Sikeston Vacation Rentals

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Our top choices for Sikeston vacation rentals

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (56 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $111
CA $149 total
includes taxes & fees
May 23 - May 24
Little Blue Cottage on Spanish

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (19 reviews)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
United States
Keegan C.
The price is CA $213
CA $422 total
includes taxes & fees
May 18 - May 19
Charming Secluded Getaway Cabin within minutes of amenities

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
7.8 out of 10, Good, (31 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
The price is CA $147
CA $297 total
includes taxes & fees
May 18 - May 19
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (34 reviews)
"Amazing stay, loved the bed and hot tub. Close to town but also away. "
United States
Maria B.
The price is CA $296
CA $438 total
includes taxes & fees
May 18 - May 19
The Twisted Sassafras Treehouse

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (155 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
The price is CA $206
CA $340 total
includes taxes & fees
May 18 - May 19
Serenity South -- Gardens, River-Views, and Refreshing Space

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (11 reviews)
"It was great. "
United States
Benjamin Q.
The price is CA $206
CA $248 total
includes taxes & fees
May 18 - May 19
Villa B offers peace and quiet with beautiful views of the countryside.

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (34 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is CA $206
CA $248 total
includes taxes & fees
May 19 - May 20
Relax in the country at Countryside Villas! - Villa A

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is CA $275
CA $433 total
includes taxes & fees
May 19 - May 20
Gorgeous 1856 Log Cabin, Completely Renovated

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (40 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $246
CA $436 total
includes taxes & fees
May 18 - May 19
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Modern Boho Getaway · 1BR Apartment · By KeenStays

Modern Boho Getaway · 1BR Apartment · By KeenStays
Cape Girardeau
The price is CA $110
CA $230 total
includes taxes & fees
May 31 - Jun 1
Modern Boho Getaway · 1BR Apartment · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
The price is CA $118
CA $239 total
includes taxes & fees
Jun 17 - Jun 18
Studio Apt | King Bed, Full Kitchen · By KeenStays

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $172
CA $275 total
includes taxes & fees
May 21 - May 22
The Cottage, Rusted Route Farms

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays
Cape Girardeau
The price is CA $138
CA $287 total
includes taxes & fees
May 18 - May 19
Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Enjoy easy access to everything from this centrally located place.

Enjoy easy access to everything from this centrally located place.
Dexter
The price is CA $147
CA $217 total
includes taxes & fees
Jun 2 - Jun 3
Enjoy easy access to everything from this centrally located place.

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $433
CA $726 total
includes taxes & fees
May 18 - May 19
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
The price is CA $688
CA $844 total
includes taxes & fees
May 30 - May 31
Building at Cape Girardeau Regional Airport

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.4 out of 10, Exceptional, (3 reviews)
"Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would be to put variable light switches so you could turn down the lighting at night. I would definitely recommend and would stay here again on my next trip to Perryville."
United States
James
The price is CA $100
CA $215 total
includes taxes & fees
Jun 1 - Jun 2
The Atrium - A Boutique Hotel

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (411 reviews)
"Great location. Cozy cabin. Would stay there again. "
United States
jeffrey s
The price is CA $161
CA $275 total
includes taxes & fees
May 20 - May 21
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.8 out of 10, Exceptional, (48 reviews)
"Cabin was clean. Contact with host was very good and helpful."
United States
Steve K.
The price is CA $150
CA $293 total
includes taxes & fees
May 20 - May 21
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (64 reviews)
"A nice quiet stay in the Shawnee Forest. Host was easy to communicate with and the cabin had everything we needed for a nice get away. Close to nature or close to shopping and dinner. It was the perfect little spot "
United States
Ruth O.
The price is CA $142
CA $264 total
includes taxes & fees
Jun 1 - Jun 2
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Find out more about Sikeston

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Sikeston. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find a vacation rental in Sikeston?

Yes, there are vacation rentals close to the most popular local attractions in Sikeston, or you can choose a more remote option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your vacation.

What's the top vacation rental in Sikeston?

Beautiful location in the secluded woods : Visitors like this Sikeston vacation home rental. It offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the larger area, you’ll find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery.

What’s a vacation rental in Sikeston like?

A vacation rental is a private property you can book for a couple of days or more in Sikeston. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you to travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for a small group gathering.