid Historical Museum](https://expedia.ca/New-Madrid-Historical-Museum-Hotels.0-l553248621532655748-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Sikeston Depot Museum](https://expedia.ca/Sikeston-Depot-Museum-Hotels.0-l6305602-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Union City Masquerade Theatre](https://expedia.ca/Union-City-Masquerade-Theatre-Hotels.0-l553248622106898510-0.Travel-Guide-Filter-Hotels)

### More Accommodation Types in Mississippi County

-   [Vacation Homes in Mississippi County](https://expedia.ca/Mississippi-County-Private-Vacation-Homes.d553248635976432410-aaPrivateVacationHomes.Travel-Guide-Accommodation)
-   [Lodges in Mississippi County](https://expedia.ca/Mississippi-County-Lodges.d553248635976432410-aaLodges.Travel-Guide-Accommodation)
-   [Cabin Rentals in Mississippi County](https://expedia.ca/Mississippi-County-Cabins.d553248635976432410-aaCabins.Travel-Guide-Accommodation)
-   [Motels in Mississippi County](https://expedia.ca/Mississippi-County-Motels.d553248635976432410-aaMotels.Travel-Guide-Accommodation)
-   [Cottages in Mississippi County](https://expedia.ca/Mississippi-County-Cottages.d553248635976432410-aaCottages.Travel-Guide-Accommodation)
-   [Apartments in Mississippi County](https://expedia.ca/Mississippi-County-Apartments.d553248635976432410-aaApartments.Travel-Guide-Accommodation)
-   [RV Parks in Mississippi County](https://expedia.ca/Mississippi-County-RV-Parks.d553248635976432410-aaRVParks.Travel-Guide-Accommodation)
-   [Condo Rentals in Mississippi County](https://expedia.ca/Mississippi-County-Condos.d553248635976432410-aaCondos.Travel-Guide-Accommodation)

### Explore more hotels

-   [Super 8 by Wyndham Charleston/Sikeston East MO](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)
-   [Quality Inn Charleston - Sikeston](https://expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information)
-   [Drury Inn & Suites Sikeston, MO](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)
-   [Hampton Inn Sikeston](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)
-   [Sleep Inn at Discovery Park of America](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)
-   [Pear Tree Inn Sikeston](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)
-   [Days Inn and Suites by Wyndham Sikeston](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)
-   [Hospitality House Union City I 69 / US 51](https://expedia.ca/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information)
-   [Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)
-   [Best Western Plus Sikeston](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

[See a list of all hotels in Mississippi County](https://expedia.ca/All-Mississippi-County-Hotels.d553248635976432410.Travel-Guide-City-All-Hotels)

### More ways to book

-   [Book Hotels in Mississippi County on Expedia.com](https://www.expedia.com/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)

### Expedia's Latest Trends

Hotels

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-   [All Inclusive Resorts and Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-All-Inclusive-Hotel.0-0-d178304-tAllInclusiveHotel.Hotel-Filter-Destinations)
-   [Hotels in Downtown St. Louis](https://expedia.ca/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Luxury-Hotel.0-0-d178304-tLuxuryHotel.Hotel-Filter-Destinations)
-   [Mountain Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Mountain-Hotels.0-0-d178304-tMountainHotels.Hotel-Filter-Destinations)
-   [Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Hotel-Destinations)
-   [Family Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Family-Hotel.0-0-d178304-tFamilyHotel.Hotel-Filter-Destinations)
-   [Hotels near Women's and Children's Hospital](https://expedia.ca/Womens-And-Childrens-Hospital-Hotels.0-l553248635974865886-0.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Cheap-Hotels.0-0-d178304-tCheapHotels.Hotel-Filter-Destinations)
-   [Hotels in Power and Light District](https://expedia.ca/Power-And-Light-District-Kansas-City-Hotels.0-n6162504-0.Travel-Guide-Filter-Hotels)
-   [Hotels in Downtown Kansas City](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels)
-   [Beach Hotel in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Beach-Hotel.0-0-d178304-tBeachHotel.Hotel-Filter-Destinations)

Flights

-   [Flights to Orange County](https://expedia.ca/Destinations-In-Orange-County.d603224.Flight-Destinations)
-   [Flights to San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Flight-Destinations)

Cars

-   [Car rentals in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Car-Rental-Destinations)
-   [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide)

Cruises

-   [Cruises from San Diego County](https://expedia.ca/Cruises-from-San-Diego-County.d178304.Cruise-Departure-Port)

Activities

-   [Things to do in Baldwin County](https://expedia.ca/Things-To-Do-In-Baldwin-County.d553248635976432245.Travel-Guide-Activities)
-   [Things to do in San Diego County](https://expedia.ca/Things-To-Do-In-San-Diego-County.d178304.Travel-Guide-Activities)
-   [Things to do in High Ridge](https://expedia.ca/Things-To-Do-In-High-Ridge.d553248634983579370.Travel-Guide-Activities)
-   [Things to do in Orange County](https://expedia.ca/Things-To-Do-In-Orange-County.d603224.Travel-Guide-Activities)
-   [Things to do in Levy County](https://expedia.ca/Things-To-Do-In-Levy-County.d553248635976432502.Travel-Guide-Activities)

Packages

-   [San Diego County Vacations](https://expedia.ca/San-Diego-County.d178304.Destination-Travel-Guides)

General

-   [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136)
-   [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828)
-   [Visit Parkville](https://expedia.ca/Parkville.dx9973)
-   [Visit Orange County](https://expedia.ca/Orange-County.dx603224)

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