Title: Sikeston Vacation Rentals from CA $151: Short-Term Rentals for 2026 | Expedia.ca

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![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 17 - Apr 19](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 29 - May 31](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 26 - Jun 28](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 24 - Jul 26](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Sikeston vacation rentals

![Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/804f0425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/9e44784b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/aa7536c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed with Sofa bed, Pets Allowed | Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/d395df9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Atrium - A Boutique Hotel

[](https://www.expedia.ca/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

Perryville

CA $99

CA $215 total

includes taxes & fees

Apr 12 - Apr 13

[](https://www.expedia.ca/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

![House (1 Bedroom) | Front of property](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/aa6e717a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/3ac16db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/d5f4e688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/02464d31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet Friendly! Countryside Couples Stay in Illinois

[](https://www.expedia.ca/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

Murphysboro

CA $136

CA $331 total

includes taxes & fees

Apr 1 - Apr 2

[](https://www.expedia.ca/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/2ec33dcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Lofts

[](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Perryville

9.2/10

Wonderful

(17 reviews)

"Great place to stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

CA $233

CA $376 total

includes taxes & fees

Apr 5 - Apr 6

[](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-14&endDate=2026-04-15&regionId=6058766&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-29&d1=2026-06-29&endDate=2026-07-02&d2=2026-07-02&lodging=CABIN)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-29&d1=2026-06-29&endDate=2026-07-02&d2=2026-07-02&lodging=VACATION_HOME)

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-29&d1=2026-06-29&endDate=2026-07-02&d2=2026-07-02&lodging=APARTMENT)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-29&d1=2026-06-29&endDate=2026-07-02&d2=2026-07-02&lodging=COTTAGE)

Aparthotels

[](https://www.expedia.ca/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-29&d1=2026-06-29&endDate=2026-07-02&d2=2026-07-02&lodging=APART_HOTEL)

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## Top Sikeston Hotel Reviews

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"This was a nice hotel, very reasonably priced, nice view, clean, and comfortable."

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

2/10 Terrible

"The only thing good about our stay was the breasfast everything else was not. Room was not cleaned properly with leftover food in 2 corners of the rook and bobby pins on ottoman. The bath tube took forever to drain same with sink. White stuff on headboard. The room was so nasty. "

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

6/10 Okay

"Not much of a breakfast. The smell entering the hotel was terrible. My husband has COPD and could barely breath. Room was nice"

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Hotel is in a convenient central area. Was clean and staff was friendly."

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston I-55

4/10 Poor

"The bed and chair was hard. Will not go back"

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Our first visit to a Drury Inn — what an amazing place. Not only was there an excellent breakfast with many choices, but there was also a light dinner served. This was all included for a very reasonable price. Our room was very clean and comfortable. We will definitely be looking for more Drury Inns as we travel. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"We very much enjoyed our stay. The evening drinks and food were great, as were the breakfast options. It was our first time staying here, but not the last."

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Yes"

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Comfort Inn & Suites Sikeston I-55](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/4da73ae3_y.jpg)

### Comfort Inn & Suites Sikeston I-55

2/10 Terrible

"I had a very disappointing experience during my stay at this hotel. From the moment I checked in, there was a strong, unpleasant odor throughout the property that made it uncomfortable to even be in the room. It’s clear that the hotel is in serious need of renovation and better upkeep. The cleanliness was especially concerning. The room did not appear to have been properly cleaned, and the bedsheets seemed unchanged from the previous guest, which is completely unacceptable. Basic hygiene standards were not met, and it made the stay feel unhygienic and unsettling. Overall, I would not recommend staying here. The management needs to address cleanliness, maintenance, and overall guest experience before it can be considered a decent place to stay. "

[](https://expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

## Find out more about Sikeston

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Sikeston. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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- [Vacation Homes in Sikeston ](https://expedia.ca/Sikeston-Private-Vacation-Homes.d6058766-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Sikeston ](https://expedia.ca/Sikeston-Cabins.d6058766-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Sikeston ](https://expedia.ca/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation)
- [Motels in Sikeston ](https://expedia.ca/Sikeston-Motels.d6058766-aaMotels.Travel-Guide-Accommodation)
- [Lodges in Sikeston ](https://expedia.ca/Sikeston-Lodges.d6058766-aaLodges.Travel-Guide-Accommodation)
- [Cottages in Sikeston ](https://expedia.ca/Sikeston-Cottages.d6058766-aaCottages.Travel-Guide-Accommodation)
- [RV Parks in Sikeston ](https://expedia.ca/Sikeston-RV-Parks.d6058766-aaRVParks.Travel-Guide-Accommodation)
- [Farmstay in Sikeston ](https://expedia.ca/Sikeston-Agritourism.d6058766-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Sikeston ](https://expedia.ca/Sikeston-Bed-And-Breakfast.d6058766-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Aparthotels in Sikeston ](https://expedia.ca/Sikeston-Apart-Hotels.d6058766-aaApartHotels.Travel-Guide-Accommodation)

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