A sunset over a calm lake with tall trees reflected in the water.

Find Spa Hotels in Charleston, MO from CA $164

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Check availability on Charleston Spa Hotels

Tonight
Oct 1 - Oct 2
Tomorrow
Oct 2 - Oct 3
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Charleston hotels with a spa

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
CA $144
CA $164 total
includes taxes & fees
Oct 11 - Oct 12
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Choose what matters most at spa hotels in Charleston

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Charleston Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"EVERYONE was EXTREMELY FRIENDLY even maintenance all FRIENDLY"
Rex 1-night trip
Posted 2 hours ago
Drury Inn & Suites Cape Girardeau
Eagle Inn Charleston

Eagle Inn Charleston

10/10 Excellent
"Great"
Jackson 1-night trip
Posted 6 months ago
Eagle Inn Charleston

Frequently asked questions

Looking for a spa hotel in Charleston?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the opera and restaurants in Charleston—your day trip starts here. Be sure to pay a visit to the churches during your stay. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Charleston?
Experience all that Charleston has to offer when you visit Mississippi River, Ohio River, and Ballard Wildlife Management Area. If you have a bit of extra time while you're in the area, you might want to check out Columbus-Belmont State Park and Big Oak Tree State Park.
What is a Charleston spa hotel?
Spa hotels in Charleston provide lodging and have an on-site spa offering services like facials and body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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