Santa Isabel Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top Santa Isabel Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
CA $1,248
per person
Nov 11 - Nov 18
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.6/10 Excellent! (1,716 reviews)
My son and I stayed one night at the Decapolis Hotel, and while the property itself is impressive, the overall experience was mixed. The hotel is immaculately clean, centrally located, and offers great views of the city. We enjoyed the modern amenities, including the large pool, glass elevator, and the convenient skywalk that connects directly to a shopping center. Unfortunately, the service did not match the quality of the facilities. Staff members were curt and unhelpful, and when we asked questions, we were often shrugged off or redirected without explanation. Other guests were assisted while we were ignored, which left a negative impression. The hotel’s open‑lobby design also created a major issue: an event took place late into the night, and the noise carried all the way up to the rooms. We weren’t able to sleep until it ended past midnight. Check‑in was another challenge. Tour groups arrived at the same time, and although two staff members were present, only one was willing to check us in. The other employee was checking in random guests but refused to assist us, pointing us toward the long tour‑group line instead. Checkout, however, was quick and easy. Overall, the hotel has excellent facilities and a great location, but the service and noise issues significantly impacted our stay.

Reviewed on Sep 5, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
CA $1,740
per person
Nov 11 - Nov 18
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
Clean rooms, great breakfast. Great air conditioning, small small pool. Great location. Friendly staff.. lots to do near by. Stairs and elevators

Reviewed on Sep 5, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
CA $1,627
per person
Oct 23 - Oct 30
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,692 reviews)
We stayed for 4 nights, family of 3 in room 3724. The view is spectacular probably one if the best view of the city. Room is spacious, lots of pillows side chairs, table desks, refrigerator, coffee machine and we were give 2 bottles of water daily. Hotel is situated in the city near all, lots of food place close by, 7mins from poin panama, 20mins to the panama canal tour. Hotel is joined to the mall very spacious and clean. Staff is helpful and go above to assist you. Room service every day no issues. My only issue was that because there is no curtain or door on the shower the room get misty and smells musty of water and mold smell. I notice most hotel not adequately containing water in the shower area and dampness equal mold and must. Other than that the water pressure is good lots of warm water and spacious bathroom. Breakfast was good. Good and healthy selection to choose from.

Reviewed on Sep 6, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

Casco Viejo
CA $2,194
per person
Nov 6 - Nov 13
found 10 hours ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.8/10 Exceptional! (29 reviews)
Nice apartment ! Clean and great location

Reviewed on Aug 13, 2026

Villa Marina Hotel

Villa Marina Hotel

CA $1,317
per person
Oct 14 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9/10 Wonderful! (176 reviews)

Ready to book your vacation to Santa Isabel?

Choose your dates

Santa Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
CA $2,689
CA $2,972 total
Sep 13 - Sep 14
includes taxes & fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala
CA $260
CA $286 total
Sep 7 - Sep 8
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón
9/10 Wonderful! (4 reviews)
"the view is beautiful! We were taken care of well."

Reviewed on Jul 26, 2026

Get rates
Caribbean getaway: beach cottage just on the sand
See all 40 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from CA $1,248 on Expedia for your Santa Isabel escape. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
May, August and September are great times to search for cheap Santa Isabel vacation packages. Choosing to travel in quieter periods means you can generally find better prices on hotels and flights.
How many days is enough for Santa Isabel?
Usually, a handful of days is enough to explore the top sights during your Santa Isabel vacation. But if you want to have more time to chill out or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Use Expedia's filters to find some of the best Santa Isabel package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your adventure for midweek, or browse for Santa Isabel package deals in the off-peak season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, flight and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the freedom to create a tailored Santa Isabel vacation by choosing your favourite type of stay, airline and car class.
When to book a vacation package to Santa Isabel?
If you're planning a spur-of-the-moment Santa Isabel adventure, check out our last-minute deals that can be booked up to a week before you go. Prefer not to wait until the last minute? You can land terrific deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Isabel?
  1. Choose when to go: Check your diary and get your bags packed. Your preferred season and the type of activities available will also help you decide when to escape to Santa Isabel.
  2. Plan your budget wisely: Besides the price of your stay, you'll need to consider other expenses too. These include transportation, food and flights. Also, put aside a little extra for unexpected costs that may arise during your trip to Santa Isabel.
  3. Decide your trip length: Consider how much time you'd like to spend discovering Santa Isabel. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
  4. Combine your accommodations and airfare: Once you've settled on your trip dates and duration, book the ideal Santa Isabel vacation package for you.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.