Title: Depew Vacation Home Rentals from CA $221: Search Top Private Vacation Homes for Rent | Expedia.ca

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## Check prices for these dates

In two weeks

[Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 24 - Apr 26](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 22 - May 24](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 19 - Jun 21](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Depew vacation homes

![Interior](https://images.trvl-media.com/lodging/114000000/113390000/113389600/113389540/ae20b9f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/114000000/113390000/113389600/113389540/c77a6c32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113390000/113389600/113389540/f5822b28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/114000000/113390000/113389600/113389540/6781f133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Old First Ward

[](https://www.expedia.ca/Buffalo-Hotels-Great-Buffalo-Getaway.h113389540.Hotel-Information)

10/10

Exceptional

(14 reviews)

"Perfect location in Buffalo, only about a 20 minute drive or less to get to Bills stadium or uptown, lots of amazing food less than 10 minutes away, perfect size for 3-6 people!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maggie N.

CA $134

CA $308 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-Great-Buffalo-Getaway.h113389540.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/108000000/107560000/107557200/107557186/c2e4ae0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107560000/107557200/107557186/b6c69c59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/108000000/107560000/107557200/107557186/87bd43c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107560000/107557200/107557186/8cd62868.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Lancaster

[](https://www.expedia.ca/Lancaster-Hotels-Luxury-Villa.h107557186.Hotel-Information)

9.6/10

Exceptional

(9 reviews)

"Really enjoyed my stay! They made us very comfortable and let us check in early due to our early flight 10/10 come check it out "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Da’Lisha P.

CA $182

CA $257 total

includes taxes & fees

Mar 4 - Mar 5

[](https://www.expedia.ca/Lancaster-Hotels-Luxury-Villa.h107557186.Hotel-Information)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/105000000/104230000/104226900/104226855/89a9c220.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/105000000/104230000/104226900/104226855/f3af483c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/105000000/104230000/104226900/104226855/5edbf8eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Towels, toilet paper](https://images.trvl-media.com/lodging/105000000/104230000/104226900/104226855/8b9e2cc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in University Heights

[](https://www.expedia.ca/Buffalo-Hotels-Peaceful-One-Bedroom-In-University-District.h104226855.Hotel-Information)

8.8/10

Excellent

(5 reviews)

"Quick weekend up in Buffalo. This place got the job done. Good size and the host was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brandon W.

CA $117

CA $221 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Buffalo-Hotels-Peaceful-One-Bedroom-In-University-District.h104226855.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/123000000/122950000/122946400/122946340/w1350h897x0y3-ca476d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/123000000/122950000/122946400/122946340/w1345h899x4y1-9c1dee6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/123000000/122950000/122946400/122946340/644cc762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122950000/122946400/122946340/w1349h899x0y1-5a6e6ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Lancaster

[](https://www.expedia.ca/Lancaster-Hotels-Perfect-Vacation-Cozy-Lancaster-Village-Bungalow.h122946340.Hotel-Information)

10/10

Exceptional

(1 review)

"No concerns. Everything as stated. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ronald F.

CA $202

CA $407 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Lancaster-Hotels-Perfect-Vacation-Cozy-Lancaster-Village-Bungalow.h122946340.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113300000/113298700/113298620/c36f461a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/114000000/113300000/113298700/113298620/26bf4477.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/114000000/113300000/113298700/113298620/0c68fffb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/114000000/113300000/113298700/113298620/ffd6a70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Orchard Park

[](https://www.expedia.ca/Buffalo-Hotels-Charming-3-Bedroom-House-In-Delightful-Orchard-Park-With-WiFi.h113298620.Hotel-Information)

9.8/10

Exceptional

(18 reviews)

"This was a great place -- the house is very clean and the location is perfect!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tony C.

CA $205

CA $521 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Buffalo-Hotels-Charming-3-Bedroom-House-In-Delightful-Orchard-Park-With-WiFi.h113298620.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/117000000/116940000/116930500/116930444/ef5715b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116940000/116930500/116930444/e9a0e435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/117000000/116940000/116930500/116930444/cb2b9cf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, foosball](https://images.trvl-media.com/lodging/117000000/116940000/116930500/116930444/5d73c7d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Grand island

[](https://www.expedia.ca/Grand-Island-Hotels-2-Bedroom-House-In-Awesome-Grand-Island-With-AC.h116930444.Hotel-Information)

10/10

Exceptional

(13 reviews)

"Accomodations were great"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ginny A.

CA $175

CA $353 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Grand-Island-Hotels-2-Bedroom-House-In-Awesome-Grand-Island-With-AC.h116930444.Hotel-Information)

![3 bedrooms, iron/ironing board](https://images.trvl-media.com/lodging/95000000/94750000/94745900/94745801/8fe243e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/95000000/94750000/94745900/94745801/a4764f47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/95000000/94750000/94745900/94745801/64b3f4e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/95000000/94750000/94745900/94745801/w1190h790x4y0-26f131d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Buffalo

[](https://www.expedia.ca/Buffalo-Hotels-69-Springville-Ave-Spacious-Home-Near-Niagara-Falls.h94745801.Hotel-Information)

9.4/10

Exceptional

(16 reviews)

"Nice home in a quiet neighborhood. Close to many shopping options. Would stay again if visiting Buffalo on a future trip."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

him06468

CA $137

CA $362 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-69-Springville-Ave-Spacious-Home-Near-Niagara-Falls.h94745801.Hotel-Information)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/107000000/106580000/106571800/106571782/96cf4a4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/107000000/106580000/106571800/106571782/e167c5c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/107000000/106580000/106571800/106571782/e5b30043.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/107000000/106580000/106571800/106571782/fc552f1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Riverside

[](https://www.expedia.ca/Buffalo-Hotels-Charming-Victorian-W-Niagara-RiversideView-2King-Arcade-GameRm-FreeParkng-Office.h106571782.Hotel-Information)

8.4/10

Very good

(5 reviews)

"Super responsive host and very accommodating with a clean and comfortable stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Daniel S.

CA $230

CA $530 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Buffalo-Hotels-Charming-Victorian-W-Niagara-RiversideView-2King-Arcade-GameRm-FreeParkng-Office.h106571782.Hotel-Information)

![](https://images.trvl-media.com/lodging/58000000/57540000/57539900/57539862/eb14431e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![](https://images.trvl-media.com/lodging/58000000/57540000/57539900/57539862/00fbd588.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![](https://images.trvl-media.com/lodging/58000000/57540000/57539900/57539862/82fb3581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![](https://images.trvl-media.com/lodging/58000000/57540000/57539900/57539862/8b6c6b96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Broadway - Fillmore

[](https://www.expedia.ca/Buffalo-Hotels-No-Chores.h57539862.Hotel-Information)

9.0/10

Wonderful

(28 reviews)

"Very nice stay highly recommend "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alexander

CA $123

CA $335 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-No-Chores.h57539862.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/102000000/101290000/101281100/101281057/9a202336.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101290000/101281100/101281057/8fc16082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101290000/101281100/101281057/393d3bb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/102000000/101290000/101281100/101281057/951436f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in West Seneca

[](https://www.expedia.ca/Buffalo-Hotels-Big-New-House-With-Huge-Parking.h101281057.Hotel-Information)

10/10

Exceptional

(4 reviews)

"Lots of bedrooms/beds, ease of use."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andy

CA $279

CA $740 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-Big-New-House-With-Huge-Parking.h101281057.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/91000000/90290000/90281300/90281252/dccf1e1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/91000000/90290000/90281300/90281252/69345dc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/91000000/90290000/90281300/90281252/a090ff32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/91000000/90290000/90281300/90281252/7bac9d2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in West Seneca

[](https://www.expedia.ca/Buffalo-Hotels-No-Chores.h90281252.Hotel-Information)

9.0/10

Wonderful

(8 reviews)

"House is pleasantly appointed. More room inside than you might guess from the quaint look from the street. We were three single adults so used all the bedrooms, bathrooms, kitchen, and living room without feeling crammed in.Beds were comfortable, house was clean, plenty of kitchenware to meet our needs.Quiet neighborhood with people walking dogs and houses decorated for fall and Halloween. Off street parking in the easily accessible driveway was nice.We were in town for a Bills game and this...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Catherine T.

CA $164

CA $431 total

includes taxes & fees

Mar 11 - Mar 12

[](https://www.expedia.ca/Buffalo-Hotels-No-Chores.h90281252.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/109000000/108150000/108148300/108148270/3872c5af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108150000/108148300/108148270/76b2d1a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV](https://images.trvl-media.com/lodging/109000000/108150000/108148300/108148270/558f184f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV](https://images.trvl-media.com/lodging/109000000/108150000/108148300/108148270/5c72d129.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Cheektowaga

[](https://www.expedia.ca/Buffalo-Hotels-Niagara-Falls.h108148270.Hotel-Information)

10/10

Exceptional

(4 reviews)

"Very affordable and close to everything in buffalo i loved it!!!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hunter

CA $246

CA $452 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-Niagara-Falls.h108148270.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/107000000/106660000/106651800/106651751/fe79aa46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/107000000/106660000/106651800/106651751/45325320.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/107000000/106660000/106651800/106651751/a9df2e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games, offices](https://images.trvl-media.com/lodging/107000000/106660000/106651800/106651751/818b39b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Akron

[](https://www.expedia.ca/Akron-Hotels-This-Spacious.h106651751.Hotel-Information)

10/10

Exceptional

(27 reviews)

"Great location, enjoyed our stay. Highly recommended. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sharon W.

CA $356

CA $709 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Akron-Hotels-This-Spacious.h106651751.Hotel-Information)

![Smart TV, stereo, offices, computer monitors](https://images.trvl-media.com/lodging/92000000/91590000/91582300/91582207/a2c9bbed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91590000/91582300/91582207/8ef8fdde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/92000000/91590000/91582300/91582207/0682ce49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/92000000/91590000/91582300/91582207/4bdbd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Depew

[](https://www.expedia.ca/Buffalo-Hotels-BuffaloNiagara-Apartment-Just-Minutes-From-Buffalo-Airport-And-Shopping-Centers.h91582207.Hotel-Information)

9.8/10

Exceptional

(29 reviews)

"Great place!"

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Eric

CA $190

CA $372 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Buffalo-Hotels-BuffaloNiagara-Apartment-Just-Minutes-From-Buffalo-Airport-And-Shopping-Centers.h91582207.Hotel-Information)

![Smart TV, books](https://images.trvl-media.com/lodging/111000000/110880000/110875600/110875509/d4466460.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110880000/110875600/110875509/c33e436b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110880000/110875600/110875509/7e8e4355.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books](https://images.trvl-media.com/lodging/111000000/110880000/110875600/110875509/e1d8bcf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in North Buffalo

[](https://www.expedia.ca/Buffalo-Hotels-Charming-3-Bedroom-House-With-AC-And-WiFi-In-Delightful-Buffalo.h110875509.Hotel-Information)

9.0/10

Wonderful

(8 reviews)

"This was perfect for my family for a weekend wedding in Buffalo. Great Location! Manager very easy to work with!Quiet Neighborhood. Walk to The Bean...best bagels ever!Will definitely rebook!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Adrienne L.

CA $116

CA $401 total

includes taxes & fees

Mar 11 - Mar 12

[](https://www.expedia.ca/Buffalo-Hotels-Charming-3-Bedroom-House-With-AC-And-WiFi-In-Delightful-Buffalo.h110875509.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99950000/99942500/99942455/42afb83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/100000000/99950000/99942500/99942455/88b5e6b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/100000000/99950000/99942500/99942455/e08dc356.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/100000000/99950000/99942500/99942455/w1290h860x0y968-f5625e7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Iron Island

[](https://www.expedia.ca/Buffalo-Hotels-The-Davey-Retreat.h99942455.Hotel-Information)

8.4/10

Very good

(11 reviews)

"It was a great place to stay for a Bills game weekend. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Robert G.

CA $155

CA $605 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-The-Davey-Retreat.h99942455.Hotel-Information)

![4 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/69000000/68460000/68459300/68459231/98d0b203.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/69000000/68460000/68459300/68459231/d6ea1fef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/69000000/68460000/68459300/68459231/075d95e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, oven, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/69000000/68460000/68459300/68459231/c528a917.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Buffalo

[](https://www.expedia.ca/Buffalo-Hotels-4-Bedrooms-3-Bathrooms-Entire-Home-For-Families.h68459231.Hotel-Information)

9.6/10

Exceptional

(53 reviews)

"Everything was great, host was excellent!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ben H.

CA $178

CA $462 total

includes taxes & fees

Mar 3 - Mar 4

[](https://www.expedia.ca/Buffalo-Hotels-4-Bedrooms-3-Bathrooms-Entire-Home-For-Families.h68459231.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/120000000/119950000/119942800/119942716/4682daf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/120000000/119950000/119942800/119942716/289a5f3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119950000/119942800/119942716/946d1c69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/120000000/119950000/119942800/119942716/5e71bf81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in South Park

[](https://www.expedia.ca/Buffalo-Hotels-Cozy-3BR-Lower-Unit-Home-In-South-Buffalo-Near-Downtown.h119942716.Hotel-Information)

9.4/10

Exceptional

(3 reviews)

"Wonderful location, comfortable beds, spacious, coming back to Buffalo, we will stay here again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maddie M.

CA $123

CA $375 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Buffalo-Hotels-Cozy-3BR-Lower-Unit-Home-In-South-Buffalo-Near-Downtown.h119942716.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/120000000/119880000/119878300/119878264/w954h683x35y0-1afdc2e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/120000000/119880000/119878300/119878264/e1d5fc1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/120000000/119880000/119878300/119878264/3fc1b637.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/120000000/119880000/119878300/119878264/w985h683x19y0-cb1443d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Hamburg

[](https://www.expedia.ca/Hamburg-Hotels-Home-In-Hamburg.h119878264.Hotel-Information)

9.8/10

Exceptional

(6 reviews)

"Very clean and convenient location. It was a great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robyn R.

CA $170

CA $427 total

includes taxes & fees

Mar 23 - Mar 24

[](https://www.expedia.ca/Hamburg-Hotels-Home-In-Hamburg.h119878264.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/100000000/99440000/99431300/99431296/17358f93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/100000000/99440000/99431300/99431296/d26a56a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/100000000/99440000/99431300/99431296/64b2a5c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/100000000/99440000/99431300/99431296/0be60b07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in West Seneca

[](https://www.expedia.ca/Buffalo-Hotels-Brand-New-Furniture-With-Parking.h99431296.Hotel-Information)

9.0/10

Wonderful

(6 reviews)

"This property was a good location for us to visit an are restaurant and visit Niagara Falls. It was a comfortable place. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jill B.

CA $148

CA $407 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Buffalo-Hotels-Brand-New-Furniture-With-Parking.h99431296.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-13&endDate=2026-03-14&regionId=6338362&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

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Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 

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## Find vacation rentals that suit your style

Aparthotels

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=APART_HOTEL)

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=VACATION_HOME)

Condos

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=CONDO)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=COTTAGE)

Villas

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=VILLA)

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America&regionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2026-05-28&d1=2026-05-28&endDate=2026-05-31&d2=2026-05-31&lodging=CABIN)

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Save an average of 15% on thousands of hotels when you're signed in

[Sign in

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Sign up, it's free

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## Top Depew Hotel Reviews

![La Quinta Inn by Wyndham Buffalo Airport](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/4969c4dc_y.jpg)

### La Quinta Inn by Wyndham Buffalo Airport

10/10 Excellent

"courteous staff, clean room, excellent stay for the price. I woulld stay here again. Thank you!"

[](https://expedia.ca/Buffalo-Hotels-La-Quinta-Inn-By-Wyndham-Buffalo-Airport.h27531.Hotel-Information)

![Garden Place Hotel](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg)

### Garden Place Hotel

10/10 Excellent

"Wonderful staff! Wonderful room!! Beautiful hotel! Will come again. Affordable too."

[](https://expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information)

![Hyatt Regency Buffalo / Hotel and Conference Center](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234_y.jpg)

### Hyatt Regency Buffalo / Hotel and Conference Center

10/10 Excellent

"clean room; very quiet; , great location to walk to restaurants and bars"

[](https://expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information)

![Hilton Garden Inn Buffalo Downtown](https://images.trvl-media.com/lodging/9000000/8750000/8745500/8745457/7db896c2_y.jpg)

### Hilton Garden Inn Buffalo Downtown

10/10 Excellent

"Clean room, clean public areas, friendly efficient staff, good restaurant"

[](https://expedia.ca/Buffalo-Hotels-Hilton-Garden-Inn-Buffalo-Downtown.h8745457.Hotel-Information)

![Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/1edd14d0_y.jpg)

### Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

10/10 Excellent

"Staff were very kind. Room was very clean. Bed was very comfortable. Airport shuttle was efficient and the driver was outstanding. Highly recommend! "

[](https://expedia.ca/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Buffalo-Airport.h973773.Hotel-Information)

![Hyatt Place Buffalo/Amherst](https://images.trvl-media.com/lodging/10000000/9460000/9456500/9456445/523e54f1_y.jpg)

### Hyatt Place Buffalo/Amherst

10/10 Excellent

"Clean room cozy and the hot tub "

[](https://expedia.ca/Buffalo-Hotels-Hyatt-Place-BuffaloAmherst.h9456445.Hotel-Information)

![Holiday Inn Express Grand Island - Niagara Falls by IHG](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg)

### Holiday Inn Express Grand Island - Niagara Falls by IHG

10/10 Excellent

"Enjoyed our stay!!!"

[](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information)

![Buffalo Airport Hotel](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d_y.jpg)

### Buffalo Airport Hotel

10/10 Excellent

"Love the room"

[](https://expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Buffalo Amherst](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072_y.jpg)

### La Quinta Inn & Suites by Wyndham Buffalo Amherst

10/10 Excellent

"."

[](https://expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information)

## Find out more about Depew

## Depew Vacation Homes information

| Number of reviews | 221                |
| ----------------- | ------------------ |
| Accommodation     | 256 Vacation Homes |
| Lowest Price      | CA $221            |
| Highest Price     | CA $740            |

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