Title: Book the Best Charleston SPA Resorts from CA $150 - Spa Hotels in Charleston, MO | Expedia.ca

  

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# Find Spa Hotels in Charleston, MO from CA $150

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## Check availability on Charleston Spa Hotels

Tonight

[Oct 8 - Oct 9](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2025-10-08&endDate=2025-10-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 9 - Oct 10](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2025-10-09&endDate=2025-10-10&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Charleston Spa Hotels

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

9.4/10

Exceptional

(1003)

"It was right off the interstate with lots of restaurant options "

CA $133

CA $150 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-22&endDate=2025-10-23&regionId=7182&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true)

## Top Charleston Hotel Reviews

![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"The lady that checked me in was amazing!"

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](//images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Clean, comfortable, spacious "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Eagle Inn Charleston](//images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a_y.jpg)

### Eagle Inn Charleston

10/10 Excellent

"Furniture missing knobs. No chair!!??? No coffee!!?? No breakfast. Nice location. Nice staff!! "

[](https://expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

## Frequently asked questions

### Looking for a spa hotel in Charleston?

> Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the opera and restaurants in Charleston—your day trip starts here. Be sure to pay a visit to the churches during your stay. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.

### What's there to see and do in Charleston?

> Experience all that Charleston has to offer when you visit Mississippi River, Ohio River, and Columbus-Belmont State Park. If you have a bit of extra time while you're in the area, you might want to check out Central Park and Big Oak Tree State Park.

### What is a Charleston spa hotel?

> Spa hotels in Charleston provide lodging and have an on-site spa offering services like facials and body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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