Title: Santa Isabel Car Rental - Search & Compare - Expedia.ca​ [Santa Isabel Travel Guide](https://expedia.ca/Santa-Isabel.dx6203540)[Hotels in Santa Isabel](https://expedia.ca/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Flights to Santa Isabel](https://expedia.ca/Cheap-Flights-To-Santa-Isabel.d6203540.Travel-Guide-Flights)[Santa Isabel Vacation Packages](https://expedia.ca/Santa-Isabel.d6203540.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Isabel Car Rental ## Search and Compare from Car Companies in Santa Isabel ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXCA-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself Members save 10% or more on over 1 million car rentals - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers to unlock big savings ## Top Car Deals in Santa Isabel \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Santa Isabel, Colón, PAN ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Isabel,%20Col%C3%B3n,%20Panama&dpln=6203540&date1=20/02/2026&date2=22/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Santa Isabel, Colón, PAN ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Isabel,%20Col%C3%B3n,%20Panama&dpln=6203540&date1=20/02/2026&date2=22/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Santa Isabel, Colón, PAN ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Isabel,%20Col%C3%B3n,%20Panama&dpln=6203540&date1=20/02/2026&date2=22/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Santa Isabel, Colón, PAN ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Isabel,%20Col%C3%B3n,%20Panama&dpln=6203540&date1=20/02/2026&date2=22/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in Santa Isabel [View all cars](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Isabel,%20Col%C3%B3n,%20Panama&dpln=6203540&date1=20/02/2026&date2=22/02/2026&crfrr=defaultFlex&SearchType=Place) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=CTG_SPRING_PROMO_6203540) ## Frequently asked questions ### How much is a rental car per day in Santa Isabel? ### What happens if I need to cancel my Santa Isabel car reservation? ### Where can I go on a road trip from Santa Isabel? > - You'll find Bridge of the Americas and loads more intriguing attractions in Arraijan. From Santa Isabel, it's 80 kilometres away. > - Why not check out the best of Colon too? Notable tourist attractions in this buzzing city include Gatun Locks. Colon is approximately 80 kilometres from Santa Isabel. > - Venao Beach is 257 kilometres from Santa Isabel and is one of the region's most breathtaking nature spots. Stretch your legs and enjoy the fresh air. ### How do I find the best car rental deals in Santa Isabel with Expedia? ### What do you need to rent a car in Santa Isabel? ### What is the cheapest car rental in Santa Isabel? ### Can I rent a car for a month or longer in Santa Isabel? ### Where can I find a Santa Isabel car rental if I am younger than 25? ## Car Rental Information | Popular car types: | [SUV](https://www.expedia.ca/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.ca/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.ca/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.ca/ground-transfers?rfrr=car.table.AirportTransportation) | ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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